{"id":"https://openalex.org/W2054501337","doi":"https://doi.org/10.1016/0277-5379(88)90291-x","title":"Teniposide (VM26): An effective treatment for brain metastases of small cell carcinoma of the lung","display_name":"Teniposide (VM26): An effective treatment for brain metastases of small cell carcinoma of the lung","publication_year":1988,"publication_date":"1988-04-01","ids":{"openalex":"https://openalex.org/W2054501337","doi":"https://doi.org/10.1016/0277-5379(88)90291-x","mag":"2054501337","pmid":"https://pubmed.ncbi.nlm.nih.gov/2838291"},"language":"en","primary_location":{"id":"doi:10.1016/0277-5379(88)90291-x","doi":"https://doi.org/10.1016/0277-5379(88)90291-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0277-5379(88)90291-x","pdf_url":null,"source":{"id":"https://openalex.org/S42075721","display_name":"European Journal of Cancer and Clinical Oncology","issn_l":"0277-5379","issn":["0277-5379","1878-5980"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer and Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022063365","display_name":"Giuseppe Giaccone","orcid":"https://orcid.org/0000-0002-7392-1965","observed_orcids":["https://orcid.org/0000-0002-7392-1965","https://orcid.org/0000-0002-5023-7562"]},"institutions":[{"id":"https://openalex.org/I4210122409","display_name":"Ospedale San Giovanni Antica Sede","ror":"https://ror.org/0321tdt28","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210122409"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Giuseppe Giaccone","raw_affiliation_strings":["Division of Medical Oncology, Ospedale S. Giovanni, Antica Sede, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Ospedale S. Giovanni, Antica Sede, Torino, Italy","institution_ids":["https://openalex.org/I4210122409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019107001","display_name":"Michela Donadio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122409","display_name":"Ospedale San Giovanni Antica Sede","ror":"https://ror.org/0321tdt28","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210122409"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michela Donadio","raw_affiliation_strings":["Division of Medical Oncology, Ospedale S. Giovanni, Antica Sede, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Ospedale S. Giovanni, Antica Sede, Torino, Italy","institution_ids":["https://openalex.org/I4210122409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110412144","display_name":"G Bonardi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122409","display_name":"Ospedale San Giovanni Antica Sede","ror":"https://ror.org/0321tdt28","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210122409"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gian Maria Bonardi","raw_affiliation_strings":["Division of Medical Oncology, Ospedale S. Giovanni, Antica Sede, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Ospedale S. Giovanni, Antica Sede, Torino, Italy","institution_ids":["https://openalex.org/I4210122409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080899232","display_name":"Franco Testore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210111911","display_name":"Azienda Sanitaria Locale di Asti","ror":"https://ror.org/019z87133","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210111911"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Franco Testore","raw_affiliation_strings":["Division of Internal Medicine, Ospedale Civile, Asti, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Internal Medicine, Ospedale Civile, Asti, Italy","institution_ids":["https://openalex.org/I4210111911"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066900859","display_name":"Alessandro Calciati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122409","display_name":"Ospedale San Giovanni Antica Sede","ror":"https://ror.org/0321tdt28","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210122409"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Calciati","raw_affiliation_strings":["Division of Medical Oncology, Ospedale S. Giovanni, Antica Sede, Torino, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Medical Oncology, Ospedale S. Giovanni, Antica Sede, Torino, Italy","institution_ids":["https://openalex.org/I4210122409"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5022063365"],"corresponding_institution_ids":["https://openalex.org/I4210122409"],"apc_list":null,"apc_paid":null,"fwci":5.6087,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.95691787,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"4","first_page":"629","last_page":"631"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.8026999831199646,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.8026999831199646,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.15880000591278076,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/teniposide","display_name":"teniposide","score":0.9869999885559082},{"id":"https://openalex.org/keywords/small-cell-lung-cancer","display_name":"small cell lung cancer","score":0.9210000038146973},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.6460000276565552},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.902999997138977},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6940000057220459},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.7950000166893005},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5770000219345093},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.9139999747276306}],"concepts":[{"id":"https://openalex.org/C2778707968","wikidata":"https://www.wikidata.org/wiki/Q417555","display_name":"Teniposide","level":4,"score":0.9773398041725159},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8422646522521973},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6443048715591431},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.575188159942627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5672355890274048},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.5307353138923645},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.48302921652793884},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.47183945775032043},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4596504867076874},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.43467289209365845},{"id":"https://openalex.org/C2779562246","wikidata":"https://www.wikidata.org/wiki/Q16918881","display_name":"Prophylactic cranial irradiation","level":4,"score":0.4175630211830139},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.41648024320602417},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34244096279144287},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.2937822937965393},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.21464380621910095},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.13567623496055603},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0},{"id":"https://openalex.org/C45393284","wikidata":"https://www.wikidata.org/wiki/Q191012","display_name":"Conventional PCI","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007970","descriptor_name":"Leukopenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011034","descriptor_name":"Podophyllotoxin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D013713","descriptor_name":"Teniposide","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D013713","descriptor_name":"Teniposide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D018288","descriptor_name":"Carcinoma, Small Cell","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/0277-5379(88)90291-x","doi":"https://doi.org/10.1016/0277-5379(88)90291-x","is_oa":false,"landing_page_url":"https://doi.org/10.1016/0277-5379(88)90291-x","pdf_url":null,"source":{"id":"https://openalex.org/S42075721","display_name":"European Journal of Cancer and Clinical Oncology","issn_l":"0277-5379","issn":["0277-5379","1878-5980"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320146","host_organization_name":"Pergamon Press","host_organization_lineage":["https://openalex.org/P4310320146"],"host_organization_lineage_names":["Pergamon Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Cancer and Clinical Oncology","raw_type":"journal-article"},{"id":"pmid:2838291","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2838291","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of cancer & clinical oncology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8700000047683716,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W1991903703","https://openalex.org/W2021585096","https://openalex.org/W2134506110","https://openalex.org/W2160112148","https://openalex.org/W2478035831","https://openalex.org/W2883623725","https://openalex.org/W6753110811"],"related_works":["https://openalex.org/W2042952079","https://openalex.org/W2409792636","https://openalex.org/W2413738683","https://openalex.org/W1930834273","https://openalex.org/W2469084411","https://openalex.org/W2391813599","https://openalex.org/W1911884635","https://openalex.org/W1968495948","https://openalex.org/W2019425434","https://openalex.org/W1970943153"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
