{"id":"https://openalex.org/W2054536628","doi":"https://doi.org/10.1158/1535-7163.targ-11-b161","title":"Abstract B161: PIK3CA mutations H1047R are associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials.","display_name":"Abstract B161: PIK3CA mutations H1047R are associated with response to PI3K/AKT/mTOR signaling pathway inhibitors in early-phase clinical trials.","publication_year":2011,"publication_date":"2011-11-01","ids":{"openalex":"https://openalex.org/W2054536628","doi":"https://doi.org/10.1158/1535-7163.targ-11-b161","mag":"2054536628"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.targ-11-b161","doi":"https://doi.org/10.1158/1535-7163.targ-11-b161","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-11-b161","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071800834","display_name":"Filip Jank\u00fa","orcid":"https://orcid.org/0000-0002-8123-4065","observed_orcids":["https://orcid.org/0000-0002-8123-4065"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Filip Janku","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005436649","display_name":"Aung Naing","orcid":"https://orcid.org/0000-0002-4803-8513","observed_orcids":["https://orcid.org/0000-0002-4803-8513"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aung Naing","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009720074","display_name":"Vanda M. T. Stepanek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vanda T. Stepanek","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069777765","display_name":"Gerald Steven Falchook","orcid":"https://orcid.org/0000-0001-9165-2191","observed_orcids":["https://orcid.org/0000-0001-9165-2191"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald S. Falchook","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026095888","display_name":"David S. Hong","orcid":"https://orcid.org/0000-0001-8721-1609","observed_orcids":["https://orcid.org/0000-0001-8721-1609"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S. Hong","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044840107","display_name":"Apostolia Maria Tsimberidou","orcid":"https://orcid.org/0000-0003-2713-233X","observed_orcids":["https://orcid.org/0000-0003-2713-233X"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Apostolia M. Tsimberidou","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045197829","display_name":"Siqing Fu","orcid":"https://orcid.org/0000-0002-1933-0419","observed_orcids":["https://orcid.org/0000-0002-1933-0419"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siqing Fu","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. Jack Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Jack Lee","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073079562","display_name":"Rajyalakshmi Luthra","orcid":"https://orcid.org/0000-0002-7133-0221","observed_orcids":["https://orcid.org/0000-0002-7133-0221"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajyalakshmi Luthra","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036211173","display_name":"Jennifer J. Wheler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer J. Wheler","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053481267","display_name":"Razelle Kurzrock","orcid":"https://orcid.org/0000-0003-4110-1214","observed_orcids":["https://orcid.org/0000-0003-4110-1214"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Razelle Kurzrock","raw_affiliation_strings":["1The University of Texas MD Anderson Cancer Center, Houston, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1The University of Texas MD Anderson Cancer Center, Houston, TX","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"11_Supplement","first_page":"B161","last_page":"B161"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pik3ca-mutation","display_name":"PIK3CA mutation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/h1047r-mutation","display_name":"H1047R mutation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-inhibitors","display_name":"PI3K/AKT/mTOR inhibitors","score":0.9819999933242798},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.777999997138977},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.6779999732971191},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.5139999985694885},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.8859999775886536},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.7609999775886536},{"id":"https://openalex.org/keywords/tumor-genotyping","display_name":"tumor genotyping","score":0.4729999899864197},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.4429999887943268},{"id":"https://openalex.org/keywords/pi3k-inhibitors","display_name":"PI3K inhibitors","score":0.4009999930858612},{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":0.7799999713897705}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7731360197067261},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.7565066814422607},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6373370289802551},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5807937383651733},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5097963213920593},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49754074215888977},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.48484981060028076},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.43406254053115845},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4318963289260864},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3980090320110321},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.274145245552063},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22654059529304504},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.21137994527816772},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19820916652679443},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.10685783624649048}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.targ-11-b161","doi":"https://doi.org/10.1158/1535-7163.targ-11-b161","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1535-7163.targ-11-b161","pdf_url":null,"source":{"id":"https://openalex.org/S48437117","display_name":"Molecular Cancer Therapeutics","issn_l":"1535-7163","issn":["1535-7163","1538-8514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Therapeutics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1978194521","https://openalex.org/W2118073504","https://openalex.org/W1839975169","https://openalex.org/W2485860988","https://openalex.org/W2139712038","https://openalex.org/W2330036869","https://openalex.org/W4245772831","https://openalex.org/W2086924064","https://openalex.org/W2074054907","https://openalex.org/W1994520717"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Activating":[2],"mutations":[3,22,71,181,274,344,363],"in":[4,11,28,275,323],"the":[5,49,92,118,249,266,334,377],"PIK3CA":[6,83,115,122,171,180,224,254,270,318,343],"gene":[7],"have":[8,36],"been":[9,38],"identified":[10],"many":[12],"malignancies.":[13],"Preclinical":[14],"and":[15,33,66,81,111,153,203,271,319,329,356,383],"early":[16],"clinical":[17],"data":[18,340],"suggest":[19,341],"that":[20,136,342],"these":[21,143],"predict":[23],"response":[24,151,349],"to":[25,40,48,100,176,229,299,350],"PI3K/AKT/mTOR":[26,93,139,351],"inhibitors":[27],"subsets":[29],"of":[30,127,164,195,265,313,337,376],"patients.":[31],"Sensitivity":[32],"resistance":[34],"mutation":[35,84,101,173,226,322],"not":[37,304,359],"reported":[39],"date.":[41],"Methods:":[42],"Patients":[43,76,169,221],"with":[44,77,89,98,121,170,178,222,253,269,301,317,348,366],"diverse":[45],"cancers":[46],"referred":[47],"Phase":[50],"I":[51],"Clinical":[52],"Trials":[53],"Program":[54],"for":[55,64,69,261],"targeted":[56],"therapy":[57],"starting":[58],"from":[59],"October":[60],"2008":[61],"were":[62,85,103,109,131],"analyzed":[63],"PIK3CA,":[65,302],"if,":[67],"possible":[68,88],"KRAS":[70,262,273,305,321,362],"using":[72],"PCR-based":[73],"DNA":[74],"sequencing.":[75],"any":[78,82],"tumor":[79],"type":[80],"treated":[86,132,251],"whenever":[87],"agents":[90],"targeting":[91],"signaling":[94],"pathway.":[95],"Treatment":[96],"outcomes":[97],"respect":[99],"types":[102],"analyzed.":[104],"Results:":[105],"Overall,":[106],"1012":[107],"patients":[108,120,177,252,268,300,316],"tested":[110],"105":[112,119],"(10%)":[113],"had":[114,183,258,280,326],"mutations.":[116],"Of":[117,142,248],"mutations,":[123,255,310],"66":[124,144,250],"(median":[125],"number":[126,336],"prior":[128],"therapies,":[129],"3)":[130],"on":[133],"a":[134,138,149,223,234,281],"protocol":[135],"included":[137],"pathway":[140],"inhibitor.":[141],"patients,":[145,338],"11":[146],"(17%)":[147],"achieved":[148],"partial":[150],"(PR)":[152],"4":[154],"(6%)":[155],"stable":[156],"disease":[157],"\u2265":[158],"6":[159],"months":[160],"(SD\u22656).":[161],"The":[162],"total":[163],"SD\u22656/PR":[165,196,290],"was":[166],"15":[167],"(23%).":[168],"H1047R":[172,345],"(n=16)":[174],"compared":[175,228,298],"other":[179],"(n=50)":[182],"higher":[184,193],"PR":[185,282,330],"rate":[186,194],"(6/16,":[187],"37.5%":[188],"vs.":[189,199,215,242,285,293],"5/50,":[190],"10%;":[191],"p=0.018),":[192],"(7/16,":[197],"44%":[198],"8/50,":[200],"16%;":[201],"p=0.037),":[202],"trend":[204],"toward":[205,233],"longer":[206],"median":[207,236],"progression-free":[208],"survival":[209],"(PFS)":[210],"(5.7":[211],"months,":[212,217,239,244],"95%CI":[213,218,240,245],"0.4\u201311.0":[214],"2.0":[216],"1.8\u20132.2;":[219],"p=0.064).":[220],"E542K":[225],"(n=11)":[227],"others":[230],"(n=55)":[231],"trended":[232],"worse":[235],"PFS":[237],"(1.8":[238],"1.4\u20132.2":[241],"2.6":[243],"1.4\u20133.8;":[246],"p=0.058).":[247],"55":[256],"(83%)":[257],"enough":[259],"tissue":[260],"testing.":[263],"None":[264],"16":[267],"simultaneous":[272],"codon":[276,306,324,354,360],"12":[277,307,355],"or":[278,289,308],"13":[279,309],"(0/16,":[283,291],"0%":[284,292],"9/39,":[286],"23%;":[287],"p=0.046)":[288],"13/39,":[294],"33.3%;":[295],"p=0.011)":[296],"as":[297],"but":[303,358],"whereas":[311,353],"2":[312,314],"(100%)":[315],"Q61H":[320],"61":[325,361],"SD\u22656":[327],"(n=1)":[328],"(n=1).":[331],"Conclusion:":[332],"Despite":[333],"small":[335],"our":[339],"are":[346,364],"associated":[347,365],"inhibitors,":[352],"13,":[357],"resistance.":[367],"Citation":[368],"Format:":[369],"{Authors}.":[370],"{Abstract":[371],"title}":[372],"[abstract].":[373],"In:":[374],"Proceedings":[375],"AACR-NCI-EORTC":[378],"International":[379],"Conference:":[380],"Molecular":[381],"Targets":[382],"Cancer":[384,396],"Therapeutics;":[385],"2011":[386],"Nov":[387],"12-16;":[388],"San":[389],"Francisco,":[390],"CA.":[391],"Philadelphia":[392],"(PA):":[393],"AACR;":[394],"Mol":[395],"Ther":[397],"2011;10(11":[398],"Suppl):Abstract":[399],"nr":[400],"B161.":[401]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-06-24T00:00:00"}
