{"id":"https://openalex.org/W2054832058","doi":"https://doi.org/10.1111/j.1749-6632.1998.tb09678.x","title":"The Semisynthetic Glycosphingolipid LIGA20 Potently Protects Neurons Against Apoptosis","display_name":"The Semisynthetic Glycosphingolipid LIGA20 Potently Protects Neurons Against Apoptosis","publication_year":1998,"publication_date":"1998-06-01","ids":{"openalex":"https://openalex.org/W2054832058","doi":"https://doi.org/10.1111/j.1749-6632.1998.tb09678.x","mag":"2054832058","pmid":"https://pubmed.ncbi.nlm.nih.gov/9668359"},"language":"en","primary_location":{"id":"doi:10.1111/j.1749-6632.1998.tb09678.x","doi":"https://doi.org/10.1111/j.1749-6632.1998.tb09678.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1998.tb09678.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029501184","display_name":"Mariko Saito","orcid":"https://orcid.org/0000-0001-9383-4458","observed_orcids":["https://orcid.org/0000-0001-9383-4458"]},"institutions":[{"id":"https://openalex.org/I125043107","display_name":"Nathan Kline Institute for Psychiatric Research","ror":"https://ror.org/01s434164","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I125043107"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MARIKO SAITO","raw_affiliation_strings":["Nathan S. Kline Institute of Psychiatric Research, Center for Neurochemistry, Orangeburg, New York 10962, USA","The Nathan S. Kline Institute of Psychiatric Research, Center for Neurochemistry, Orangeburg, New York 10962 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nathan S. Kline Institute of Psychiatric Research, Center for Neurochemistry, Orangeburg, New York 10962, USA","institution_ids":["https://openalex.org/I125043107"]},{"raw_affiliation_string":"The Nathan S. Kline Institute of Psychiatric Research, Center for Neurochemistry, Orangeburg, New York 10962 USA","institution_ids":["https://openalex.org/I125043107"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048825104","display_name":"Alessandro Guidotti","orcid":"https://orcid.org/0000-0003-4480-0010","observed_orcids":["https://orcid.org/0000-0003-4480-0010"]},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"ALESSANDRO GUIDOTTI","raw_affiliation_strings":["The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago College of Medicine, Chicago, Illinois 60612 USA","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074369828","display_name":"Martin J. Berg","orcid":"https://orcid.org/0000-0002-7353-8851","observed_orcids":["https://orcid.org/0000-0002-7353-8851"]},"institutions":[{"id":"https://openalex.org/I125043107","display_name":"Nathan Kline Institute for Psychiatric Research","ror":"https://ror.org/01s434164","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I125043107"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"MARTIN J. BERG","raw_affiliation_strings":["The Nathan S. Kline Institute of Psychiatric Research, Center for Neurochemistry, Orangeburg, New York 10962 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Nathan S. Kline Institute of Psychiatric Research, Center for Neurochemistry, Orangeburg, New York 10962 USA","institution_ids":["https://openalex.org/I125043107"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5012767879","display_name":"Neville Marks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125043107","display_name":"Nathan Kline Institute for Psychiatric Research","ror":"https://ror.org/01s434164","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I125043107"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"NEVILLE MARKS","raw_affiliation_strings":["The Nathan S. Kline Institute of Psychiatric Research, Center for Neurochemistry, Orangeburg, New York 10962 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Nathan S. Kline Institute of Psychiatric Research, Center for Neurochemistry, Orangeburg, New York 10962 USA","institution_ids":["https://openalex.org/I125043107"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048825104"],"corresponding_institution_ids":["https://openalex.org/I39422238"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":null,"fwci":0.5507,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.61521047,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"845","issue":"1","first_page":"253","last_page":"262"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5601000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.5601000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.36550000309944153,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.04800000041723251,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gm1-ganglioside","display_name":"GM1 ganglioside","score":0.8769999742507935},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9319999814033508},{"id":"https://openalex.org/keywords/neuronal-apoptosis","display_name":"neuronal apoptosis","score":0.8349999785423279},{"id":"https://openalex.org/keywords/cerebellar-granule-cells","display_name":"cerebellar granule cells","score":0.9160000085830688},{"id":"https://openalex.org/keywords/caspase-3-activation","display_name":"caspase-3 activation","score":0.9449999928474426},{"id":"https://openalex.org/keywords/ethanol-induced-apoptosis","display_name":"ethanol-induced apoptosis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/c6-ceramide","display_name":"C6-ceramide","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C155878803","wikidata":"https://www.wikidata.org/wiki/Q5205755","display_name":"DNA laddering","level":5,"score":0.7870047092437744},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7822504639625549},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6881277561187744},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.6751164793968201},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6556736826896667},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5890015363693237},{"id":"https://openalex.org/C2776931407","wikidata":"https://www.wikidata.org/wiki/Q418892","display_name":"Glycosphingolipid","level":2,"score":0.48916342854499817},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4122101068496704},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39603692293167114},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3536182641983032},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2703949809074402},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2541373372077942},{"id":"https://openalex.org/C43759708","wikidata":"https://www.wikidata.org/wiki/Q3749256","display_name":"DNA fragmentation","level":4,"score":0.1938188672065735}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003546","descriptor_name":"Cysteine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005677","descriptor_name":"G(M1) Ganglioside","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D005677","descriptor_name":"G(M1) Ganglioside","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1749-6632.1998.tb09678.x","doi":"https://doi.org/10.1111/j.1749-6632.1998.tb09678.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1749-6632.1998.tb09678.x","pdf_url":null,"source":{"id":"https://openalex.org/S8802318","display_name":"Annals of the New York Academy of Sciences","issn_l":"0077-8923","issn":["0077-8923","1749-6632"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:9668359","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9668359","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of the New York Academy of Sciences","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W142053782","https://openalex.org/W1492302205","https://openalex.org/W1499591683","https://openalex.org/W1509047385","https://openalex.org/W1517497091","https://openalex.org/W1824128596","https://openalex.org/W1874084602","https://openalex.org/W1963921090","https://openalex.org/W1967531650","https://openalex.org/W1984866351","https://openalex.org/W1986750235","https://openalex.org/W1987785848","https://openalex.org/W1990285880","https://openalex.org/W1993336052","https://openalex.org/W2002503549","https://openalex.org/W2017087879","https://openalex.org/W2017169241","https://openalex.org/W2017729786","https://openalex.org/W2036428426","https://openalex.org/W2049110705","https://openalex.org/W2051276468","https://openalex.org/W2052853635","https://openalex.org/W2058117427","https://openalex.org/W2058848229","https://openalex.org/W2060865344","https://openalex.org/W2072286244","https://openalex.org/W2089843401","https://openalex.org/W2101699819","https://openalex.org/W2107100596","https://openalex.org/W2126544407","https://openalex.org/W2156179144","https://openalex.org/W2222594107","https://openalex.org/W2255740363","https://openalex.org/W4407024738"],"related_works":["https://openalex.org/W2222594107","https://openalex.org/W2073768944","https://openalex.org/W2060865344","https://openalex.org/W2083979657","https://openalex.org/W2170070101","https://openalex.org/W1984562258","https://openalex.org/W1969587155","https://openalex.org/W2089547463","https://openalex.org/W2377701701","https://openalex.org/W2380411244"],"abstract_inverted_index":{"LIGA20":[0,80,90,103],"(a":[1],"semisynthetic":[2],"GM1":[3],"with":[4,77],"n-dichloroacetyl":[5],"sphingosine)":[6],"having":[7],"antinecrotic":[8],"properties":[9],"was":[10],"evaluated":[11],"as":[12,20],"an":[13],"antiapoptotic":[14],"agent":[15,108],"using":[16],"cerebellar":[17],"granule":[18],"cells":[19,110],"a":[21,53,70,105],"neuronal":[22],"model.":[23],"Neurons":[24],"exposed":[25],"to":[26,40],"medium":[27],"containing":[28],"5":[29],"mM":[30],"K+":[31],"in":[32,44,55],"absence":[33],"of":[34,114],"serum":[35],"(apoptotic":[36],"medium)":[37],"for":[38,63,81],"up":[39],"22":[41],"h":[42],"resulted":[43],"65%":[45],"cell":[46,67,115],"death,":[47],"accompanied":[48],"by":[49,95],"oligonucleosomal":[50],"laddering,":[51],"and":[52,66,98],"15-fold-increase":[54],"caspase-3":[56],"activity.":[57],"The":[58],"relationships":[59],"between":[60,72],"times":[61],"required":[62],"enzyme":[64],"activation":[65],"death":[68],"suggests":[69],"linkage":[71],"these":[73],"two":[74],"events.":[75],"Pretreatment":[76],"10":[78,82],"microM":[79],"min":[83],"significantly":[84],"attenuated":[85,92],"the":[86],"aforementioned":[87],"apoptotic":[88],"changes.":[89],"also":[91],"apoptosis":[93],"induced":[94],"Pb2+,":[96],"ethanol,":[97],"C6-ceramide.":[99],"Data":[100],"show":[101],"that":[102],"is":[104],"versatile":[106],"neuroprotective":[107],"protecting":[109],"from":[111],"multiple":[112],"pathways":[113],"death.":[116]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}