{"id":"https://openalex.org/W2054770710","doi":"https://doi.org/10.1021/bm400615n","title":"Acetal-Linked Paclitaxel Prodrug Micellar Nanoparticles as a Versatile and Potent Platform for Cancer Therapy","display_name":"Acetal-Linked Paclitaxel Prodrug Micellar Nanoparticles as a Versatile and Potent Platform for Cancer Therapy","publication_year":2013,"publication_date":"2013-06-18","ids":{"openalex":"https://openalex.org/W2054770710","doi":"https://doi.org/10.1021/bm400615n","mag":"2054770710","pmid":"https://pubmed.ncbi.nlm.nih.gov/23777504"},"language":"en","primary_location":{"id":"doi:10.1021/bm400615n","doi":"https://doi.org/10.1021/bm400615n","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bm400615n","pdf_url":null,"source":{"id":"https://openalex.org/S11629336","display_name":"Biomacromolecules","issn_l":"1525-7797","issn":["1525-7797","1526-4602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035082233","display_name":"Yudan Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yudan Gu","raw_affiliation_strings":["Biomedical\rPolymers Laboratory and Jiangsu Key Laboratory\rof Advanced Functional Polymer Design and Application, Department\rof Polymer Science and Engineering, College of Chemistry, Chemical\rEngineering and Materials Science, Soochow University, Suzhou 215123, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical\rPolymers Laboratory and Jiangsu Key Laboratory\rof Advanced Functional Polymer Design and Application, Department\rof Polymer Science and Engineering, College of Chemistry, Chemical\rEngineering and Materials Science, Soochow University, Suzhou 215123, P. R. China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051063828","display_name":"Yinan Zhong","orcid":"https://orcid.org/0000-0003-4683-3940","observed_orcids":["https://orcid.org/0000-0003-4683-3940"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinan Zhong","raw_affiliation_strings":["Biomedical\rPolymers Laboratory and Jiangsu Key Laboratory\rof Advanced Functional Polymer Design and Application, Department\rof Polymer Science and Engineering, College of Chemistry, Chemical\rEngineering and Materials Science, Soochow University, Suzhou 215123, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical\rPolymers Laboratory and Jiangsu Key Laboratory\rof Advanced Functional Polymer Design and Application, Department\rof Polymer Science and Engineering, College of Chemistry, Chemical\rEngineering and Materials Science, Soochow University, Suzhou 215123, P. R. China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026189929","display_name":"Fenghua Meng","orcid":"https://orcid.org/0000-0002-8608-7738","observed_orcids":["https://orcid.org/0000-0002-8608-7738"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fenghua Meng","raw_affiliation_strings":["Biomedical\rPolymers Laboratory and Jiangsu Key Laboratory\rof Advanced Functional Polymer Design and Application, Department\rof Polymer Science and Engineering, College of Chemistry, Chemical\rEngineering and Materials Science, Soochow University, Suzhou 215123, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical\rPolymers Laboratory and Jiangsu Key Laboratory\rof Advanced Functional Polymer Design and Application, Department\rof Polymer Science and Engineering, College of Chemistry, Chemical\rEngineering and Materials Science, Soochow University, Suzhou 215123, P. R. China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113980369","display_name":"Ru Cheng","orcid":"https://orcid.org/0000-0002-0879-5069","observed_orcids":["https://orcid.org/0000-0002-0879-5069"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ru Cheng","raw_affiliation_strings":["Biomedical\rPolymers Laboratory and Jiangsu Key Laboratory\rof Advanced Functional Polymer Design and Application, Department\rof Polymer Science and Engineering, College of Chemistry, Chemical\rEngineering and Materials Science, Soochow University, Suzhou 215123, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical\rPolymers Laboratory and Jiangsu Key Laboratory\rof Advanced Functional Polymer Design and Application, Department\rof Polymer Science and Engineering, College of Chemistry, Chemical\rEngineering and Materials Science, Soochow University, Suzhou 215123, P. R. China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100443251","display_name":"Chao Deng","orcid":"https://orcid.org/0000-0001-7697-9874","observed_orcids":["https://orcid.org/0000-0001-7697-9874"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chao Deng","raw_affiliation_strings":["Biomedical\rPolymers Laboratory and Jiangsu Key Laboratory\rof Advanced Functional Polymer Design and Application, Department\rof Polymer Science and Engineering, College of Chemistry, Chemical\rEngineering and Materials Science, Soochow University, Suzhou 215123, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical\rPolymers Laboratory and Jiangsu Key Laboratory\rof Advanced Functional Polymer Design and Application, Department\rof Polymer Science and Engineering, College of Chemistry, Chemical\rEngineering and Materials Science, Soochow University, Suzhou 215123, P. R. China","institution_ids":["https://openalex.org/I3923682"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039037778","display_name":"Zhiyuan Zhong","orcid":"https://orcid.org/0000-0003-4175-4741","observed_orcids":["https://orcid.org/0000-0003-4175-4741","https://orcid.org/0000-0001-5503-9293"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiyuan Zhong","raw_affiliation_strings":["Biomedical\rPolymers Laboratory and Jiangsu Key Laboratory\rof Advanced Functional Polymer Design and Application, Department\rof Polymer Science and Engineering, College of Chemistry, Chemical\rEngineering and Materials Science, Soochow University, Suzhou 215123, P. R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical\rPolymers Laboratory and Jiangsu Key Laboratory\rof Advanced Functional Polymer Design and Application, Department\rof Polymer Science and Engineering, College of Chemistry, Chemical\rEngineering and Materials Science, Soochow University, Suzhou 215123, P. R. China","institution_ids":["https://openalex.org/I3923682"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026189929","https://openalex.org/A5039037778"],"corresponding_institution_ids":["https://openalex.org/I3923682"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":7.3023,"has_fulltext":false,"cited_by_count":189,"citation_normalized_percentile":{"value":0.986565,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"14","issue":"8","first_page":"2772","last_page":"2780"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel-prodrug","display_name":"paclitaxel prodrug","score":0.9570000171661377},{"id":"https://openalex.org/keywords/micellar-nanoparticles","display_name":"micellar nanoparticles","score":0.949999988079071},{"id":"https://openalex.org/keywords/ph-responsive-drug-release","display_name":"pH-responsive drug release","score":0.7310000061988831},{"id":"https://openalex.org/keywords/folate-targeted-drug-delivery","display_name":"folate-targeted drug delivery","score":0.7749999761581421},{"id":"https://openalex.org/keywords/folate-receptor","display_name":"folate receptor","score":0.8199999928474426},{"id":"https://openalex.org/keywords/paclitaxel-resistance","display_name":"paclitaxel resistance","score":0.7799999713897705},{"id":"https://openalex.org/keywords/kb-cells","display_name":"KB cells","score":0.718999981880188},{"id":"https://openalex.org/keywords/hela-cells","display_name":"HeLa cells","score":0.9909999966621399},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.875},{"id":"https://openalex.org/keywords/cancer-therapy","display_name":"cancer therapy","score":0.33399999141693115}],"concepts":[{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.8991086483001709},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7602900266647339},{"id":"https://openalex.org/C2777516009","wikidata":"https://www.wikidata.org/wiki/Q194207","display_name":"Ethylene glycol","level":2,"score":0.7086296081542969},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.5705084800720215},{"id":"https://openalex.org/C11268172","wikidata":"https://www.wikidata.org/wiki/Q421110","display_name":"Micelle","level":3,"score":0.5217864513397217},{"id":"https://openalex.org/C54400483","wikidata":"https://www.wikidata.org/wiki/Q1793202","display_name":"PEG ratio","level":2,"score":0.46762996912002563},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.4630216956138611},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.4117785096168518},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.32283303141593933},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.21866074204444885},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.20637404918670654},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.07890468835830688},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0701344907283783},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C10138342","wikidata":"https://www.wikidata.org/wiki/Q43015","display_name":"Finance","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000080","descriptor_name":"Acetals","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008823","descriptor_name":"Micelles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011092","descriptor_name":"Polyethylene Glycols","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053769","descriptor_name":"Nanocapsules","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1021/bm400615n","doi":"https://doi.org/10.1021/bm400615n","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bm400615n","pdf_url":null,"source":{"id":"https://openalex.org/S11629336","display_name":"Biomacromolecules","issn_l":"1525-7797","issn":["1525-7797","1526-4602"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"journal-article"},{"id":"pmid:23777504","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23777504","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomacromolecules","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1087259","https://openalex.org/W1976689981","https://openalex.org/W1992321454","https://openalex.org/W1994408672","https://openalex.org/W1994964874","https://openalex.org/W1996292197","https://openalex.org/W1997972415","https://openalex.org/W2000304753","https://openalex.org/W2005033237","https://openalex.org/W2013980860","https://openalex.org/W2020797655","https://openalex.org/W2024787650","https://openalex.org/W2025868380","https://openalex.org/W2026100316","https://openalex.org/W2027432937","https://openalex.org/W2029041094","https://openalex.org/W2030498396","https://openalex.org/W2037041572","https://openalex.org/W2039225729","https://openalex.org/W2040071171","https://openalex.org/W2048042220","https://openalex.org/W2051160517","https://openalex.org/W2053426009","https://openalex.org/W2053613167","https://openalex.org/W2056647735","https://openalex.org/W2059183805","https://openalex.org/W2061435221","https://openalex.org/W2061510929","https://openalex.org/W2062469291","https://openalex.org/W2073721747","https://openalex.org/W2077118523","https://openalex.org/W2082511916","https://openalex.org/W2082587127","https://openalex.org/W2083710155","https://openalex.org/W2084689208","https://openalex.org/W2088039815","https://openalex.org/W2099797949","https://openalex.org/W2140895387","https://openalex.org/W2141395077","https://openalex.org/W2145786098","https://openalex.org/W2153957030","https://openalex.org/W2154906079","https://openalex.org/W2156694810","https://openalex.org/W2162745286","https://openalex.org/W2184694295","https://openalex.org/W2317933941","https://openalex.org/W2325630249"],"related_works":["https://openalex.org/W2746757605","https://openalex.org/W2772776876","https://openalex.org/W6958046028","https://openalex.org/W3043119713","https://openalex.org/W1970940359","https://openalex.org/W3112958167","https://openalex.org/W2742715679","https://openalex.org/W4392885160","https://openalex.org/W2183885099","https://openalex.org/W2078502872"],"abstract_inverted_index":{"Endosomal":[0],"pH-activatable":[1],"paclitaxel":[2],"(PTX)":[3],"prodrug":[4,121,139,162,191,197,223,232,252],"micellar":[5,98,192,253],"nanoparticles":[6,99,122,163,193,233,254],"were":[7],"designed":[8],"and":[9,31,56,66,86,131,151,170,176,199,243,261],"prepared":[10],"by":[11],"conjugating":[12],"PTX":[13,43,62,80,108,120,134,138,161,179,190,196,222,231,242,251],"onto":[14],"water-soluble":[15],"poly(ethylene":[16],"glycol)-b-poly(acrylic":[17],"acid)":[18],"(PEG-PAA)":[19],"block":[20,30],"copolymers":[21],"via":[22],"an":[23],"acid-labile":[24],"acetal":[25],"bond":[26],"to":[27,47,168,209,239],"the":[28,227],"PAA":[29],"investigated":[32],"for":[33,264],"potent":[34,262],"growth":[35],"inhibition":[36],"of":[37,53,103,133],"human":[38],"cancer":[39,265],"cells":[40,172,213],"in":[41,88,111,126,144],"vitro.":[42],"was":[44,123,135],"readily":[45],"conjugated":[46],"PEG-PAA":[48],"with":[49,100,214],"high":[50,165],"drug":[51,117],"contents":[52],"21.6,":[54],"27.0,":[55],"42.8":[57],"wt":[58,201],"%":[59,202],"(denoted":[60],"as":[61,75,182,184,257],"prodrugs":[63],"1,":[64],"2,":[65],"3,":[67],"respectively)":[68,181],"using":[69],"ethyl":[70],"glycol":[71],"vinyl":[72],"ether":[73],"(EGVE)":[74],"a":[76,258],"linker.":[77],"The":[78,110],"resulting":[79],"conjugates":[81],"had":[82],"defined":[83],"molecular":[84],"weights":[85],"self-assembled":[87],"phosphate":[89],"buffer":[90],"(PB,":[91],"pH":[92,148,152],"7.4,":[93,153],"10":[94],"mM)":[95],"into":[96],"monodisperse":[97],"average":[101],"sizes":[102],"158.3-180.3":[104],"nm":[105],"depending":[106],"on":[107,195],"contents.":[109],"vitro":[112],"release":[113,118,241],"studies":[114],"showed":[115,157],"that":[116,158],"from":[119,137],"highly":[124,259],"pH-dependent,":[125],"which":[127],"ca.":[128],"86.9%,":[129],"66.4%":[130],"29.0%":[132],"released":[136],"3":[140,198,224],"at":[141,147],"37":[142],"\u00b0C":[143],"48":[145],"h":[146],"5.0,":[149],"6.0,":[150],"respectively.":[154],"MTT":[155],"assays":[156],"these":[159],"pH-sensitive":[160],"exhibited":[164],"antitumor":[166],"effect":[167],"KB":[169,212],"HeLa":[171],"(IC(50)":[173],"=":[174],"0.18":[175],"0.9":[177],"\u03bcg":[178],"equiv/mL,":[180],"well":[183],"PTX-resistant":[185],"A549":[186],"cells.":[187],"Notably,":[188],"folate-decorated":[189],"based":[194],"20":[200],"folate-poly(ethylene":[203],"glycol)-b-poly(D,L-lactide)":[204],"(FA-PEG-PLA)":[205],"displayed":[206],"apparent":[207],"targetability":[208],"folate":[210],"receptor-overexpressing":[211],"IC(50)":[215],"over":[216],"12":[217],"times":[218],"lower":[219],"than":[220],"nontargeting":[221],"under":[225,245],"otherwise":[226],"same":[228],"conditions.":[229],"Furthermore,":[230],"could":[234],"also":[235],"load":[236],"doxorubicin":[237],"(DOX)":[238],"simultaneously":[240],"DOX":[244],"mildly":[246],"acidic":[247],"pH.":[248],"These":[249],"acetal-linked":[250],"have":[255],"appeared":[256],"versatile":[260],"platform":[263],"therapy.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":20},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":23},{"year":2014,"cited_by_count":14},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}