{"id":"https://openalex.org/W2054476713","doi":"https://doi.org/10.1093/carcin/15.12.2709","title":"Evidence for a high-affinity enzyme in rat esophageal microsomes which \u03b1-hydroxylates N\u2019-nitrosonornicotine","display_name":"Evidence for a high-affinity enzyme in rat esophageal microsomes which \u03b1-hydroxylates N\u2019-nitrosonornicotine","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W2054476713","doi":"https://doi.org/10.1093/carcin/15.12.2709","mag":"2054476713","pmid":"https://pubmed.ncbi.nlm.nih.gov/8001225"},"language":"en","primary_location":{"id":"doi:10.1093/carcin/15.12.2709","doi":"https://doi.org/10.1093/carcin/15.12.2709","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/15.12.2709","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022126431","display_name":"Sharon E. Murphy","orcid":"https://orcid.org/0000-0001-5391-8104","observed_orcids":["https://orcid.org/0000-0001-5391-8104"]},"institutions":[{"id":"https://openalex.org/I4210167017","display_name":"Institute for Cancer Prevention","ror":"https://ror.org/05t7jxa31","country_code":"US","type":"other","lineage":["https://openalex.org/I4210167017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sharon E. Murphy","raw_affiliation_strings":["American Health Foundation, Valhalla, NY 10595","American Health FoundationOne Dana Road, Valhalla, NY 10595, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"American Health Foundation, Valhalla, NY 10595","institution_ids":["https://openalex.org/I4210167017"]},{"raw_affiliation_string":"American Health FoundationOne Dana Road, Valhalla, NY 10595, USA","institution_ids":["https://openalex.org/I4210167017"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024948139","display_name":"Deborah A. Spina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210167017","display_name":"Institute for Cancer Prevention","ror":"https://ror.org/05t7jxa31","country_code":"US","type":"other","lineage":["https://openalex.org/I4210167017"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah A. Spina","raw_affiliation_strings":["American Health Foundation One Dana Road, Valhalla, NY 10595, USA","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"American Health Foundation One Dana Road, Valhalla, NY 10595, USA","institution_ids":["https://openalex.org/I4210167017"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4835,"currency":"USD","value_usd":4835},"apc_paid":null,"fwci":1.0578,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.7653587,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"15","issue":"12","first_page":"2709","last_page":"2713"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/n-nitrosonornicotine","display_name":"N'-nitrosonornicotine","score":0.9940000176429749},{"id":"https://openalex.org/keywords/alpha-hydroxylation","display_name":"\u03b1-hydroxylation","score":0.8389999866485596},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9350000023841858},{"id":"https://openalex.org/keywords/nitrosamine-activation","display_name":"nitrosamine activation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/2-hydroxylation","display_name":"2-hydroxylation","score":0.8970000147819519},{"id":"https://openalex.org/keywords/5-hydroxylation","display_name":"5-hydroxylation","score":0.9330000281333923},{"id":"https://openalex.org/keywords/tissue-specific-metabolism","display_name":"tissue-specific metabolism","score":0.49799999594688416},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.7870000004768372},{"id":"https://openalex.org/keywords/enzyme-binding-affinity","display_name":"enzyme affinity","score":0.42100000381469727}],"concepts":[{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.8661826848983765},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.8189510107040405},{"id":"https://openalex.org/C2777395278","wikidata":"https://www.wikidata.org/wiki/Q413779","display_name":"Nitrosamine","level":3,"score":0.8065735101699829},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7319296002388},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.5738738775253296},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5450490117073059},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.5151287317276001},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.4783886671066284},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.41234296560287476},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.39537423849105835}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002248","descriptor_name":"Carbon Monoxide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004947","descriptor_name":"Esophagus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D004947","descriptor_name":"Esophagus","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D006900","descriptor_name":"Hydroxylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D008862","descriptor_name":"Microsomes, Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009249","descriptor_name":"NADP","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009602","descriptor_name":"Nitrosamines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011916","descriptor_name":"Rats, Inbred F344","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/carcin/15.12.2709","doi":"https://doi.org/10.1093/carcin/15.12.2709","is_oa":false,"landing_page_url":"https://doi.org/10.1093/carcin/15.12.2709","pdf_url":null,"source":{"id":"https://openalex.org/S184620562","display_name":"Carcinogenesis","issn_l":"0143-3334","issn":["0143-3334","1460-2180"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"journal-article"},{"id":"pmid:8001225","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8001225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carcinogenesis","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.766700029373169}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1491389018","display_name":null,"funder_award_id":"CA 17613","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G338396427","display_name":null,"funder_award_id":"CA 29580","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G6716625449","display_name":"EXPERIMENTAL TOBACCO CARCINOGENESIS","funder_award_id":"P01CA029580","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7097651146","display_name":"CANCER CENTER SUPPORT GRANT","funder_award_id":"P30CA017613","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4253919132","https://openalex.org/W2122693992","https://openalex.org/W2055182999","https://openalex.org/W2153943451","https://openalex.org/W2003098351","https://openalex.org/W2298000810","https://openalex.org/W2132557826","https://openalex.org/W2013033524","https://openalex.org/W2090215356","https://openalex.org/W1516686185"],"abstract_inverted_index":{"The":[0,95,118,248],"tobacco-specific":[1],"nitrosamine":[2],"N'-nitrosonornicotine":[3],"(NNN)":[4],"induces":[5],"esophageal":[6,104,204,254,266],"but":[7],"not":[8,185,243],"liver":[9,51,165,225],"tumors":[10],"in":[11,16,23,223,245,271,280],"the":[12,24,30,37,40,62,69,129,145,150,156,174,191,200,224,246,262,275],"rat.":[13],"This":[14,73],"may":[15],"part":[17,272],"be":[18,144],"due":[19,273],"to":[20,47,57,122,137,143,160,274],"tissue-specific":[21],"differences":[22],"activation":[25,146,277],"of":[26,32,39,64,68,101,120,152,158,162,176,182,194,202,211,250,278],"this":[27,220,281],"nitrosamine.":[28],"Therefore,":[29],"metabolism":[31,49,181],"NNN":[33,56,102,130,163,177,183,195,258,265,279],"by":[34,50,82,90,103,164,230],"microsomes":[35,54,105,166],"from":[36,134],"mucosa":[38],"rat":[41],"esophagus":[42],"was":[43,80,106,113,124,132,167,184],"characterized":[44],"and":[45,60,66,79,111,170],"compared":[46],"its":[48,226],"microsomes.":[52],"Esophageal":[53],"metabolized":[55],"both":[58],"4-hydroxy-1-(3-pyridyl)-1-butanone":[59],"2-hydroxy-5-(3-pyridyl)tetrahydrofuran,":[61],"products":[63],"2'-":[65,159],"5'-hydroxylation":[67,123,161],"pyrrolidine":[70],"ring,":[71],"respectively.":[72],"activity":[74,227],"required":[75],"an":[76,203],"NADPH-generating":[77],"system":[78],"inhibited":[81],"carbon":[83],"monoxide,":[84],"suggesting":[85],"that":[86,256,264],"it":[87,213],"is":[88,141,214,228,259,268],"mediated":[89],"a":[91,216,251],"cytochrome":[92,217],"P450":[93],"enzyme.":[94],"apparent":[96],"KM":[97,253],"for":[98,149,209],"total":[99],"alpha-hydroxylation":[100,210],"49":[107],"+/-":[108,115,126],"6.5":[109],"microM":[110,136],"Vmax":[112,234],"113":[114],"3.7":[116],"pmol/mg/min.":[117],"ratio":[119,157],"2'-hydroxylation":[121],"3.2":[125],"0.5":[127],"when":[128],"concentration":[131,175,193],"varied":[133],"1":[135],"2":[138,188],"mM.":[139],"2'-Hydroxylation":[140],"believed":[142],"pathway":[147],"responsible":[148],"tumorigenicity":[151,267],"NNN.":[153,239],"In":[154],"contrast,":[155],"between":[168],"0.71":[169],"0.23":[171],"depending":[172],"on":[173],"used.":[178,196],"Hepatic":[179],"microsomal":[180],"saturated":[186],"at":[187,269],"mM":[189],"NNN,":[190],"highest":[192],"These":[197,240],"results":[198],"confirm":[199],"existence":[201],"enzyme":[205,221,255],"with":[206,261],"high":[207,231,233],"affinity":[208],"NNN;":[212],"probably":[215],"P450.":[218],"If":[219],"exists":[222],"masked":[229],"KM,":[232],"enzymes":[235,241],"which":[236],"also":[237],"alpha-hydroxylate":[238],"are":[242],"present":[244],"esophagus.":[247],"presence":[249],"low":[252],"2'-hydroxylates":[257],"consistent":[260],"hypothesis":[263],"least":[270],"efficient":[276],"tissue.":[282]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
