{"id":"https://openalex.org/W2054781352","doi":"https://doi.org/10.1359/jbmr.1999.14.7.1104","title":"Glucocorticoids Decrease Interleukin-6 Levels and Induce Mineralization of Cultured Osteogenic Cells from Children with Fibrous Dysplasia","display_name":"Glucocorticoids Decrease Interleukin-6 Levels and Induce Mineralization of Cultured Osteogenic Cells from Children with Fibrous Dysplasia","publication_year":1999,"publication_date":"1999-07-01","ids":{"openalex":"https://openalex.org/W2054781352","doi":"https://doi.org/10.1359/jbmr.1999.14.7.1104","mag":"2054781352","pmid":"https://pubmed.ncbi.nlm.nih.gov/10404010"},"language":"en","primary_location":{"id":"doi:10.1359/jbmr.1999.14.7.1104","doi":"https://doi.org/10.1359/jbmr.1999.14.7.1104","is_oa":false,"landing_page_url":"https://doi.org/10.1359/jbmr.1999.14.7.1104","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087206684","display_name":"Robert P. Stanton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1326254912","display_name":"Alfred I. duPont Hospital for Children","ror":"https://ror.org/00jyx0v10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1326254912","https://openalex.org/I4210108049"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert P. Stanton","raw_affiliation_strings":["Department of Orthopaedics, Alfred I. duPont Hospital for Children, Wilmington, Delaware, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics, Alfred I. duPont Hospital for Children, Wilmington, Delaware, U.S.A","institution_ids":["https://openalex.org/I1326254912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091066839","display_name":"Grace M. Hobson","orcid":"https://orcid.org/0000-0002-5275-5953","observed_orcids":["https://orcid.org/0000-0002-5275-5953"]},"institutions":[{"id":"https://openalex.org/I1326254912","display_name":"Alfred I. duPont Hospital for Children","ror":"https://ror.org/00jyx0v10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1326254912","https://openalex.org/I4210108049"]},{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grace M. Hobson","raw_affiliation_strings":["Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A","Department of Research, Alfred I. duPont Hospital for Children, Wilmington, Delaware, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Research, Alfred I. duPont Hospital for Children, Wilmington, Delaware, U.S.A","institution_ids":["https://openalex.org/I1326254912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011641860","display_name":"Ben E. Montgomery","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1326254912","display_name":"Alfred I. duPont Hospital for Children","ror":"https://ror.org/00jyx0v10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1326254912","https://openalex.org/I4210108049"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben E. Montgomery","raw_affiliation_strings":["Department of Research, Alfred I. duPont Hospital for Children, Wilmington, Delaware, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, Alfred I. duPont Hospital for Children, Wilmington, Delaware, U.S.A","institution_ids":["https://openalex.org/I1326254912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078730709","display_name":"Priscilla A. Moses","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1326254912","display_name":"Alfred I. duPont Hospital for Children","ror":"https://ror.org/00jyx0v10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1326254912","https://openalex.org/I4210108049"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priscilla A. Moses","raw_affiliation_strings":["Department of Research, Alfred I. duPont Hospital for Children, Wilmington, Delaware, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, Alfred I. duPont Hospital for Children, Wilmington, Delaware, U.S.A","institution_ids":["https://openalex.org/I1326254912"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006892855","display_name":"Susan M. Kirwin","orcid":"https://orcid.org/0000-0003-2008-4654","observed_orcids":["https://orcid.org/0000-0003-2008-4654"]},"institutions":[{"id":"https://openalex.org/I1326254912","display_name":"Alfred I. duPont Hospital for Children","ror":"https://ror.org/00jyx0v10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1326254912","https://openalex.org/I4210108049"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan M. Smith-Kirwin","raw_affiliation_strings":["Department of Research, Alfred I. duPont Hospital for Children, Wilmington, Delaware, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, Alfred I. duPont Hospital for Children, Wilmington, Delaware, U.S.A","institution_ids":["https://openalex.org/I1326254912"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082786623","display_name":"Vicky L. Funanage","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1326254912","display_name":"Alfred I. duPont Hospital for Children","ror":"https://ror.org/00jyx0v10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1326254912","https://openalex.org/I4210108049"]},{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vicky L. Funanage","raw_affiliation_strings":["Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A","Department of Research, Alfred I. duPont Hospital for Children, Wilmington, Delaware, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I149251103"]},{"raw_affiliation_string":"Department of Research, Alfred I. duPont Hospital for Children, Wilmington, Delaware, U.S.A","institution_ids":["https://openalex.org/I1326254912"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3780,"currency":"USD","value_usd":3780},"apc_paid":null,"fwci":0.6452,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.69143643,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"14","issue":"7","first_page":"1104","last_page":"1114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibrous-dysplasia","display_name":"fibrous dysplasia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.9589999914169312},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":1.0},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/mesenchymal-stem-cells","display_name":"mesenchymal stem cells","score":0.8769999742507935},{"id":"https://openalex.org/keywords/gnas-mutation","display_name":"GNAS mutation","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mccune-albright-syndrome","display_name":"McCune-Albright syndrome","score":0.9340000152587891},{"id":"https://openalex.org/keywords/bone-mineralization","display_name":"bone mineralization","score":0.8090000152587891},{"id":"https://openalex.org/keywords/osteoclast-activity","display_name":"osteoclast activity","score":0.7799999713897705},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.609000027179718},{"id":"https://openalex.org/keywords/pediatric-bone-disease","display_name":"pediatric bone disease","score":0.6909999847412109}],"concepts":[{"id":"https://openalex.org/C2781362533","wikidata":"https://www.wikidata.org/wiki/Q1410864","display_name":"Fibrous dysplasia","level":2,"score":0.6849400401115417},{"id":"https://openalex.org/C111696902","wikidata":"https://www.wikidata.org/wiki/Q6864413","display_name":"Mineralization (soil science)","level":3,"score":0.6236904859542847},{"id":"https://openalex.org/C3020625565","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin 1\u03b2","level":4,"score":0.6105480194091797},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.45615899562835693},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4055289626121521},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.38258492946624756},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.368797242641449},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3653441369533539},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35037124156951904},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32963258028030396},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.312103807926178},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.25231027603149414},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.09932208061218262},{"id":"https://openalex.org/C159750122","wikidata":"https://www.wikidata.org/wiki/Q96621023","display_name":"Soil water","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D002113","descriptor_name":"Calcification, Physiologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005357","descriptor_name":"Fibrous Dysplasia of Bone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005357","descriptor_name":"Fibrous Dysplasia of Bone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008775","descriptor_name":"Methylprednisolone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019205","descriptor_name":"GTP-Binding Protein alpha Subunits, Gs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1359/jbmr.1999.14.7.1104","doi":"https://doi.org/10.1359/jbmr.1999.14.7.1104","is_oa":false,"landing_page_url":"https://doi.org/10.1359/jbmr.1999.14.7.1104","pdf_url":null,"source":{"id":"https://openalex.org/S128199769","display_name":"Journal of Bone and Mineral Research","issn_l":"0884-0431","issn":["0884-0431","1523-4681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Bone and Mineral Research","raw_type":"journal-article"},{"id":"pmid:10404010","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10404010","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320313557","display_name":"Nemours Foundation","ror":"https://ror.org/01mzw6m29"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W26493126","https://openalex.org/W157721590","https://openalex.org/W239911627","https://openalex.org/W1587747486","https://openalex.org/W1593083333","https://openalex.org/W1965174761","https://openalex.org/W1967092942","https://openalex.org/W1967485605","https://openalex.org/W1970360897","https://openalex.org/W1972526384","https://openalex.org/W1975884987","https://openalex.org/W1977556078","https://openalex.org/W1986276800","https://openalex.org/W1986526390","https://openalex.org/W1990854759","https://openalex.org/W1991062723","https://openalex.org/W1991235090","https://openalex.org/W1991926326","https://openalex.org/W1992781889","https://openalex.org/W1996028579","https://openalex.org/W2006928673","https://openalex.org/W2008634935","https://openalex.org/W2011683420","https://openalex.org/W2016910756","https://openalex.org/W2039094079","https://openalex.org/W2050858140","https://openalex.org/W2051349203","https://openalex.org/W2063159496","https://openalex.org/W2068135722","https://openalex.org/W2098734814","https://openalex.org/W2101146104","https://openalex.org/W2105735597","https://openalex.org/W2115641485","https://openalex.org/W2116840132","https://openalex.org/W2127599101","https://openalex.org/W2130892618","https://openalex.org/W2163875590","https://openalex.org/W2314225431","https://openalex.org/W2337777109","https://openalex.org/W4210991541"],"related_works":["https://openalex.org/W2126935472","https://openalex.org/W2103139312","https://openalex.org/W239911627","https://openalex.org/W2108907613","https://openalex.org/W150262101","https://openalex.org/W2334263069","https://openalex.org/W3823193","https://openalex.org/W2255711579","https://openalex.org/W2002722689","https://openalex.org/W4407619870"],"abstract_inverted_index":{"Fibrous":[0],"dysplasia":[1],"(FD)":[2],"is":[3,27,43,61],"a":[4,62,72,79,171,185,210],"progressive":[5],"bone":[6,20,42,76,144],"disease":[7,31],"in":[8,14,34,38,49,68,86,93,121,126,219],"which":[9,39,50,69],"abnormal":[10,127],"fibroblast":[11],"proliferation":[12],"results":[13],"the":[15,35,46,65,87,94,112,122,156,175,189,192,198,224],"replacement":[16],"of":[17,64,75,81,97,159,174,188,213,233],"normal":[18,193],"cancellous":[19],"with":[21,100,167,244],"an":[22],"immature":[23],"fibrous":[24],"tissue":[25],"that":[26,138,230],"poorly":[28],"mineralized.":[29],"The":[30,58,106],"manifests":[32],"itself":[33],"monostotic":[36,102,181],"form":[37,48,67],"only":[40],"one":[41],"involved":[44],"and":[45,78,130,194,216],"polyostotic":[47,66,104,168],"multiple":[51],"bones":[52],"at":[53],"different":[54],"sites":[55],"are":[56],"affected.":[57],"McCune-Albright":[59],"syndrome":[60],"variation":[63],"patients":[70,98,166,183,243],"demonstrate":[71],"greater":[73],"extent":[74],"involvement":[77],"variety":[80],"endocrinopathies.":[82],"Somatic":[83],"activating":[84],"mutations":[85,114],"GNAS":[88],"gene":[89],"have":[90,139,149],"been":[91,140],"demonstrated":[92],"fibrotic":[95],"lesions":[96],"affected":[99,123,157],"either":[101],"or":[103],"FD.":[105,245],"increased":[107,117,131],"cAMP":[108],"levels":[109,120,218],"caused":[110,209],"by":[111],"G-protein":[113],"lead":[115,237],"to":[116,203,238],"interleukin-6":[118],"(IL-6)":[119],"tissues,":[124],"resulting":[125],"osteoblast":[128],"differentiation":[129],"osteoclastic":[132],"activity.":[133],"Utilizing":[134],"cell":[135],"culture":[136],"techniques":[137],"developed":[141],"for":[142,242],"mammalian":[143],"marrow":[145],"stromal":[146],"cells,":[147],"we":[148],"successfully":[150],"cultured":[151,164,222],"osteogenic":[152,199,220],"stem":[153],"cells":[154,179,196,221],"from":[155,165,180,223],"stroma":[158],"11":[160],"FD":[161,169,182,195,225],"patients.":[162,226],"Cells":[163],"showed":[170,184],"high":[172],"frequency":[173,187],"Gsalpha":[176],"mutation,":[177],"whereas":[178],"low":[186],"mutation.":[190],"Both":[191],"displayed":[197],"phenotype":[200],"when":[201],"exposed":[202],"medium":[204],"containing":[205],"glucocorticoids.":[206],"Glucocorticoids":[207],"also":[208],"dramatic":[211],"inhibition":[212],"IL-6":[214],"mRNA":[215],"protein":[217],"These":[227],"findings":[228],"suggest":[229],"chemical":[231],"alteration":[232],"cellular":[234],"function":[235],"may":[236],"new":[239],"treatment":[240],"options":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}