{"id":"https://openalex.org/W2054862954","doi":"https://doi.org/10.1006/bbrc.2000.3200","title":"Epigallocatechin Gallate Inhibits Histamine Release from Rat Basophilic Leukemia (RBL-2H3) Cells: Role of Tyrosine Phosphorylation Pathway","display_name":"Epigallocatechin Gallate Inhibits Histamine Release from Rat Basophilic Leukemia (RBL-2H3) Cells: Role of Tyrosine Phosphorylation Pathway","publication_year":2000,"publication_date":"2000-08-01","ids":{"openalex":"https://openalex.org/W2054862954","doi":"https://doi.org/10.1006/bbrc.2000.3200","mag":"2054862954","pmid":"https://pubmed.ncbi.nlm.nih.gov/10924324"},"language":"en","primary_location":{"id":"doi:10.1006/bbrc.2000.3200","doi":"https://doi.org/10.1006/bbrc.2000.3200","is_oa":false,"landing_page_url":"https://doi.org/10.1006/bbrc.2000.3200","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kohei Yamashita","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kohei Yamashita","raw_affiliation_strings":["Department of Immunology and Microbiology, Nihon University School of Medicine, Tokyo, 173-8610, Japan","Department of Gynecology and Obstetrics, Nihon University School of Medicine, Tokyo, 173-8610, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbiology, Nihon University School of Medicine, Tokyo, 173-8610, Japan","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Nihon University School of Medicine, Tokyo, 173-8610, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007909935","display_name":"Yoshihiro Suzuki","orcid":"https://orcid.org/0000-0002-1148-5379","observed_orcids":["https://orcid.org/0000-0002-1148-5379"]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshihiro Suzuki","raw_affiliation_strings":["Department of Immunology and Microbiology, Nihon University School of Medicine, Tokyo, 173-8610, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbiology, Nihon University School of Medicine, Tokyo, 173-8610, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Takashi Matsui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Matsui","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Nihon University School of Medicine, Tokyo, 173-8610, Japan","Department of Immunology and Microbiology, Nihon University School of Medicine, Tokyo, 173-8610, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Nihon University School of Medicine, Tokyo, 173-8610, Japan","institution_ids":["https://openalex.org/I104946051"]},{"raw_affiliation_string":"Department of Immunology and Microbiology, Nihon University School of Medicine, Tokyo, 173-8610, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031542615","display_name":"Tetsuro Yoshimaru","orcid":"https://orcid.org/0000-0001-8582-3011","observed_orcids":["https://orcid.org/0000-0001-8582-3011"]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tetsuro Yoshimaru","raw_affiliation_strings":["Department of Immunology and Microbiology, Nihon University School of Medicine, Tokyo, 173-8610, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbiology, Nihon University School of Medicine, Tokyo, 173-8610, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109064098","display_name":"Mitsuo Yamaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Mitsuo Yamaki","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Nihon University School of Medicine, Tokyo, 173-8610, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Nihon University School of Medicine, Tokyo, 173-8610, Japan","institution_ids":["https://openalex.org/I104946051"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017169237","display_name":"Miki Suzuki\u2010Karasaki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65143321","display_name":"Hitachi (Japan)","ror":"https://ror.org/02exqgm79","country_code":"JP","type":"company","lineage":["https://openalex.org/I65143321"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Miki Suzuki-Karasaki","raw_affiliation_strings":["Pharmaceutical Research Laboratory, Hitachi Chemical Co., Ltd. Ibaraki, 317-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Laboratory, Hitachi Chemical Co., Ltd. Ibaraki, 317-8555, Japan","institution_ids":["https://openalex.org/I65143321"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073453510","display_name":"Satoshi Hayakawa","orcid":"https://orcid.org/0000-0002-1022-1443","observed_orcids":["https://orcid.org/0000-0002-1022-1443"]},"institutions":[{"id":"https://openalex.org/I65143321","display_name":"Hitachi (Japan)","ror":"https://ror.org/02exqgm79","country_code":"JP","type":"company","lineage":["https://openalex.org/I65143321"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Satoshi Hayakawa","raw_affiliation_strings":["Pharmaceutical Research Laboratory, Hitachi Chemical Co., Ltd. Ibaraki, 317-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research Laboratory, Hitachi Chemical Co., Ltd. Ibaraki, 317-8555, Japan","institution_ids":["https://openalex.org/I65143321"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066291252","display_name":"Kazufumi Shimizu","orcid":"https://orcid.org/0000-0001-8175-5437","observed_orcids":["https://orcid.org/0000-0001-8175-5437"]},"institutions":[{"id":"https://openalex.org/I104946051","display_name":"Nihon University","ror":"https://ror.org/05jk51a88","country_code":"JP","type":"education","lineage":["https://openalex.org/I104946051"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazufumi Shimizu","raw_affiliation_strings":["Department of Immunology and Microbiology, Nihon University School of Medicine, Tokyo, 173-8610, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbiology, Nihon University School of Medicine, Tokyo, 173-8610, Japan","institution_ids":["https://openalex.org/I104946051"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5007909935"],"corresponding_institution_ids":["https://openalex.org/I104946051"],"apc_list":{"value":3110,"currency":"USD","value_usd":3110},"apc_paid":null,"fwci":1.4144,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.80484258,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"274","issue":"3","first_page":"603","last_page":"608"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects","score":0.06379999965429306,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigallocatechin-gallate","display_name":"epigallocatechin gallate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/histamine-release","display_name":"histamine release","score":0.9490000009536743},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.9610000252723694},{"id":"https://openalex.org/keywords/rbl-2h3-cells","display_name":"RBL-2H3 cells","score":0.9750000238418579},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/focal-adhesion-kinase","display_name":"focal adhesion kinase","score":0.9279999732971191},{"id":"https://openalex.org/keywords/piceatannol","display_name":"piceatannol","score":0.878000020980835},{"id":"https://openalex.org/keywords/tea-polyphenols","display_name":"tea polyphenols","score":0.8960000276565552},{"id":"https://openalex.org/keywords/epicatechin","display_name":"epicatechin","score":0.8320000171661377},{"id":"https://openalex.org/keywords/a23187","display_name":"A23187","score":0.8939999938011169},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibition","display_name":"tyrosine kinase inhibition","score":0.8130000233650208}],"concepts":[{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.7849199771881104},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.7723298072814941},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6662741899490356},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.5961980819702148},{"id":"https://openalex.org/C85528070","wikidata":"https://www.wikidata.org/wiki/Q643602","display_name":"Protein tyrosine phosphatase","level":3,"score":0.5859574675559998},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.5094819664955139},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.495458722114563},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.48809754848480225},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.45421987771987915},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3973138928413391},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3816874027252197},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37741830945014954},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2758517265319824},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17044973373413086},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.12734517455101013}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D002392","descriptor_name":"Catechin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006636","descriptor_name":"Histamine Release","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007942","descriptor_name":"Leukemia, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007942","descriptor_name":"Leukemia, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015471","descriptor_name":"Leukemia, Basophilic, Acute","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015471","descriptor_name":"Leukemia, Basophilic, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1006/bbrc.2000.3200","doi":"https://doi.org/10.1006/bbrc.2000.3200","is_oa":false,"landing_page_url":"https://doi.org/10.1006/bbrc.2000.3200","pdf_url":null,"source":{"id":"https://openalex.org/S151589183","display_name":"Biochemical and Biophysical Research Communications","issn_l":"0006-291X","issn":["0006-291X","1090-2104"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and Biophysical Research Communications","raw_type":"journal-article"},{"id":"pmid:10924324","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10924324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical and biophysical research communications","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W136542906","https://openalex.org/W1479871091","https://openalex.org/W1481543280","https://openalex.org/W1519260014","https://openalex.org/W1525138398","https://openalex.org/W1618519163","https://openalex.org/W1968430250","https://openalex.org/W1979855676","https://openalex.org/W1996703875","https://openalex.org/W2003202244","https://openalex.org/W2006892275","https://openalex.org/W2009335336","https://openalex.org/W2013335354","https://openalex.org/W2025018535","https://openalex.org/W2042209841","https://openalex.org/W2048345403","https://openalex.org/W2061575199","https://openalex.org/W2068598785","https://openalex.org/W2152450698","https://openalex.org/W2158093352","https://openalex.org/W2399303500","https://openalex.org/W4249736906"],"related_works":["https://openalex.org/W2003202244","https://openalex.org/W747074841","https://openalex.org/W1996703875","https://openalex.org/W1970721312","https://openalex.org/W1979766475","https://openalex.org/W2017921920","https://openalex.org/W2113731091","https://openalex.org/W1981375884","https://openalex.org/W2018859022","https://openalex.org/W2054314998"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}