{"id":"https://openalex.org/W2054906410","doi":"https://doi.org/10.1111/j.1365-2885.2008.00952.x","title":"Safety, pharmacokinetics and use of the novel NK\u20101 receptor antagonist maropitant (Cerenia TM ) for the prevention of emesis and motion sickness in cats","display_name":"Safety, pharmacokinetics and use of the novel NK\u20101 receptor antagonist maropitant (Cerenia TM ) for the prevention of emesis and motion sickness in cats","publication_year":2008,"publication_date":"2008-05-08","ids":{"openalex":"https://openalex.org/W2054906410","doi":"https://doi.org/10.1111/j.1365-2885.2008.00952.x","mag":"2054906410","pmid":"https://pubmed.ncbi.nlm.nih.gov/18471143"},"language":"en","primary_location":{"id":"doi:10.1111/j.1365-2885.2008.00952.x","doi":"https://doi.org/10.1111/j.1365-2885.2008.00952.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2885.2008.00952.x","pdf_url":null,"source":{"id":"https://openalex.org/S23625584","display_name":"Journal of Veterinary Pharmacology and Therapeutics","issn_l":"0140-7783","issn":["0140-7783","1365-2885"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Pharmacology and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111900966","display_name":"M. Anne Hickman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. A. HICKMAN","raw_affiliation_strings":["Pfizer Animal Health, Discovery Research, Pfizer Inc, Kalamazoo, MI 49001, USA","Pfizer Animal Health, Discovery Research, Pfizer Inc, Kalamazoo, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Animal Health, Discovery Research, Pfizer Inc, Kalamazoo, MI 49001, USA","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Pfizer Animal Health, Discovery Research, Pfizer Inc, Kalamazoo, MI, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113661686","display_name":"Steven R. Cox","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. R. COX","raw_affiliation_strings":["Pfizer Animal Health, Discovery Research, Pfizer Inc, Kalamazoo, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Animal Health, Discovery Research, Pfizer Inc, Kalamazoo, MI, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053715070","display_name":"Sean P. Mahabir","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. MAHABIR","raw_affiliation_strings":["Pfizer Animal Health, Discovery Research, Pfizer Inc, Kalamazoo, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Animal Health, Discovery Research, Pfizer Inc, Kalamazoo, MI, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000294015","display_name":"Christine Miskell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. MISKELL","raw_affiliation_strings":["Pfizer Animal Health, Discovery Research, Pfizer Inc, Kalamazoo, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Animal Health, Discovery Research, Pfizer Inc, Kalamazoo, MI, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068034539","display_name":"John Chia-Yang Lin","orcid":"https://orcid.org/0000-0002-2596-969X","observed_orcids":["https://orcid.org/0000-0002-2596-969X"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. LIN","raw_affiliation_strings":["Pfizer Animal Health, Discovery Research, Pfizer Inc, Kalamazoo, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Animal Health, Discovery Research, Pfizer Inc, Kalamazoo, MI, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. BUNGER","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. BUNGER","raw_affiliation_strings":["Pfizer Animal Health, Discovery Research, Pfizer Inc, Kalamazoo, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Animal Health, Discovery Research, Pfizer Inc, Kalamazoo, MI, USA","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109546750","display_name":"Robert B. McCall","orcid":"https://orcid.org/0009-0008-8811-151X","observed_orcids":["https://orcid.org/0009-0008-8811-151X"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"R. B. McCALL","raw_affiliation_strings":["Pfizer Animal Health, Discovery Research, Pfizer Inc, Kalamazoo, MI, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Animal Health, Discovery Research, Pfizer Inc, Kalamazoo, MI, USA","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109546750"],"corresponding_institution_ids":["https://openalex.org/I180857899"],"apc_list":{"value":4520,"currency":"USD","value_usd":4520},"apc_paid":null,"fwci":5.4764,"has_fulltext":false,"cited_by_count":128,"citation_normalized_percentile":{"value":0.95449602,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"31","issue":"3","first_page":"220","last_page":"229"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11785","display_name":"Nausea and vomiting management","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.026200000196695328,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/maropitant","display_name":"maropitant","score":1.0},{"id":"https://openalex.org/keywords/nk1-receptor-antagonists","display_name":"NK1 receptor antagonists","score":0.9610000252723694},{"id":"https://openalex.org/keywords/cats","display_name":"cats","score":0.8840000033378601},{"id":"https://openalex.org/keywords/antiemetic-activity","display_name":"antiemetic activity","score":0.6909999847412109},{"id":"https://openalex.org/keywords/emesis-prevention","display_name":"emesis prevention","score":0.8109999895095825},{"id":"https://openalex.org/keywords/motion-sickness","display_name":"motion sickness","score":0.9829999804496765},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8840000033378601},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.8759999871253967},{"id":"https://openalex.org/keywords/bioavailability","display_name":"bioavailability","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C2779336972","wikidata":"https://www.wikidata.org/wiki/Q309067","display_name":"Motion sickness","level":2,"score":0.6969107389450073},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6032748818397522},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.5199047923088074},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5093358755111694},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4734850823879242},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3845604360103607},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22767487168312073},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.198055237531662},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1720433235168457}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009041","descriptor_name":"Motion Sickness","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D009041","descriptor_name":"Motion Sickness","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D009041","descriptor_name":"Motion Sickness","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D011812","descriptor_name":"Quinuclidines","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011812","descriptor_name":"Quinuclidines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011812","descriptor_name":"Quinuclidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D014839","descriptor_name":"Vomiting","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D064729","descriptor_name":"Neurokinin-1 Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1365-2885.2008.00952.x","doi":"https://doi.org/10.1111/j.1365-2885.2008.00952.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1365-2885.2008.00952.x","pdf_url":null,"source":{"id":"https://openalex.org/S23625584","display_name":"Journal of Veterinary Pharmacology and Therapeutics","issn_l":"0140-7783","issn":["0140-7783","1365-2885"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Veterinary Pharmacology and Therapeutics","raw_type":"journal-article"},{"id":"pmid:18471143","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18471143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of veterinary pharmacology and therapeutics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W36583777","https://openalex.org/W154326007","https://openalex.org/W240780613","https://openalex.org/W639474554","https://openalex.org/W1530619192","https://openalex.org/W1645088964","https://openalex.org/W1966546066","https://openalex.org/W1968698882","https://openalex.org/W1980143995","https://openalex.org/W1983413945","https://openalex.org/W2000639482","https://openalex.org/W2017744461","https://openalex.org/W2021204422","https://openalex.org/W2021465015","https://openalex.org/W2021563089","https://openalex.org/W2028281991","https://openalex.org/W2046581354","https://openalex.org/W2069306418","https://openalex.org/W2072300509","https://openalex.org/W2122695097","https://openalex.org/W2154000630","https://openalex.org/W2157559025","https://openalex.org/W2171587188","https://openalex.org/W2951411646","https://openalex.org/W3027496201"],"related_works":["https://openalex.org/W2021563089","https://openalex.org/W2280931102","https://openalex.org/W2746106045","https://openalex.org/W2515831360","https://openalex.org/W2377296786","https://openalex.org/W1996683804","https://openalex.org/W2940222134","https://openalex.org/W2129179344","https://openalex.org/W2116810402","https://openalex.org/W4389816734"],"abstract_inverted_index":{"The":[0,140],"present":[1],"study":[2],"characterizes":[3],"the":[4,11,18,45,51,171],"safety,":[5],"pharmacokinetics,":[6],"and":[7,60,88,99,104,109,147,180],"anti-emetic":[8,47,183],"effects":[9],"of":[10,21,28,50,58,75,96,102,126,153],"selective":[12],"NK-1":[13,172],"receptor":[14,173],"antagonist":[15,174],"maropitant":[16,22,76,129,175],"in":[17,39,77,161,165,185],"cat.":[19],"Safety":[20],"was":[23,36,113,158],"determined":[24,80,114],"following":[25,81],"15":[26],"days":[27],"subcutaneous":[29],"(SC)":[30],"administration":[31],"at":[32,41,54,71],"0.5-5":[33],"mg/kg.":[34],"Maropitant":[35,91,155],"well":[37,177],"tolerated":[38],"cats":[40,78],"doses":[42],"that":[43,170],"exceeded":[44],"efficacious":[46],"dose":[48,83],"range":[49],"drug":[52],"by":[53,119,122,138],"least":[55],"a":[56,93,100,148],"factor":[57],"10":[59],"adverse":[61],"clinical":[62],"signs":[63],"or":[64,121,133],"pathological":[65],"safety":[66],"findings":[67],"were":[68,79],"not":[69],"noted":[70],"any":[72],"dose.The":[73],"pharmacokinetics":[74],"single":[82],"oral":[84,144],"(PO),":[85],"intravenous":[86],"(IV)":[87],"SC":[89,132],"administration.":[90],"had":[92,142],"terminal":[94],"half-life":[95],"13-17":[97],"h":[98],"bioavailability":[101],"50":[103],"117%":[105],"when":[106],"administered":[107,130],"PO":[108,134],"SC,":[110],"respectively.":[111],"Efficacy":[112],"against":[115],"emesis":[116,136,164],"induced":[117],"either":[118],"xylazine":[120],"motion.":[123],"A":[124],"dosage":[125],"1":[127],"mg/kg":[128],"IV,":[131],"prevented":[135],"elicited":[137],"xylazine.":[139],"compound":[141],"good":[143],"antiemetic":[145],"activity":[146],"long":[149],"(24":[150],"h)":[151],"duration":[152],"action.":[154],"(1.0":[156],"mg/kg)":[157],"highly":[159],"effective":[160],"preventing":[162],"motion-induced":[163],"cats.":[166,186],"These":[167],"studies":[168],"indicate":[169],"is":[176],"tolerated,":[178],"safe":[179],"has":[181],"excellent":[182],"properties":[184]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
