{"id":"https://openalex.org/W2054907115","doi":"https://doi.org/10.1161/01.cir.64.4.760","title":"Borderline hypertension: relationship between age, hemodynamics and circulating catecholamines.","display_name":"Borderline hypertension: relationship between age, hemodynamics and circulating catecholamines.","publication_year":1981,"publication_date":"1981-10-01","ids":{"openalex":"https://openalex.org/W2054907115","doi":"https://doi.org/10.1161/01.cir.64.4.760","mag":"2054907115","pmid":"https://pubmed.ncbi.nlm.nih.gov/7273377"},"language":"en","primary_location":{"id":"doi:10.1161/01.cir.64.4.760","doi":"https://doi.org/10.1161/01.cir.64.4.760","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.64.4.760","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.64.4.760","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.64.4.760","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5021945153","display_name":"Franz H. Messerli","orcid":"https://orcid.org/0000-0002-4107-2583","observed_orcids":["https://orcid.org/0000-0002-4107-2583"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F H Messerli","raw_affiliation_strings":["F H Messerli"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F H Messerli","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111755269","display_name":"Edward D. Frohlich","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E D Frohlich","raw_affiliation_strings":["E D Frohlich"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"E D Frohlich","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111745776","display_name":"D H Suarez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D H Suarez","raw_affiliation_strings":["D H Suarez"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"D H Suarez","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003460768","display_name":"Efrain Reisin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Reisin","raw_affiliation_strings":["E Reisin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"E Reisin","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003468332","display_name":"Gerald R. Dreslinski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G R Dreslinski","raw_affiliation_strings":["G R Dreslinski"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"G R Dreslinski","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024567725","display_name":"F G Dunn","orcid":"https://orcid.org/0000-0002-0235-0085","observed_orcids":["https://orcid.org/0000-0002-0235-0085"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F G Dunn","raw_affiliation_strings":["F G Dunn"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F G Dunn","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111702058","display_name":"Francis E. Cole","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F E Cole","raw_affiliation_strings":["F E Cole"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F E Cole","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.819,"has_fulltext":true,"cited_by_count":154,"citation_normalized_percentile":{"value":0.97568257,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"64","issue":"4","first_page":"760","last_page":"764"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.003800000064074993,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-output","display_name":"cardiac output","score":0.7289999723434448},{"id":"https://openalex.org/keywords/renal-blood-flow","display_name":"renal blood flow","score":0.9829999804496765},{"id":"https://openalex.org/keywords/systemic-vascular-resistance","display_name":"systemic vascular resistance","score":0.9300000071525574},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.8889999985694885},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.8859999775886536},{"id":"https://openalex.org/keywords/circulating-catecholamines","display_name":"circulating catecholamines","score":0.8169999718666077},{"id":"https://openalex.org/keywords/intravascular-volume","display_name":"intravascular volume","score":0.8240000009536743},{"id":"https://openalex.org/keywords/hyperdynamic-circulation","display_name":"hyperdynamic circulation","score":0.8289999961853027}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9133699536323547},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7362661361694336},{"id":"https://openalex.org/C2778514916","wikidata":"https://www.wikidata.org/wiki/Q186242","display_name":"Norepinephrine","level":3,"score":0.684125542640686},{"id":"https://openalex.org/C2775859304","wikidata":"https://www.wikidata.org/wiki/Q132621","display_name":"Epinephrine","level":2,"score":0.6467195153236389},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.6380311250686646},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.6339278221130371},{"id":"https://openalex.org/C142225936","wikidata":"https://www.wikidata.org/wiki/Q1129139","display_name":"Renal blood flow","level":3,"score":0.5879768133163452},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5607218146324158},{"id":"https://openalex.org/C31861589","wikidata":"https://www.wikidata.org/wiki/Q618068","display_name":"Cardiac index","level":4,"score":0.5528714060783386},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.48115289211273193},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4788675010204315},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4293908178806305},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.4120026230812073},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.23952478170394897},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001810","descriptor_name":"Blood Volume","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002395","descriptor_name":"Catecholamines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1161/01.cir.64.4.760","doi":"https://doi.org/10.1161/01.cir.64.4.760","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.64.4.760","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.64.4.760","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},{"id":"pmid:7273377","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7273377","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.625.4388","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.625.4388","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://circ.ahajournals.org/content/64/4/760.full.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1161/01.cir.64.4.760","doi":"https://doi.org/10.1161/01.cir.64.4.760","is_oa":true,"landing_page_url":"https://doi.org/10.1161/01.cir.64.4.760","pdf_url":"https://www.ahajournals.org/doi/pdf/10.1161/01.CIR.64.4.760","source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2054907115.pdf","grobid_xml":"https://content.openalex.org/works/W2054907115.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1491824732","https://openalex.org/W1887431935","https://openalex.org/W1963989474","https://openalex.org/W1969483062","https://openalex.org/W1972270547","https://openalex.org/W1979935281","https://openalex.org/W1999533387","https://openalex.org/W2006760408","https://openalex.org/W2015454845","https://openalex.org/W2017455661","https://openalex.org/W2017508342","https://openalex.org/W2061732868","https://openalex.org/W2062587801","https://openalex.org/W2062851415","https://openalex.org/W2073091034","https://openalex.org/W2074614015","https://openalex.org/W2086449816","https://openalex.org/W2102253954","https://openalex.org/W2114914136","https://openalex.org/W2117773619","https://openalex.org/W2145515888","https://openalex.org/W2152272825","https://openalex.org/W2395656666","https://openalex.org/W2400024552","https://openalex.org/W2411689448","https://openalex.org/W2419896127","https://openalex.org/W2435631623","https://openalex.org/W2987147922"],"related_works":["https://openalex.org/W7100749298","https://openalex.org/W2033757938","https://openalex.org/W2395574992","https://openalex.org/W2027895758","https://openalex.org/W2092210189","https://openalex.org/W2009486323","https://openalex.org/W1978516498","https://openalex.org/W2409125263","https://openalex.org/W2310128014","https://openalex.org/W1993544958"],"abstract_inverted_index":{"The":[0,237],"relationships":[1],"between":[2],"age,":[3,62],"systemic":[4],"and":[5,12,14,23,43,106,125,168,184,206,233,243],"renal":[6,44,107,135,207],"hemodynamics,":[7],"circulating":[8,241],"catecholamines":[9],"(norepinephrine,":[10],"epinephrine":[11,162,246],"dopamine)":[13],"intravascular":[15],"volumes":[16],"were":[17,56],"studied":[18],"in":[19,24,64,78,90,121,126,138,216,240,245,250,260,267],"38":[20],"normotensive":[21,52],"subjects":[22,53,140],"77":[25],"patients":[26,33,66,91,217,224],"with":[27,119,134,152,174,186],"borderline":[28,80,211],"essential":[29],"hypertension.":[30],"Borderline":[31],"hypertensive":[32,81],"had":[34],"a":[35,264],"higher":[36],"cardiac":[37,175,204,235],"index":[38],"(p":[39,47,86],"less":[40,48,87,103,114,145,158,181,193],"than":[41,49,51,58,88,93,104,115,146,159,182,194,219],"0.02)":[42,89],"blood":[45,108,136,170,208],"flow":[46,109,137],"0.05)":[50],"if":[54],"they":[55],"younger":[57,218],"30":[59,221],"years":[60],"of":[61,210,253],"whereas":[63,161],"older":[65,92,269],"no":[67],"difference":[68],"was":[69,76],"observed.":[70],"In":[71],"contrast,":[72],"total":[73,169,230],"peripheral":[74,187,231],"resistance":[75,188,232],"normal":[77,234],"young":[79,262],"patients,":[82],"but":[83],"significantly":[84],"increased":[85,151],"age":[94,120,153,220],"40":[95],"years.":[96,222],"Cardiac":[97,129],"output":[98,130,176,205],"(r":[99,110,141,154,177,189],"=":[100,111,142,155,178,190],"-0.28,":[101],"p":[102,113,144,157,180,192],"0.01)":[105],"-0.47,":[112],"0.001)":[116,183],"correlated":[117,132,172],"inversely":[118,185],"the":[122,200,251,254,261,268],"entire":[123],"population":[124],"both":[127],"subgroups.":[128],"also":[131],"closely":[133],"all":[139],"0.45,":[143],"0.001).":[147,195],"Circulating":[148],"norepinephrine":[149,242],"levels":[150,247],"0.25,":[156],"0.05),":[160],"concentration":[163],"tended":[164],"to":[165,263],"decrease.":[166],"Plasma":[167],"volume":[171],"directly":[173],"0.39,":[179],"-0.34,":[191],"These":[196],"data":[197],"indicate":[198],"that":[199],"hyperdynamic":[201],"circulation":[202],"(high":[203],"flow)":[209],"hypertension":[212,259,266],"is":[213],"found":[214],"predominantly":[215],"Older":[223],"are":[225],"characterized":[226],"by":[227],"an":[228],"elevated":[229],"output.":[236],"age-dependent":[238],"increase":[239],"decrease":[244],"may":[248],"participate":[249],"shift":[252],"hemodynamic":[255],"profile":[256],"from":[257],"high-cardiac-output":[258],"high-arteriolar-resistance":[265],"patient.":[270]},"counts_by_year":[{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
