{"id":"https://openalex.org/W2054885243","doi":"https://doi.org/10.1038/ng.1007","title":"Predicting phenotypic variation in yeast from individual genome sequences","display_name":"Predicting phenotypic variation in yeast from individual genome sequences","publication_year":2011,"publication_date":"2011-11-13","ids":{"openalex":"https://openalex.org/W2054885243","doi":"https://doi.org/10.1038/ng.1007","mag":"2054885243","pmid":"https://pubmed.ncbi.nlm.nih.gov/22081227"},"language":"en","primary_location":{"id":"doi:10.1038/ng.1007","doi":"https://doi.org/10.1038/ng.1007","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ng.1007","pdf_url":null,"source":{"id":"https://openalex.org/S137905309","display_name":"Nature Genetics","issn_l":"1061-4036","issn":["1061-4036","1546-1718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Genetics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052006543","display_name":"Rob Jelier","orcid":"https://orcid.org/0000-0002-6395-1407","observed_orcids":["https://orcid.org/0000-0002-6395-1407"]},"institutions":[{"id":"https://openalex.org/I4210097140","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/010jaxs89","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210097140","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rob Jelier","raw_affiliation_strings":["European Molecular Biology Laboratory, Centre for Genomic Regulation, Systems Biology Research Unit, Barcelona, Spain","European Molecular Biology Laboratory\u2014Centre for Genomic Regulation (EMBL-CRG) Systems Biology Research Unit, Centre for Genomic Regulation, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory, Centre for Genomic Regulation, Systems Biology Research Unit, Barcelona, Spain","institution_ids":["https://openalex.org/I4210097140","https://openalex.org/I4210137962"]},{"raw_affiliation_string":"European Molecular Biology Laboratory\u2014Centre for Genomic Regulation (EMBL-CRG) Systems Biology Research Unit, Centre for Genomic Regulation, Barcelona, Spain","institution_ids":["https://openalex.org/I4210097140","https://openalex.org/I4210137962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005931107","display_name":"Jennifer I. Semple","orcid":"https://orcid.org/0000-0001-7221-9560","observed_orcids":["https://orcid.org/0000-0001-7221-9560"]},"institutions":[{"id":"https://openalex.org/I4210097140","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/010jaxs89","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210097140","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jennifer I Semple","raw_affiliation_strings":["European Molecular Biology Laboratory\u2014Centre for Genomic Regulation (EMBL-CRG) Systems Biology Research Unit, Centre for Genomic Regulation, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory\u2014Centre for Genomic Regulation (EMBL-CRG) Systems Biology Research Unit, Centre for Genomic Regulation, Barcelona, Spain","institution_ids":["https://openalex.org/I4210097140","https://openalex.org/I4210137962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042612420","display_name":"Rosa Garc\u00eda-Verdugo","orcid":"https://orcid.org/0000-0002-6039-8861","observed_orcids":["https://orcid.org/0000-0002-6039-8861"]},"institutions":[{"id":"https://openalex.org/I4210097140","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/010jaxs89","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210097140","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Rosa Garcia-Verdugo","raw_affiliation_strings":["European Molecular Biology Laboratory\u2014Centre for Genomic Regulation (EMBL-CRG) Systems Biology Research Unit, Centre for Genomic Regulation, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory\u2014Centre for Genomic Regulation (EMBL-CRG) Systems Biology Research Unit, Centre for Genomic Regulation, Barcelona, Spain","institution_ids":["https://openalex.org/I4210097140","https://openalex.org/I4210137962"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071772605","display_name":"Ben Lehner","orcid":"https://orcid.org/0000-0002-8817-1124","observed_orcids":["https://orcid.org/0000-0002-8817-1124"]},"institutions":[{"id":"https://openalex.org/I11932220","display_name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","ror":"https://ror.org/0371hy230","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I11932220"]},{"id":"https://openalex.org/I4210097140","display_name":"European Molecular Biology Laboratory","ror":"https://ror.org/010jaxs89","country_code":"ES","type":"government","lineage":["https://openalex.org/I4210097140","https://openalex.org/I4210138560"]},{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Ben Lehner","raw_affiliation_strings":["European Molecular Biology Laboratory\u2014Centre for Genomic Regulation (EMBL-CRG) Systems Biology Research Unit, Centre for Genomic Regulation, Barcelona, Spain","Instituci\u00f3 Catalana de Recerca Estudis Avan\u00e7ats (ICREA), Centre for Genomic Regulation, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Molecular Biology Laboratory\u2014Centre for Genomic Regulation (EMBL-CRG) Systems Biology Research Unit, Centre for Genomic Regulation, Barcelona, Spain","institution_ids":["https://openalex.org/I4210097140","https://openalex.org/I4210137962"]},{"raw_affiliation_string":"Instituci\u00f3 Catalana de Recerca Estudis Avan\u00e7ats (ICREA), Centre for Genomic Regulation, Barcelona, Spain","institution_ids":["https://openalex.org/I11932220","https://openalex.org/I4210137962"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071772605"],"corresponding_institution_ids":["https://openalex.org/I11932220","https://openalex.org/I4210097140","https://openalex.org/I4210137962"],"apc_list":{"value":12690,"currency":"USD","value_usd":12690},"apc_paid":null,"fwci":3.3168,"has_fulltext":true,"cited_by_count":77,"citation_normalized_percentile":{"value":0.9376985,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"43","issue":"12","first_page":"1270","last_page":"1274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.4092000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.4092000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.2556000053882599,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases","score":0.07419999688863754,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phenotype-prediction","display_name":"phenotype prediction","score":0.8640000224113464},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.9789999723434448},{"id":"https://openalex.org/keywords/genome-sequence","display_name":"genome sequence","score":0.5139999985694885},{"id":"https://openalex.org/keywords/growth-rate","display_name":"growth rate","score":0.5370000004768372},{"id":"https://openalex.org/keywords/environmental-factors","display_name":"environmental factors","score":0.5580000281333923},{"id":"https://openalex.org/keywords/loss-of-function-screen","display_name":"loss-of-function screen","score":0.7990000247955322},{"id":"https://openalex.org/keywords/protein-function","display_name":"protein function","score":0.4819999933242798},{"id":"https://openalex.org/keywords/functional-gene-networks","display_name":"functional gene networks","score":0.6790000200271606},{"id":"https://openalex.org/keywords/gene-connectivity","display_name":"gene connectivity","score":0.38499999046325684},{"id":"https://openalex.org/keywords/phenotypic-variation","display_name":"phenotypic variability","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9152034521102905},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.6815465092658997},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.6163074970245361},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6057592034339905},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5564398169517517},{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5133396983146667},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4638500213623047},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4142584204673767},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20341593027114868},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016681","descriptor_name":"Genome, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017124","descriptor_name":"Conserved Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054643","descriptor_name":"INDEL Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/ng.1007","doi":"https://doi.org/10.1038/ng.1007","is_oa":false,"landing_page_url":"https://doi.org/10.1038/ng.1007","pdf_url":null,"source":{"id":"https://openalex.org/S137905309","display_name":"Nature Genetics","issn_l":"1061-4036","issn":["1061-4036","1546-1718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Genetics","raw_type":"journal-article"},{"id":"pmid:22081227","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22081227","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature genetics","raw_type":"Journal Article"},{"id":"pmh:oai:lirias2repo.kuleuven.be:123456789/423337","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22081227","pdf_url":null,"source":{"id":"https://openalex.org/S7407055369","display_name":"Lirias","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Genetics, vol. 43 (12)","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322930","display_name":"Ministerio de Ciencia e Innovaci\u00f3n","ror":null},{"id":"https://openalex.org/F4320334830","display_name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","ror":"https://ror.org/01n4pqe45"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1967220526","https://openalex.org/W1970250905","https://openalex.org/W1971431550","https://openalex.org/W1975880030","https://openalex.org/W1992140809","https://openalex.org/W2001036679","https://openalex.org/W2006204029","https://openalex.org/W2012016911","https://openalex.org/W2039279598","https://openalex.org/W2046618236","https://openalex.org/W2052815101","https://openalex.org/W2057029228","https://openalex.org/W2074755764","https://openalex.org/W2089035513","https://openalex.org/W2100751507","https://openalex.org/W2113649367","https://openalex.org/W2120428260","https://openalex.org/W2127981150","https://openalex.org/W2128995100","https://openalex.org/W2133102806","https://openalex.org/W2134092731","https://openalex.org/W2138000345","https://openalex.org/W2142437744","https://openalex.org/W2142642738","https://openalex.org/W2144362290","https://openalex.org/W2145187337","https://openalex.org/W2147461734","https://openalex.org/W2157825442","https://openalex.org/W2160825263","https://openalex.org/W2164004777","https://openalex.org/W2165870010","https://openalex.org/W2170392103","https://openalex.org/W2171777347","https://openalex.org/W2885727518","https://openalex.org/W3047916294","https://openalex.org/W4211208250"],"related_works":["https://openalex.org/W2026563142","https://openalex.org/W4413872917","https://openalex.org/W2160588775","https://openalex.org/W2253060287","https://openalex.org/W2007738469","https://openalex.org/W1225266517","https://openalex.org/W2273359432","https://openalex.org/W1950636151","https://openalex.org/W7099259799","https://openalex.org/W4294622178"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}