{"id":"https://openalex.org/W2054944874","doi":"https://doi.org/10.1074/jbc.274.41.29063","title":"Modulation of L-type Calcium Channel Expression during Retinoic Acid-induced Differentiation of H9C2 Cardiac Cells","display_name":"Modulation of L-type Calcium Channel Expression during Retinoic Acid-induced Differentiation of H9C2 Cardiac Cells","publication_year":1999,"publication_date":"1999-10-01","ids":{"openalex":"https://openalex.org/W2054944874","doi":"https://doi.org/10.1074/jbc.274.41.29063","mag":"2054944874","pmid":"https://pubmed.ncbi.nlm.nih.gov/10506158"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.274.41.29063","doi":"https://doi.org/10.1074/jbc.274.41.29063","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.41.29063","pdf_url":"http://www.jbc.org/article/S0021925819519445/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925819519445/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105268794","display_name":"Claudine M\u00e9nard","orcid":"https://orcid.org/0009-0006-2324-9484","observed_orcids":["https://orcid.org/0009-0006-2324-9484","https://orcid.org/0000-0002-1876-8902"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claudine M\u00e9nard","raw_affiliation_strings":["IGH-CNRS UPR 1142, 141 rue de la Cardonille, 34396 Montpellier cedex 05, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IGH-CNRS UPR 1142, 141 rue de la Cardonille, 34396 Montpellier cedex 05, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017000913","display_name":"Sandrine Pupier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Sandrine Pupier","raw_affiliation_strings":["From the IGH-CNRS UPR 1142, 141 rue de la Cardonille, 34396 Montpellier cedex 05, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the IGH-CNRS UPR 1142, 141 rue de la Cardonille, 34396 Montpellier cedex 05, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078536251","display_name":"Dominique Mornet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Dominique Mornet","raw_affiliation_strings":["From the IGH-CNRS UPR 1142 , 141 rue de la Cardonille , 34396 Montpellier cedex 05 , France and the \u2021Muscles et Pathologies , INSERM , St Eloi , 34000 Montpellier , France","Muscles et Pathologies, INSERM, St Eloi, 34000 Montpellier, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the IGH-CNRS UPR 1142 , 141 rue de la Cardonille , 34396 Montpellier cedex 05 , France and the \u2021Muscles et Pathologies , INSERM , St Eloi , 34000 Montpellier , France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210163339"]},{"raw_affiliation_string":"Muscles et Pathologies, INSERM, St Eloi, 34000 Montpellier, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059493238","display_name":"Magali Kitzmann","orcid":"https://orcid.org/0000-0003-4359-266X","observed_orcids":["https://orcid.org/0000-0003-4359-266X"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Magali Kitzmann","raw_affiliation_strings":["From the IGH-CNRS UPR 1142, 141 rue de la Cardonille, 34396 Montpellier cedex 05, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the IGH-CNRS UPR 1142, 141 rue de la Cardonille, 34396 Montpellier cedex 05, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037127640","display_name":"Jo\u00ebl Nargeot","orcid":"https://orcid.org/0000-0003-2893-5636","observed_orcids":["https://orcid.org/0000-0003-2893-5636"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jo\u00ebl Nargeot","raw_affiliation_strings":["From the IGH-CNRS UPR 1142, 141 rue de la Cardonille, 34396 Montpellier cedex 05, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the IGH-CNRS UPR 1142, 141 rue de la Cardonille, 34396 Montpellier cedex 05, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163339"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041198374","display_name":"Philippe Lory","orcid":"https://orcid.org/0000-0002-1638-7604","observed_orcids":["https://orcid.org/0000-0002-1638-7604"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210163339","display_name":"Institut de G\u00e9n\u00e9tique Humaine","ror":"https://ror.org/05ee10k25","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I19894307","https://openalex.org/I4210096427","https://openalex.org/I4210163339"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Philippe Lory","raw_affiliation_strings":["From the IGH-CNRS UPR 1142, 141 rue de la Cardonille, 34396 Montpellier cedex 05, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the IGH-CNRS UPR 1142, 141 rue de la Cardonille, 34396 Montpellier cedex 05, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163339"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5041198374"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210163339"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.8622,"has_fulltext":true,"cited_by_count":185,"citation_normalized_percentile":{"value":0.67676913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"274","issue":"41","first_page":"29063","last_page":"29070"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.6269999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.6269999742507935,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.3555000126361847,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/l-type-calcium-channels","display_name":"L-type calcium channels","score":0.8600000143051147},{"id":"https://openalex.org/keywords/retinoic-acid","display_name":"retinoic acid","score":0.878000020980835},{"id":"https://openalex.org/keywords/cardiomyocyte-differentiation","display_name":"cardiomyocyte differentiation","score":0.7929999828338623},{"id":"https://openalex.org/keywords/h9c2-cells","display_name":"H9c2 cells","score":0.9760000109672546},{"id":"https://openalex.org/keywords/alpha1c-subunit","display_name":"alpha1C subunit","score":0.8309999704360962},{"id":"https://openalex.org/keywords/skeletal-muscle-differentiation","display_name":"skeletal muscle differentiation","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C60870556","wikidata":"https://www.wikidata.org/wiki/Q2300675","display_name":"Transdifferentiation","level":3,"score":0.655160665512085},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.5906288623809814},{"id":"https://openalex.org/C3763915","wikidata":"https://www.wikidata.org/wiki/Q3331437","display_name":"Myogenesis","level":3,"score":0.5851048231124878},{"id":"https://openalex.org/C26805974","wikidata":"https://www.wikidata.org/wiki/Q7117837","display_name":"P19 cell","level":5,"score":0.5316202044487},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.517774224281311},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4921776354312897},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47411540150642395},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.4723972976207733},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.45544883608818054},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.4526429772377014},{"id":"https://openalex.org/C18699975","wikidata":"https://www.wikidata.org/wiki/Q14905735","display_name":"Voltage-dependent calcium channel","level":3,"score":0.43454238772392273},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.41780585050582886},{"id":"https://openalex.org/C117499352","wikidata":"https://www.wikidata.org/wiki/Q2600696","display_name":"L-type calcium channel","level":4,"score":0.4141950011253357},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39558398723602295},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.39187878370285034},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3206386864185333},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.28486207127571106},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.2199568748474121},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.192363440990448},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.16151270270347595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14698821306228638},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12362417578697205},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09389451146125793},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.09135004878044128}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014212","descriptor_name":"Tretinoin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020746","descriptor_name":"Calcium Channels, L-Type","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.274.41.29063","doi":"https://doi.org/10.1074/jbc.274.41.29063","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.41.29063","pdf_url":"http://www.jbc.org/article/S0021925819519445/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:10506158","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10506158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.274.41.29063","doi":"https://doi.org/10.1074/jbc.274.41.29063","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.274.41.29063","pdf_url":"http://www.jbc.org/article/S0021925819519445/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2054944874.pdf","grobid_xml":"https://content.openalex.org/works/W2054944874.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1596115288","https://openalex.org/W1826549280","https://openalex.org/W1899877571","https://openalex.org/W1901485533","https://openalex.org/W1911535392","https://openalex.org/W1927684145","https://openalex.org/W1969590456","https://openalex.org/W1976271397","https://openalex.org/W1977273311","https://openalex.org/W1987199597","https://openalex.org/W1987416588","https://openalex.org/W1989714306","https://openalex.org/W1991690216","https://openalex.org/W1994446230","https://openalex.org/W1994862194","https://openalex.org/W2002652075","https://openalex.org/W2003758393","https://openalex.org/W2016980442","https://openalex.org/W2025086061","https://openalex.org/W2033926629","https://openalex.org/W2036607708","https://openalex.org/W2038221909","https://openalex.org/W2046286320","https://openalex.org/W2050384831","https://openalex.org/W2058753860","https://openalex.org/W2062831895","https://openalex.org/W2084126214","https://openalex.org/W2085927442","https://openalex.org/W2097066872","https://openalex.org/W2108966702","https://openalex.org/W2112431248","https://openalex.org/W2123111727","https://openalex.org/W2134812217","https://openalex.org/W2134902160","https://openalex.org/W2136628069","https://openalex.org/W2149884613","https://openalex.org/W2152967019","https://openalex.org/W2172530119","https://openalex.org/W2187635291","https://openalex.org/W2292186667","https://openalex.org/W2325001261","https://openalex.org/W2399414035"],"related_works":["https://openalex.org/W4210368469","https://openalex.org/W2025018203","https://openalex.org/W6977328850","https://openalex.org/W2166747313","https://openalex.org/W4414823164","https://openalex.org/W2602657212","https://openalex.org/W2339089826","https://openalex.org/W2033926629","https://openalex.org/W4385505871","https://openalex.org/W2747717460"],"abstract_inverted_index":{"The":[0,107],"molecular":[1],"mechanisms":[2],"underlying":[3],"the":[4,22,170,173,180],"developmental":[5],"regulation":[6],"of":[7,25,50,87,109,125,145,184],"L-type":[8,31,90,138,164],"voltage-dependent":[9],"Ca(2+)":[10,61,139,165,185],"channels":[11,140,186],"(VDCCs)":[12],"are":[13,141],"still":[14],"unknown.":[15],"In":[16,81,152],"this":[17,126],"study,":[18],"we":[19,130],"have":[20],"characterized":[21],"expression":[23,86,183],"patterns":[24],"skeletal":[26,89,111,136,149],"(alpha(1S))":[27],"and":[28,72,112,135,148],"cardiac":[29,60,113,123,134,147,162,189],"(alpha(1C))":[30,163],"VDCCs":[32],"during":[33],"cardiogenic":[34],"differentiation":[35,124],"in":[36,100,158,179,187],"H9C2":[37,51,102],"cells":[38,52],"that":[39,47,97,116,133,157,172],"derived":[40],"from":[41],"embryonic":[42],"rat":[43],"heart.":[44],"We":[45],"report":[46],"chronic":[48],"treatment":[49,84],"with":[53],"10":[54],"nM":[55],"all-trans-retinoic":[56],"acid":[57],"(all-trans-RA)":[58],"enhanced":[59],"channel":[62,166],"expression,":[63,167],"as":[64,76,78],"demonstrated":[65],"by":[66,118],"reverse":[67],"transcription-polymerase":[68],"chain":[69],"reaction,":[70],"immunoblotting,":[71],"indirect":[73],"immunofluorescence":[74],"studies,":[75],"well":[77],"patch-clamp":[79],"experiments.":[80],"addition,":[82],"RA":[83,160,174],"prevented":[85],"functional":[88,143],"VDCCs,":[91],"which":[92],"were":[93],"restricted":[94],"to":[95],"myotubes":[96],"spontaneously":[98],"appear":[99],"control":[101],"cultures":[103],"undergoing":[104],"myogenic":[105,120],"transdifferentiation.":[106],"use":[108],"specific":[110,182],"markers":[114,144],"indicated":[115],"RA,":[117],"preventing":[119],"transdifferentiation,":[121],"preserves":[122],"cell":[127],"line.":[128],"Altogether,":[129],"provide":[131],"evidence":[132],"subtype-specific":[137],"relevant":[142],"differentiated":[146],"myocytes,":[150],"respectively.":[151],"conclusion,":[153],"our":[154],"data":[155],"demonstrate":[156],"vitro":[159],"stimulates":[161],"therefore":[168],"supporting":[169],"hypothesis":[171],"pathway":[175],"might":[176],"be":[177],"involved":[178],"tissue":[181],"mature":[188],"cells.":[190]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}