{"id":"https://openalex.org/W2054724044","doi":"https://doi.org/10.1083/jcb.200708021","title":"Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint","display_name":"Stable hZW10 kinetochore residency, mediated by hZwint-1 interaction, is essential for the mitotic checkpoint","publication_year":2008,"publication_date":"2008-02-11","ids":{"openalex":"https://openalex.org/W2054724044","doi":"https://doi.org/10.1083/jcb.200708021","mag":"2054724044","pmid":"https://pubmed.ncbi.nlm.nih.gov/18268100","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2234252"},"language":"en","primary_location":{"id":"doi:10.1083/jcb.200708021","doi":"https://doi.org/10.1083/jcb.200708021","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.200708021","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2234252","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083885755","display_name":"Jakub K. Famulski","orcid":"https://orcid.org/0000-0002-3619-4113","observed_orcids":["https://orcid.org/0000-0002-3619-4113","https://orcid.org/0009-0005-3968-1282"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jakub K. Famulski","raw_affiliation_strings":["1Department of Oncology, University of Alberta, Edmonton, Alberta, Canada T6G 1Z2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Oncology, University of Alberta, Edmonton, Alberta, Canada T6G 1Z2","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091878718","display_name":"Larissa Joy Vos","orcid":"https://orcid.org/0000-0002-7810-3718","observed_orcids":["https://orcid.org/0000-0002-7810-3718"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Larissa Vos","raw_affiliation_strings":["1Department of Oncology, University of Alberta, Edmonton, Alberta, Canada T6G 1Z2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Oncology, University of Alberta, Edmonton, Alberta, Canada T6G 1Z2","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100680897","display_name":"Xuejun Sun","orcid":"https://orcid.org/0000-0003-2387-5531","observed_orcids":["https://orcid.org/0000-0003-2387-5531"]},"institutions":[{"id":"https://openalex.org/I4405258411","display_name":"Cross Cancer Institute","ror":"https://ror.org/00m3k3802","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405258411"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Xuejun Sun","raw_affiliation_strings":["2Experimental Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada T6G 1Z2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Experimental Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada T6G 1Z2","institution_ids":["https://openalex.org/I4405258411"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5085269203","display_name":"Gordon K. T. Chan","orcid":"https://orcid.org/0000-0003-0497-9407","observed_orcids":["https://orcid.org/0000-0003-0497-9407"]},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]},{"id":"https://openalex.org/I4405258411","display_name":"Cross Cancer Institute","ror":"https://ror.org/00m3k3802","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I4405258411"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Gordon Chan","raw_affiliation_strings":["1Department of Oncology, University of Alberta, Edmonton, Alberta, Canada T6G 1Z2","2Experimental Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada T6G 1Z2"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Oncology, University of Alberta, Edmonton, Alberta, Canada T6G 1Z2","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"2Experimental Oncology, Cross Cancer Institute, Edmonton, Alberta, Canada T6G 1Z2","institution_ids":["https://openalex.org/I4405258411"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5085269203"],"corresponding_institution_ids":["https://openalex.org/I154425047","https://openalex.org/I4405258411"],"apc_list":null,"apc_paid":null,"fwci":1.8899,"has_fulltext":false,"cited_by_count":74,"citation_normalized_percentile":{"value":0.8379948,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"180","issue":"3","first_page":"507","last_page":"520"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinetochore","display_name":"kinetochore","score":0.8109999895095825},{"id":"https://openalex.org/keywords/spindle-assembly-checkpoint","display_name":"spindle assembly checkpoint","score":0.8889999985694885},{"id":"https://openalex.org/keywords/chromosome-segregation","display_name":"chromosome segregation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7990000247955322}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8963429927825928},{"id":"https://openalex.org/C192838845","wikidata":"https://www.wikidata.org/wiki/Q908912","display_name":"Kinetochore","level":4,"score":0.8924642205238342},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.7069998979568481},{"id":"https://openalex.org/C175732170","wikidata":"https://www.wikidata.org/wiki/Q9064829","display_name":"Spindle checkpoint","level":5,"score":0.5818213224411011},{"id":"https://openalex.org/C54086632","wikidata":"https://www.wikidata.org/wiki/Q5512671","display_name":"G2-M DNA damage checkpoint","level":5,"score":0.5729596018791199},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5614909529685974},{"id":"https://openalex.org/C105696609","wikidata":"https://www.wikidata.org/wiki/Q1068809","display_name":"Cell cycle checkpoint","level":4,"score":0.3984089493751526},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3779861032962799},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.2922476530075073},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.15764224529266357},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.10755646228790283},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07226762175559998}],"mesh":[{"descriptor_ui":"D002868","descriptor_name":"Chromosomal Proteins, Non-Histone","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002868","descriptor_name":"Chromosomal Proteins, Non-Histone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008677","descriptor_name":"Metaphase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008869","descriptor_name":"Microtubule-Associated Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008938","descriptor_name":"Mitosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008941","descriptor_name":"Spindle Apparatus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009687","descriptor_name":"Nuclear Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018386","descriptor_name":"Kinetochores","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018386","descriptor_name":"Kinetochores","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D018797","descriptor_name":"Cell Cycle Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018816","descriptor_name":"Genes, cdc","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020090","descriptor_name":"Chromosome Segregation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D036681","descriptor_name":"Fluorescence Recovery After Photobleaching","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1083/jcb.200708021","doi":"https://doi.org/10.1083/jcb.200708021","is_oa":false,"landing_page_url":"https://doi.org/10.1083/jcb.200708021","pdf_url":null,"source":{"id":"https://openalex.org/S96410829","display_name":"The Journal of Cell Biology","issn_l":"0021-9525","issn":["0021-9525","1540-8140"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Cell Biology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2234252","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2234252","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},{"id":"pmid:18268100","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18268100","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of cell biology","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.282.5772","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.282.5772","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/b0/bd/J_Cell_Biol_2008_Feb_11_180(3)_507-520.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2234252","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2234252","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W1508230049","https://openalex.org/W1540858422","https://openalex.org/W1896640083","https://openalex.org/W1910209889","https://openalex.org/W1934294339","https://openalex.org/W1965475092","https://openalex.org/W1980779852","https://openalex.org/W1989582949","https://openalex.org/W2005383283","https://openalex.org/W2006419165","https://openalex.org/W2007388359","https://openalex.org/W2009514478","https://openalex.org/W2015187344","https://openalex.org/W2017518375","https://openalex.org/W2022239608","https://openalex.org/W2029384672","https://openalex.org/W2033120822","https://openalex.org/W2036068405","https://openalex.org/W2048938594","https://openalex.org/W2053743856","https://openalex.org/W2057523896","https://openalex.org/W2058703970","https://openalex.org/W2079195903","https://openalex.org/W2089193589","https://openalex.org/W2099009321","https://openalex.org/W2114460232","https://openalex.org/W2124325309","https://openalex.org/W2126683450","https://openalex.org/W2131863700","https://openalex.org/W2136460759","https://openalex.org/W2143471239","https://openalex.org/W2157471438","https://openalex.org/W2159709285","https://openalex.org/W2161965142","https://openalex.org/W2170535602","https://openalex.org/W2186830799","https://openalex.org/W2343964752"],"related_works":["https://openalex.org/W7096459963","https://openalex.org/W2161965142","https://openalex.org/W2100577737","https://openalex.org/W2143471239","https://openalex.org/W2071259832","https://openalex.org/W1540858422","https://openalex.org/W2089193589","https://openalex.org/W1934294339","https://openalex.org/W2036068405","https://openalex.org/W4392148726"],"abstract_inverted_index":{"The":[0],"mitotic":[1,126],"checkpoint":[2,17,127],"is":[3,80,115,123],"an":[4,33],"essential":[5,124],"surveillance":[6],"mechanism":[7],"that":[8,57,74,107],"ensures":[9],"high":[10],"fidelity":[11],"chromosome":[12],"segregation":[13],"during":[14,87],"mitosis.":[15],"Mitotic":[16],"function":[18],"depends":[19],"on":[20,117],"numerous":[21],"kinetochore":[22,43,110],"proteins,":[23],"including":[24],"ZW10,":[25],"ROD,":[26],"and":[27,122],"Zwilch":[28],"(the":[29],"ROD-ZW10-Zwilch":[30],"complex).":[31],"Through":[32],"extensive":[34],"mutagenesis":[35],"screen":[36],"of":[37,46,83,101],"hZW10,":[38],"we":[39,71,105],"have":[40,72],"mapped":[41],"the":[42,51,102],"localization":[44],"domain":[45],"hZW10":[47,75,109],"as":[48,50],"well":[49],"hZwint-1":[52],"interaction":[53,119],"domain.":[54],"We":[55],"find":[56,106],"hZwint-1-noninteracting":[58],"mutants":[59],"still":[60],"localize":[61],"to":[62],"kinetochores.":[63],"In":[64],"addition,":[65],"using":[66],"fluorescence":[67],"recovery":[68],"after":[69],"photobleaching,":[70],"found":[73],"residency":[76,111],"at":[77,90,112],"metaphase":[78],"kinetochores":[79,114],"brief":[81],"(half-time":[82],"13":[84],"s).":[85],"However,":[86],"prometaphase":[88,113],"or":[89],"unattached":[91],"kinetochores,":[92],"enhanced":[93],"green":[94],"fluorescent":[95],"protein-hZW10":[96],"becomes":[97],"a":[98],"stable":[99,108],"component":[100],"kinetochore.":[103],"Moreover,":[104],"dependent":[116],"its":[118],"with":[120],"hZwint-1,":[121],"for":[125],"arrest.":[128]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
