{"id":"https://openalex.org/W2054522650","doi":"https://doi.org/10.1155/2012/671386","title":"Effects of Different Electroacupuncture Scheduling Regimens on Murine Bone Tumor-Induced Hyperalgesia: Sex Differences and Role of Inflammation","display_name":"Effects of Different Electroacupuncture Scheduling Regimens on Murine Bone Tumor-Induced Hyperalgesia: Sex Differences and Role of Inflammation","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2054522650","doi":"https://doi.org/10.1155/2012/671386","mag":"2054522650","pmid":"https://pubmed.ncbi.nlm.nih.gov/23320035","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3541553"},"language":"en","primary_location":{"id":"doi:10.1155/2012/671386","doi":"https://doi.org/10.1155/2012/671386","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/671386","pdf_url":"https://downloads.hindawi.com/journals/ecam/2012/671386.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2054522650"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/ecam/2012/671386.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011175253","display_name":"Branden A. Smeester","orcid":"https://orcid.org/0000-0001-9421-1711","observed_orcids":["https://orcid.org/0000-0001-9421-1711"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Branden A. Smeester","raw_affiliation_strings":["Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA"],"raw_orcid":"https://orcid.org/0000-0001-9421-1711","affiliations":[{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017193459","display_name":"Mona M. Al-Gizawiy","orcid":"https://orcid.org/0000-0003-3489-4025","observed_orcids":["https://orcid.org/0000-0003-3489-4025"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mona Al-Gizawiy","raw_affiliation_strings":["Department of Radiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA"],"raw_orcid":"https://orcid.org/0000-0003-3489-4025","affiliations":[{"raw_affiliation_string":"Department of Radiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA","institution_ids":["https://openalex.org/I204308271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040912906","display_name":"Alvin James Beitz","orcid":"https://orcid.org/0000-0002-2640-2628","observed_orcids":["https://orcid.org/0000-0002-2640-2628"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alvin J. Beitz","raw_affiliation_strings":["Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA","Department of Veterinary and Biomedical Sciences, University of Minnesota, Room 205 Veterinary Medicine Building, 1971 Commonwealth Avenue, St. Paul, MN 55108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"Department of Veterinary and Biomedical Sciences, University of Minnesota, Room 205 Veterinary Medicine Building, 1971 Commonwealth Avenue, St. Paul, MN 55108, USA","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5040912906"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":5.2653,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.93566723,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2012","issue":null,"first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11327","display_name":"Acupuncture Treatment Research Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14028","display_name":"Healthcare and Venom Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electroacupuncture","display_name":"electroacupuncture","score":0.9909999966621399},{"id":"https://openalex.org/keywords/treatment-scheduling","display_name":"treatment scheduling","score":0.5649999976158142},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9380000233650208},{"id":"https://openalex.org/keywords/tumor-inflammation","display_name":"tumor inflammation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/tumor-associated-neutrophils","display_name":"tumor-associated neutrophils","score":0.9490000009536743},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/antinociception","display_name":"antinociception","score":0.8379999995231628}],"concepts":[{"id":"https://openalex.org/C2776202274","wikidata":"https://www.wikidata.org/wiki/Q11784952","display_name":"Electroacupuncture","level":4,"score":0.8753651976585388},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.8082767128944397},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.6730092763900757},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6493525505065918},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6319288611412048},{"id":"https://openalex.org/C2780820201","wikidata":"https://www.wikidata.org/wiki/Q173235","display_name":"Analgesic","level":2,"score":0.6188117265701294},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4656646251678467},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40508902072906494},{"id":"https://openalex.org/C56837625","wikidata":"https://www.wikidata.org/wiki/Q121713","display_name":"Acupuncture","level":3,"score":0.38777342438697815},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3595244586467743},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3479822874069214},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1373695433139801},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.12432217597961426},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/2012/671386","doi":"https://doi.org/10.1155/2012/671386","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/671386","pdf_url":"https://downloads.hindawi.com/journals/ecam/2012/671386.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},{"id":"pmid:23320035","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23320035","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-based complementary and alternative medicine : eCAM","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3541553","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3541553/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evid Based Complement Alternat Med","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.816.3155","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.816.3155","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/d3/19/ECAM2012-671386.PMC3541553.pdf","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1155/2012/671386","doi":"https://doi.org/10.1155/2012/671386","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2012/671386","pdf_url":"https://downloads.hindawi.com/journals/ecam/2012/671386.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G739529736","display_name":"Cancer Pain: Nerve/Tumor Interactions","funder_award_id":"R01CA084233","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2054522650.pdf","grobid_xml":"https://content.openalex.org/works/W2054522650.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W19745091","https://openalex.org/W69860482","https://openalex.org/W174401574","https://openalex.org/W1479905500","https://openalex.org/W1592184520","https://openalex.org/W1966848942","https://openalex.org/W1967865659","https://openalex.org/W1968778093","https://openalex.org/W1970446666","https://openalex.org/W1972059159","https://openalex.org/W1975203143","https://openalex.org/W1977289872","https://openalex.org/W1977693246","https://openalex.org/W1980049196","https://openalex.org/W1989046785","https://openalex.org/W1994492108","https://openalex.org/W1995044919","https://openalex.org/W1998413720","https://openalex.org/W1998869482","https://openalex.org/W2001753985","https://openalex.org/W2005426891","https://openalex.org/W2006930395","https://openalex.org/W2009093325","https://openalex.org/W2010841339","https://openalex.org/W2011399984","https://openalex.org/W2014979420","https://openalex.org/W2022061266","https://openalex.org/W2023103353","https://openalex.org/W2025170599","https://openalex.org/W2025892582","https://openalex.org/W2026312732","https://openalex.org/W2027321893","https://openalex.org/W2030137402","https://openalex.org/W2032895646","https://openalex.org/W2034871834","https://openalex.org/W2036676356","https://openalex.org/W2041060509","https://openalex.org/W2056304146","https://openalex.org/W2057311530","https://openalex.org/W2057882256","https://openalex.org/W2058371150","https://openalex.org/W2063018480","https://openalex.org/W2067045406","https://openalex.org/W2073516340","https://openalex.org/W2074143255","https://openalex.org/W2079641633","https://openalex.org/W2081891742","https://openalex.org/W2086239521","https://openalex.org/W2089153751","https://openalex.org/W2092458500","https://openalex.org/W2102524947","https://openalex.org/W2105605572","https://openalex.org/W2122438864","https://openalex.org/W2122766544","https://openalex.org/W2123080797","https://openalex.org/W2127387778","https://openalex.org/W2129189215","https://openalex.org/W2147357983","https://openalex.org/W2153179242","https://openalex.org/W2157041856","https://openalex.org/W2158173921","https://openalex.org/W2158657379","https://openalex.org/W2159301559","https://openalex.org/W2159556577","https://openalex.org/W2162296777","https://openalex.org/W2165735379","https://openalex.org/W2499826130"],"related_works":["https://openalex.org/W1970446666","https://openalex.org/W2041060509","https://openalex.org/W2129189215","https://openalex.org/W3025544892","https://openalex.org/W2752198960","https://openalex.org/W2013455418","https://openalex.org/W2125969902","https://openalex.org/W2020827950","https://openalex.org/W2752158147"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"have":[2],"shown":[3],"that":[4,129,169],"electroacupuncture":[5],"(EA)":[6],"is":[7,21,176],"able":[8],"to":[9,59,78],"reduce":[10],"hyperalgesia":[11,51],"in":[12,52,104,114,119,124,135,144,156,161,181],"rodent":[13],"models":[14],"of":[15,31,44,110],"persistent":[16],"pain,":[17],"but":[18,116],"very":[19],"little":[20],"known":[22],"about":[23],"the":[24,37,42,60,81,188],"analgesic":[25,108],"effects":[26,43],"and":[27,54,84,184],"potential":[28],"sex":[29,122],"differences":[30,123],"different":[32,46],"EA":[33,47,57,89,196],"treatment":[34,90,171],"regimens.":[35],"In":[36],"present":[38],"study,":[39],"we":[40],"examined":[41],"five":[45],"treatments":[48],"on":[49,68],"tumor-induced":[50,173],"male":[53],"female":[55,105],"mice.":[56],"applied":[58],"ST-36":[61],"acupoint":[62],"either":[63],"twice":[64],"weekly":[65],"(EA-2X/3)":[66],"beginning":[67,95],"postimplantation":[69],"day":[70],"(PID)":[71],"3":[72],"or":[73],"prophylactically":[74],"three":[75],"times":[76],"prior":[77],"implantation":[79],"produced":[80,100,152],"most":[82],"robust":[83],"longest":[85],"lasting":[86],"antinociceptive":[87,102],"effects.":[88],"given":[91],"once":[92],"per":[93],"week":[94],"at":[96,147,187],"PID":[97,148],"7":[98],"only":[99],"an":[101],"effect":[103,109],"animals.":[106],"The":[107],"EA-2X/3":[111,130,151,170],"began":[112],"earlier":[113],"males,":[115],"lasted":[117],"longer":[118],"females":[120],"indicating":[121],"EA.":[125],"We":[126],"further":[127],"demonstrate":[128],"elicits":[131],"a":[132,141,153,179],"marked":[133],"decrease":[134,180],"tumor-associated":[136,145,157,182],"inflammation":[137,183],"as":[138,159],"evidenced":[139],"by":[140,194],"significant":[142,154],"reduction":[143,155],"neutrophils":[146],"7.":[149],"Moreover,":[150],"PGE(2)":[158,185],"measured":[160],"microperfusate":[162],"samples.":[163],"Collectively,":[164],"these":[165],"data":[166],"provide":[167],"evidence":[168],"reduces":[172,197],"hyperalgesia,":[174],"which":[175,195],"associated":[177],"with":[178],"concentration":[186],"tumor":[189,198],"site":[190],"suggesting":[191],"possible":[192],"mechanisms":[193],"nociception.":[199]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
