{"id":"https://openalex.org/W2054618296","doi":"https://doi.org/10.1016/j.bcp.2004.08.021","title":"Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate","display_name":"Inhibition of angiogenesis in vivo and growth of Kaposi's sarcoma xenograft tumors by the anti-malarial artesunate","publication_year":2004,"publication_date":"2004-10-13","ids":{"openalex":"https://openalex.org/W2054618296","doi":"https://doi.org/10.1016/j.bcp.2004.08.021","mag":"2054618296","pmid":"https://pubmed.ncbi.nlm.nih.gov/15548382"},"language":"en","primary_location":{"id":"doi:10.1016/j.bcp.2004.08.021","doi":"https://doi.org/10.1016/j.bcp.2004.08.021","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bcp.2004.08.021","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030637337","display_name":"Raffaella Dell\u2019Eva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raffaella Dell\u2019Eva","raw_affiliation_strings":["Molecular Oncology, National Cancer Research Institute (IST), Largo Rosanna Benzi 10, 16132 Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology, National Cancer Research Institute (IST), Largo Rosanna Benzi 10, 16132 Genova, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038566079","display_name":"Ulrich Pfeffer","orcid":"https://orcid.org/0000-0003-0872-4671","observed_orcids":["https://orcid.org/0000-0003-0872-4671"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ulrich Pfeffer","raw_affiliation_strings":["Molecular Oncology, National Cancer Research Institute (IST), Largo Rosanna Benzi 10, 16132 Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology, National Cancer Research Institute (IST), Largo Rosanna Benzi 10, 16132 Genova, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053751434","display_name":"Roberta Ven\u00e8","orcid":"https://orcid.org/0000-0002-2522-3716","observed_orcids":["https://orcid.org/0000-0002-2522-3716"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roberta Ven\u00e9","raw_affiliation_strings":["Molecular Oncology, National Cancer Research Institute (IST), Largo Rosanna Benzi 10, 16132 Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology, National Cancer Research Institute (IST), Largo Rosanna Benzi 10, 16132 Genova, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036563195","display_name":"Luca Anfosso","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luca Anfosso","raw_affiliation_strings":["Molecular Oncology, National Cancer Research Institute (IST), Largo Rosanna Benzi 10, 16132 Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology, National Cancer Research Institute (IST), Largo Rosanna Benzi 10, 16132 Genova, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111751923","display_name":"Alessandra Forlani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alessandra Forlani","raw_affiliation_strings":["Molecular Oncology, National Cancer Research Institute (IST), Largo Rosanna Benzi 10, 16132 Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology, National Cancer Research Institute (IST), Largo Rosanna Benzi 10, 16132 Genova, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031245175","display_name":"Adriana Albini","orcid":"https://orcid.org/0000-0002-9624-5103","observed_orcids":["https://orcid.org/0000-0002-9624-5103"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adriana Albini","raw_affiliation_strings":["Molecular Oncology, National Cancer Research Institute (IST), Largo Rosanna Benzi 10, 16132 Genova, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Oncology, National Cancer Research Institute (IST), Largo Rosanna Benzi 10, 16132 Genova, Italy","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033575797","display_name":"Thomas Efferth","orcid":"https://orcid.org/0000-0002-2637-1681","observed_orcids":["https://orcid.org/0000-0002-2637-1681"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Thomas Efferth","raw_affiliation_strings":["Center for Molecular Biology, University of Heidelberg (ZMBH), Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Biology, University of Heidelberg (ZMBH), Im Neuenheimer Feld 282, D-69120 Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5033575797"],"corresponding_institution_ids":["https://openalex.org/I223822909"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":2.8303,"has_fulltext":false,"cited_by_count":231,"citation_normalized_percentile":{"value":0.91626848,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":100},"biblio":{"volume":"68","issue":"12","first_page":"2359","last_page":"2366"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.8041999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.17409999668598175,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12278","display_name":"Vascular Tumors and Angiosarcomas","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artesunate","display_name":"artesunate","score":0.9789999723434448},{"id":"https://openalex.org/keywords/kaposi-sarcoma","display_name":"Kaposi's sarcoma","score":0.9860000014305115},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.9369999766349792},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.7480000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8399999737739563},{"id":"https://openalex.org/keywords/endothelial-cell-proliferation","display_name":"endothelial cell proliferation","score":0.6779999732971191},{"id":"https://openalex.org/keywords/artemisinin-derivatives","display_name":"artemisinin derivatives","score":0.8389999866485596},{"id":"https://openalex.org/keywords/antimalarial-drugs","display_name":"antimalarial drugs","score":0.7319999933242798},{"id":"https://openalex.org/keywords/tumor-vascularization","display_name":"tumor vascularization","score":0.7419999837875366}],"concepts":[{"id":"https://openalex.org/C2778059366","wikidata":"https://www.wikidata.org/wiki/Q707939","display_name":"Artesunate","level":4,"score":0.7582300901412964},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.7395246028900146},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.6016502380371094},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5874199271202087},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5183714032173157},{"id":"https://openalex.org/C2778608917","wikidata":"https://www.wikidata.org/wiki/Q6787805","display_name":"Matrigel","level":3,"score":0.47947463393211365},{"id":"https://openalex.org/C2779236070","wikidata":"https://www.wikidata.org/wiki/Q725345","display_name":"Kaposi's sarcoma","level":4,"score":0.4753703474998474},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46602439880371094},{"id":"https://openalex.org/C2778439243","wikidata":"https://www.wikidata.org/wiki/Q7157043","display_name":"Pazopanib","level":4,"score":0.4554516673088074},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4006080627441406},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3640102446079254},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2692982256412506},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.24193230271339417},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.20675107836723328},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.18384519219398499},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1447906494140625},{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.1194750964641571},{"id":"https://openalex.org/C3018958071","wikidata":"https://www.wikidata.org/wiki/Q149348","display_name":"Human herpesvirus","level":3,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077332","descriptor_name":"Artesunate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000962","descriptor_name":"Antimalarials","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007797","descriptor_name":"Laminin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008819","descriptor_name":"Mice, Nude","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009368","descriptor_name":"Neoplasm Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012514","descriptor_name":"Sarcoma, Kaposi","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012717","descriptor_name":"Sesquiterpenes","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018919","descriptor_name":"Neovascularization, Physiologic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D045726","descriptor_name":"Metalloproteases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bcp.2004.08.021","doi":"https://doi.org/10.1016/j.bcp.2004.08.021","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bcp.2004.08.021","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},{"id":"pmid:15548382","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15548382","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309746","display_name":"Compagnia di San Paolo","ror":"https://ror.org/00d1b1c41"},{"id":"https://openalex.org/F4320310702","display_name":"National Cancer Research Institute","ror":"https://ror.org/02mp0vf47"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W70378851","https://openalex.org/W135187131","https://openalex.org/W1554860885","https://openalex.org/W1581131161","https://openalex.org/W1621000076","https://openalex.org/W1945827446","https://openalex.org/W1960393275","https://openalex.org/W1968849966","https://openalex.org/W1970370517","https://openalex.org/W1971874117","https://openalex.org/W1984525563","https://openalex.org/W1995685700","https://openalex.org/W1995709950","https://openalex.org/W2009313534","https://openalex.org/W2010558751","https://openalex.org/W2018661082","https://openalex.org/W2019647403","https://openalex.org/W2022680659","https://openalex.org/W2028102269","https://openalex.org/W2030428837","https://openalex.org/W2036948109","https://openalex.org/W2037199214","https://openalex.org/W2038028403","https://openalex.org/W2040450077","https://openalex.org/W2040468456","https://openalex.org/W2044811771","https://openalex.org/W2048523274","https://openalex.org/W2054288813","https://openalex.org/W2058556636","https://openalex.org/W2067051421","https://openalex.org/W2079473945","https://openalex.org/W2082601154","https://openalex.org/W2084796179","https://openalex.org/W2087626865","https://openalex.org/W2090590677","https://openalex.org/W2096398678","https://openalex.org/W2097988986","https://openalex.org/W2108089761","https://openalex.org/W2110863828","https://openalex.org/W2111123972","https://openalex.org/W2114188952","https://openalex.org/W2116218122","https://openalex.org/W2136560830","https://openalex.org/W2139878820","https://openalex.org/W2142777712","https://openalex.org/W2148976224","https://openalex.org/W2152291745","https://openalex.org/W2169661325","https://openalex.org/W2169938865","https://openalex.org/W2233190715","https://openalex.org/W2313420621","https://openalex.org/W2320970642","https://openalex.org/W2410411234","https://openalex.org/W6714799713"],"related_works":["https://openalex.org/W2032680197","https://openalex.org/W2468521972","https://openalex.org/W2043724241","https://openalex.org/W7098726266","https://openalex.org/W2019647403","https://openalex.org/W2359270860","https://openalex.org/W2350810805","https://openalex.org/W1524602812","https://openalex.org/W7100941047","https://openalex.org/W2382456250"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":13},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":19},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":17},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}