{"id":"https://openalex.org/W2054516994","doi":"https://doi.org/10.1182/blood-2009-01-197988","title":"Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with \u03b19\u03b21 and \u03b14\u03b21 integrins","display_name":"Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with \u03b19\u03b21 and \u03b14\u03b21 integrins","publication_year":2009,"publication_date":"2009-05-06","ids":{"openalex":"https://openalex.org/W2054516994","doi":"https://doi.org/10.1182/blood-2009-01-197988","mag":"2054516994","pmid":"https://pubmed.ncbi.nlm.nih.gov/19417209"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2009-01-197988","doi":"https://doi.org/10.1182/blood-2009-01-197988","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2009-01-197988","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5035657449","display_name":"Jochen Grassinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jochen Grassinger","raw_affiliation_strings":["Australian Stem Cell Centre, Clayton, Australia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Stem Cell Centre, Clayton, Australia,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057615707","display_name":"David N. Haylock","orcid":"https://orcid.org/0000-0002-4483-1063","observed_orcids":["https://orcid.org/0000-0002-4483-1063"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David N. Haylock","raw_affiliation_strings":["Australian Stem Cell Centre, Clayton, Australia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Stem Cell Centre, Clayton, Australia,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069221110","display_name":"Melonie Joanne Storan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melonie J. Storan","raw_affiliation_strings":["Australian Stem Cell Centre, Clayton, Australia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Stem Cell Centre, Clayton, Australia,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000152087","display_name":"Gemma Haines Olsen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gemma O. Haines","raw_affiliation_strings":["Australian Stem Cell Centre, Clayton, Australia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Stem Cell Centre, Clayton, Australia,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Brenda Williams","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brenda Williams","raw_affiliation_strings":["Australian Stem Cell Centre, Clayton, Australia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Stem Cell Centre, Clayton, Australia,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110354393","display_name":"Genevieve A. Whitty","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Genevieve A. Whitty","raw_affiliation_strings":["Australian Stem Cell Centre, Clayton, Australia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Stem Cell Centre, Clayton, Australia,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070284200","display_name":"Andrew R. Vinson","orcid":"https://orcid.org/0000-0003-0241-121X","observed_orcids":["https://orcid.org/0000-0003-0241-121X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew R. Vinson","raw_affiliation_strings":["Australian Stem Cell Centre, Clayton, Australia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Stem Cell Centre, Clayton, Australia,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112071230","display_name":"Cheang Ly Be","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cheang Ly Be","raw_affiliation_strings":["Australian Stem Cell Centre, Clayton, Australia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Stem Cell Centre, Clayton, Australia,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007605785","display_name":"Songhui Li","orcid":"https://orcid.org/0000-0003-4033-4366","observed_orcids":["https://orcid.org/0000-0003-4033-4366"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Songhui Li","raw_affiliation_strings":["Australian Stem Cell Centre, Clayton, Australia,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Stem Cell Centre, Clayton, Australia,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021900786","display_name":"Esben Skipper S\u00f8rensen","orcid":"https://orcid.org/0000-0002-7050-3354","observed_orcids":["https://orcid.org/0000-0002-7050-3354"]},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Esben S. S\u00f8rensen","raw_affiliation_strings":["Department of Molecular Biology, University of Aarhus, Aarhus C, Denmark;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology, University of Aarhus, Aarhus C, Denmark;","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049883489","display_name":"Patrick Tam","orcid":"https://orcid.org/0000-0001-6950-8388","observed_orcids":["https://orcid.org/0000-0001-6950-8388"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I146584863","display_name":"Children's Medical Research Institute","ror":"https://ror.org/01bsaey45","country_code":"AU","type":"facility","lineage":["https://openalex.org/I146584863"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Patrick P.L. Tam","raw_affiliation_strings":["Embryology Unit, Children's Medical Research Institute, University of Sydney, Westmead, Australia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Embryology Unit, Children's Medical Research Institute, University of Sydney, Westmead, Australia;","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I146584863"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027560531","display_name":"David T. Denhardt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4390039325","display_name":"Rutgers Cancer Institute","ror":"https://ror.org/0060x3y55","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4390039325"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David T. Denhardt","raw_affiliation_strings":["Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, and affiliated with the Cancer Institute of New Jersey, Trenton;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, and affiliated with the Cancer Institute of New Jersey, Trenton;","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4390039325"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006496734","display_name":"Dean Sheppard","orcid":"https://orcid.org/0000-0002-6277-2036","observed_orcids":["https://orcid.org/0000-0002-6277-2036"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean Sheppard","raw_affiliation_strings":["University of California, San Francisco, Mission Bay;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, San Francisco, Mission Bay;","institution_ids":["https://openalex.org/I180670191"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057159907","display_name":"Peter Choong","orcid":"https://orcid.org/0000-0002-3522-7374","observed_orcids":["https://orcid.org/0000-0002-3522-7374"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]},{"id":"https://openalex.org/I4210087110","display_name":"St Vincent's Hospital Melbourne","ror":"https://ror.org/001kjn539","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I4210087110","https://openalex.org/I4210098850"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Peter F. Choong","raw_affiliation_strings":["Department of Orthopaedics and University of Melbourne Department of Surgery, St Vincent's Hospital Melbourne, Fitzroy, Australia; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics and University of Melbourne Department of Surgery, St Vincent's Hospital Melbourne, Fitzroy, Australia; and","institution_ids":["https://openalex.org/I165779595","https://openalex.org/I4210087110"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080139485","display_name":"Susan K. Nilsson","orcid":"https://orcid.org/0000-0002-7926-7335","observed_orcids":["https://orcid.org/0000-0002-7926-7335"]},"institutions":[{"id":"https://openalex.org/I165779595","display_name":"The University of Melbourne","ror":"https://ror.org/01ej9dk98","country_code":"AU","type":"education","lineage":["https://openalex.org/I165779595"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Susan K. Nilsson","raw_affiliation_strings":["Australian Stem Cell Centre, Clayton, Australia,","Department of Pathology, University of Melbourne, Parkville, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Australian Stem Cell Centre, Clayton, Australia,","institution_ids":[]},{"raw_affiliation_string":"Department of Pathology, University of Melbourne, Parkville, Australia","institution_ids":["https://openalex.org/I165779595"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":7.0789,"has_fulltext":false,"cited_by_count":206,"citation_normalized_percentile":{"value":0.98172324,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"114","issue":"1","first_page":"49","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12110","display_name":"Bone and Dental Protein Studies","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.08370000123977661,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.8709999918937683},{"id":"https://openalex.org/keywords/hematopoietic-progenitor-cells","display_name":"hematopoietic progenitor cells","score":0.8830000162124634},{"id":"https://openalex.org/keywords/integrin-alpha9beta1","display_name":"integrin \u03b19\u03b21","score":0.9729999899864197},{"id":"https://openalex.org/keywords/integrin-alpha4beta1","display_name":"alpha4beta1 integrin","score":0.9980000257492065},{"id":"https://openalex.org/keywords/bone-marrow-microenvironment","display_name":"bone marrow microenvironment","score":0.9430000185966492},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.625},{"id":"https://openalex.org/keywords/chemotaxis","display_name":"chemotaxis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/cell-retention","display_name":"cell retention","score":0.5},{"id":"https://openalex.org/keywords/bone-marrow-transplantation","display_name":"bone marrow transplantation","score":0.45500001311302185},{"id":"https://openalex.org/keywords/peripheral-blood-counts","display_name":"peripheral blood cell counts","score":0.3019999861717224}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7605791091918945},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.7393670678138733},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.6813757419586182},{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.6806004047393799},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6746827363967896},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5733525156974792},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.5131457448005676},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.4754761755466461},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.46517086029052734},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.4539274573326111},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34071072936058044},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.16576656699180603},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.15646037459373474},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09060859680175781},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002633","descriptor_name":"Chemotaxis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006410","descriptor_name":"Hematopoiesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016023","descriptor_name":"Integrins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016179","descriptor_name":"Granulocyte Colony-Stimulating Factor","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039041","descriptor_name":"Integrin alpha4beta1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039041","descriptor_name":"Integrin alpha4beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053495","descriptor_name":"Osteopontin","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D053495","descriptor_name":"Osteopontin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053495","descriptor_name":"Osteopontin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D053495","descriptor_name":"Osteopontin","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2009-01-197988","doi":"https://doi.org/10.1182/blood-2009-01-197988","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2009-01-197988","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:19417209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19417209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:publications/ce5a5a70-3e2a-11de-8dc9-000ea68e967b","doi":null,"is_oa":false,"landing_page_url":"https://pure.au.dk/portal/en/publications/ce5a5a70-3e2a-11de-8dc9-000ea68e967b","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Grassinger, J, Haylock, D N, Storan, M J, Heines, G O, Williams, B, Whitty, G A, Vinson, A R, Be, C L, Li, S, S\u00f8rensen, E S, Tam, P PL, Denhardt, D T, Sheppard, D, Choong, P F & Nilsson, S K 2009, 'Thrombin cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with {alpha}9{beta}1 and {alpha}4{beta}1 integrins', Blood, vol. 114, no. 1, pp. 49-59.","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320334737","display_name":"National Medical Research Council","ror":"https://ror.org/04x3cxs03"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W174869347","https://openalex.org/W323623424","https://openalex.org/W331740097","https://openalex.org/W1510287206","https://openalex.org/W1557108213","https://openalex.org/W1567385135","https://openalex.org/W1588199014","https://openalex.org/W1595321012","https://openalex.org/W1599513095","https://openalex.org/W1839610592","https://openalex.org/W1945564869","https://openalex.org/W1966723290","https://openalex.org/W1972843541","https://openalex.org/W1973430810","https://openalex.org/W1975631153","https://openalex.org/W1975666052","https://openalex.org/W1978598034","https://openalex.org/W1995446704","https://openalex.org/W1997374120","https://openalex.org/W1999644185","https://openalex.org/W2006859618","https://openalex.org/W2013326206","https://openalex.org/W2021276131","https://openalex.org/W2021278376","https://openalex.org/W2026803473","https://openalex.org/W2033659945","https://openalex.org/W2034378488","https://openalex.org/W2037068771","https://openalex.org/W2040370843","https://openalex.org/W2046086515","https://openalex.org/W2046555610","https://openalex.org/W2049205344","https://openalex.org/W2050472349","https://openalex.org/W2061285112","https://openalex.org/W2063014147","https://openalex.org/W2063122439","https://openalex.org/W2069667029","https://openalex.org/W2075831592","https://openalex.org/W2082462757","https://openalex.org/W2083246183","https://openalex.org/W2086238431","https://openalex.org/W2090890518","https://openalex.org/W2092227613","https://openalex.org/W2099186644","https://openalex.org/W2101112712","https://openalex.org/W2101163518","https://openalex.org/W2112509531","https://openalex.org/W2120372000","https://openalex.org/W2123318803","https://openalex.org/W2160570558","https://openalex.org/W2161630702","https://openalex.org/W2166179228","https://openalex.org/W2167677178","https://openalex.org/W2169584423","https://openalex.org/W2172071407","https://openalex.org/W2182436467","https://openalex.org/W2201129205","https://openalex.org/W2402156397","https://openalex.org/W2416298840","https://openalex.org/W4244803411","https://openalex.org/W6712846460","https://openalex.org/W6716702231"],"related_works":["https://openalex.org/W7073993186","https://openalex.org/W7095740206","https://openalex.org/W2392117993","https://openalex.org/W2554150323","https://openalex.org/W2970536958","https://openalex.org/W1555207396","https://openalex.org/W2021276131","https://openalex.org/W1492917338","https://openalex.org/W2745554006","https://openalex.org/W2051592049"],"abstract_inverted_index":{"Osteopontin":[0],"(OPN),":[1],"a":[2,97,125,136],"multifunctional":[3],"acidic":[4],"glycoprotein,":[5],"expressed":[6],"by":[7],"osteoblasts":[8],"within":[9,32,52],"the":[10,14,19,33,45,53,69,91,101,149,169],"endosteal":[11],"region":[12],"of":[13,21,49,85,107,151,158],"bone":[15],"marrow":[16],"(BM)":[17],"suppresses":[18],"proliferation":[20],"hemopoietic":[22,60,108],"stem":[23,61,109,128,164],"and":[24,27,74,93,105,110,115,129,143,165],"progenitor":[25,111,130,166],"cells":[26,62,112,161,167],"also":[28],"regulates":[29],"their":[30,117,133],"lodgment":[31],"BM":[34,118],"after":[35],"transplantation.":[36],"Herein":[37],"we":[38],"demonstrate":[39],"that":[40,72,138],"OPN":[41,66,86,121],"cleavage":[42,83],"fragments":[43],"are":[44],"most":[46],"abundant":[47],"forms":[48],"this":[50],"protein":[51],"BM.":[54],"Studies":[55],"aimed":[56],"to":[57,90],"determine":[58],"how":[59],"(HSCs)":[63],"interact":[64],"with":[65,141],"revealed":[67],"for":[68,127],"first":[70],"time":[71],"murine":[73],"human":[75],"HSCs":[76],"express":[77],"alpha(9)beta(1)":[78,92,142],"integrin.":[79],"The":[80],"N-terminal":[81],"thrombin":[82],"fragment":[84],"through":[87],"its":[88],"binding":[89],"alpha(4)beta(1)":[94,144],"integrins":[95],"plays":[96],"key":[98],"role":[99],"in":[100,135,148,168],"attraction,":[102],"retention,":[103],"regulation,":[104],"release":[106],"to,":[113],"in,":[114],"from":[116],"niche.":[119],"Thrombin-cleaved":[120],"(trOPN)":[122],"acts":[123],"as":[124],"chemoattractant":[126],"cells,":[131],"mediating":[132],"migration":[134],"manner":[137],"involves":[139],"interaction":[140],"integrins.":[145],"In":[146],"addition,":[147],"absence":[150],"OPN,":[152],"there":[153],"is":[154],"an":[155],"increased":[156],"number":[157],"white":[159],"blood":[160],"and,":[162],"specifically,":[163],"peripheral":[170],"circulation.":[171]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
