{"id":"https://openalex.org/W2054779977","doi":"https://doi.org/10.1371/journal.pone.0095878","title":"Induction of the CLOCK Gene by E2-ER\u03b1 Signaling Promotes the Proliferation of Breast Cancer Cells","display_name":"Induction of the CLOCK Gene by E2-ER\u03b1 Signaling Promotes the Proliferation of Breast Cancer Cells","publication_year":2014,"publication_date":"2014-05-02","ids":{"openalex":"https://openalex.org/W2054779977","doi":"https://doi.org/10.1371/journal.pone.0095878","mag":"2054779977","pmid":"https://pubmed.ncbi.nlm.nih.gov/24789043","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4008427"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0095878","doi":"https://doi.org/10.1371/journal.pone.0095878","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0095878","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095878&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095878&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110105270","display_name":"Liyun Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liyun Xiao","raw_affiliation_strings":["School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057278186","display_name":"Alan K. Chang","orcid":"https://orcid.org/0009-0006-3842-939X","observed_orcids":["https://orcid.org/0009-0006-3842-939X"]},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Alan K. Chang","raw_affiliation_strings":["School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048493869","display_name":"Ming\u2010Xi Zang","orcid":"https://orcid.org/0000-0003-4533-0524","observed_orcids":["https://orcid.org/0000-0003-4533-0524"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming-Xi Zang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016329517","display_name":"Hai-Lian Bi","orcid":"https://orcid.org/0000-0002-9825-6973","observed_orcids":["https://orcid.org/0000-0002-9825-6973"]},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hailian Bi","raw_affiliation_strings":["School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100437429","display_name":"Shujing Li","orcid":"https://orcid.org/0000-0002-8643-1244","observed_orcids":["https://orcid.org/0000-0002-8643-1244"]},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shujing Li","raw_affiliation_strings":["School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100415843","display_name":"Miao Wang","orcid":"https://orcid.org/0000-0002-4858-3247","observed_orcids":["https://orcid.org/0000-0002-4858-3247"]},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Miao Wang","raw_affiliation_strings":["School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077815631","display_name":"Xinrong Xing","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinrong Xing","raw_affiliation_strings":["School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China","institution_ids":["https://openalex.org/I27357992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022348241","display_name":"Huijian Wu","orcid":"https://orcid.org/0000-0001-5257-0089","observed_orcids":["https://orcid.org/0000-0001-5257-0089"]},"institutions":[{"id":"https://openalex.org/I27357992","display_name":"Dalian University of Technology","ror":"https://ror.org/023hj5876","country_code":"CN","type":"education","lineage":["https://openalex.org/I27357992"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huijian Wu","raw_affiliation_strings":["School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China; School of Life Science and Medicine, Dalian University of Technology, Panjin, China","School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China","School of Life Science and Medicine, Dalian University of Technology, Panjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China; School of Life Science and Medicine, Dalian University of Technology, Panjin, China","institution_ids":["https://openalex.org/I27357992"]},{"raw_affiliation_string":"School of Life Science and Biotechnology, Dalian University of Technology, Dalian, China","institution_ids":["https://openalex.org/I27357992"]},{"raw_affiliation_string":"School of Life Science and Medicine, Dalian University of Technology, Panjin, China","institution_ids":["https://openalex.org/I27357992"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022348241"],"corresponding_institution_ids":["https://openalex.org/I27357992"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.9573,"has_fulltext":true,"cited_by_count":97,"citation_normalized_percentile":{"value":0.90874826,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"9","issue":"5","first_page":"e95878","last_page":"e95878"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.8999000191688538,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.09589999914169312,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clock-genes","display_name":"clock genes","score":0.8619999885559082},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.8360000252723694},{"id":"https://openalex.org/keywords/estrogen-signaling","display_name":"estrogen signaling","score":0.652999997138977},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6589999794960022},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.968999981880188},{"id":"https://openalex.org/keywords/circadian-clock","display_name":"circadian clock","score":0.9599999785423279},{"id":"https://openalex.org/keywords/estrogen-response-element","display_name":"estrogen response element","score":0.6510000228881836},{"id":"https://openalex.org/keywords/eralpha-positive-breast-cancer","display_name":"ER\u03b1-positive breast cancer","score":0.7839999794960022},{"id":"https://openalex.org/keywords/circadian-rhythm-disruption","display_name":"circadian rhythm disruption","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7428165674209595},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7292159199714661},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.6256371736526489},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.612418532371521},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5959181785583496},{"id":"https://openalex.org/C184738001","wikidata":"https://www.wikidata.org/wiki/Q14908739","display_name":"CLOCK","level":4,"score":0.5795783996582031},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5299462080001831},{"id":"https://openalex.org/C172313692","wikidata":"https://www.wikidata.org/wiki/Q14902310","display_name":"Estrogen receptor alpha","level":5,"score":0.4717325270175934},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41209733486175537},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36889004707336426},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3686993420124054},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.36453983187675476},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.27880433201789856},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2691616117954254},{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.25417906045913696},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2095445692539215},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09174484014511108}],"mesh":[{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004967","descriptor_name":"Estrogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015533","descriptor_name":"Transcriptional Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047628","descriptor_name":"Estrogen Receptor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056926","descriptor_name":"CLOCK Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0095878","doi":"https://doi.org/10.1371/journal.pone.0095878","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0095878","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095878&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2992552","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4008427","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4008427","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4008427","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24789043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24789043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.772.9111","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.772.9111","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/55/19/pone.0095878.PMC4008427.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:51a7d16b7da64b088538cffa8f1776d5","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/51a7d16b7da64b088538cffa8f1776d5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 9, Iss 5, p e95878 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0095878","doi":"https://doi.org/10.1371/journal.pone.0095878","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0095878","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0095878&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1828425977","display_name":null,"funder_award_id":"973 Program","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4294004302","display_name":null,"funder_award_id":"31171353","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7149893178","display_name":null,"funder_award_id":"2011CB504201","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G8271300600","display_name":null,"funder_award_id":"31271500","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2054779977.pdf","grobid_xml":"https://content.openalex.org/works/W2054779977.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W1764983374","https://openalex.org/W1969790866","https://openalex.org/W1972243139","https://openalex.org/W1973507159","https://openalex.org/W1974392774","https://openalex.org/W1981497491","https://openalex.org/W1985508575","https://openalex.org/W1989292149","https://openalex.org/W1991761316","https://openalex.org/W1996307323","https://openalex.org/W1997336170","https://openalex.org/W1998242092","https://openalex.org/W1999930997","https://openalex.org/W2007174847","https://openalex.org/W2008403211","https://openalex.org/W2009365973","https://openalex.org/W2009504099","https://openalex.org/W2010394258","https://openalex.org/W2010611789","https://openalex.org/W2010940374","https://openalex.org/W2013809140","https://openalex.org/W2016578587","https://openalex.org/W2017333590","https://openalex.org/W2021748681","https://openalex.org/W2022323452","https://openalex.org/W2024913322","https://openalex.org/W2026283962","https://openalex.org/W2035059302","https://openalex.org/W2043880865","https://openalex.org/W2046646461","https://openalex.org/W2048478622","https://openalex.org/W2053878253","https://openalex.org/W2055466079","https://openalex.org/W2056505464","https://openalex.org/W2059778973","https://openalex.org/W2073003786","https://openalex.org/W2075177970","https://openalex.org/W2079923381","https://openalex.org/W2080954244","https://openalex.org/W2081882184","https://openalex.org/W2095412797","https://openalex.org/W2098714571","https://openalex.org/W2101600063","https://openalex.org/W2102375302","https://openalex.org/W2103226094","https://openalex.org/W2103852823","https://openalex.org/W2112632901","https://openalex.org/W2117868576","https://openalex.org/W2118977196","https://openalex.org/W2129288956","https://openalex.org/W2137252071","https://openalex.org/W2142622103","https://openalex.org/W2148307287","https://openalex.org/W2149105939","https://openalex.org/W2149784338","https://openalex.org/W2152544605","https://openalex.org/W2152856165","https://openalex.org/W2156009048","https://openalex.org/W2156670752","https://openalex.org/W2163531378","https://openalex.org/W2164407724","https://openalex.org/W2167281518","https://openalex.org/W2172104926"],"related_works":["https://openalex.org/W7095706402","https://openalex.org/W2053878253","https://openalex.org/W2025954237","https://openalex.org/W2016578587","https://openalex.org/W4401812431","https://openalex.org/W2017333590","https://openalex.org/W2739364291","https://openalex.org/W2073003786","https://openalex.org/W3034155944","https://openalex.org/W7097572202"],"abstract_inverted_index":{"Growing":[0],"genetic":[1],"and":[2,15,59,95,104],"epidemiological":[3],"evidence":[4],"suggests":[5],"a":[6],"direct":[7],"connection":[8],"between":[9],"the":[10,19,26,52,111,116,125],"disruption":[11],"of":[12,21,54,67,75,98,113,120,127,130],"circadian":[13,27],"rhythm":[14],"breast":[16,44,69,79,87,137,157],"cancer.":[17],"Moreover,":[18],"expression":[20,56,74],"several":[22],"molecular":[23],"components":[24],"constituting":[25],"clock":[28],"machinery":[29],"has":[30],"been":[31],"found":[32],"to":[33,115],"be":[34,148],"modulated":[35],"by":[36,57,102],"estrogen-estrogen":[37],"receptor":[38],"\u03b1":[39],"(E2-ER\u03b1)":[40],"signaling":[41],"in":[42,62,77,135,156],"ER\u03b1-positive":[43,78,85,136],"cancer":[45,88,138,158],"cells.":[46,139,159],"In":[47,106],"this":[48],"study,":[49],"we":[50],"investigated":[51],"regulation":[53],"CLOCK":[55,76,99,121,131,146],"ER\u03b1":[58,114],"its":[60],"roles":[61],"cell":[63,89,133,154],"proliferation.":[64],"Immunohistochemical":[65],"analysis":[66],"human":[68,86],"tumor":[70,80],"samples":[71],"revealed":[72],"high":[73],"samples.":[81],"Subsequent":[82],"experiments":[83],"using":[84],"lines":[90],"showed":[91],"that":[92,145,152],"both":[93],"protein":[94],"mRNA":[96],"levels":[97],"were":[100],"up-regulated":[101],"E2":[103,109],"ER\u03b1.":[105],"these":[107,142],"cells,":[108],"promoted":[110],"binding":[112],"EREs":[117],"(estrogen-response":[118],"elements)":[119],"promoter,":[122],"thereby":[123],"up-regulating":[124],"transcription":[126],"CLOCK.":[128],"Knockdown":[129],"attenuated":[132],"proliferation":[134,155],"Taken":[140],"together,":[141],"results":[143],"demonstrated":[144],"could":[147],"an":[149],"important":[150],"gene":[151],"mediates":[153]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}