{"id":"https://openalex.org/W2054463474","doi":"https://doi.org/10.1242/jcs.090852","title":"Influence of matrix metalloproteinase MMP-9 on dendritic spine morphology","display_name":"Influence of matrix metalloproteinase MMP-9 on dendritic spine morphology","publication_year":2011,"publication_date":"2011-09-06","ids":{"openalex":"https://openalex.org/W2054463474","doi":"https://doi.org/10.1242/jcs.090852","mag":"2054463474","pmid":"https://pubmed.ncbi.nlm.nih.gov/21896646"},"language":"en","primary_location":{"id":"doi:10.1242/jcs.090852","doi":"https://doi.org/10.1242/jcs.090852","is_oa":true,"landing_page_url":"https://doi.org/10.1242/jcs.090852","pdf_url":"https://journals.biologists.com/jcs/article-pdf/124/19/3369/1444684/3369.pdf","source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.biologists.com/jcs/article-pdf/124/19/3369/1444684/3369.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012453539","display_name":"Piotr Michaluk","orcid":"https://orcid.org/0000-0003-2306-3314","observed_orcids":["https://orcid.org/0000-0003-2306-3314"]},"institutions":[{"id":"https://openalex.org/I16778253","display_name":"Instytut Biologii Do\u015bwiadczalnej im. Marcelego Nenckiego","ror":"https://ror.org/04waf7p94","country_code":"PL","type":"facility","lineage":["https://openalex.org/I16778253","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL","PL"],"is_corresponding":true,"raw_author_name":"Piotr Michaluk","raw_affiliation_strings":["Department of Molecular and Cellular Neurobiology, The Nencki Institute, Pasteura 3, 02-093 Warsaw, Poland","Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Neurobiology, The Nencki Institute, Pasteura 3, 02-093 Warsaw, Poland","institution_ids":["https://openalex.org/I16778253"]},{"raw_affiliation_string":"Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Center Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041403658","display_name":"Marcin Wawrzyniak","orcid":"https://orcid.org/0000-0002-6911-8010","observed_orcids":["https://orcid.org/0000-0002-6911-8010","https://orcid.org/0009-0005-6937-5745"]},"institutions":[{"id":"https://openalex.org/I16778253","display_name":"Instytut Biologii Do\u015bwiadczalnej im. Marcelego Nenckiego","ror":"https://ror.org/04waf7p94","country_code":"PL","type":"facility","lineage":["https://openalex.org/I16778253","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marcin Wawrzyniak","raw_affiliation_strings":["Department of Molecular and Cellular Neurobiology, The Nencki Institute, Pasteura 3, 02-093 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Neurobiology, The Nencki Institute, Pasteura 3, 02-093 Warsaw, Poland","institution_ids":["https://openalex.org/I16778253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042843482","display_name":"Przemyslaw Alot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16778253","display_name":"Instytut Biologii Do\u015bwiadczalnej im. Marcelego Nenckiego","ror":"https://ror.org/04waf7p94","country_code":"PL","type":"facility","lineage":["https://openalex.org/I16778253","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Przemyslaw Alot","raw_affiliation_strings":["Department of Molecular and Cellular Neurobiology, The Nencki Institute, Pasteura 3, 02-093 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Neurobiology, The Nencki Institute, Pasteura 3, 02-093 Warsaw, Poland","institution_ids":["https://openalex.org/I16778253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086623048","display_name":"Marcin Szczot","orcid":"https://orcid.org/0000-0002-3902-059X","observed_orcids":["https://orcid.org/0000-0002-3902-059X"]},"institutions":[{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Marcin Szczot","raw_affiliation_strings":["Laboratory of Neuroscience, Department of Biophysics, Wroclaw Medical University, Chalubinskiego 3, 50-367 Wroclaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroscience, Department of Biophysics, Wroclaw Medical University, Chalubinskiego 3, 50-367 Wroclaw, Poland","institution_ids":["https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023153210","display_name":"Paulina Wyrembek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Paulina Wyrembek","raw_affiliation_strings":["Laboratory of Neuroscience, Department of Biophysics, Wroclaw Medical University, Chalubinskiego 3, 50-367 Wroclaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroscience, Department of Biophysics, Wroclaw Medical University, Chalubinskiego 3, 50-367 Wroclaw, Poland","institution_ids":["https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046852033","display_name":"Katarzyna Mercik","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Katarzyna Mercik","raw_affiliation_strings":["Laboratory of Neuroscience, Department of Biophysics, Wroclaw Medical University, Chalubinskiego 3, 50-367 Wroclaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroscience, Department of Biophysics, Wroclaw Medical University, Chalubinskiego 3, 50-367 Wroclaw, Poland","institution_ids":["https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110341393","display_name":"Nikolay I. Medvedev","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204136569","display_name":"The Open University","ror":"https://ror.org/05mzfcs16","country_code":"GB","type":"education","lineage":["https://openalex.org/I204136569"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nikolay Medvedev","raw_affiliation_strings":["Department of Life Sciences, The Open University, Milton Keynes MK7 6AA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, The Open University, Milton Keynes MK7 6AA, UK","institution_ids":["https://openalex.org/I204136569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110232715","display_name":"Ewa Wilczek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16778253","display_name":"Instytut Biologii Do\u015bwiadczalnej im. Marcelego Nenckiego","ror":"https://ror.org/04waf7p94","country_code":"PL","type":"facility","lineage":["https://openalex.org/I16778253","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Ewa Wilczek","raw_affiliation_strings":["Department of Neurophysiology, The Nencki Institute, Pasteura 3, 02-093 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurophysiology, The Nencki Institute, Pasteura 3, 02-093 Warsaw, Poland","institution_ids":["https://openalex.org/I16778253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080520407","display_name":"Mathias De Roo","orcid":"https://orcid.org/0000-0001-9912-6954","observed_orcids":["https://orcid.org/0000-0001-9912-6954"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Mathias De Roo","raw_affiliation_strings":["Department of Neuroscience, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036628343","display_name":"Werner Zuschratter","orcid":"https://orcid.org/0000-0002-9845-6393","observed_orcids":["https://orcid.org/0000-0002-9845-6393"]},"institutions":[{"id":"https://openalex.org/I96578850","display_name":"Leibniz Institute for Neurobiology","ror":"https://ror.org/01zwmgk08","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I96578850"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Werner Zuschratter","raw_affiliation_strings":["Laboratory for Electron- and Laserscanning Microscopy, Leibniz Institute for Neurobiology, Brenneckestra\u00dfe 6, 39118 Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Electron- and Laserscanning Microscopy, Leibniz Institute for Neurobiology, Brenneckestra\u00dfe 6, 39118 Magdeburg, Germany","institution_ids":["https://openalex.org/I96578850"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101943347","display_name":"Dominique M\u00fcller","orcid":"https://orcid.org/0000-0003-0729-7313","observed_orcids":["https://orcid.org/0000-0003-0729-7313"]},"institutions":[{"id":"https://openalex.org/I114457229","display_name":"University of Geneva","ror":"https://ror.org/01swzsf04","country_code":"CH","type":"education","lineage":["https://openalex.org/I114457229"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Dominique Muller","raw_affiliation_strings":["Department of Neuroscience, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Faculty of Medicine, University of Geneva, 1 rue Michel-Servet, CH-1211 Geneva 4, Switzerland","institution_ids":["https://openalex.org/I114457229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070005083","display_name":"Grzegorz Marek Wilczynski","orcid":"https://orcid.org/0000-0001-6667-0291","observed_orcids":["https://orcid.org/0000-0001-6667-0291"]},"institutions":[{"id":"https://openalex.org/I16778253","display_name":"Instytut Biologii Do\u015bwiadczalnej im. Marcelego Nenckiego","ror":"https://ror.org/04waf7p94","country_code":"PL","type":"facility","lineage":["https://openalex.org/I16778253","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Grzegorz M. Wilczynski","raw_affiliation_strings":["Department of Neurophysiology, The Nencki Institute, Pasteura 3, 02-093 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurophysiology, The Nencki Institute, Pasteura 3, 02-093 Warsaw, Poland","institution_ids":["https://openalex.org/I16778253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091870155","display_name":"Jerzy Wladyslaw Mozrzymas","orcid":"https://orcid.org/0000-0003-1674-1818","observed_orcids":["https://orcid.org/0000-0003-1674-1818"]},"institutions":[{"id":"https://openalex.org/I385303915","display_name":"Wroclaw Medical University","ror":"https://ror.org/01qpw1b93","country_code":"PL","type":"education","lineage":["https://openalex.org/I385303915"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Jerzy W. Mozrzymas","raw_affiliation_strings":["Laboratory of Neuroscience, Department of Biophysics, Wroclaw Medical University, Chalubinskiego 3, 50-367 Wroclaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Neuroscience, Department of Biophysics, Wroclaw Medical University, Chalubinskiego 3, 50-367 Wroclaw, Poland","institution_ids":["https://openalex.org/I385303915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101974573","display_name":"Michael G. Stewart","orcid":"https://orcid.org/0000-0002-8920-9155","observed_orcids":["https://orcid.org/0000-0002-8920-9155"]},"institutions":[{"id":"https://openalex.org/I204136569","display_name":"The Open University","ror":"https://ror.org/05mzfcs16","country_code":"GB","type":"education","lineage":["https://openalex.org/I204136569"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Michael G. Stewart","raw_affiliation_strings":["Department of Life Sciences, The Open University, Milton Keynes MK7 6AA, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, The Open University, Milton Keynes MK7 6AA, UK","institution_ids":["https://openalex.org/I204136569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010975119","display_name":"Leszek Kaczmarek","orcid":"https://orcid.org/0000-0002-7207-3490","observed_orcids":["https://orcid.org/0000-0002-7207-3490","https://orcid.org/0000-0002-2085-9846"]},"institutions":[{"id":"https://openalex.org/I16778253","display_name":"Instytut Biologii Do\u015bwiadczalnej im. Marcelego Nenckiego","ror":"https://ror.org/04waf7p94","country_code":"PL","type":"facility","lineage":["https://openalex.org/I16778253","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Leszek Kaczmarek","raw_affiliation_strings":["Department of Molecular and Cellular Neurobiology, The Nencki Institute, Pasteura 3, 02-093 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Neurobiology, The Nencki Institute, Pasteura 3, 02-093 Warsaw, Poland","institution_ids":["https://openalex.org/I16778253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042164534","display_name":"Jakub W\u0142odarczyk","orcid":"https://orcid.org/0000-0001-8343-2340","observed_orcids":["https://orcid.org/0000-0001-8343-2340"]},"institutions":[{"id":"https://openalex.org/I16778253","display_name":"Instytut Biologii Do\u015bwiadczalnej im. Marcelego Nenckiego","ror":"https://ror.org/04waf7p94","country_code":"PL","type":"facility","lineage":["https://openalex.org/I16778253","https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Jakub Wlodarczyk","raw_affiliation_strings":["Department of Molecular and Cellular Neurobiology, The Nencki Institute, Pasteura 3, 02-093 Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Neurobiology, The Nencki Institute, Pasteura 3, 02-093 Warsaw, Poland","institution_ids":["https://openalex.org/I16778253"]}]}],"institutions":[],"countries_distinct_count":5,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5010975119","https://openalex.org/A5012453539","https://openalex.org/A5042164534"],"corresponding_institution_ids":["https://openalex.org/I16778253","https://openalex.org/I3018483916"],"apc_list":null,"apc_paid":null,"fwci":7.0277,"has_fulltext":true,"cited_by_count":218,"citation_normalized_percentile":{"value":0.98417403,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"124","issue":"19","first_page":"3369","last_page":"3380"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.9038000106811523,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.08510000258684158,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.9879999756813049},{"id":"https://openalex.org/keywords/spine-morphology","display_name":"dendritic spine morphology","score":0.8939999938011169},{"id":"https://openalex.org/keywords/hippocampal-neurons","display_name":"hippocampal neurons","score":0.8259999752044678},{"id":"https://openalex.org/keywords/synaptic-remodeling","display_name":"synaptic remodeling","score":0.9269999861717224},{"id":"https://openalex.org/keywords/miniature-synaptic-currents","display_name":"miniature synaptic currents","score":0.8399999737739563},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.843999981880188},{"id":"https://openalex.org/keywords/dissociated-neuronal-cultures","display_name":"dissociated neuronal cultures","score":0.7630000114440918}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8615149259567261},{"id":"https://openalex.org/C174884520","wikidata":"https://www.wikidata.org/wiki/Q902079","display_name":"Dendritic spine","level":3,"score":0.8251112103462219},{"id":"https://openalex.org/C53250682","wikidata":"https://www.wikidata.org/wiki/Q5256674","display_name":"Dendritic filopodia","level":4,"score":0.6994070410728455},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.6473126411437988},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6261487007141113},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.5340496301651001},{"id":"https://openalex.org/C84248122","wikidata":"https://www.wikidata.org/wiki/Q5256671","display_name":"Dendrite (mathematics)","level":2,"score":0.4585942327976227},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4475180506706238},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.4051598012447357},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.232918381690979},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14602670073509216},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002846","descriptor_name":"Chromatography, Affinity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017729","descriptor_name":"Presynaptic Terminals","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019012","descriptor_name":"Integrin beta1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019706","descriptor_name":"Excitatory Postsynaptic Potentials","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020780","descriptor_name":"Matrix Metalloproteinase 9","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D046509","descriptor_name":"Tissue Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D049229","descriptor_name":"Dendritic Spines","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055647","descriptor_name":"Rats, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057075","descriptor_name":"Enzyme Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061251","descriptor_name":"Primary Cell Culture","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1242/jcs.090852","doi":"https://doi.org/10.1242/jcs.090852","is_oa":true,"landing_page_url":"https://doi.org/10.1242/jcs.090852","pdf_url":"https://journals.biologists.com/jcs/article-pdf/124/19/3369/1444684/3369.pdf","source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},{"id":"pmid:21896646","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21896646","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cell science","raw_type":"Journal Article"},{"id":"pmh:oai:unige.ch:unige:25597","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:25597","pdf_url":"https://access.archive-ouverte.unige.ch/access/metadata/0ba7ad53-b722-41a0-92d1-19b9216e537e/download","source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0021-9533","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.991.9370","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.991.9370","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jcs.biologists.org/content/joces/124/19/3369.full.pdf","raw_type":"text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.996.6640","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.996.6640","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://jcs.biologists.org/content/joces/early/2011/09/06/jcs.090852.full.pdf","raw_type":"text"},{"id":"pmh:oai:open-archive.highwire.org:joces:124/19/3369","doi":null,"is_oa":false,"landing_page_url":"http://jcs.biologists.org/cgi/content/short/124/19/3369","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:oro.open.ac.uk:29598","doi":null,"is_oa":false,"landing_page_url":"https://oro.open.ac.uk/29598/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401187","display_name":"Open Research Online (The Open University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204136569","host_organization_name":"The Open University","host_organization_lineage":["https://openalex.org/I204136569"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"PeerReviewed"},{"id":"pmh:oai:unige.ch:aou:unige:25597","doi":null,"is_oa":true,"landing_page_url":"https://archive-ouverte.unige.ch/unige:25597","pdf_url":null,"source":{"id":"https://openalex.org/S4306402259","display_name":"Archive ouverte UNIGE (University of Geneva)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I114457229","host_organization_name":"University of Geneva","host_organization_lineage":["https://openalex.org/I114457229"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0021-9533","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1242/jcs.090852","doi":"https://doi.org/10.1242/jcs.090852","is_oa":true,"landing_page_url":"https://doi.org/10.1242/jcs.090852","pdf_url":"https://journals.biologists.com/jcs/article-pdf/124/19/3369/1444684/3369.pdf","source":{"id":"https://openalex.org/S5677253","display_name":"Journal of Cell Science","issn_l":"0021-9533","issn":["0021-9533","1477-9137"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cell Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320321042","display_name":"Fundacja na rzecz Nauki Polskiej","ror":"https://ror.org/048zd9m77"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2054463474.pdf","grobid_xml":"https://content.openalex.org/works/W2054463474.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1526182404","https://openalex.org/W1581404300","https://openalex.org/W1619234695","https://openalex.org/W1775494655","https://openalex.org/W1911664005","https://openalex.org/W1963655929","https://openalex.org/W1964178903","https://openalex.org/W1965819088","https://openalex.org/W1966155655","https://openalex.org/W1966706677","https://openalex.org/W1968072037","https://openalex.org/W1977637789","https://openalex.org/W1983553517","https://openalex.org/W1990561503","https://openalex.org/W1993391624","https://openalex.org/W1993442664","https://openalex.org/W1995949213","https://openalex.org/W1997218140","https://openalex.org/W1998928587","https://openalex.org/W2001528712","https://openalex.org/W2003177515","https://openalex.org/W2010735934","https://openalex.org/W2021502161","https://openalex.org/W2026644728","https://openalex.org/W2030126027","https://openalex.org/W2030776545","https://openalex.org/W2032873693","https://openalex.org/W2037476043","https://openalex.org/W2038939944","https://openalex.org/W2039969351","https://openalex.org/W2041458184","https://openalex.org/W2043060853","https://openalex.org/W2043899734","https://openalex.org/W2046562305","https://openalex.org/W2048047884","https://openalex.org/W2051507702","https://openalex.org/W2054881131","https://openalex.org/W2059148325","https://openalex.org/W2067686344","https://openalex.org/W2071052050","https://openalex.org/W2078344536","https://openalex.org/W2079054696","https://openalex.org/W2081147459","https://openalex.org/W2085015211","https://openalex.org/W2086337788","https://openalex.org/W2087009636","https://openalex.org/W2088446997","https://openalex.org/W2091187766","https://openalex.org/W2092759474","https://openalex.org/W2093161000","https://openalex.org/W2102444756","https://openalex.org/W2105028929","https://openalex.org/W2107611011","https://openalex.org/W2109129502","https://openalex.org/W2114462905","https://openalex.org/W2117308838","https://openalex.org/W2122303778","https://openalex.org/W2128049766","https://openalex.org/W2136124678","https://openalex.org/W2137979527","https://openalex.org/W2138147085","https://openalex.org/W2139053813","https://openalex.org/W2141654359","https://openalex.org/W2143323131","https://openalex.org/W2143485434","https://openalex.org/W2144471136","https://openalex.org/W2145493769","https://openalex.org/W2146459259","https://openalex.org/W2156085478","https://openalex.org/W2162033779","https://openalex.org/W2171288469","https://openalex.org/W2490181205","https://openalex.org/W4293029111"],"related_works":["https://openalex.org/W7098769786","https://openalex.org/W7095140194","https://openalex.org/W2058884892","https://openalex.org/W2019831056","https://openalex.org/W7096922575","https://openalex.org/W1977637789","https://openalex.org/W2158253469","https://openalex.org/W2095031298","https://openalex.org/W2171288469","https://openalex.org/W2509926648"],"abstract_inverted_index":{"An":[0],"increasing":[1],"body":[2],"of":[3,22,44,50,99,112],"data":[4],"has":[5],"shown":[6],"that":[7,41,128],"matrix":[8],"metalloproteinase-9":[9],"(MMP-9),":[10],"an":[11],"extracellularly":[12],"acting,":[13],"Zn(2+)-dependent":[14],"endopeptidase,":[15],"is":[16,83,130],"important":[17],"not":[18,106],"only":[19],"for":[20,29],"pathologies":[21],"the":[23,54,96,108],"central":[24],"nervous":[25],"system":[26],"but":[27],"also":[28,91],"neuronal":[30,69,73],"plasticity.":[31],"Here,":[32],"we":[33],"use":[34],"three":[35],"independent":[36],"experimental":[37],"models":[38,58],"to":[39],"show":[40],"enzymatic":[42],"activity":[43],"MMP-9":[45,89,129],"causes":[46],"elongation":[47],"and":[48,71,110],"thinning":[49],"dendritic":[51,81,116],"spines":[52],"in":[53,95,115,133],"hippocampal":[55],"neurons.":[56],"These":[57],"are:":[59],"a":[60,93],"recently":[61],"developed":[62],"transgenic":[63],"rat":[64],"overexpressing":[65],"autoactivating":[66,78],"MMP-9,":[67],"dissociated":[68],"cultures,":[70],"organotypic":[72],"cultures":[74],"treated":[75],"with":[76,122],"recombinant":[77],"MMP-9.":[79],"This":[80],"effect":[82],"mediated":[84],"by":[85],"integrin":[86],"\u03b21":[87],"signalling.":[88],"treatment":[90],"produces":[92],"change":[94,107],"decay":[97],"time":[98],"miniature":[100],"synaptic":[101,113,134],"currents;":[102],"however,":[103],"it":[104],"does":[105],"abundance":[109],"localization":[111],"markers":[114],"protrusions.":[117],"Our":[118],"results,":[119],"considered":[120],"together":[121],"several":[123],"recent":[124],"studies,":[125],"strongly":[126],"imply":[127],"functionally":[131],"involved":[132],"remodelling.":[135]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":19},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":20},{"year":2013,"cited_by_count":23},{"year":2012,"cited_by_count":14}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}