{"id":"https://openalex.org/W2054499580","doi":"https://doi.org/10.1097/00001756-199612200-00074","title":"Alzheimer\u02bcs PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid \u03b2-peptide","display_name":"Alzheimer\u02bcs PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid \u03b2-peptide","publication_year":1996,"publication_date":"1996-12-01","ids":{"openalex":"https://openalex.org/W2054499580","doi":"https://doi.org/10.1097/00001756-199612200-00074","mag":"2054499580","pmid":"https://pubmed.ncbi.nlm.nih.gov/9051814"},"language":"en","primary_location":{"id":"doi:10.1097/00001756-199612200-00074","doi":"https://doi.org/10.1097/00001756-199612200-00074","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001756-199612200-00074","pdf_url":null,"source":{"id":"https://openalex.org/S121278948","display_name":"Neuroreport","issn_l":"0959-4965","issn":["0959-4965","1473-558X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroReport","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2054499580"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041778328","display_name":"Qing Guo","orcid":"https://orcid.org/0000-0002-3251-508X","observed_orcids":["https://orcid.org/0000-0002-3251-508X"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Guo","raw_affiliation_strings":["Sanders-Brown Research Center on Aging, University of Kentucky, Lexington 40536-0230, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanders-Brown Research Center on Aging, University of Kentucky, Lexington 40536-0230, USA","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103006742","display_name":"Katsutoshi Furukawa","orcid":"https://orcid.org/0000-0002-8047-4606","observed_orcids":["https://orcid.org/0000-0002-8047-4606"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katsutoshi Furukawa","raw_affiliation_strings":["Sanders-Brown Research Center on Aging and Department of Anatomy & Neurobiology, 211 Sanders-Brown Building, University of Kentucky, Lexington KY 40536-0230","Division of Brain Science"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanders-Brown Research Center on Aging and Department of Anatomy & Neurobiology, 211 Sanders-Brown Building, University of Kentucky, Lexington KY 40536-0230","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Division of Brain Science","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084891516","display_name":"Bryce L. Sopher","orcid":"https://orcid.org/0000-0001-6399-0783","observed_orcids":["https://orcid.org/0000-0001-6399-0783"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryce L. Sopher","raw_affiliation_strings":["Department of Pathology, University of Washington, Seattle, WA 98195-7470, USA","University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Washington, Seattle, WA 98195-7470, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111883680","display_name":"Dao G. Pham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dao G. Pham","raw_affiliation_strings":["Department of Pathology, University of Washington, Seattle, WA 98195-7470, USA","University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Washington, Seattle, WA 98195-7470, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102761100","display_name":"Jun Xie","orcid":"https://orcid.org/0000-0002-6161-5696","observed_orcids":["https://orcid.org/0000-0002-6161-5696","https://orcid.org/0009-0007-5845-9702","https://orcid.org/0000-0001-9340-2997"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jun Xie","raw_affiliation_strings":["Sanders-Brown Research Center on Aging and Department of Anatomy & Neurobiology, 211 Sanders-Brown Building, University of Kentucky, Lexington KY 40536-0230","#N##TAB##TAB##TAB##TAB# Univ. of Kentucky#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanders-Brown Research Center on Aging and Department of Anatomy & Neurobiology, 211 Sanders-Brown Building, University of Kentucky, Lexington KY 40536-0230","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Univ. of Kentucky#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063533620","display_name":"Nic Robinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nic Robinson","raw_affiliation_strings":["Sanders-Brown Research Center on Aging and Department of Anatomy & Neurobiology, 211 Sanders-Brown Building, University of Kentucky, Lexington KY 40536-0230","#N##TAB##TAB##TAB##TAB# Univ. of Kentucky#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sanders-Brown Research Center on Aging and Department of Anatomy & Neurobiology, 211 Sanders-Brown Building, University of Kentucky, Lexington KY 40536-0230","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Univ. of Kentucky#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059153511","display_name":"George M. Martin","orcid":"https://orcid.org/0000-0002-7974-818X","observed_orcids":["https://orcid.org/0000-0002-7974-818X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George M. Martin","raw_affiliation_strings":["Department of Pathology, University of Washington, Seattle, WA 98195-7470, USA","University of Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Washington, Seattle, WA 98195-7470, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"University of Washington","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083040475","display_name":"Mark P. Mattson","orcid":"https://orcid.org/0000-0002-9816-4155","observed_orcids":["https://orcid.org/0000-0002-9816-4155","https://orcid.org/0009-0000-5542-5565"]},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark P. Mattson","raw_affiliation_strings":["Corresponding Author: Mark P. Mattson","Sanders-Brown Research Center on Aging and Department of Anatomy & Neurobiology, 211 Sanders-Brown Building, University of Kentucky, Lexington KY 40536-0230","#N##TAB##TAB##TAB##TAB# Univ. of Kentucky#N##TAB##TAB##TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Corresponding Author: Mark P. Mattson","institution_ids":[]},{"raw_affiliation_string":"Sanders-Brown Research Center on Aging and Department of Anatomy & Neurobiology, 211 Sanders-Brown Building, University of Kentucky, Lexington KY 40536-0230","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"#N##TAB##TAB##TAB##TAB# Univ. of Kentucky#N##TAB##TAB##TAB#","institution_ids":["https://openalex.org/I143302722"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5083040475"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":null,"apc_paid":null,"fwci":8.7566,"has_fulltext":false,"cited_by_count":321,"citation_normalized_percentile":{"value":0.9877949,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"379","last_page":"383"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/presenilin-1","display_name":"presenilin 1","score":0.9679999947547913},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.8629999756813049},{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.9589999914169312},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.8460000157356262},{"id":"https://openalex.org/keywords/pc12-cells","display_name":"PC12 cells","score":0.8930000066757202},{"id":"https://openalex.org/keywords/er-calcium-release","display_name":"endoplasmic reticulum calcium release","score":0.9419999718666077},{"id":"https://openalex.org/keywords/voltage-gated-calcium-channels","display_name":"voltage-gated calcium channels","score":0.8100000023841858},{"id":"https://openalex.org/keywords/nifedipine","display_name":"nifedipine","score":0.9639999866485596},{"id":"https://openalex.org/keywords/dantrolene","display_name":"dantrolene","score":0.9990000128746033},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6909999847412109},{"id":"https://openalex.org/keywords/carbachol","display_name":"carbachol","score":0.8650000095367432},{"id":"https://openalex.org/keywords/bradykinin","display_name":"bradykinin","score":0.8999999761581421},{"id":"https://openalex.org/keywords/early-onset-alzheimer-s-disease","display_name":"early-onset Alzheimer's disease","score":0.8180000185966492}],"concepts":[{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.6785630583763123},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5361573100090027},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5187861919403076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4570997953414917},{"id":"https://openalex.org/C175344181","wikidata":"https://www.wikidata.org/wiki/Q907198","display_name":"Presenilin","level":4,"score":0.4256311357021332},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.4214520752429962},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.4211205244064331},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39037007093429565},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3762931823730469},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.328808456659317},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.27894067764282227},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.2780570685863495},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16211482882499695},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.14101791381835938},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1250227689743042},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004721","descriptor_name":"Endoplasmic Reticulum","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D009410","descriptor_name":"Nerve Degeneration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D016716","descriptor_name":"PC12 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018727","descriptor_name":"Muscarinic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053764","descriptor_name":"Presenilin-1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00001756-199612200-00074","doi":"https://doi.org/10.1097/00001756-199612200-00074","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00001756-199612200-00074","pdf_url":null,"source":{"id":"https://openalex.org/S121278948","display_name":"Neuroreport","issn_l":"0959-4965","issn":["0959-4965","1473-558X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroReport","raw_type":"journal-article"},{"id":"pmid:9051814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9051814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroreport","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G173579906","display_name":"LEADERSHIP AND EXCELLANCE IN ALZHEIMERS DISEASE AWARD","funder_award_id":"R35AG010917","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G2512053474","display_name":"Calcium Regulation in Brain Aging and Alzheimer's Disease","funder_award_id":"P01AG010836","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G740621808","display_name":"B-AMYLOID AND NEURONAL CALCIUM MISREGULATION","funder_award_id":"R01NS030583","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":8,"referenced_works":["https://openalex.org/W1973170979","https://openalex.org/W1981845572","https://openalex.org/W2009883535","https://openalex.org/W2028091371","https://openalex.org/W2051314670","https://openalex.org/W2113529592","https://openalex.org/W2132787891","https://openalex.org/W2144083888"],"related_works":["https://openalex.org/W4300457050","https://openalex.org/W2084488755","https://openalex.org/W1611341694","https://openalex.org/W1975742456","https://openalex.org/W2055585878","https://openalex.org/W2233364919","https://openalex.org/W2075045129","https://openalex.org/W2110974867","https://openalex.org/W2044577531"],"abstract_inverted_index":{"Mutations":[0],"in":[1,48],"the":[2,105,109],"presenilin-1":[3],"(PS-1)":[4],"gene":[5],"on":[6],"chromosome":[7],"14":[8],"are":[9],"linked":[10],"to":[11,36,55,76,84,121],"autosomal":[12],"dominant":[13],"early-onset":[14],"Alzheimer's":[15],"disease.":[16],"The":[17],"amino":[18],"acid":[19],"sequence":[20],"of":[21,44,72,90,98,108],"PS-1":[22,33,45,110,116],"predicts":[23],"an":[24],"integral":[25],"membrane":[26],"protein":[27],"and":[28,58,81,95],"immunocytochemical":[29],"studies":[30],"indicate":[31],"that":[32,42,60],"is":[34],"localized":[35],"endoplasmic":[37],"reticulum":[38],"(ER).":[39],"We":[40],"report":[41],"expression":[43],"mutation":[46],"L286V":[47,68],"cultured":[49],"PC12":[50],"cells":[51],"exaggerates":[52],"Ca2+":[53,62,99,114],"responses":[54],"agonists":[56],"(carbachol":[57],"bradykinin)":[59],"induce":[61],"release":[63,100],"from":[64,101],"ER.":[65],"Cells":[66],"expressing":[67],"exhibit":[69],"enhanced":[70],"elevations":[71],"[Ca2+]i":[73],"following":[74],"exposure":[75],"amyloid":[77],"beta-peptide":[78],"(A":[79],"beta)":[80],"increased":[82],"vulnerability":[83],"A":[85,122],"beta":[86],"toxicity.":[87],"An":[88],"antagonist":[89],"voltage-dependent":[91],"calcium":[92],"channels":[93],"(nifedipine),":[94],"a":[96],"blocker":[97],"ER":[102],"(dantrolene),":[103],"counteract":[104],"adverse":[106],"consequences":[107],"mutation.":[111],"By":[112],"perturbing":[113],"homeostasis,":[115],"mutations":[117],"may":[118],"sensitize":[119],"neurons":[120],"beta-induced":[123],"apoptosis.":[124]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":12}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
