{"id":"https://openalex.org/W2054584654","doi":"https://doi.org/10.1042/bj20081240","title":"Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-\u03b3 agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions","display_name":"Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-\u03b3 agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions","publication_year":2008,"publication_date":"2008-09-11","ids":{"openalex":"https://openalex.org/W2054584654","doi":"https://doi.org/10.1042/bj20081240","mag":"2054584654","pmid":"https://pubmed.ncbi.nlm.nih.gov/18783346","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3936483"},"language":"en","primary_location":{"id":"doi:10.1042/bj20081240","doi":"https://doi.org/10.1042/bj20081240","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20081240","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3936483","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007640637","display_name":"Guang William Wong","orcid":"https://orcid.org/0000-0002-5286-6506","observed_orcids":["https://orcid.org/0000-0002-5286-6506"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"G.\u00a0William Wong","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Cambridge, MA 02142, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142, U.S.A","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044046885","display_name":"Sarah A. Krawczyk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah\u00a0A. Krawczyk","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Cambridge, MA 02142, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142, U.S.A","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028906264","display_name":"Claire Kitidis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire Kitidis-Mitrokostas","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Cambridge, MA 02142, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142, U.S.A","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079392786","display_name":"Tracy Revett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracy Revett","raw_affiliation_strings":["Cardiovascular and Metabolic Diseases, Wyeth Research, Cambridge, MA 02140, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular and Metabolic Diseases, Wyeth Research, Cambridge, MA 02140, U.S.A","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064772594","display_name":"Ruth E. Gimeno","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4403928396","display_name":"Wyeth","ror":"https://ror.org/035j24j42","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899","https://openalex.org/I4403928396"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ruth Gimeno","raw_affiliation_strings":["Cardiovascular and Metabolic Diseases, Wyeth Research, Cambridge, MA 02140, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular and Metabolic Diseases, Wyeth Research, Cambridge, MA 02140, U.S.A","institution_ids":["https://openalex.org/I4403928396"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076111394","display_name":"Harvey F. Lodish","orcid":"https://orcid.org/0000-0002-7029-7415","observed_orcids":["https://orcid.org/0000-0002-7029-7415"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Harvey\u00a0F. Lodish","raw_affiliation_strings":["Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, U.S.A","Whitehead Institute for Biomedical Research, Cambridge, MA 02142, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, U.S.A","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA 02142, U.S.A","institution_ids":["https://openalex.org/I4210157710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007640637","https://openalex.org/A5076111394"],"corresponding_institution_ids":["https://openalex.org/I4210157710","https://openalex.org/I63966007"],"apc_list":null,"apc_paid":null,"fwci":4.4946,"has_fulltext":false,"cited_by_count":377,"citation_normalized_percentile":{"value":0.95020209,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"416","issue":"2","first_page":"161","last_page":"177"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ctrp","display_name":"CTRP","score":0.6869999766349792},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.9160000085830688},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.5989999771118164},{"id":"https://openalex.org/keywords/tissue-specific-expression","display_name":"tissue-specific gene expression","score":0.6470000147819519},{"id":"https://openalex.org/keywords/ppargamma-agonists","display_name":"PPAR\u03b3 agonists","score":0.8769999742507935},{"id":"https://openalex.org/keywords/rosiglitazone","display_name":"rosiglitazone","score":0.9980000257492065},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.6930000185966492},{"id":"https://openalex.org/keywords/heterotrimers","display_name":"heterotrimers","score":0.7319999933242798},{"id":"https://openalex.org/keywords/oligomerization","display_name":"oligomerization","score":0.7239999771118164},{"id":"https://openalex.org/keywords/disulfide-bonds","display_name":"disulfide bonds","score":0.8209999799728394},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.5529999732971191},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9660000205039978},{"id":"https://openalex.org/keywords/myotubes","display_name":"myotubes","score":0.7599999904632568},{"id":"https://openalex.org/keywords/insulin-sensitivity","display_name":"insulin sensitivity","score":0.4690000116825104},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C2776782570","wikidata":"https://www.wikidata.org/wiki/Q357439","display_name":"Adiponectin","level":4,"score":0.7491128444671631},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5257989764213562},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4829099178314209},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.4741641581058502},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47399723529815674},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4129272699356079},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.41077107191085815},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34266799688339233},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3340164124965668},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.2004656195640564},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.16737157106399536},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003094","descriptor_name":"Collagen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017154","descriptor_name":"Stromal Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017395","descriptor_name":"Plasminogen Activator Inhibitor 1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017667","descriptor_name":"Adipocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018932","descriptor_name":"Chemokine CCL2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020738","descriptor_name":"Leptin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D047495","descriptor_name":"PPAR gamma","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D052242","descriptor_name":"Adiponectin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1042/bj20081240","doi":"https://doi.org/10.1042/bj20081240","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj20081240","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmid:18783346","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18783346","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2917546","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3936483","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3936483","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3936483","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Biochem J","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2917546","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3936483","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1819478311","display_name":"Metabolic Control by novel Acrp30-like proteins","funder_award_id":"1f32dk067835-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3576461079","display_name":null,"funder_award_id":"F32DK067835","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G438724982","display_name":null,"funder_award_id":"R37 DK47618\u201019","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4716423166","display_name":"T-cadherin as an Acrp30/Adiponectin Receptor","funder_award_id":"K08HL077499","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4795433956","display_name":"ADIPOCYTE PROTEIN SECRETION AND INSULIN ACTION","funder_award_id":"R37DK047618","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G4940513870","display_name":null,"funder_award_id":"HL077499-01","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7454096242","display_name":"Lincs and miRs that regulate brown fat formation and function","funder_award_id":"R01DK047618","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W286198423","https://openalex.org/W1505805443","https://openalex.org/W1524321743","https://openalex.org/W1526730706","https://openalex.org/W1587875569","https://openalex.org/W1883703584","https://openalex.org/W1981261500","https://openalex.org/W1993800499","https://openalex.org/W2001727439","https://openalex.org/W2010188590","https://openalex.org/W2010374889","https://openalex.org/W2012531860","https://openalex.org/W2038280977","https://openalex.org/W2042216382","https://openalex.org/W2043419594","https://openalex.org/W2046019914","https://openalex.org/W2049965571","https://openalex.org/W2052777370","https://openalex.org/W2053135489","https://openalex.org/W2055388500","https://openalex.org/W2062162775","https://openalex.org/W2065697164","https://openalex.org/W2069497802","https://openalex.org/W2076939762","https://openalex.org/W2078374645","https://openalex.org/W2078895436","https://openalex.org/W2083788791","https://openalex.org/W2084271278","https://openalex.org/W2087408139","https://openalex.org/W2091759162","https://openalex.org/W2094661843","https://openalex.org/W2095236486","https://openalex.org/W2097794068","https://openalex.org/W2100221605","https://openalex.org/W2101048587","https://openalex.org/W2101414552","https://openalex.org/W2127934772","https://openalex.org/W2133055307","https://openalex.org/W2136861985","https://openalex.org/W2142504521","https://openalex.org/W2144045634","https://openalex.org/W2153093693","https://openalex.org/W2155787979","https://openalex.org/W2156260257","https://openalex.org/W2166280318","https://openalex.org/W2166993053","https://openalex.org/W2168761911","https://openalex.org/W2169206971","https://openalex.org/W2171835251","https://openalex.org/W2172061231","https://openalex.org/W2187321354","https://openalex.org/W2401079384","https://openalex.org/W4321162519"],"related_works":["https://openalex.org/W1974762968","https://openalex.org/W2057091500","https://openalex.org/W3158431767","https://openalex.org/W4409103419","https://openalex.org/W2058931648","https://openalex.org/W2088845323","https://openalex.org/W2045566514","https://openalex.org/W2028954455","https://openalex.org/W3175154962","https://openalex.org/W2025327530"],"abstract_inverted_index":{"The":[0],"insulin-sensitizing":[1],"hormone,":[2],"adiponectin,":[3,163],"belongs":[4],"to":[5,89,142,212,278],"the":[6,31,37,62,103,130,143,281,287],"expanding":[7],"C1q/TNF":[8],"(tumour":[9],"necrosis":[10],"factor)":[11],"family":[12,19,223,291],"of":[13,20,65,73,93,105,148,153,220,245,286,289,292],"proteins.":[14],"We":[15],"recently":[16],"identified":[17],"a":[18,96,210,263],"adiponectin":[21],"paralogues":[22],"designated":[23],"as":[24,170,206],"CTRP":[25,166],"(C1q/TNF-related":[26],"protein)":[27],"1-7,":[28],"and":[29,47,59,67,78,107,126,132,145,155,178,202,232,271,284,297],"in":[30,83,119,129,159,239,295],"present":[32,38],"study":[33],"describe":[34],"CTRP10.":[35],"In":[36,56,266],"study,":[39],"we":[40],"show":[41],"that":[42,227],"CTRP1,":[43,74,122,225],"CTRP2,":[44,75,123],"CTRP3,":[45,76,124,175],"CTRP5":[46,125],"CTRP7":[48,79],"transcripts":[49,69,80],"are":[50,81,114,133,157,181,204],"expressed":[51,61,118],"predominantly":[52],"by":[53,192],"adipose":[54],"tissue.":[55],"contrast,":[57],"placenta":[58],"eye":[60],"highest":[63],"levels":[64,72,139,152],"CTRP6":[66,77,109,127,156,177],"CTRP10":[68,179],"respectively.":[70],"Expression":[71],"up-regulated":[82],"8-week-old":[84],"obese":[85],"(ob/ob)":[86],"mice":[87,94,249],"relative":[88],"lean":[90],"controls.":[91],"Treatment":[92],"with":[95],"PPAR-gamma":[97],"(peroxisome-proliferator-activated":[98],"receptor-gamma)":[99],"agonist,":[100],"rosiglitazone,":[101],"increased":[102,158],"expression":[104],"CTRP1":[106,154,247,259],"decreased":[108],"transcript":[110],"levels.":[111,255],"All":[112],"CTRPs":[113],"secreted":[115,165,205,293],"glycoproteins":[116,294],"when":[117],"mammalian":[120],"cells.":[121],"circulate":[128],"blood":[131],"potential":[134],"endocrine":[135],"hormones;":[136],"their":[137,171,193,252],"serum":[138,151,253],"vary":[140],"according":[141],"sex":[144],"genetic":[146],"background":[147],"mice.":[149,161],"Importantly,":[150],"adiponectin-null":[160],"Like":[162],"all":[164],"proteins":[167],"form":[168],"trimers":[169,180],"basic":[172],"structural":[173],"units.":[174],"CTRP5,":[176],"further":[182,279],"assembled":[183],"into":[184,248],"higher-order":[185],"oligomeric":[186],"complexes":[187],"via":[188],"disulfide":[189],"bonding":[190],"mediated":[191],"N-terminal":[194],"cysteine":[195],"residues.":[196],"Besides":[197],"forming":[198],"homo-oligomers,":[199],"CTRP1/CTRP6,":[200],"CTRP2/CTRP7":[201],"adiponectin/CTRP2":[203],"heterotrimers,":[207],"thus":[208],"providing":[209],"mechanism":[211],"potentially":[213],"generate":[214],"functionally":[215],"distinct":[216],"ligands.":[217],"Functional":[218],"characterization":[219],"one":[221],"such":[222],"member,":[224],"showed":[226],"it":[228],"specifically":[229],"activates":[230],"Akt":[231],"p44/42-MAPK":[233],"(mitogen-activated":[234],"protein":[235],"kinase)":[236],"signalling":[237],"pathways":[238],"differentiated":[240],"mouse":[241],"myotubes.":[242],"Moreover,":[243],"injection":[244],"recombinant":[246],"significantly":[250],"reduced":[251],"glucose":[254],"Thus":[256],"at":[257],"least":[258],"may":[260],"be":[261],"considered":[262],"novel":[264],"adipokine.":[265],"summary,":[267],"these":[268],"molecular,":[269],"biochemical":[270],"functional":[272],"data":[273],"provide":[274],"an":[275],"important":[276],"framework":[277],"address":[280],"physiological":[282],"functions":[283],"mechanisms":[285],"action":[288],"this":[290],"normal":[296],"disease":[298],"states.":[299]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":22},{"year":2023,"cited_by_count":20},{"year":2022,"cited_by_count":28},{"year":2021,"cited_by_count":30},{"year":2020,"cited_by_count":35},{"year":2019,"cited_by_count":32},{"year":2018,"cited_by_count":27},{"year":2017,"cited_by_count":24},{"year":2016,"cited_by_count":35},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}