{"id":"https://openalex.org/W2054880901","doi":"https://doi.org/10.2202/1553-3840.1315","title":"Extract of North American Ginseng (Panax Quinquefolius), Administered to Leukemic, Juvenile Mice Extends their Life Span","display_name":"Extract of North American Ginseng (Panax Quinquefolius), Administered to Leukemic, Juvenile Mice Extends their Life Span","publication_year":2011,"publication_date":"2011-02-23","ids":{"openalex":"https://openalex.org/W2054880901","doi":"https://doi.org/10.2202/1553-3840.1315","mag":"2054880901","pmid":"https://pubmed.ncbi.nlm.nih.gov/22754952"},"language":"en","primary_location":{"id":"doi:10.2202/1553-3840.1315","doi":"https://doi.org/10.2202/1553-3840.1315","is_oa":false,"landing_page_url":"https://doi.org/10.2202/1553-3840.1315","pdf_url":null,"source":{"id":"https://openalex.org/S186077364","display_name":"Journal of Complementary and Integrative Medicine","issn_l":"1553-3840","issn":["1553-3840","2194-6329"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Complementary and Integrative Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103447146","display_name":"Sandra C. Miller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Sandra C Miller","raw_affiliation_strings":["McGill University","McGill University, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University","institution_ids":["https://openalex.org/I5023651"]},{"raw_affiliation_string":"McGill University, Canada","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027127978","display_name":"Danielle Delorme","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5023651","display_name":"McGill University","ror":"https://ror.org/01pxwe438","country_code":"CA","type":"education","lineage":["https://openalex.org/I5023651"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Danielle Delorme","raw_affiliation_strings":["McGill University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McGill University","institution_ids":["https://openalex.org/I5023651"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110105696","display_name":"Jacqueline J. Shan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacqueline J. Shan","raw_affiliation_strings":["Afexa Life Sciences Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Afexa Life Sciences Inc","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2400,"currency":"EUR","value_usd":2712},"apc_paid":null,"fwci":1.3029,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.73750711,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"8","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11889","display_name":"Ginseng Biological Effects and Applications","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/panax-quinquefolius","display_name":"Panax quinquefolius","score":0.9980000257492065},{"id":"https://openalex.org/keywords/leukemic-mice","display_name":"leukemic mice","score":0.6840000152587891},{"id":"https://openalex.org/keywords/lifespan-extension","display_name":"lifespan extension","score":0.800000011920929},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8740000128746033},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5070000290870667},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.5370000004768372}],"concepts":[{"id":"https://openalex.org/C115961737","wikidata":"https://www.wikidata.org/wiki/Q1516282","display_name":"Juvenile","level":2,"score":0.7345186471939087},{"id":"https://openalex.org/C2988516024","wikidata":"https://www.wikidata.org/wiki/Q441195","display_name":"Life span","level":2,"score":0.7299066781997681},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.527773380279541},{"id":"https://openalex.org/C2779232237","wikidata":"https://www.wikidata.org/wiki/Q20817212","display_name":"Ginseng","level":3,"score":0.5049417614936829},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36305102705955505},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3517443537712097},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.34682297706604004},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29033493995666504},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.10883355140686035},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.09766119718551636},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005894","descriptor_name":"Panax","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007938","descriptor_name":"Leukemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008811","descriptor_name":"Mice, Inbred DBA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009656","descriptor_name":"North America","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010936","descriptor_name":"Plant Extracts","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2202/1553-3840.1315","doi":"https://doi.org/10.2202/1553-3840.1315","is_oa":false,"landing_page_url":"https://doi.org/10.2202/1553-3840.1315","pdf_url":null,"source":{"id":"https://openalex.org/S186077364","display_name":"Journal of Complementary and Integrative Medicine","issn_l":"1553-3840","issn":["1553-3840","2194-6329"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Complementary and Integrative Medicine","raw_type":"journal-article"},{"id":"pmid:22754952","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22754952","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of complementary & integrative medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1506843431","https://openalex.org/W81306185","https://openalex.org/W2025367249","https://openalex.org/W2185627329","https://openalex.org/W2186782387","https://openalex.org/W1604746555","https://openalex.org/W2054988774","https://openalex.org/W2083044708","https://openalex.org/W2138873750","https://openalex.org/W2895741933"],"abstract_inverted_index":{"In":[0],"a":[1,12,99,137],"recent":[2],"study":[3,49,214],"involving":[4],"normal,":[5,190],"juvenile":[6],"mice,":[7,185,192,228],"we":[8,194],"showed":[9],"that":[10,126,174,198,218,231],"CVT-E002,":[11,54],"proprietary":[13],"extract":[14,66],"(Afexa":[15],"Life":[16],"Sciences,":[17],"Inc.)":[18],"of":[19,30,37,53,71,106,132,151,160,205,211,225,234],"North":[20],"American":[21],"ginseng,":[22],"Panax":[23],"quinquefolius,":[24],"significantly":[25,128,176,200],"enhanced":[26],"the":[27,34,51,115,130,202,212,222,232],"absolute":[28],"levels":[29],"cells":[31,179],"acting":[32],"at":[33,103],"first":[35,116],"line":[36],"defense":[38],"in":[39,77,98,136,145,180,189,238,243],"tumor":[40,91],"combat,":[41],"i.e.,":[42,140],"natural":[43],"killer":[44],"(NK)":[45],"cells.":[46],"The":[47,65,90,123,209],"present":[48,213],"evaluated":[50],"effect":[52],"on":[55],"life":[56,131,203,223,240],"span":[57,204,224,241],"when":[58],"administered":[59,68,93],"intraperitoneally":[60,94],"to":[61,69,82,87],"leukemic,":[62,133,183,206,226],"infant/juvenile":[63,191,227,246],"mice.":[64,208,247],"was":[67,92,143],"groups":[70,80],"mice":[72,135],"daily":[73],"for":[74,119],"14":[75],"days":[76,105],"several":[78],"dosing":[79],"up":[81],"50mg/day":[83],"from":[84],"age":[85,107],"7":[86,104],"21":[88],"days.":[89],"under":[95],"sterile":[96],"conditions,":[97],"laminar":[100],"flow":[101],"hood":[102],"(0.5":[108],"x":[109],"10(6)":[110],"leukemic":[111,245],"cells),":[112],"immediately":[113],"preceding":[114],"CVT-E002":[117,127,175,199,220,235],"injection":[118],"each":[120],"dose":[121,233],"group.":[122],"data":[124],"revealed":[125],"extends":[129,201,221],"young":[134],"dose-specific":[138],"manner,":[139],"20":[141],"mg/day":[142],"effective":[144],"extending":[146],"life,":[147],"while":[148],"lower":[149],"doses":[150,159],"5,":[152],"10":[153],"mg":[154,164],"as":[155,157,186,188],"well":[156,187],"higher":[158],"30,":[161],"40,":[162],"50":[163],"per":[165],"day":[166],"were":[167],"completely":[168],"ineffective.":[169],"We":[170],"have":[171,195],"already":[172],"shown":[173,197],"elevates":[177],"NK":[178],"normal":[181],"and":[182,193,229],"adult":[184,207],"also":[196],"results":[210],"did":[215],"indeed":[216],"show":[217],"(i)":[219],"(ii)":[230],"is":[236],"critical":[237],"achieving":[239],"augmentation":[242],"these":[244]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
