{"id":"https://openalex.org/W2054472226","doi":"https://doi.org/10.1177/026988119100500102","title":"Quantitative trait loci and psychopharmacology","display_name":"Quantitative trait loci and psychopharmacology","publication_year":1991,"publication_date":"1991-01-01","ids":{"openalex":"https://openalex.org/W2054472226","doi":"https://doi.org/10.1177/026988119100500102","mag":"2054472226","pmid":"https://pubmed.ncbi.nlm.nih.gov/22282114"},"language":"en","primary_location":{"id":"doi:10.1177/026988119100500102","doi":"https://doi.org/10.1177/026988119100500102","is_oa":false,"landing_page_url":"https://doi.org/10.1177/026988119100500102","pdf_url":null,"source":{"id":"https://openalex.org/S136368880","display_name":"Journal of Psychopharmacology","issn_l":"0269-8811","issn":["0269-8811","1461-7285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007723142","display_name":"Robert J. Plomin","orcid":"https://orcid.org/0000-0002-0756-3629","observed_orcids":["https://orcid.org/0000-0002-0756-3629","https://orcid.org/0000-0003-3925-3913"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Plomin","raw_affiliation_strings":["Center for Developmental and Health Genetics, Pennsylvania State University, University Park, PA 16802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Developmental and Health Genetics, Pennsylvania State University, University Park, PA 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037786289","display_name":"Gerald E. McClearn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald E. McClearn","raw_affiliation_strings":["Center for Developmental and Health Genetics, Pennsylvania State University, University Park, PA 16802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Developmental and Health Genetics, Pennsylvania State University, University Park, PA 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028098028","display_name":"Grazyna Gora-Maslak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grazyna Gora-Maslak","raw_affiliation_strings":["Center for Developmental and Health Genetics, Pennsylvania State University, University Park, PA 16802, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Developmental and Health Genetics, Pennsylvania State University, University Park, PA 16802, USA","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130769515"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":0.809,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.71943629,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"5","issue":"1","first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0608999989926815,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.03220000118017197,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quantitative-trait-loci","display_name":"quantitative trait loci","score":1.0},{"id":"https://openalex.org/keywords/recombinant-inbred-lines","display_name":"recombinant inbred lines","score":0.8399999737739563},{"id":"https://openalex.org/keywords/bxd-mice","display_name":"BXD mice","score":0.8519999980926514},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.5929999947547913},{"id":"https://openalex.org/keywords/behavioral-genetics","display_name":"behavioral genetics","score":0.6100000143051147},{"id":"https://openalex.org/keywords/individual-differences-in-drug-response","display_name":"individual differences in drug response","score":0.7540000081062317},{"id":"https://openalex.org/keywords/genetic-correlation","display_name":"genetic correlation","score":0.6690000295639038},{"id":"https://openalex.org/keywords/polygenic-traits","display_name":"polygenic traits","score":0.5329999923706055},{"id":"https://openalex.org/keywords/genetic-variance","display_name":"genetic variance","score":0.36399999260902405},{"id":"https://openalex.org/keywords/psychopharmacology","display_name":"psychopharmacology","score":0.6959999799728394}],"concepts":[{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.8865086436271667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6636229753494263},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.602695882320404},{"id":"https://openalex.org/C21249469","wikidata":"https://www.wikidata.org/wiki/Q5433313","display_name":"Family-based QTL mapping","level":5,"score":0.5417729616165161},{"id":"https://openalex.org/C106934330","wikidata":"https://www.wikidata.org/wiki/Q1971873","display_name":"Trait","level":2,"score":0.512064516544342},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.49214309453964233},{"id":"https://openalex.org/C175783326","wikidata":"https://www.wikidata.org/wiki/Q185055","display_name":"Mendelian inheritance","level":3,"score":0.470465749502182},{"id":"https://openalex.org/C76725341","wikidata":"https://www.wikidata.org/wiki/Q1893126","display_name":"Inbred strain","level":3,"score":0.4580094516277313},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43134137988090515},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37793633341789246},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3367186188697815},{"id":"https://openalex.org/C122735190","wikidata":"https://www.wikidata.org/wiki/Q715789","display_name":"Gene mapping","level":4,"score":0.3267059624195099},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12104466557502747},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.06286856532096863},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1177/026988119100500102","doi":"https://doi.org/10.1177/026988119100500102","is_oa":false,"landing_page_url":"https://doi.org/10.1177/026988119100500102","pdf_url":null,"source":{"id":"https://openalex.org/S136368880","display_name":"Journal of Psychopharmacology","issn_l":"0269-8811","issn":["0269-8811","1461-7285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:22282114","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22282114","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of psychopharmacology (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.895.9037","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.895.9037","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jop.sagepub.com/content/5/1/1.full.pdf","raw_type":"text"},{"id":"pmh:oai:kclpure.kcl.ac.uk:publications/c76581ab-18c7-40c8-a4ca-dfc394e9ad8e","doi":null,"is_oa":false,"landing_page_url":"https://kclpure.kcl.ac.uk/portal/en/publications/c76581ab-18c7-40c8-a4ca-dfc394e9ad8e","pdf_url":null,"source":{"id":"https://openalex.org/S4306400216","display_name":"Research Portal (King's College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I183935753","host_organization_name":"King's College London","host_organization_lineage":["https://openalex.org/I183935753"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plomin, R, McClearn, G E & Gora-Maslak, G 1991, 'Quantitative trait loci and psychopharmacology', Journal of Psychopharmacology, vol. 5, no. 1, pp. 1-9. https://doi.org/10.1177/026988119100500102","raw_type":"info:eu-repo/semantics/publishedVersion"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W40752833","https://openalex.org/W1479752016","https://openalex.org/W1485802059","https://openalex.org/W1542010734","https://openalex.org/W1557101715","https://openalex.org/W1558833418","https://openalex.org/W1775762265","https://openalex.org/W1904144572","https://openalex.org/W1963924361","https://openalex.org/W1972666433","https://openalex.org/W1983088153","https://openalex.org/W1990833731","https://openalex.org/W1991838756","https://openalex.org/W1992827909","https://openalex.org/W2015429247","https://openalex.org/W2021308822","https://openalex.org/W2031319177","https://openalex.org/W2035304341","https://openalex.org/W2035946064","https://openalex.org/W2036908756","https://openalex.org/W2037675805","https://openalex.org/W2039401119","https://openalex.org/W2042736429","https://openalex.org/W2048578647","https://openalex.org/W2059389533","https://openalex.org/W2060653895","https://openalex.org/W2063265623","https://openalex.org/W2079214445","https://openalex.org/W2084785057","https://openalex.org/W2088829922","https://openalex.org/W2107031757","https://openalex.org/W2114999674","https://openalex.org/W2135277953","https://openalex.org/W2136193641","https://openalex.org/W2141088880","https://openalex.org/W2155921107","https://openalex.org/W2415919590","https://openalex.org/W2469656041","https://openalex.org/W2498774021","https://openalex.org/W2505891767","https://openalex.org/W2584647260","https://openalex.org/W2628074563","https://openalex.org/W2905618940","https://openalex.org/W4206471153","https://openalex.org/W4233568251","https://openalex.org/W4249237407","https://openalex.org/W4300870773"],"related_works":["https://openalex.org/W7095642189","https://openalex.org/W2015429247","https://openalex.org/W2057527166","https://openalex.org/W2035615794","https://openalex.org/W1972896949","https://openalex.org/W2054102777","https://openalex.org/W2034108986","https://openalex.org/W2081081016","https://openalex.org/W2077126634","https://openalex.org/W1580441185"],"abstract_inverted_index":{"Unlike":[0],"simple":[1],"Mendelian":[2],"characteristics,":[3],"individual":[4],"differences":[5],"in":[6],"behavior,":[7],"including":[8],"behavioral":[9,55],"responses":[10],"to":[11,27,49,143,152],"drugs,":[12],"are":[13],"generally":[14],"distributed":[15],"continuously,":[16],"show":[17],"substantial":[18],"non-genetic":[19],"as":[20,22,104,176,178],"well":[21,177],"genetic":[23,115,158,172,184,208],"influence,":[24],"and":[25,110,126,145,148,188,216,222],"appear":[26],"be":[28,141],"influenced":[29],"by":[30],"many":[31],"genes":[32,62],"rather":[33],"than":[34,112],"one":[35],"or":[36],"two":[37],"major":[38,199],"genes.":[39],"For":[40],"these":[41,183],"reasons,":[42],"application":[43],"of":[44,46,68,80,87,132,167,182,191,195,201,210],"techniques":[45],"molecular":[47,207],"biology":[48],"identify":[50,144],"DNA":[51],"sequences":[52],"responsible":[53],"for":[54,65,157,160,206],"variation":[56],"requires":[57],"strategies":[58],"that":[59,63],"can":[60,140,170],"detect":[61],"account":[64,156],"small":[66],"amounts":[67],"variation,":[69],"so-called":[70],"quantitative":[71],"trait":[72],"loci":[73],"(QTL).":[74],"One":[75],"such":[76,103,192],"strategy":[77],"involves":[78],"analyses":[79],"association":[81],"using":[82],"recombinant":[83],"inbred":[84,121],"(RI)":[85],"strains":[86,109,122,135],"mice.":[88],"The":[89,186],"RI":[90,101,134,203],"QTL":[91,147,155,180,204],"approach":[92,139,169,205],"is":[93,136,197],"especially":[94],"valuable":[95],"when":[96,118,127],"researchers":[97],"use":[98],"the":[99,119,128,133,138,150,154,179,198,202],"same":[100],"series,":[102],"BXD,":[105],"which":[106,153],"has":[107],"26":[108],"more":[111],"300":[113],"mapped":[114],"markers.":[116],"Even":[117],"progenitor":[120],"do":[123],"not":[124],"differ":[125],"strain":[129],"distribution":[130],"pattern":[131],"continuous,":[137],"used":[142],"map":[146],"estimate":[149],"extent":[151],"variance":[159],"a":[161,193],"particular":[162],"phenotype.":[163],"A":[164],"multivariate":[165],"extension":[166],"this":[168],"assess":[171],"correlations":[173],"among":[174],"measures":[175],"underpinnings":[181],"correlations.":[185],"cumulative":[187],"integrative":[189],"nature":[190],"program":[194],"research":[196],"benefit":[200],"analysis":[209],"psychopharmacological":[211],"processes,":[212],"their":[213,217],"physiological":[214],"infrastructure,":[215],"interface":[218],"with":[219],"other":[220],"biological":[221],"behavioural":[223],"systems.":[224]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2016-06-24T00:00:00"}