{"id":"https://openalex.org/W2054922925","doi":"https://doi.org/10.7326/0003-4819-68-5-1184_2","title":"The Induction of Asthma Attacks by Saline.","display_name":"The Induction of Asthma Attacks by Saline.","publication_year":1968,"publication_date":"1968-05-01","ids":{"openalex":"https://openalex.org/W2054922925","doi":"https://doi.org/10.7326/0003-4819-68-5-1184_2","mag":"2054922925"},"language":"en","primary_location":{"id":"doi:10.7326/0003-4819-68-5-1184_2","doi":"https://doi.org/10.7326/0003-4819-68-5-1184_2","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-68-5-1184_2","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048656238","display_name":"Eugene R. Bleecker","orcid":"https://orcid.org/0000-0002-4767-3494","observed_orcids":["https://orcid.org/0000-0002-4767-3494"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Eugene R. Bleecker","raw_affiliation_strings":["Brooklyn, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brooklyn, New York","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"E. R. McFadden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. R. McFadden","raw_affiliation_strings":["Brooklyn, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brooklyn, New York","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thomas Luparello","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Luparello","raw_affiliation_strings":["Brooklyn, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brooklyn, New York","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Harold A. Lyons","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Harold A. Lyons","raw_affiliation_strings":["Brooklyn, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brooklyn, New York","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5048656238"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16910331,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"68","issue":"5","first_page":"1184","last_page":"1184"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12208","display_name":"Occupational exposure and asthma","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.8659999966621399},{"id":"https://openalex.org/keywords/bronchospasm","display_name":"bronchospasm","score":0.8519999980926514},{"id":"https://openalex.org/keywords/placebo-effect","display_name":"placebo effect","score":0.5550000071525574},{"id":"https://openalex.org/keywords/allergen-inhalation","display_name":"allergen inhalation","score":0.5189999938011169},{"id":"https://openalex.org/keywords/airway-resistance","display_name":"airway resistance","score":0.7630000114440918},{"id":"https://openalex.org/keywords/conductance","display_name":"conductance","score":0.5659999847412109},{"id":"https://openalex.org/keywords/thoracic-gas-volume","display_name":"thoracic gas volume","score":0.890999972820282},{"id":"https://openalex.org/keywords/attention","display_name":"attention","score":0.3529999852180481},{"id":"https://openalex.org/keywords/dust","display_name":"dust","score":0.3009999990463257},{"id":"https://openalex.org/keywords/pollen","display_name":"pollen","score":0.7749999761581421},{"id":"https://openalex.org/keywords/animal-dander","display_name":"animal dander","score":0.8840000033378601}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8906258344650269},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.6071216464042664},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.6038163900375366},{"id":"https://openalex.org/C2778088044","wikidata":"https://www.wikidata.org/wiki/Q279330","display_name":"Bronchospasm","level":3,"score":0.5654271841049194},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.49865221977233887},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4482281506061554},{"id":"https://openalex.org/C73362275","wikidata":"https://www.wikidata.org/wiki/Q181277","display_name":"Plethysmograph","level":2,"score":0.42897799611091614},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4157640337944031},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2652647793292999},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11209732294082642},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7326/0003-4819-68-5-1184_2","doi":"https://doi.org/10.7326/0003-4819-68-5-1184_2","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-68-5-1184_2","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2320154214","https://openalex.org/W1919304416","https://openalex.org/W2084213600","https://openalex.org/W2806541464","https://openalex.org/W2326720322","https://openalex.org/W2140058882","https://openalex.org/W2056496988","https://openalex.org/W2361048260","https://openalex.org/W2142200104","https://openalex.org/W2406882547"],"abstract_inverted_index":{"s1":[0],"May":[1,216,229],"1968The":[2],"Induction":[3],"of":[4,76,79,84,105,115,136],"Asthma":[5],"Attacks":[6],"by":[7,29,40,49,60,81,147],"Saline.Eugene":[8],"R.":[9,12,24,33,194,197],"Bleecker,":[10],"E.":[11,32,196],"McFadden":[13,34],"Jr.,":[14,35],"M.D.,":[15,18,22,55,206],"Thomas":[16,43,200],"Luparello,":[17,44,201],"Harold":[19,52,203],"A.":[20,53,204],"Lyons,":[21,54,205],"F.A.C.P.Eugene":[23],"BleeckerSearch":[25],"for":[26,37,46,57],"more":[27,38,47,58],"papers":[28,39,48,59],"this":[30,41,50,61],"author,":[31,42,51],"M.D.Search":[36,45],"F.A.C.P.Search":[56],"authorAuthor,":[62],"Article,":[63,189],"and":[64,140,152,164,190],"Disclosure":[65,191],"Informationhttps://doi.org/10.7326/0003-4819-68-5-1184_2":[66],"SectionsAboutPDF":[67],"ToolsAdd":[68],"to":[69,159],"favoritesDownload":[70],"CitationsTrack":[71],"CitationsPermissions":[72],"ShareFacebookTwitterLinkedInRedditEmail":[73],"ExcerptThe":[74],"induction":[75],"acute":[77],"attacks":[78,118],"bronchospasm":[80],"the":[82,113,129,185],"use":[83],"a":[85,167],"placebo":[86],"was":[87,95,132,157],"investigated":[88],"in":[89],"40":[90],"asthmatic":[91],"subjects.":[92],"Each":[93],"patient":[94],"told":[96],"that":[97,108],"he":[98,109],"would":[99],"be":[100],"inhaling":[101],"5":[102],"different":[103],"concentrations":[104],"some":[106],"allergen":[107],"had":[110],"indicated":[111],"as":[112,166],"cause":[114],"his":[116],"asthma":[117],"(for":[119],"example,":[120],"dust,":[121],"pollens,":[122],"animal":[123],"danders,":[124],"etc.).":[125],"In":[126],"all":[127],"cases":[128],"substance":[130],"inhaled":[131],"physiologic":[133],"saline.":[134],"Measurements":[135],"airway":[137],"resistance":[138],"(Ra)":[139],"thoracic":[141],"gas":[142,169],"volume":[143,170],"(TGV)":[144],"were":[145],"determined":[146],"pressure":[148],"body":[149],"plethysmography":[150],"before":[151],"after":[153],"each":[154],"inhalation.":[155],"Ra":[156],"converted":[158],"its":[160],"reciprocal":[161],"conductance":[162],"(Ga)":[163],"expressed":[165],"conductance-thoracic":[168],"ratio":[171],"(Ga/TGV).":[172],"The...":[173],"This":[174],"content":[175],"is":[176],"PDF":[177,186,231],"only.":[178],"To":[179],"continue":[180],"reading":[181],"please":[182],"click":[183],"on":[184],"icon.":[187],"Author,":[188],"InformationAuthors:":[192],"Eugene":[193],"Bleecker;":[195],"McFaddenJr.,":[198],"M.D.;":[199,202],"F.A.C.P.Affiliations:":[207],"Brooklyn,":[208],"New":[209],"York":[210],"PreviousarticleNextarticle":[211],"Advertisement":[212],"FiguresReferencesRelatedDetails":[213],"Metrics":[214],"1":[215,223,228],"1968Volume":[217],"68,":[218],"Issue":[219,226],"5Page:":[220],"1184-1184KeywordsAllergensAsthmaAttentionDustInhalationPollen":[221],"ePublished:":[222],"December":[224],"2008":[225],"Published:":[227],"1968":[230],"downloadLoading":[232],"...":[233]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}