{"id":"https://openalex.org/W2054470690","doi":"https://doi.org/10.1182/blood-2010-02-270405","title":"Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation","display_name":"Inducible Fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation","publication_year":2010,"publication_date":"2010-08-24","ids":{"openalex":"https://openalex.org/W2054470690","doi":"https://doi.org/10.1182/blood-2010-02-270405","mag":"2054470690","pmid":"https://pubmed.ncbi.nlm.nih.gov/20733157"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2010-02-270405","doi":"https://doi.org/10.1182/blood-2010-02-270405","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2010-02-270405","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014815935","display_name":"Jo\u00eblle Starck","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jo\u00eblle Starck","raw_affiliation_strings":["Centre National de la Recherche Scientifique (CNRS), Centre de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, Villeurbanne, France","Universit\u00e9 de Lyon, Lyon, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique (CNRS), Centre de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, Villeurbanne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210159560"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, Lyon, France; and","institution_ids":["https://openalex.org/I203339264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083667432","display_name":"Mich\u00e8le Weiss\u2010Gayet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Mich\u00e8le Weiss-Gayet","raw_affiliation_strings":["Centre National de la Recherche Scientifique (CNRS), Centre de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, Villeurbanne, France","Universit\u00e9 de Lyon, Lyon, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique (CNRS), Centre de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, Villeurbanne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210159560"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, Lyon, France; and","institution_ids":["https://openalex.org/I203339264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045011596","display_name":"Colette Gonnet","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Colette Gonnet","raw_affiliation_strings":["Centre National de la Recherche Scientifique (CNRS), Centre de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, Villeurbanne, France","Universit\u00e9 de Lyon, Lyon, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique (CNRS), Centre de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, Villeurbanne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210159560"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, Lyon, France; and","institution_ids":["https://openalex.org/I203339264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012015140","display_name":"Boris Guyot","orcid":"https://orcid.org/0000-0002-4512-7123","observed_orcids":["https://orcid.org/0000-0002-4512-7123"]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Boris Guyot","raw_affiliation_strings":["Centre National de la Recherche Scientifique (CNRS), Centre de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, Villeurbanne, France","Universit\u00e9 de Lyon, Lyon, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique (CNRS), Centre de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, Villeurbanne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210159560"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, Lyon, France; and","institution_ids":["https://openalex.org/I203339264"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111745972","display_name":"J.-M. Vicat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jean-Michel Vicat","raw_affiliation_strings":["Centre National de la Recherche Scientifique (CNRS), Centre de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, Villeurbanne, France","Universit\u00e9 de Lyon, Lyon, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique (CNRS), Centre de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, Villeurbanne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210159560"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, Lyon, France; and","institution_ids":["https://openalex.org/I203339264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087929889","display_name":"Fran\u00e7ois Morl\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I203339264","display_name":"Universit\u00e9 de Lyon","ror":"https://ror.org/01rk35k63","country_code":"FR","type":"education","lineage":["https://openalex.org/I203339264"]},{"id":"https://openalex.org/I4210159560","display_name":"Centre de G\u00e9n\u00e9tique Mol\u00e9culaire","ror":"https://ror.org/052ahj806","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I4210114748","https://openalex.org/I4210139971","https://openalex.org/I4210159560"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Morl\u00e9","raw_affiliation_strings":["Centre National de la Recherche Scientifique (CNRS), Centre de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, Villeurbanne, France","Universit\u00e9 de Lyon, Lyon, France; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre National de la Recherche Scientifique (CNRS), Centre de G\u00e9n\u00e9tique Mol\u00e9culaire et Cellulaire, Villeurbanne, France","institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I4210159560"]},{"raw_affiliation_string":"Universit\u00e9 de Lyon, Lyon, France; and","institution_ids":["https://openalex.org/I203339264"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":2.9422,"has_fulltext":false,"cited_by_count":51,"citation_normalized_percentile":{"value":0.91505072,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"116","issue":"23","first_page":"4795","last_page":"4805"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.03920000046491623,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.007799999788403511,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fli1","display_name":"FLI1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ets-transcription-factors","display_name":"ETS transcription factors","score":0.9800000190734863},{"id":"https://openalex.org/keywords/megakaryopoiesis","display_name":"megakaryopoiesis","score":0.8339999914169312},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"erythropoiesis","score":0.8650000095367432},{"id":"https://openalex.org/keywords/myeloid-lineage-commitment","display_name":"myeloid lineage commitment","score":0.7910000085830688},{"id":"https://openalex.org/keywords/erythroid-progenitor-proliferation","display_name":"erythroid progenitor proliferation","score":0.6439999938011169},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.8740000128746033},{"id":"https://openalex.org/keywords/common-myeloid-progenitors","display_name":"common myeloid progenitors","score":0.921999990940094},{"id":"https://openalex.org/keywords/inducible-gene-deletion","display_name":"inducible gene deletion","score":0.7049999833106995}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6307110786437988},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.6220948696136475},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.5597765445709229},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5438696146011353},{"id":"https://openalex.org/C2779664074","wikidata":"https://www.wikidata.org/wiki/Q3518405","display_name":"Terminal (telecommunication)","level":2,"score":0.48921656608581543},{"id":"https://openalex.org/C2994430510","wikidata":"https://www.wikidata.org/wiki/Q3270846","display_name":"Myeloid cells","level":3,"score":0.47305408120155334},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.45656877756118774},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.44448235630989075},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44290590286254883},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3723955452442169},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35987937450408936},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30523401498794556},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002454","descriptor_name":"Cell Differentiation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002469","descriptor_name":"Cell Separation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008533","descriptor_name":"Megakaryocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022423","descriptor_name":"Myeloid Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051789","descriptor_name":"Proto-Oncogene Protein c-fli-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2010-02-270405","doi":"https://doi.org/10.1182/blood-2010-02-270405","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood-2010-02-270405","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:20733157","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20733157","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:HAL:hal-00709071v1","doi":null,"is_oa":false,"landing_page_url":"https://hal.science/hal-00709071","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Blood, 2010, 116 (23), pp.4795-805. ⟨10.1182/blood-2010-02-270405⟩","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.7246000170707703,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W1930242451","https://openalex.org/W1970056549","https://openalex.org/W1974659776","https://openalex.org/W1975397036","https://openalex.org/W1976808787","https://openalex.org/W1980091579","https://openalex.org/W1982130774","https://openalex.org/W1984407446","https://openalex.org/W1994254285","https://openalex.org/W2000303521","https://openalex.org/W2011346553","https://openalex.org/W2013150998","https://openalex.org/W2014625679","https://openalex.org/W2027666734","https://openalex.org/W2033687970","https://openalex.org/W2038970416","https://openalex.org/W2039078045","https://openalex.org/W2052701435","https://openalex.org/W2055736709","https://openalex.org/W2071970572","https://openalex.org/W2075904779","https://openalex.org/W2079640943","https://openalex.org/W2083368306","https://openalex.org/W2084775802","https://openalex.org/W2097411559","https://openalex.org/W2101518963","https://openalex.org/W2102782482","https://openalex.org/W2102954487","https://openalex.org/W2103532641","https://openalex.org/W2104499325","https://openalex.org/W2107789195","https://openalex.org/W2109578628","https://openalex.org/W2110981938","https://openalex.org/W2111519012","https://openalex.org/W2116230332","https://openalex.org/W2117151537","https://openalex.org/W2122571618","https://openalex.org/W2133352456","https://openalex.org/W2134462640","https://openalex.org/W2138983604","https://openalex.org/W2142673763","https://openalex.org/W2148479558","https://openalex.org/W2150729435","https://openalex.org/W2150740984","https://openalex.org/W2153503145","https://openalex.org/W2153619276","https://openalex.org/W2154699417","https://openalex.org/W2171006421","https://openalex.org/W2412296989","https://openalex.org/W4236153851"],"related_works":["https://openalex.org/W4395668856","https://openalex.org/W2084775802","https://openalex.org/W2013150998","https://openalex.org/W1964610000","https://openalex.org/W2014625679","https://openalex.org/W37621795","https://openalex.org/W2513847293","https://openalex.org/W2620822975","https://openalex.org/W4243381079","https://openalex.org/W2098863206"],"abstract_inverted_index":{"This":[0],"study":[1,166],"investigated":[2],"the":[3,6,81,115,133,153,176,185,192],"role":[4],"of":[5,85,96,106,129,135,144,155,187,194,202,205],"ETS":[7],"transcription":[8],"factor":[9],"Fli-1":[10,20,23,169],"in":[11,25,35,51,109,118,152],"adult":[12,26],"myelopoiesis":[13],"using":[14],"new":[15],"transgenic":[16],"mice":[17],"allowing":[18],"inducible":[19],"gene":[21],"deletion.":[22],"deletion":[24],"induced":[27],"mild":[28],"thrombocytopenia":[29],"associated":[30],"with":[31],"a":[32,93,124,136,199],"drastic":[33,116],"decrease":[34,117,143],"large":[36,76,119],"mature":[37,77,120],"megakaryocytes":[38,121],"number.":[39],"Bone":[40],"marrow":[41],"bipotent":[42],"megakaryocytic-erythrocytic":[43],"progenitors":[44,148,158,190],"(MEPs)":[45],"increased":[46,60],"by":[47],"50%":[48],"without":[49],"increase":[50,141],"erythrocytic":[52,189],"and":[53,101,111,142,146,159,180,197],"megakaryocytic":[54,137,206],"common":[55,160],"myeloid":[56,161],"progenitor":[57,182],"progeny,":[58],"suggesting":[59],"production":[61],"from":[62],"upstream":[63],"stem":[64,177],"cells.":[65,99],"These":[66],"MEPs":[67],"were":[68,149],"almost":[69],"unable":[70],"to":[71],"generate":[72],"pure":[73],"colonies":[74,86,91],"containing":[75,92],"megakaryocytes,":[78],"but":[79,122],"generated":[80],"same":[82],"total":[83],"number":[84,95],"mainly":[87],"identifiable":[88],"as":[89],"erythroid":[90],"reduced":[94],"more":[97],"differentiated":[98],"Cytological":[100],"fluorescence-activated":[102],"cell":[103],"sorting":[104],"analyses":[105],"MEP":[107],"progeny":[108,154],"semisolid":[110],"liquid":[112],"cultures":[113],"confirmed":[114],"revealed":[123],"surprisingly":[125],"modest":[126],"(50%)":[127],"reduction":[128],"CD41-positive":[130],"cells":[131],"indicating":[132],"persistence":[134],"commitment":[138,173],"potential.":[139],"Symmetrical":[140],"monocytic":[145],"granulocytic":[147],"also":[150],"observed":[151],"purified":[156],"granulocytic-monocytic":[157,181],"progenitors.":[162],"In":[163],"summary,":[164],"this":[165],"indicates":[167],"that":[168],"controls":[170],"several":[171],"lineages":[172],"decisions":[174],"at":[175,191],"cell,":[178],"MEP,":[179],"levels,":[183],"stimulates":[184],"proliferation":[186],"committed":[188],"expense":[193],"their":[195],"differentiation,":[196],"is":[198],"major":[200],"regulator":[201],"late":[203],"stages":[204],"differentiation.":[207]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}