{"id":"https://openalex.org/W2054598108","doi":"https://doi.org/10.1097/prs.0b013e31822b65e4","title":"Regenerative Surgery in Cranioplasty Revisited","display_name":"Regenerative Surgery in Cranioplasty Revisited","publication_year":2011,"publication_date":"2011-10-27","ids":{"openalex":"https://openalex.org/W2054598108","doi":"https://doi.org/10.1097/prs.0b013e31822b65e4","mag":"2054598108","pmid":"https://pubmed.ncbi.nlm.nih.gov/22030488"},"language":"en","primary_location":{"id":"doi:10.1097/prs.0b013e31822b65e4","doi":"https://doi.org/10.1097/prs.0b013e31822b65e4","is_oa":false,"landing_page_url":"https://doi.org/10.1097/prs.0b013e31822b65e4","pdf_url":null,"source":{"id":"https://openalex.org/S100736837","display_name":"Plastic & Reconstructive Surgery","issn_l":"0032-1052","issn":["0032-1052","1076-5751","1529-4242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079071540","display_name":"Darren M. Smith","orcid":"https://orcid.org/0000-0003-4381-9553","observed_orcids":["https://orcid.org/0000-0003-4381-9553"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Darren M. Smith","raw_affiliation_strings":["Pittsburgh, Pa. From the Division of Plastic Surgery, University of Pittsburgh","the Division of Plastic Surgery, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pittsburgh, Pa. From the Division of Plastic Surgery, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"the Division of Plastic Surgery, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Gregory M. Cooper","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gregory M. Cooper","raw_affiliation_strings":["the Division of Plastic Surgery, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Division of Plastic Surgery, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049740435","display_name":"Ahmed M. Afifi","orcid":"https://orcid.org/0000-0001-6637-8426","observed_orcids":["https://orcid.org/0000-0001-6637-8426"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmed M. Afifi","raw_affiliation_strings":["the Division of Plastic Surgery, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Division of Plastic Surgery, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087605552","display_name":"Mark P. Mooney","orcid":"https://orcid.org/0000-0002-1943-9967","observed_orcids":["https://orcid.org/0000-0002-1943-9967"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark P. Mooney","raw_affiliation_strings":["the Division of Plastic Surgery, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Division of Plastic Surgery, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084705544","display_name":"James Cray","orcid":"https://orcid.org/0000-0002-8512-7005","observed_orcids":["https://orcid.org/0000-0002-8512-7005"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Cray","raw_affiliation_strings":["the Division of Plastic Surgery, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Division of Plastic Surgery, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051666296","display_name":"J. Peter Rubin","orcid":"https://orcid.org/0000-0003-2040-6051","observed_orcids":["https://orcid.org/0000-0003-2040-6051"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Peter Rubin","raw_affiliation_strings":["the Division of Plastic Surgery, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Division of Plastic Surgery, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029117296","display_name":"Kacey Gribbin Marra","orcid":"https://orcid.org/0000-0002-8437-4864","observed_orcids":["https://orcid.org/0000-0002-8437-4864"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kacey G. Marra","raw_affiliation_strings":["the Division of Plastic Surgery, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Division of Plastic Surgery, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109431121","display_name":"Joseph E. Losee","orcid":"https://orcid.org/0000-0003-2973-0683","observed_orcids":["https://orcid.org/0000-0003-2973-0683"]},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph E. Losee","raw_affiliation_strings":["the Division of Plastic Surgery, University of Pittsburgh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Division of Plastic Surgery, University of Pittsburgh","institution_ids":["https://openalex.org/I170201317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I170201317"],"apc_list":null,"apc_paid":null,"fwci":3.971,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.93640425,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"128","issue":"5","first_page":"1053","last_page":"1060"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cranioplasty","display_name":"cranioplasty","score":0.8679999709129333},{"id":"https://openalex.org/keywords/bone-defects","display_name":"bone defects","score":0.32100000977516174},{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":0.9620000123977661},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.9649999737739563},{"id":"https://openalex.org/keywords/osteoinduction","display_name":"osteoinduction","score":0.7960000038146973},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.7979999780654907},{"id":"https://openalex.org/keywords/craniofacial-reconstruction","display_name":"craniofacial reconstruction","score":0.8149999976158142},{"id":"https://openalex.org/keywords/rabbit-model","display_name":"rabbit model","score":0.5049999952316284},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.34299999475479126}],"concepts":[{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.7614068388938904},{"id":"https://openalex.org/C2779918246","wikidata":"https://www.wikidata.org/wiki/Q613203","display_name":"Calvaria","level":3,"score":0.7054577469825745},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6531249284744263},{"id":"https://openalex.org/C2778849931","wikidata":"https://www.wikidata.org/wiki/Q18960","display_name":"Sponge","level":2,"score":0.5655218362808228},{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.44635897874832153},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.4321350157260895},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4284246563911438},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.37409061193466187},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3588297367095947},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.1856374740600586},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1773911714553833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1757771074771881},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1614445447921753},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.16126129031181335},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.08742570877075195},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D019651","descriptor_name":"Plastic Surgery Procedures","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019736","descriptor_name":"Prostheses and Implants","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D033581","descriptor_name":"Stem Cell Transplantation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055396","descriptor_name":"Bone Morphogenetic Protein 2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1097/prs.0b013e31822b65e4","doi":"https://doi.org/10.1097/prs.0b013e31822b65e4","is_oa":false,"landing_page_url":"https://doi.org/10.1097/prs.0b013e31822b65e4","pdf_url":null,"source":{"id":"https://openalex.org/S100736837","display_name":"Plastic & Reconstructive Surgery","issn_l":"0032-1052","issn":["0032-1052","1076-5751","1529-4242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery","raw_type":"journal-article"},{"id":"pmid:22030488","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22030488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and reconstructive surgery","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1975463875","https://openalex.org/W2057129435","https://openalex.org/W2057598022","https://openalex.org/W2144623968","https://openalex.org/W2638080320","https://openalex.org/W2908949596","https://openalex.org/W2330270078","https://openalex.org/W2055753036","https://openalex.org/W2031860980","https://openalex.org/W1973891854"],"abstract_inverted_index":{"BACKGROUND:":[0],"Reconstruction":[1],"of":[2,12,24,30,62,143,236,240,249],"the":[3,27,31,36,43,54,59,203,234,247,256],"pediatric":[4],"calvaria":[5],"is":[6,16,33,49,213],"frequently":[7],"complicated":[8],"by":[9,141],"a":[10,214],"shortage":[11],"bone.":[13],"This":[14],"problem":[15,254],"most":[17],"apparent":[18],"between":[19],"2":[20],"and":[21,35,57,70,121,135,174,239,242],"10":[22],"years":[23],"age,":[25],"when":[26],"osteogenic":[28],"potential":[29],"dura":[32],"diminished":[34],"diploic":[37],"space":[38],"has":[39],"not":[40,224],"matured":[41],"to":[42,217],"point":[44],"that":[45],"split-thickness":[46],"calvarial":[47],"grafting":[48],"practical.":[50],"In":[51],"this":[52,227,253],"article,":[53],"authors":[55],"evaluate":[56],"compare":[58],"relative":[60],"efficacy":[61,248],"adipose-derived":[63,71,114,123,165,176],"stem":[64,72,115,124,166,177,221],"cells,":[65],"bone":[66],"morphogenetic":[67],"protein":[68],"(BMP)-2,":[69],"cells":[73,116,125,167,178,222],"osteoinduced":[74,122,175],"with":[75,133,187],"BMP-2":[76,109],"in":[77,89,149,205,233,255],"addressing":[78],"these":[79],"defects.":[80],"METHODS:":[81],"Cranial":[82],"defects":[83,204],"measuring":[84],"15\u00d715":[85],"mm":[86],"were":[87,97,193],"created":[88],"New":[90],"Zealand":[91],"White":[92],"rabbits.":[93],"Five":[94],"treatment":[95],"modalities":[96],"compared:":[98],"no":[99],"repair":[100],"(surgical":[101],"control);":[102,108],"untreated":[103],"acellular":[104,111,118,127,159,169,180],"collagen":[105,112,119,128,160,170,181,191],"sponge":[106,161,171,182,192],"(vehicle":[107],"on":[110,117,126,168,179,194],"sponge;":[113,120],"sponge.":[129],"Osteogenesis":[130],"was":[131,139,152],"assessed":[132],"radiology":[134],"histology.":[136],"Statistical":[137],"significance":[138],"determined":[140],"analysis":[142],"variance.":[144],"RESULTS:":[145],"No":[146],"significant":[147],"difference":[148],"osseous":[150],"healing":[151],"observed":[153],"among":[154],"empty":[155],"controls":[156],"(32.8":[157],"percent),":[158,164,173],"alone":[162],"(34.4":[163],"(33.9":[172],"(40.2":[183],"percent).":[184],"Defects":[185],"reconstructed":[186],"recombinant":[188],"human":[189],"BMP-2/acellular":[190],"average":[195],"96.9":[196],"percent":[197],"ossified,":[198],"significantly":[199,225],"(p<0.05)":[200],"more":[201],"than":[202],"all":[206],"other":[207],"groups.":[208],"CONCLUSIONS:":[209],"BMP-2-based":[210],"tissue":[211],"engineering":[212],"viable":[215],"approach":[216],"craniofacial":[218,237],"reconstruction.":[219],"Adipose-derived":[220],"did":[223],"augment":[226],"process":[228],"as":[229],"modeled":[230],"here.":[231],"Advances":[232],"understanding":[235],"biology,":[238],"protein-":[241],"cell-based":[243],"therapies,":[244],"will":[245],"enhance":[246],"tissue-engineering":[250],"strategies":[251],"for":[252],"future.":[257]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}