{"id":"https://openalex.org/W2054944592","doi":"https://doi.org/10.1097/ypg.0b013e328353fb63","title":"Functional studies and rare variant screening of SLC1A1/EAAC1 in males with obsessive\u2013compulsive disorder","display_name":"Functional studies and rare variant screening of SLC1A1/EAAC1 in males with obsessive\u2013compulsive disorder","publication_year":2012,"publication_date":"2012-07-18","ids":{"openalex":"https://openalex.org/W2054944592","doi":"https://doi.org/10.1097/ypg.0b013e328353fb63","mag":"2054944592","pmid":"https://pubmed.ncbi.nlm.nih.gov/22617815","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6486951"},"language":"en","primary_location":{"id":"doi:10.1097/ypg.0b013e328353fb63","doi":"https://doi.org/10.1097/ypg.0b013e328353fb63","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ypg.0b013e328353fb63","pdf_url":null,"source":{"id":"https://openalex.org/S41645954","display_name":"Psychiatric Genetics","issn_l":"0955-8829","issn":["0955-8829","1473-5873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatric Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6486951","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053558359","display_name":"Jeremy M. Veenstra-VanderWeele","orcid":"https://orcid.org/0000-0002-6349-1076","observed_orcids":["https://orcid.org/0000-0002-6349-1076"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["CA","US"],"is_corresponding":true,"raw_author_name":"Jeremy Veenstra-VanderWeele","raw_affiliation_strings":["Department of Psychiatry, University of Vanderbilt, Nashville, Tennessee, USA. j.vvw@vanderbilt.edu","Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Vanderbilt, Nashville, Tennessee, USA. j.vvw@vanderbilt.edu","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102892626","display_name":"Tim Xu","orcid":"https://orcid.org/0000-0001-8392-4345","observed_orcids":["https://orcid.org/0000-0001-8392-4345"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Tim Xu","raw_affiliation_strings":["Department of Psychiatry, Vanderbilt University, Nashville, TN, USA","Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009266915","display_name":"Alicia M. Ruggiero","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Alicia M. Ruggiero","raw_affiliation_strings":["Department of Pharmacology, Vanderbilt University, Nashville, TN, USA","Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103486484","display_name":"Lauren R. Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Lauren R. Anderson","raw_affiliation_strings":["Department of Psychiatry, Vanderbilt University, Nashville, TN, USA","Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102120539","display_name":"Shaine T. Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Shaine T. Jones","raw_affiliation_strings":["Department of Psychiatry, Vanderbilt University, Nashville, TN, USA","Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Vanderbilt University, Nashville, TN, USA","institution_ids":["https://openalex.org/I200719446"]},{"raw_affiliation_string":"Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089202034","display_name":"Joseph A. Himle","orcid":"https://orcid.org/0000-0002-3161-7850","observed_orcids":["https://orcid.org/0000-0002-3161-7850"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Joseph A. Himle","raw_affiliation_strings":["Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA","Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056370228","display_name":"James L. Kennedy","orcid":"https://orcid.org/0000-0002-8733-3806","observed_orcids":["https://orcid.org/0000-0002-8733-3806"]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"James L. Kennedy","raw_affiliation_strings":["Neurogenetics Section, Centre for Addiction and Mental Health, and","Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurogenetics Section, Centre for Addiction and Mental Health, and","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036285184","display_name":"Margaret Anne Richter","orcid":"https://orcid.org/0000-0001-5450-2936","observed_orcids":["https://orcid.org/0000-0001-5450-2936"]},"institutions":[{"id":"https://openalex.org/I1323843004","display_name":"Sunnybrook Health Science Centre","ror":"https://ror.org/03wefcv03","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1323843004"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Margaret A. Richter","raw_affiliation_strings":["Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada","Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I1323843004","https://openalex.org/I185261750"]},{"raw_affiliation_string":"Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027815153","display_name":"Gregory L. Hanna","orcid":"https://orcid.org/0000-0002-0742-6990","observed_orcids":["https://orcid.org/0000-0002-0742-6990"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Gregory L. Hanna","raw_affiliation_strings":["Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA","Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007250735","display_name":"Paul Daniel Arnold","orcid":"https://orcid.org/0000-0003-2496-4624","observed_orcids":["https://orcid.org/0000-0003-2496-4624"]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I2801317318","display_name":"Hospital for Sick Children","ror":"https://ror.org/057q4rt57","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801317318"]}],"countries":["CA","US"],"is_corresponding":false,"raw_author_name":"Paul D. Arnold","raw_affiliation_strings":["Department of Psychiatry, Hospital for Sick Children, Toronto, ON, Canada","Neurogenetics Section, Centre for Addiction and Mental Health, and","Program in Genetics and Genomic Biology, Hospital for Sick Children, Toronto, ON, Canada","Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Hospital for Sick Children, Toronto, ON, Canada","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"Neurogenetics Section, Centre for Addiction and Mental Health, and","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Program in Genetics and Genomic Biology, Hospital for Sick Children, Toronto, ON, Canada","institution_ids":["https://openalex.org/I2801317318"]},{"raw_affiliation_string":"Accepted January 15, 2012; Departments of aPsychiatry; Margaret A. Richter, Gregory L. Hanna, and Paul D. Arnold have contributed equally to the writing of this article.; Received May 20, 2011; bPharmacology; cPediatrics; dCenter for Molecular Neuroscience; e-mail: [email\u00a0protected]; eKennedy Center for Research on Human Development, University of Vanderbilt, Nashville, Tennessee; fDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA; fax: +1 615 936 7475; gNeurogenetics Section, Centre for Addiction and Mental Health; hDepartment of Psychiatry, Sunnybrook Health Sciences Centre, University of Toronto; iProgram in Genetics and Genomic Biology; jDepartment of Psychiatry, Hospital for Sick Children, Toronto, Ontario, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5053558359"],"corresponding_institution_ids":["https://openalex.org/I185261750","https://openalex.org/I200719446","https://openalex.org/I27837315"],"apc_list":null,"apc_paid":null,"fwci":3.6657,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.9188334,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"22","issue":"5","first_page":"256","last_page":"260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/slc1a1","display_name":"SLC1A1","score":0.902999997138977},{"id":"https://openalex.org/keywords/eaac1","display_name":"EAAC1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/glutamate-transporters","display_name":"glutamate transporters","score":0.8489999771118164},{"id":"https://openalex.org/keywords/obsessive-compulsive-disorder","display_name":"obsessive-compulsive disorder","score":0.9990000128746033},{"id":"https://openalex.org/keywords/rare-variants","display_name":"rare variants","score":0.7170000076293945},{"id":"https://openalex.org/keywords/missense-mutations","display_name":"missense mutations","score":0.8190000057220459},{"id":"https://openalex.org/keywords/transporter-function","display_name":"transporter function","score":0.5210000276565552},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.5019999742507935},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.3959999978542328}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6415061354637146},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.5358181595802307},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5043123960494995},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.499584436416626},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4616592824459076},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.44412633776664734},{"id":"https://openalex.org/C113657865","wikidata":"https://www.wikidata.org/wiki/Q5419641","display_name":"Excitatory amino-acid transporter","level":4,"score":0.419726699590683},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.35074707865715027},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.317402720451355},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.287303626537323},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.07192575931549072}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018698","descriptor_name":"Glutamic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050580","descriptor_name":"Excitatory Amino Acid Transporter 3","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1097/ypg.0b013e328353fb63","doi":"https://doi.org/10.1097/ypg.0b013e328353fb63","is_oa":false,"landing_page_url":"https://doi.org/10.1097/ypg.0b013e328353fb63","pdf_url":null,"source":{"id":"https://openalex.org/S41645954","display_name":"Psychiatric Genetics","issn_l":"0955-8829","issn":["0955-8829","1473-5873"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatric Genetics","raw_type":"journal-article"},{"id":"pmid:22617815","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22617815","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychiatric genetics","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5467519","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6486951","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6486951","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6486951","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Psychiatr Genet","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5467519","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6486951","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2106850534","display_name":"Murine Genetic Models of Autism","funder_award_id":"K08MH081066","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G3455872698","display_name":"MOLECULAR GENETICS OF OBSESSIVE COMPULSIVE DISORDER","funder_award_id":"R01MH058376","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G5838706957","display_name":"The Vanderbilt Institute for Clinical and Translational Research (VICTR) KL2","funder_award_id":"KL2RR024977","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G5931501762","display_name":"FAMILY STUDY OF OBSESSIVE-COMPULSIVE DISORDER","funder_award_id":"K20MH001065","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G6057065594","display_name":"The Vanderbilt Institute for Clinical and Translational Research (VICTR) TL1","funder_award_id":"TL1RR024978","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G6628171993","display_name":"The Vanderbilt Institute for Clinical and Translational Research (VICTR) UL1","funder_award_id":"UL1RR024975","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"}],"funders":[{"id":"https://openalex.org/F4320309151","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1568552337","https://openalex.org/W1664703379","https://openalex.org/W1679634005","https://openalex.org/W1966460145","https://openalex.org/W1969063946","https://openalex.org/W1973748621","https://openalex.org/W1981139906","https://openalex.org/W1990016886","https://openalex.org/W1994727775","https://openalex.org/W1997031801","https://openalex.org/W1997727568","https://openalex.org/W2000092485","https://openalex.org/W2004195391","https://openalex.org/W2006001020","https://openalex.org/W2027249547","https://openalex.org/W2034703968","https://openalex.org/W2050161506","https://openalex.org/W2050301036","https://openalex.org/W2073953555","https://openalex.org/W2075363163","https://openalex.org/W2078966869","https://openalex.org/W2081841619","https://openalex.org/W2082011456","https://openalex.org/W2083347740","https://openalex.org/W2090993584","https://openalex.org/W2097386588","https://openalex.org/W2100339260","https://openalex.org/W2103064125","https://openalex.org/W2105697752","https://openalex.org/W2114409847","https://openalex.org/W2123822033","https://openalex.org/W2138137036","https://openalex.org/W2140166139","https://openalex.org/W2142097068","https://openalex.org/W2143027421","https://openalex.org/W2147627275","https://openalex.org/W2152284414","https://openalex.org/W2154076220","https://openalex.org/W2171629666"],"related_works":["https://openalex.org/W2100339260","https://openalex.org/W2097386588","https://openalex.org/W2154076220","https://openalex.org/W2129095074","https://openalex.org/W7097181666","https://openalex.org/W1973748621","https://openalex.org/W2078966869","https://openalex.org/W1981139906","https://openalex.org/W2143027421","https://openalex.org/W2105697752"],"abstract_inverted_index":{"Several":[0],"studies":[1,24],"have":[2,25,41],"found":[3,108],"that":[4,37,109],"the":[5,78,94,97,110,133],"neuronal":[6,142],"glutamate":[7],"transporter":[8,89],"gene":[9],"SLC1A1/EAAC1":[10,138],"is":[11,83],"associated":[12],"with":[13,17,48,65],"obsessive-compulsive":[14],"disorder":[15],"(OCD),":[16],"a":[18],"stronger":[19],"association":[20],"in":[21,53,104,120],"males.":[22],"Previous":[23],"primarily":[26],"focused":[27],"on":[28,141],"common":[29],"single-nucleotide":[30],"polymorphisms,":[31],"rather":[32],"than":[33,85],"rare":[34,51,137],"functional":[35],"variants":[36],"are":[38],"likely":[39],"to":[40,114,131,147],"larger":[42],"effects.":[43],"We":[44,92],"screened":[45],"184":[46],"males":[47],"OCD":[49],"for":[50,86],"variation":[52,60],"SLC1A1":[54,70,99],"exons;":[55],"however,":[56],"no":[57],"new":[58],"coding":[59],"was":[61],"found.":[62],"When":[63],"combined":[64],"previous":[66],"screens,":[67],"only":[68],"one":[69,98],"amino":[71],"acid":[72],"variant":[73,101,140],"has":[74],"been":[75],"detected":[76],"among":[77],"841":[79],"individuals":[80],"screened,":[81],"which":[82],"less":[84],"other":[87],"neurotransmitter":[88],"genes":[90],"(P=0.0001).":[91],"characterized":[93],"function":[95,143],"of":[96,135],"missense":[100],"reported":[102],"previously":[103],"OCD,":[105],"Thr164Ala,":[106],"and":[107,117,144],"Ala164":[111,139],"allele":[112],"leads":[113],"decreased":[115],"Vmax":[116],"Km":[118],"(P<0.0001)":[119],"transfected":[121],"human":[122],"embryonic":[123],"kidney":[124],"cells.":[125],"Further":[126],"work":[127],"will":[128],"be":[129],"necessary":[130],"understand":[132],"impact":[134],"this":[136],"circuitry":[145],"relevant":[146],"OCD.":[148]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}