{"id":"https://openalex.org/W2054720022","doi":"https://doi.org/10.1016/s0167-4838(99)00234-4","title":"Non-oxidative modification of lens crystallins by kynurenine: a novel post-translational protein modification with possible relevance to ageing and cataract","display_name":"Non-oxidative modification of lens crystallins by kynurenine: a novel post-translational protein modification with possible relevance to ageing and cataract","publication_year":2000,"publication_date":"2000-02-01","ids":{"openalex":"https://openalex.org/W2054720022","doi":"https://doi.org/10.1016/s0167-4838(99)00234-4","mag":"2054720022","pmid":"https://pubmed.ncbi.nlm.nih.gov/10669791"},"language":"en","primary_location":{"id":"doi:10.1016/s0167-4838(99)00234-4","doi":"https://doi.org/10.1016/s0167-4838(99)00234-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0167-4838(99)00234-4","pdf_url":null,"source":{"id":"https://openalex.org/S4394735818","display_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","issn_l":"0167-4838","issn":["0167-4838","1879-2588"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030922535","display_name":"Brett Garner","orcid":"https://orcid.org/0000-0002-5312-4352","observed_orcids":["https://orcid.org/0000-0002-5312-4352"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Brett Garner","raw_affiliation_strings":["Australian Cataract Research Foundation, University of Wollongong, Wollongong, NSW, Australia. brett@glycob.ox.ac.uk","Australian Cataract Research Foundation, University of Wollongong, Wollongong, NSW 2522, Australia","Department of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Cataract Research Foundation, University of Wollongong, Wollongong, NSW, Australia. brett@glycob.ox.ac.uk","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Australian Cataract Research Foundation, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Department of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109876756","display_name":"Denis C. Shaw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118347636","display_name":"Australian National University","ror":"https://ror.org/019wvm592","country_code":"AU","type":"education","lineage":["https://openalex.org/I118347636"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Denis C. Shaw","raw_affiliation_strings":["Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia","institution_ids":["https://openalex.org/I118347636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068721780","display_name":"Robyn A. Lindner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Robyn A. Lindner","raw_affiliation_strings":["Department of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033863920","display_name":"John A. Carver","orcid":"https://orcid.org/0000-0002-2441-8108","observed_orcids":["https://orcid.org/0000-0002-2441-8108"]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"John A. Carver","raw_affiliation_strings":["Department of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110058663","display_name":"Roger J.W. Truscott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204824540","display_name":"University of Wollongong","ror":"https://ror.org/00jtmb277","country_code":"AU","type":"education","lineage":["https://openalex.org/I204824540"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Roger J.W. Truscott","raw_affiliation_strings":["Australian Cataract Research Foundation, University of Wollongong, Wollongong, NSW 2522, Australia","Department of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Cataract Research Foundation, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]},{"raw_affiliation_string":"Department of Chemistry, University of Wollongong, Wollongong, NSW 2522, Australia","institution_ids":["https://openalex.org/I204824540"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5030922535"],"corresponding_institution_ids":["https://openalex.org/I204824540"],"apc_list":null,"apc_paid":null,"fwci":2.4929,"has_fulltext":false,"cited_by_count":80,"citation_normalized_percentile":{"value":0.89457219,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"1476","issue":"2","first_page":"265","last_page":"278"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.3840000033378601,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.3840000033378601,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.16979999840259552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0843999981880188,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lens-crystallins","display_name":"lens crystallins","score":0.8859999775886536},{"id":"https://openalex.org/keywords/kynurenine","display_name":"kynurenine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/post-translational-modification","display_name":"post-translational modification","score":0.9390000104904175},{"id":"https://openalex.org/keywords/lens-aging","display_name":"lens aging","score":0.7509999871253967},{"id":"https://openalex.org/keywords/glutathione-adducts","display_name":"glutathione adducts","score":0.8700000047683716},{"id":"https://openalex.org/keywords/alpha-beta-unsaturated-carbonyl-compounds","display_name":"\u03b1,\u03b2-unsaturated carbonyl compounds","score":0.796999990940094},{"id":"https://openalex.org/keywords/carboxymethylation","display_name":"carboxymethylation","score":0.7089999914169312},{"id":"https://openalex.org/keywords/succinylation","display_name":"succinylation","score":0.996999979019165},{"id":"https://openalex.org/keywords/nucleophilic-amino-acids","display_name":"nucleophilic amino acids","score":0.6859999895095825},{"id":"https://openalex.org/keywords/covalent-protein-adducts","display_name":"covalent protein adducts","score":0.6039999723434448}],"concepts":[{"id":"https://openalex.org/C2777503454","wikidata":"https://www.wikidata.org/wiki/Q415768","display_name":"Kynurenine","level":4,"score":0.838910698890686},{"id":"https://openalex.org/C7263354","wikidata":"https://www.wikidata.org/wiki/Q2992167","display_name":"Crystallin","level":2,"score":0.731665849685669},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6749449372291565},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5645861625671387},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5470921397209167},{"id":"https://openalex.org/C2776016237","wikidata":"https://www.wikidata.org/wiki/Q178430","display_name":"Lysine","level":3,"score":0.49306198954582214},{"id":"https://openalex.org/C108204754","wikidata":"https://www.wikidata.org/wiki/Q353392","display_name":"Adduct","level":2,"score":0.4791085720062256},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.45771661400794983},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.45656782388687134},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.45393407344818115},{"id":"https://openalex.org/C2776710720","wikidata":"https://www.wikidata.org/wiki/Q80417","display_name":"Kynurenine pathway","level":5,"score":0.45070454478263855},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.4449279308319092},{"id":"https://openalex.org/C204921945","wikidata":"https://www.wikidata.org/wiki/Q899689","display_name":"Side chain","level":3,"score":0.4181051254272461},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.41532281041145325},{"id":"https://openalex.org/C2776706248","wikidata":"https://www.wikidata.org/wiki/Q181003","display_name":"Tryptophan","level":3,"score":0.3401634097099304},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.15604168176651},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002386","descriptor_name":"Cataract","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003459","descriptor_name":"Crystallins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003459","descriptor_name":"Crystallins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007737","descriptor_name":"Kynurenine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007737","descriptor_name":"Kynurenine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/s0167-4838(99)00234-4","doi":"https://doi.org/10.1016/s0167-4838(99)00234-4","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0167-4838(99)00234-4","pdf_url":null,"source":{"id":"https://openalex.org/S4394735818","display_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","issn_l":"0167-4838","issn":["0167-4838","1879-2588"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["norway-1"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology","raw_type":"journal-article"},{"id":"pmid:10669791","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10669791","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochimica et biophysica acta","raw_type":"Journal Article"},{"id":"pmh:oai:digital.library.adelaide.edu.au:2440/47995","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2440/47995","pdf_url":null,"source":{"id":"https://openalex.org/S4306401835","display_name":"Adelaide Research & Scholarship (AR&S) (University of Adelaide)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5681781","host_organization_name":"The University of Adelaide","host_organization_lineage":["https://openalex.org/I5681781"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://doi.org/10.1016/s0167-4838(99)00234-4","raw_type":"Journal article"},{"id":"pmh:oai:openresearch-repository.anu.edu.au:1885/90265","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1885/90265","pdf_url":null,"source":{"id":"https://openalex.org/S4306402539","display_name":"ANU Open Research (Australian National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118347636","host_organization_name":"Australian National University","host_organization_lineage":["https://openalex.org/I118347636"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biochimica et Biophysica Acta: International journal of Biochemistry and Biophysics","raw_type":"Journal article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W37100866","https://openalex.org/W73347127","https://openalex.org/W148976868","https://openalex.org/W199114747","https://openalex.org/W251903133","https://openalex.org/W1534702626","https://openalex.org/W1555045491","https://openalex.org/W1578904753","https://openalex.org/W1964477637","https://openalex.org/W1967288593","https://openalex.org/W1967513516","https://openalex.org/W1975223648","https://openalex.org/W1976138256","https://openalex.org/W1980605019","https://openalex.org/W1984870526","https://openalex.org/W1991147418","https://openalex.org/W2000560813","https://openalex.org/W2002602401","https://openalex.org/W2006967854","https://openalex.org/W2015247226","https://openalex.org/W2019096786","https://openalex.org/W2046055524","https://openalex.org/W2050438710","https://openalex.org/W2058345849","https://openalex.org/W2058841561","https://openalex.org/W2059326898","https://openalex.org/W2062007365","https://openalex.org/W2064370438","https://openalex.org/W2066303560","https://openalex.org/W2073772006","https://openalex.org/W2073848785","https://openalex.org/W2075303826","https://openalex.org/W2086786075","https://openalex.org/W2094409793","https://openalex.org/W2099542937","https://openalex.org/W2128147129","https://openalex.org/W2144273071","https://openalex.org/W2144544590","https://openalex.org/W2327459353","https://openalex.org/W2327820049","https://openalex.org/W2394770924"],"related_works":["https://openalex.org/W1967513516","https://openalex.org/W179873424","https://openalex.org/W2042994636","https://openalex.org/W2040792371","https://openalex.org/W160143334","https://openalex.org/W1976138256","https://openalex.org/W1989886508","https://openalex.org/W2033447168","https://openalex.org/W2115542084","https://openalex.org/W2081624154"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}