{"id":"https://openalex.org/W2054495051","doi":"https://doi.org/10.1191/0961203303lu409oa","title":"Neuronal-binding antibodies from patients with antiphospholipid syndrome induce cognitive deficits following intrathecal passive transfer","display_name":"Neuronal-binding antibodies from patients with antiphospholipid syndrome induce cognitive deficits following intrathecal passive transfer","publication_year":2003,"publication_date":"2003-06-01","ids":{"openalex":"https://openalex.org/W2054495051","doi":"https://doi.org/10.1191/0961203303lu409oa","mag":"2054495051","pmid":"https://pubmed.ncbi.nlm.nih.gov/12873044"},"language":"en","primary_location":{"id":"doi:10.1191/0961203303lu409oa","doi":"https://doi.org/10.1191/0961203303lu409oa","is_oa":false,"landing_page_url":"https://doi.org/10.1191/0961203303lu409oa","pdf_url":null,"source":{"id":"https://openalex.org/S115920904","display_name":"Lupus","issn_l":"0961-2033","issn":["0961-2033","1477-0962"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lupus","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074738902","display_name":"Yehuda Shoenfeld","orcid":"https://orcid.org/0000-0003-2802-4090","observed_orcids":["https://orcid.org/0000-0003-2802-4090","https://orcid.org/0000-0003-0185-9637"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Y Shoenfeld","raw_affiliation_strings":["Department of Medicine B and Research Center for Autoimmune Diseases,                         Sheba Medical Center, Tel Hashomer Israel,","Department of Medicine B and Research Center for Autoimmune Diseases,Sheba MedicalCenter, Tel Hashomer, Israel. shoenfel@post.tau.ac.il"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine B and Research Center for Autoimmune Diseases,                         Sheba Medical Center, Tel Hashomer Israel,","institution_ids":["https://openalex.org/I2799810450"]},{"raw_affiliation_string":"Department of Medicine B and Research Center for Autoimmune Diseases,Sheba MedicalCenter, Tel Hashomer, Israel. shoenfel@post.tau.ac.il","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112895153","display_name":"A. Nahum","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"A Nahum","raw_affiliation_strings":["Department of Medicine B and Research Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine B and Research Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000197056","display_name":"Amos D. Korczyn","orcid":"https://orcid.org/0000-0001-5721-0437","observed_orcids":["https://orcid.org/0000-0001-5721-0437"]},"institutions":[{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"A D Korczyn","raw_affiliation_strings":["Department of Physiology & Pharmacology Sackler Faculty of Medicine, Tel Aviv, Israel, Department of Neurology and Neuroimmunology Service, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology & Pharmacology Sackler Faculty of Medicine, Tel Aviv, Israel, Department of Neurology and Neuroimmunology Service, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel","institution_ids":["https://openalex.org/I2799807261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111841868","display_name":"Marina Dano","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"M Dano","raw_affiliation_strings":["Department of Neurology and Neuroimmunology Service, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Neuroimmunology Service, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel","institution_ids":["https://openalex.org/I2799807261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110045264","display_name":"R Rabinowitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"R Rabinowitz","raw_affiliation_strings":["Department of Physiology & Pharmacology Sackler Faculty of Medicine, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology & Pharmacology Sackler Faculty of Medicine, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004771713","display_name":"Orit Beilin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"O Beilin","raw_affiliation_strings":["Department of Physiology & Pharmacology Sackler Faculty of Medicine, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology & Pharmacology Sackler Faculty of Medicine, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013311937","display_name":"Chaim G. Pick","orcid":"https://orcid.org/0000-0001-7114-339X","observed_orcids":["https://orcid.org/0000-0001-7114-339X"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"C G Pick","raw_affiliation_strings":["Department of Anatomy & Anthropology, Sackler Faculty of Medicine, Tel Aviv, Israel","Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy & Anthropology, Sackler Faculty of Medicine, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111524751","display_name":"Leonor Leider\u2013Trejo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"L Leider-Trejo","raw_affiliation_strings":["Department of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel","institution_ids":["https://openalex.org/I2799807261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082461660","display_name":"\u041b \u0410 \u041a\u0430\u043b\u0430\u0448\u043d\u0438\u043a\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0003-1142-0548","observed_orcids":["https://orcid.org/0000-0003-1142-0548"]},"institutions":[{"id":"https://openalex.org/I4210159010","display_name":"Research Center of Neurology","ror":"https://ror.org/05b74sw86","country_code":"RU","type":"healthcare","lineage":["https://openalex.org/I4210159010"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L Kalashnikova","raw_affiliation_strings":["Institute of Neurology, Moscow, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Neurology, Moscow, Russia","institution_ids":["https://openalex.org/I4210159010"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102905134","display_name":"Miri Blank","orcid":"https://orcid.org/0000-0001-7248-6853","observed_orcids":["https://orcid.org/0000-0001-7248-6853"]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"M Blank","raw_affiliation_strings":["Department of Medicine B and Research Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine B and Research Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072166912","display_name":"Joab Chapman","orcid":"https://orcid.org/0000-0002-2161-9764","observed_orcids":["https://orcid.org/0000-0002-2161-9764"]},"institutions":[{"id":"https://openalex.org/I2799807261","display_name":"Tel Aviv Sourasky Medical Center","ror":"https://ror.org/04nd58p63","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799807261"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"J Chapman","raw_affiliation_strings":["Department of Physiology & Pharmacology Sackler Faculty of Medicine, Tel Aviv, Israel, Department of Neurology and Neuroimmunology Service, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology & Pharmacology Sackler Faculty of Medicine, Tel Aviv, Israel, Department of Neurology and Neuroimmunology Service, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel","institution_ids":["https://openalex.org/I2799807261"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5074738902"],"corresponding_institution_ids":["https://openalex.org/I2799810450"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":2.2678,"has_fulltext":false,"cited_by_count":123,"citation_normalized_percentile":{"value":0.87146695,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"12","issue":"6","first_page":"436","last_page":"442"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11627","display_name":"Autoimmune Neurological Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiphospholipid-syndrome","display_name":"antiphospholipid syndrome","score":0.9819999933242798},{"id":"https://openalex.org/keywords/antiphospholipid-antibodies","display_name":"antiphospholipid antibodies","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.8109999895095825},{"id":"https://openalex.org/keywords/intracerebroventricular-injection","display_name":"intracerebroventricular administration","score":0.8289999961853027},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.640999972820282},{"id":"https://openalex.org/keywords/cerebral-cortex","display_name":"cerebral cortex","score":0.996999979019165},{"id":"https://openalex.org/keywords/learning-and-memory-impairment","display_name":"learning and memory impairment","score":0.7120000123977661},{"id":"https://openalex.org/keywords/autoantibody-pathogenesis","display_name":"autoantibody pathogenesis","score":0.7089999914169312}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9111126661300659},{"id":"https://openalex.org/C157820659","wikidata":"https://www.wikidata.org/wiki/Q1320251","display_name":"Intrathecal","level":2,"score":0.7004347443580627},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.664509654045105},{"id":"https://openalex.org/C2776874634","wikidata":"https://www.wikidata.org/wiki/Q582207","display_name":"Antiphospholipid syndrome","level":3,"score":0.6400492191314697},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4711640775203705},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3738037347793579},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.31652769446372986},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.1660541594028473}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000704","descriptor_name":"Analysis of Variance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001707","descriptor_name":"Biopsy, Needle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003072","descriptor_name":"Cognition Disorders","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007278","descriptor_name":"Injections, Spinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008809","descriptor_name":"Mice, Inbred C3H","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011336","descriptor_name":"Probability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016736","descriptor_name":"Antiphospholipid Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016736","descriptor_name":"Antiphospholipid Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D017152","descriptor_name":"Antibodies, Antiphospholipid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1191/0961203303lu409oa","doi":"https://doi.org/10.1191/0961203303lu409oa","is_oa":false,"landing_page_url":"https://doi.org/10.1191/0961203303lu409oa","pdf_url":null,"source":{"id":"https://openalex.org/S115920904","display_name":"Lupus","issn_l":"0961-2033","issn":["0961-2033","1477-0962"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lupus","raw_type":"journal-article"},{"id":"pmid:12873044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12873044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lupus","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W109073711","https://openalex.org/W1600697457","https://openalex.org/W1845037068","https://openalex.org/W1964150247","https://openalex.org/W1968748995","https://openalex.org/W1974356256","https://openalex.org/W1981060739","https://openalex.org/W1983620158","https://openalex.org/W1989335453","https://openalex.org/W1990011919","https://openalex.org/W1991659850","https://openalex.org/W1997693267","https://openalex.org/W2000280076","https://openalex.org/W2001611219","https://openalex.org/W2007876469","https://openalex.org/W2012709258","https://openalex.org/W2024078671","https://openalex.org/W2027816939","https://openalex.org/W2035685706","https://openalex.org/W2037420818","https://openalex.org/W2040236551","https://openalex.org/W2047906671","https://openalex.org/W2064974599","https://openalex.org/W2066839033","https://openalex.org/W2067829992","https://openalex.org/W2083337281","https://openalex.org/W2087479520","https://openalex.org/W2103720854","https://openalex.org/W2119072065","https://openalex.org/W2164710236","https://openalex.org/W2394620182","https://openalex.org/W2407241302","https://openalex.org/W2411397182","https://openalex.org/W2418979198","https://openalex.org/W2442707916","https://openalex.org/W2465710368","https://openalex.org/W2992551083"],"related_works":["https://openalex.org/W1966266371","https://openalex.org/W1977462460","https://openalex.org/W2020428253","https://openalex.org/W2040134794","https://openalex.org/W2070162478","https://openalex.org/W6929612958","https://openalex.org/W2013474514","https://openalex.org/W1997693267","https://openalex.org/W1972368562","https://openalex.org/W4210319767"],"abstract_inverted_index":{"Antiphospholipid":[0],"antibodies":[1],"(aPL)":[2],"have":[3],"been":[4],"suggested":[5],"to":[6,53,68,113,141,144,168,227,251],"play":[7,257],"a":[8,100,258],"role":[9,260],"in":[10,99,121,147,163,235,261],"causing":[11],"cognitive":[12,105],"and":[13,95,97,150,203,231],"behavioral":[14],"impairments.":[15],"In":[16],"the":[17,22,43,110,114,119,148,164,169,178,182,186,195,220,238,244,252,262],"present":[18],"study":[19],"we":[20],"investigated":[21],"pathogenic":[23],"potential":[24],"of":[25,31,45,118,129,177,185,219,237,264,267],"aPL":[26,179,247],"by":[27,57,127],"intracerebro-ventricular":[28],"(ICV)":[29],"administration":[30],"immunoglobulins":[32],"(IgG)":[33],"from":[34,42,77,81,135,217],"patients":[35,223],"with":[36,74,109,131,158,174],"antiphospholipid":[37],"syndrome":[38],"(APS).":[39],"IgG,":[40],"purified":[41,76],"sera":[44,79],"four":[46,122],"APS":[47,137],"patients,":[48],"was":[49,125,139],"tested":[50],"for":[51,92],"binding":[52],"normal":[54],"mouse":[55,228],"brain":[56,229],"immunohistological":[58],"staining.":[59],"These":[60,241],"IgG":[61,75,134,160,180,215],"(7.5":[62],"microg)":[63],"were":[64,89,107],"injected":[65,73,157,216],"ICV":[66],"unilaterally":[67],"male":[69],"C3H":[70],"mice.":[71],"Mice":[72,153],"pooled":[78],"derived":[80],"healthy":[82],"subjects":[83],"served":[84],"as":[85],"controls.":[86],"The":[87,104,116],"mice":[88,120,187],"examined":[90],"neurologically":[91],"motor":[93],"function":[94],"coordination,":[96],"cognitively":[98],"Morris":[101],"water":[102,165,239],"maze.":[103,240],"tests":[106],"performed":[108,161],"experimenter":[111],"blinded":[112],"treatment.":[115],"performance":[117,184,236],"separate":[123],"experiments":[124],"compared":[126,167],"analysis":[128],"variance":[130],"repeated":[132],"measures.":[133],"one":[136],"patient":[138],"found":[140],"bind":[142],"best":[143],"neuronal":[145],"structures":[146],"hippocampus":[149],"cerebral":[151],"cortex.":[152],"(n":[154,171],"=":[155,172],"43)":[156],"this":[159],"worse":[162],"maze":[166],"controls":[170],"45)":[173],"significant":[175],"effects":[176],"on":[181,192,204],"overall":[183],"(treatment,":[188],"P":[189,200,212],"<":[190,201,213],"0.03),":[191],"learning":[193],"throughout":[194],"experiment":[196],"(treatment":[197,208],"x":[198,209],"day,":[199],"0.02)":[202],"short":[205],"term":[206],"memory":[207],"day":[210],"xtrial,":[211],"0.002).":[214],"two":[218],"three":[221],"other":[222],"also":[224],"bound":[225],"specifically":[226],"neurons":[230],"produced":[232],"an":[233],"impairment":[234],"results":[242],"support":[243],"hypothesis":[245],"that":[246,248],"gain":[249],"access":[250],"central":[253],"nervous":[254],"system":[255],"may":[256],"direct":[259],"pathogenesis":[263],"neurological":[265],"manifestations":[266],"APS.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}