{"id":"https://openalex.org/W2054728757","doi":"https://doi.org/10.1097/00005344-199219001-00007","title":"Carvedilol in Hypertension: Effects on Hemodynamics and 24-Hour Blood Pressure","display_name":"Carvedilol in Hypertension: Effects on Hemodynamics and 24-Hour Blood Pressure","publication_year":1992,"publication_date":"1992-01-01","ids":{"openalex":"https://openalex.org/W2054728757","doi":"https://doi.org/10.1097/00005344-199219001-00007","mag":"2054728757","pmid":"https://pubmed.ncbi.nlm.nih.gov/1378146"},"language":"en","primary_location":{"id":"doi:10.1097/00005344-199219001-00007","doi":"https://doi.org/10.1097/00005344-199219001-00007","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-199219001-00007","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013225403","display_name":"Per Lund-Johansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]},{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"Per Lund-Johansen","raw_affiliation_strings":["Section of Cardiology, Medical Department, University of Bergen, School of Medicine, Haukeland Hospital, Bergen, Norway","and reprint requests to Dr. P. Lund-Johansen at Section of Cardiology, Medical Department, Haukeland Hospital, 5021 Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardiology, Medical Department, University of Bergen, School of Medicine, Haukeland Hospital, Bergen, Norway","institution_ids":["https://openalex.org/I2800740805","https://openalex.org/I4432739"]},{"raw_affiliation_string":"and reprint requests to Dr. P. Lund-Johansen at Section of Cardiology, Medical Department, Haukeland Hospital, 5021 Bergen, Norway","institution_ids":["https://openalex.org/I2800740805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038806566","display_name":"Per Omvik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]},{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Per Omvik","raw_affiliation_strings":["Section of Cardiology, Medical Department, University of Bergen, School of Medicine, Haukeland Hospital, Bergen, Norway","and reprint requests to Dr. P. Lund-Johansen at Section of Cardiology, Medical Department, Haukeland Hospital, 5021 Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardiology, Medical Department, University of Bergen, School of Medicine, Haukeland Hospital, Bergen, Norway","institution_ids":["https://openalex.org/I2800740805","https://openalex.org/I4432739"]},{"raw_affiliation_string":"and reprint requests to Dr. P. Lund-Johansen at Section of Cardiology, Medical Department, Haukeland Hospital, 5021 Bergen, Norway","institution_ids":["https://openalex.org/I2800740805"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111605273","display_name":"Jan Erik Nordrehaug","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]},{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"Jan Erik Nordrehaug","raw_affiliation_strings":["Section of Cardiology, Medical Department, University of Bergen, School of Medicine, Haukeland Hospital, Bergen, Norway","and reprint requests to Dr. P. Lund-Johansen at Section of Cardiology, Medical Department, Haukeland Hospital, 5021 Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardiology, Medical Department, University of Bergen, School of Medicine, Haukeland Hospital, Bergen, Norway","institution_ids":["https://openalex.org/I2800740805","https://openalex.org/I4432739"]},{"raw_affiliation_string":"and reprint requests to Dr. P. Lund-Johansen at Section of Cardiology, Medical Department, Haukeland Hospital, 5021 Bergen, Norway","institution_ids":["https://openalex.org/I2800740805"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056816871","display_name":"William B. White","orcid":"https://orcid.org/0000-0001-8936-967X","observed_orcids":["https://orcid.org/0000-0001-8936-967X","https://orcid.org/0000-0001-7310-8491"]},"institutions":[{"id":"https://openalex.org/I2800740805","display_name":"Haukeland University Hospital","ror":"https://ror.org/03np4e098","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2800740805"]},{"id":"https://openalex.org/I4432739","display_name":"University of Bergen","ror":"https://ror.org/03zga2b32","country_code":"NO","type":"education","lineage":["https://openalex.org/I4432739"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"William White","raw_affiliation_strings":["Section of Cardiology, Medical Department, University of Bergen, School of Medicine, Haukeland Hospital, Bergen, Norway","and reprint requests to Dr. P. Lund-Johansen at Section of Cardiology, Medical Department, Haukeland Hospital, 5021 Bergen, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Cardiology, Medical Department, University of Bergen, School of Medicine, Haukeland Hospital, Bergen, Norway","institution_ids":["https://openalex.org/I2800740805","https://openalex.org/I4432739"]},{"raw_affiliation_string":"and reprint requests to Dr. P. Lund-Johansen at Section of Cardiology, Medical Department, Haukeland Hospital, 5021 Bergen, Norway","institution_ids":["https://openalex.org/I2800740805"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5013225403"],"corresponding_institution_ids":["https://openalex.org/I2800740805","https://openalex.org/I4432739"],"apc_list":null,"apc_paid":null,"fwci":1.3987,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.80870209,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"19","issue":"Supplement 1","first_page":"S27","last_page":"S34"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13381","display_name":"Heart rate and cardiovascular health","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/carvedilol","display_name":"carvedilol","score":1.0},{"id":"https://openalex.org/keywords/essential-hypertension","display_name":"essential hypertension","score":0.996999979019165},{"id":"https://openalex.org/keywords/antihypertensive-drugs","display_name":"antihypertensive drugs","score":0.8130000233650208},{"id":"https://openalex.org/keywords/beta-adrenergic-blockade","display_name":"beta-adrenergic blockade","score":0.8960000276565552},{"id":"https://openalex.org/keywords/alpha-1-adrenergic-blockade","display_name":"alpha-1 adrenergic blockade","score":0.8799999952316284},{"id":"https://openalex.org/keywords/vasodilation","display_name":"vasodilation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/central-hemodynamics","display_name":"central hemodynamics","score":0.8100000023841858},{"id":"https://openalex.org/keywords/exercise-hemodynamics","display_name":"exercise hemodynamics","score":0.8999999761581421},{"id":"https://openalex.org/keywords/systemic-vascular-resistance","display_name":"systemic vascular resistance","score":0.5740000009536743},{"id":"https://openalex.org/keywords/blood-pressure-reduction","display_name":"blood pressure reduction","score":0.7120000123977661},{"id":"https://openalex.org/keywords/24-hour-ambulatory-blood-pressure-monitoring","display_name":"24-hour ambulatory blood pressure monitoring","score":0.7789999842643738},{"id":"https://openalex.org/keywords/stroke-volume-index","display_name":"stroke volume index","score":0.593999981880188}],"concepts":[{"id":"https://openalex.org/C2780591200","wikidata":"https://www.wikidata.org/wiki/Q412534","display_name":"Carvedilol","level":3,"score":0.9492058753967285},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6187540888786316},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5734052658081055},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48942652344703674},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.15536031126976013}],"mesh":[{"descriptor_ui":"D000077261","descriptor_name":"Carvedilol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002227","descriptor_name":"Carbazoles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002302","descriptor_name":"Cardiac Output","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006339","descriptor_name":"Heart Rate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011412","descriptor_name":"Propanolamines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D014655","descriptor_name":"Vascular Resistance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015150","descriptor_name":"Echocardiography, Doppler","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015444","descriptor_name":"Exercise","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00005344-199219001-00007","doi":"https://doi.org/10.1097/00005344-199219001-00007","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00005344-199219001-00007","pdf_url":null,"source":{"id":"https://openalex.org/S61167191","display_name":"Journal of Cardiovascular Pharmacology","issn_l":"0160-2446","issn":["0160-2446","1533-4023"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiovascular Pharmacology","raw_type":"journal-article"},{"id":"pmid:1378146","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1378146","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiovascular pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2412251445","https://openalex.org/W2243275958","https://openalex.org/W7099211345","https://openalex.org/W2049474252","https://openalex.org/W2044921749","https://openalex.org/W2081285602","https://openalex.org/W2075378983","https://openalex.org/W1979838633","https://openalex.org/W1987658456","https://openalex.org/W1986547506"],"abstract_inverted_index":{"Nineteen":[0],"men":[1],"(mean":[2],"age,":[3],"44":[4],"years)":[5],"with":[6,111],"moderately":[7],"severe":[8],"essential":[9],"hypertension":[10],"were":[11,37,82,148],"studied":[12],"invasively":[13],"at":[14,32,114],"rest":[15,33,115],"and":[16,29,34,40,61,69,91,94,116,132,145,230,240,249],"during":[17,35],"exercise.":[18],"After":[19,72],"initial":[20],"predrug":[21],"recordings,":[22],"patients":[23],"received":[24],"25":[25],"mg":[26],"carvedilol":[27],"orally,":[28],"central":[30],"hemodynamics":[31,81,153],"exercise":[36],"recorded":[38],"1":[39,59,93],"2":[41,95],"h":[42,86,96,106],"after":[43,87,97,107],"tablet":[44],"intake":[45],"to":[46,217,224],"evaluate":[47],"the":[48,62,88,108,112,118,177,241],"immediate":[49],"effects":[50],"of":[51,75,160,182,244],"carvedilol.":[52],"Blood":[53,212],"pressure":[54,123,159,195,202],"decreased":[55,214],"by":[56,126,139,150,170,190],"11%":[57],"within":[58],"h,":[60],"hemodynamic":[63,242],"results":[64],"indicated":[65],"a":[66,155],"combination":[67],"beta-blocking":[68],"vasodilating":[70],"effect.":[71],"6-9":[73],"months":[74],"treatment":[76,104],"(dose,":[77],"25-100":[78],"mg),":[79],"supine":[80,119],"recorded,":[83],"first":[84],"12-24":[85],"last":[89,109],"dose":[90,110],"then":[92],"an":[98,236],"additional":[99],"25-mg":[100],"dose.":[101],"During":[102],"chronic":[103],"(2":[105],"patient":[113],"in":[117,157,173,179,204,209,221,228],"position),":[120],"mean":[121],"arterial":[122],"was":[124,137,188],"reduced":[125,138,149,189],"17%":[127,161],"(p":[128,162],"less":[129,163],"than":[130,164],"0.001)":[131],"total":[133],"peripheral":[134,185],"resistance":[135,186],"index":[136,147,168,187],"6%":[140],"(NS),":[141,172],"whereas":[142],"heart":[143,180],"rate":[144,181],"cardiac":[146],"12%.":[151],"Exercise":[152,166],"demonstrated":[154,199],"decrease":[156],"blood":[158,194,201],"0.001).":[165],"stroke":[167],"increased":[169],"5%":[171,191],"part":[174],"compensating":[175],"for":[176],"reduction":[178],"17%.":[183],"Total":[184],"(NS).":[192],"Twenty-four-hour":[193],"monitoring":[196],"(Accutracker":[197],"II)":[198],"significant":[200],"reductions":[203],"awake":[205,229],"as":[206,208],"well":[207],"asleep":[210,231],"patients.":[211],"pressures":[213],"from":[215,222],"163/102":[216],"141/84":[218],"mm":[219,226],"Hg":[220,227],"135/78":[223],"122/68":[225],"patients;":[232],"respectively.":[233],"Carvedilol":[234],"is":[235],"effective":[237],"antihypertensive":[238],"agent,":[239],"mode":[243],"action":[245],"reflects":[246],"alpha":[247],"1-":[248],"beta":[250],"1-blocking":[251],"activities.":[252]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}