{"id":"https://openalex.org/W2054517500","doi":"https://doi.org/10.1097/00007435-197804000-00006","title":"A Single Large Dose of Trimethoprim\u2014Sulfamethoxazole Fails to Cure Gonococcal Urethritis in Men","display_name":"A Single Large Dose of Trimethoprim\u2014Sulfamethoxazole Fails to Cure Gonococcal Urethritis in Men","publication_year":1978,"publication_date":"1978-04-01","ids":{"openalex":"https://openalex.org/W2054517500","doi":"https://doi.org/10.1097/00007435-197804000-00006","mag":"2054517500","pmid":"https://pubmed.ncbi.nlm.nih.gov/10328033"},"language":"en","primary_location":{"id":"doi:10.1097/00007435-197804000-00006","doi":"https://doi.org/10.1097/00007435-197804000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007435-197804000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S170339494","display_name":"Sexually Transmitted Diseases","issn_l":"0148-5717","issn":["0148-5717","1537-4521"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexually Transmitted Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014329748","display_name":"Richard B. Prior","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RICHARD B. PRIOR","raw_affiliation_strings":["Department of Medicine, Ohio State University College of Medicine, Columbus 43210, USA","From the Division of Infectious Diseases, Department of Medicine, The Ohio State University College of Medicine, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Ohio State University College of Medicine, Columbus 43210, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"From the Division of Infectious Diseases, Department of Medicine, The Ohio State University College of Medicine, Columbus, Ohio","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109313287","display_name":"Robert J. Fass","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROBERT J. FASS","raw_affiliation_strings":["the Division of Infectious Diseases, Department of Medicine, The Ohio State University College of Medicine, Columbus, Ohio","From the Division of Infectious Diseases, Department of Medicine, The Ohio State University College of Medicine, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Division of Infectious Diseases, Department of Medicine, The Ohio State University College of Medicine, Columbus, Ohio","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"From the Division of Infectious Diseases, Department of Medicine, The Ohio State University College of Medicine, Columbus, Ohio","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":null,"display_name":"ROBERT L. PERKINS","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"ROBERT L. PERKINS","raw_affiliation_strings":["the Division of Infectious Diseases, Department of Medicine, The Ohio State University College of Medicine, Columbus, Ohio","From the Division of Infectious Diseases, Department of Medicine, The Ohio State University College of Medicine, Columbus, Ohio"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the Division of Infectious Diseases, Department of Medicine, The Ohio State University College of Medicine, Columbus, Ohio","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"From the Division of Infectious Diseases, Department of Medicine, The Ohio State University College of Medicine, Columbus, Ohio","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":0.8478,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.72596685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"5","issue":"2","first_page":"62","last_page":"64"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10428","display_name":"Reproductive tract infections research","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gonococcal-urethritis","display_name":"gonococcal urethritis","score":0.9909999966621399},{"id":"https://openalex.org/keywords/neisseria-gonorrhoeae","display_name":"Neisseria gonorrhoeae","score":0.984000027179718},{"id":"https://openalex.org/keywords/trimethoprim-sulfamethoxazole","display_name":"trimethoprim-sulfamethoxazole","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ampicillin","display_name":"ampicillin","score":0.8429999947547913},{"id":"https://openalex.org/keywords/probenecid","display_name":"probenecid","score":0.9449999928474426},{"id":"https://openalex.org/keywords/antibiotic-susceptibility","display_name":"antibiotic susceptibility","score":0.7540000081062317},{"id":"https://openalex.org/keywords/cure-rate","display_name":"cure rate","score":0.6710000038146973},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.4309999942779541},{"id":"https://openalex.org/keywords/men","display_name":"men","score":0.3070000112056732}],"concepts":[{"id":"https://openalex.org/C2776021129","wikidata":"https://www.wikidata.org/wiki/Q244150","display_name":"Ampicillin","level":3,"score":0.8462486863136292},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8415423631668091},{"id":"https://openalex.org/C2780728791","wikidata":"https://www.wikidata.org/wiki/Q422665","display_name":"Trimethoprim","level":3,"score":0.7642706632614136},{"id":"https://openalex.org/C2779425571","wikidata":"https://www.wikidata.org/wiki/Q415843","display_name":"Sulfamethoxazole","level":3,"score":0.6943821907043457},{"id":"https://openalex.org/C2776769776","wikidata":"https://www.wikidata.org/wiki/Q900898","display_name":"Probenecid","level":2,"score":0.6504418849945068},{"id":"https://openalex.org/C2994123057","wikidata":"https://www.wikidata.org/wiki/Q1595418","display_name":"Cure rate","level":2,"score":0.6241147518157959},{"id":"https://openalex.org/C2779166590","wikidata":"https://www.wikidata.org/wiki/Q131129","display_name":"Neisseria gonorrhoeae","level":2,"score":0.609734058380127},{"id":"https://openalex.org/C2778416477","wikidata":"https://www.wikidata.org/wiki/Q1122485","display_name":"Urethritis","level":2,"score":0.6044588685035706},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.468110054731369},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45283907651901245},{"id":"https://openalex.org/C2909292399","wikidata":"https://www.wikidata.org/wiki/Q19903202","display_name":"Agar Dilution Method","level":4,"score":0.44925153255462646},{"id":"https://openalex.org/C2778082588","wikidata":"https://www.wikidata.org/wiki/Q101896","display_name":"Gonorrhea","level":3,"score":0.4373205304145813},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.41974273324012756},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.33011215925216675},{"id":"https://openalex.org/C176947019","wikidata":"https://www.wikidata.org/wiki/Q597889","display_name":"Minimum inhibitory concentration","level":3,"score":0.2098155915737152},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.13313329219818115},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.06913727521896362},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06305527687072754}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000667","descriptor_name":"Ampicillin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000667","descriptor_name":"Ampicillin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000892","descriptor_name":"Anti-Infective Agents, Urinary","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000892","descriptor_name":"Anti-Infective Agents, Urinary","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004359","descriptor_name":"Drug Therapy, Combination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006069","descriptor_name":"Gonorrhea","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009344","descriptor_name":"Neisseria gonorrhoeae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011339","descriptor_name":"Probenecid","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012076","descriptor_name":"Renal Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014526","descriptor_name":"Urethritis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015662","descriptor_name":"Trimethoprim, Sulfamethoxazole Drug Combination","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015662","descriptor_name":"Trimethoprim, Sulfamethoxazole Drug Combination","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016037","descriptor_name":"Single-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00007435-197804000-00006","doi":"https://doi.org/10.1097/00007435-197804000-00006","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00007435-197804000-00006","pdf_url":null,"source":{"id":"https://openalex.org/S170339494","display_name":"Sexually Transmitted Diseases","issn_l":"0148-5717","issn":["0148-5717","1537-4521"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexually Transmitted Diseases","raw_type":"journal-article"},{"id":"pmid:10328033","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10328033","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sexually transmitted diseases","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2011658279","https://openalex.org/W2020944978","https://openalex.org/W1990319781","https://openalex.org/W1973363028","https://openalex.org/W7096234336","https://openalex.org/W1508994645","https://openalex.org/W2093210832","https://openalex.org/W3024534123","https://openalex.org/W2007824161","https://openalex.org/W2005481735"],"abstract_inverted_index":{"In":[0],"a":[1,14,154],"single-blind":[2],"study,":[3],"50":[4],"men":[5],"who":[6],"had":[7],"acute":[8],"gonococcal":[9],"urethritis":[10],"were":[11,41,58,91,110,136,168,180],"treated":[12],"with":[13,60,150],"single":[15],"oral":[16],"dose":[17],"of":[18,38,88,99,108,125,134,176],"either":[19,184],"720":[20],"mg":[21,26],"trimethoprim":[22],"(TMP)":[23],"plus":[24,33],"3,600":[25],"sulfamethoxazole":[27],"(SMZ)":[28],"or":[29,62,95,104,112,121,138,172,186],"3.5":[30],"g":[31,35],"ampicillin":[32,151],"1":[34],"probenecid.":[36],"Isolates":[37],"Neisseria":[39],"gonorrhoeae":[40,90],"tested":[42],"for":[43,72,129],"in-vitro":[44],"susceptibility":[45],"to":[46,64],"the":[47,75,86,106],"chemotherapeutic":[48],"agents":[49],"administered":[50],"by":[51,93,170],"agar-dilution":[52],"and":[53,56,131],"disk-diffusion":[54],"methods,":[55],"results":[57],"correlated":[59],"cure":[61,65,76,146],"failure":[63,116],"as":[66],"determined":[67],"bacteriologically.":[68],"Among":[69],"patients":[70],"returning":[71],"follow":[73],"up,":[74],"rate":[77,147,155],"after":[78,148,161,183],"TMP/SMZ":[79,100,126,162,185],"was":[80,83,117,127,152],"69%.":[81],"Cure":[82],"predictable":[84,118],"when":[85,105,119,132],"isolates":[87,167],"N.":[89],"inhibited":[92,169],"<":[94,137,143,164,171],"=":[96,113,122,139,173],"0.63/11.87":[97],"micrograms/ml":[98,124],"(fixed":[101],"ratio,":[102],"1:19)":[103],"zones":[107,133],"inhibition":[109,130,135],">":[111,120],"23":[114],"mm;":[115],"1.25/23.75":[123],"necessary":[128],"21":[140],"mm":[141],"(P":[142,163],"0.02).":[144],"The":[145],"therapy":[149],"100%,":[153],"significantly":[156],"higher":[157],"than":[158],"that":[159],"found":[160],"0.02);":[165],"all":[166],"0.16":[174],"microgram/ml":[175],"ampicillin.":[177,187],"Adverse":[178],"reactions":[179],"not":[181],"seen":[182]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}