{"id":"https://openalex.org/W2054560552","doi":"https://doi.org/10.1002/cyto.b.10056","title":"Comparative measurement of spontaneous apoptosis in pediatric acute leukemia by different techniques","display_name":"Comparative measurement of spontaneous apoptosis in pediatric acute leukemia by different techniques","publication_year":2003,"publication_date":"2003-10-21","ids":{"openalex":"https://openalex.org/W2054560552","doi":"https://doi.org/10.1002/cyto.b.10056","mag":"2054560552","pmid":"https://pubmed.ncbi.nlm.nih.gov/14582133"},"language":"en","primary_location":{"id":"doi:10.1002/cyto.b.10056","doi":"https://doi.org/10.1002/cyto.b.10056","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cyto.b.10056","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.10056","source":{"id":"https://openalex.org/S87401112","display_name":"Cytometry Part B Clinical Cytometry","issn_l":"1552-4949","issn":["1552-4949","1552-4957"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry Part B: Clinical Cytometry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.10056","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055409448","display_name":"Valery P. Savitski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149403","display_name":"Belarusian Research Center For Pediatric Oncology and Hematology","ror":"https://ror.org/046mhfn38","country_code":"BY","type":"facility","lineage":["https://openalex.org/I4210145375","https://openalex.org/I4210149403"]}],"countries":["BY"],"is_corresponding":false,"raw_author_name":"Valery P. Savitskiy","raw_affiliation_strings":["Belarussian Center for Pediatric Oncology & Hematology, Minsk, Belarus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Belarussian Center for Pediatric Oncology & Hematology, Minsk, Belarus","institution_ids":["https://openalex.org/I4210149403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087940131","display_name":"\u0422. \u0412. \u0428\u043c\u0430\u043d","orcid":"https://orcid.org/0000-0001-8669-8005","observed_orcids":["https://orcid.org/0000-0001-8669-8005"]},"institutions":[{"id":"https://openalex.org/I4210149403","display_name":"Belarusian Research Center For Pediatric Oncology and Hematology","ror":"https://ror.org/046mhfn38","country_code":"BY","type":"facility","lineage":["https://openalex.org/I4210145375","https://openalex.org/I4210149403"]}],"countries":["BY"],"is_corresponding":false,"raw_author_name":"Tatiana V. Shman","raw_affiliation_strings":["Belarussian Center for Pediatric Oncology & Hematology, Minsk, Belarus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Belarussian Center for Pediatric Oncology & Hematology, Minsk, Belarus","institution_ids":["https://openalex.org/I4210149403"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112167437","display_name":"Michael P. Potapnev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210149403","display_name":"Belarusian Research Center For Pediatric Oncology and Hematology","ror":"https://ror.org/046mhfn38","country_code":"BY","type":"facility","lineage":["https://openalex.org/I4210145375","https://openalex.org/I4210149403"]}],"countries":["BY"],"is_corresponding":true,"raw_author_name":"Michael P. Potapnev","raw_affiliation_strings":["Belarussian Center for Pediatric Oncology & Hematology, Minsk, Belarus"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Belarussian Center for Pediatric Oncology & Hematology, Minsk, Belarus","institution_ids":["https://openalex.org/I4210149403"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112167437"],"corresponding_institution_ids":["https://openalex.org/I4210149403"],"apc_list":{"value":3800,"currency":"USD","value_usd":3800},"apc_paid":null,"fwci":1.0235,"has_fulltext":true,"cited_by_count":49,"citation_normalized_percentile":{"value":0.76063418,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"56B","issue":"1","first_page":"16","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.5195000171661377,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.5195000171661377,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.4562999904155731,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.009399999864399433,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spontaneous-apoptosis","display_name":"spontaneous apoptosis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/childhood-acute-leukemia","display_name":"childhood acute leukemia","score":0.921999990940094},{"id":"https://openalex.org/keywords/acute-lymphoblastic-leukemia","display_name":"acute lymphoblastic leukemia","score":0.9959999918937683},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":1.0},{"id":"https://openalex.org/keywords/apoptosis-detection-methods","display_name":"apoptosis detection methods","score":0.8399999737739563},{"id":"https://openalex.org/keywords/acridine-orange-staining","display_name":"acridine orange staining","score":0.7580000162124634},{"id":"https://openalex.org/keywords/annexin-v","display_name":"annexin V","score":0.6859999895095825},{"id":"https://openalex.org/keywords/phosphatidylserine-exposure","display_name":"phosphatidylserine exposure","score":0.9139999747276306},{"id":"https://openalex.org/keywords/b-lineage-all","display_name":"B-lineage ALL","score":0.7739999890327454},{"id":"https://openalex.org/keywords/t-lineage-all","display_name":"T-lineage ALL","score":0.9779999852180481},{"id":"https://openalex.org/keywords/leukemia-cell-culture","display_name":"leukemia cell culture","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.872421383857727},{"id":"https://openalex.org/C2779102032","wikidata":"https://www.wikidata.org/wiki/Q342717","display_name":"Acridine orange","level":3,"score":0.6374498605728149},{"id":"https://openalex.org/C2779637612","wikidata":"https://www.wikidata.org/wiki/Q2354337","display_name":"Phosphatidylserine","level":4,"score":0.6356134414672852},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.6268014907836914},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.6238657236099243},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5818853378295898},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.5359358191490173},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5064584016799927},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5013294219970703},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.489790678024292},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.45557963848114014},{"id":"https://openalex.org/C53009064","wikidata":"https://www.wikidata.org/wiki/Q167","display_name":"Pi","level":2,"score":0.4482104480266571},{"id":"https://openalex.org/C2780339063","wikidata":"https://www.wikidata.org/wiki/Q5201367","display_name":"Cytometry","level":3,"score":0.42579177021980286},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3616408109664917},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33680444955825806},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07070353627204895},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06644290685653687},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.05605068802833557},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008564","descriptor_name":"Membrane Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013194","descriptor_name":"Staining and Labeling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015470","descriptor_name":"Leukemia, Myeloid, Acute","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D016130","descriptor_name":"Immunophenotyping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D054198","descriptor_name":"Precursor Cell Lymphoblastic Leukemia-Lymphoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/cyto.b.10056","doi":"https://doi.org/10.1002/cyto.b.10056","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cyto.b.10056","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.10056","source":{"id":"https://openalex.org/S87401112","display_name":"Cytometry Part B Clinical Cytometry","issn_l":"1552-4949","issn":["1552-4949","1552-4957"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry Part B: Clinical Cytometry","raw_type":"journal-article"},{"id":"pmid:14582133","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14582133","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry. Part B, Clinical cytometry","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1002/cyto.b.10056","doi":"https://doi.org/10.1002/cyto.b.10056","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cyto.b.10056","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cyto.b.10056","source":{"id":"https://openalex.org/S87401112","display_name":"Cytometry Part B Clinical Cytometry","issn_l":"1552-4949","issn":["1552-4949","1552-4957"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cytometry Part B: Clinical Cytometry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320952","display_name":"International Science and Technology Center","ror":"https://ror.org/03fn1w943"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2054560552.pdf","grobid_xml":"https://content.openalex.org/works/W2054560552.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W113456750","https://openalex.org/W134636856","https://openalex.org/W1973166702","https://openalex.org/W1975785759","https://openalex.org/W1979868434","https://openalex.org/W1980741638","https://openalex.org/W1986776963","https://openalex.org/W2009410162","https://openalex.org/W2013201897","https://openalex.org/W2020316909","https://openalex.org/W2054387254","https://openalex.org/W2059793819","https://openalex.org/W2077036453","https://openalex.org/W2077255444","https://openalex.org/W2078395075","https://openalex.org/W2085016616","https://openalex.org/W2085787713","https://openalex.org/W2092441665","https://openalex.org/W2097834971","https://openalex.org/W2125113345","https://openalex.org/W2276617466","https://openalex.org/W2301875097","https://openalex.org/W2327387659","https://openalex.org/W2331137050","https://openalex.org/W2337195173","https://openalex.org/W2409862460","https://openalex.org/W2411414349"],"related_works":["https://openalex.org/W294881759","https://openalex.org/W2135856723","https://openalex.org/W2353528100","https://openalex.org/W2025501147","https://openalex.org/W2185840557","https://openalex.org/W2414354803","https://openalex.org/W2917218382","https://openalex.org/W2809679755","https://openalex.org/W2029928445","https://openalex.org/W2301875097"],"abstract_inverted_index":{"BACKGROUND:":[0],"To":[1],"distinguish":[2],"between":[3,127,142],"subgroups":[4],"of":[5,12,16,32,59,121,145,149,159,164,182,194,202,205,210],"patients":[6,134],"with":[7,34,68,135,147,171],"acute":[8,35,43,215],"leukemia,":[9],"the":[10,29,81,85,119,143,195,199],"rate":[11,120],"spontaneous":[13,96,189,211],"(culture-induced)":[14],"apoptosis":[15,60,97,112,122,190,203,212],"leukemic":[17],"cells":[18,26,90,124,146,166,186],"was":[19,61,102,111,125],"evaluated":[20],"using":[21,78],"five":[22],"methods.":[23,106],"METHODS:":[24],"Leukemic":[25],"(cells)":[27],"from":[28],"bone":[30],"marrow":[31],"children":[33],"lymphoblastic":[36],"leukemia":[37,45],"(ALL,":[38],"n":[39,47],"=":[40,48],"112)":[41],"and":[42,129,157,184],"myeloid":[44],"(AML,":[46],"30)":[49],"were":[50,91],"cultured":[51],"for":[52,207],"20":[53],"h":[54],"in":[55,118,123,191,213],"vitro.":[56,192],"The":[57,107,162],"level":[58,144],"detected":[62,103],"by":[63,73,104,114],"fluorescent":[64],"microscopy":[65],"after":[66,76],"staining":[67,77],"acridine":[69],"orange":[70],"(AO)":[71],"or":[72,84],"flow":[74],"cytometry":[75],"PI,":[79],"JC-1,":[80],"APO-BRDU":[82],"kit,":[83],"AnnexinV-FITC":[86],"kit.":[87],"RESULTS:":[88],"ALL":[89,131,183],"significantly":[92],"more":[93],"sensitive":[94,109],"to":[95,187],"versus":[98],"AML":[99,185],"cells,":[100],"as":[101],"all":[105],"least":[108],"technique":[110],"detection":[113],"sub-G1-peak/PI-staining.":[115],"No":[116],"difference":[117],"determined":[126],"T-":[128],"B-lineage":[130,136],"patients.":[132],"In":[133],"ALL,":[137],"strong":[138],"positive":[139],"correlation":[140],"existed":[141],"loss":[148],"mitochondrial":[150],"membrane":[151],"potential":[152],"(JC-1),":[153],"chromatin":[154],"condensation":[155],"(AO),":[156],"externalization":[158],"phosphatidylserine":[160],"(AnnexinV+PI+).":[161],"proportion":[163],"AnnexinV+PI-":[165],"had":[167],"no":[168],"correlative":[169],"link":[170],"any":[172],"other":[173],"apoptotic":[174],"cell":[175],"subpopulation.":[176],"CONCLUSIONS:":[177],"We":[178],"found":[179],"different":[180],"sensitivities":[181],"undergoing":[188],"Detection":[193],"early/intermediate,":[196],"but":[197],"not":[198],"late":[200],"stage":[201],"is":[204],"preferable":[206],"correct":[208],"assignment":[209],"pediatric":[214],"leukemia.":[216]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
