{"id":"https://openalex.org/W2054456989","doi":"https://doi.org/10.1097/00124743-199708000-00004","title":"Effect of Tenidap on Metalloproteinase Gene Expression in Rheumatoid Arthritis","display_name":"Effect of Tenidap on Metalloproteinase Gene Expression in Rheumatoid Arthritis","publication_year":1997,"publication_date":"1997-08-01","ids":{"openalex":"https://openalex.org/W2054456989","doi":"https://doi.org/10.1097/00124743-199708000-00004","mag":"2054456989","pmid":"https://pubmed.ncbi.nlm.nih.gov/19078187"},"language":"en","primary_location":{"id":"doi:10.1097/00124743-199708000-00004","doi":"https://doi.org/10.1097/00124743-199708000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00124743-199708000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S129376536","display_name":"JCR Journal of Clinical Rheumatology","issn_l":"1076-1608","issn":["1076-1608","1536-7355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCR: Journal of Clinical Rheumatology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114005045","display_name":"Bruce H. Littman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4210132395","display_name":"University of California San Diego Medical Center","ror":"https://ror.org/03aw5sn18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4210132395"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce H. Littman","raw_affiliation_strings":["Pfizer Central Research, Groton, Connecticut (B.H.L); Hospital of the University of Pennsylvania and the Veterans Administration Medical Center, Philadelphia, Pennsylvania (H.R.S.); University of California San Diego Medical Center, San Diego, California (D.L.B., M.H.W., G.S.F.)","Hospital of the University of Pennsylvania and the Veterans Administration Medical Center, Philadelphia, Pennsylvania (H.R.S.)","Pfizer Central Research, Groton, Connecticut (B.H.L)","University of California San Diego Medical Center, San Diego, California (D.L.B., M.H.W., G.S.F.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer Central Research, Groton, Connecticut (B.H.L); Hospital of the University of Pennsylvania and the Veterans Administration Medical Center, Philadelphia, Pennsylvania (H.R.S.); University of California San Diego Medical Center, San Diego, California (D.L.B., M.H.W., G.S.F.)","institution_ids":["https://openalex.org/I2799810409","https://openalex.org/I4210132395"]},{"raw_affiliation_string":"Hospital of the University of Pennsylvania and the Veterans Administration Medical Center, Philadelphia, Pennsylvania (H.R.S.)","institution_ids":["https://openalex.org/I2799810409"]},{"raw_affiliation_string":"Pfizer Central Research, Groton, Connecticut (B.H.L)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"University of California San Diego Medical Center, San Diego, California (D.L.B., M.H.W., G.S.F.)","institution_ids":["https://openalex.org/I4210132395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028635978","display_name":"H. Ralph Schumacher","orcid":"https://orcid.org/0000-0002-8700-5570","observed_orcids":["https://orcid.org/0000-0002-8700-5570"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4210132395","display_name":"University of California San Diego Medical Center","ror":"https://ror.org/03aw5sn18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4210132395"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. Ralph Schumacher","raw_affiliation_strings":["Hospital of the University of Pennsylvania and the Veterans Administration Medical Center, Philadelphia, Pennsylvania (H.R.S.)","Pfizer Central Research, Groton, Connecticut (B.H.L)","University of California San Diego Medical Center, San Diego, California (D.L.B., M.H.W., G.S.F.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of the University of Pennsylvania and the Veterans Administration Medical Center, Philadelphia, Pennsylvania (H.R.S.)","institution_ids":["https://openalex.org/I2799810409"]},{"raw_affiliation_string":"Pfizer Central Research, Groton, Connecticut (B.H.L)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"University of California San Diego Medical Center, San Diego, California (D.L.B., M.H.W., G.S.F.)","institution_ids":["https://openalex.org/I4210132395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017339700","display_name":"David L. Boyle","orcid":"https://orcid.org/0000-0002-1454-2834","observed_orcids":["https://orcid.org/0000-0002-1454-2834"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4210132395","display_name":"University of California San Diego Medical Center","ror":"https://ror.org/03aw5sn18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4210132395"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Boyle","raw_affiliation_strings":["Hospital of the University of Pennsylvania and the Veterans Administration Medical Center, Philadelphia, Pennsylvania (H.R.S.)","Pfizer Central Research, Groton, Connecticut (B.H.L)","University of California San Diego Medical Center, San Diego, California (D.L.B., M.H.W., G.S.F.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of the University of Pennsylvania and the Veterans Administration Medical Center, Philadelphia, Pennsylvania (H.R.S.)","institution_ids":["https://openalex.org/I2799810409"]},{"raw_affiliation_string":"Pfizer Central Research, Groton, Connecticut (B.H.L)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"University of California San Diego Medical Center, San Diego, California (D.L.B., M.H.W., G.S.F.)","institution_ids":["https://openalex.org/I4210132395"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030335777","display_name":"Michael H. Weisman","orcid":"https://orcid.org/0000-0001-5568-388X","observed_orcids":["https://orcid.org/0000-0001-5568-388X"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4210132395","display_name":"University of California San Diego Medical Center","ror":"https://ror.org/03aw5sn18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4210132395"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael H. Weisman","raw_affiliation_strings":["Hospital of the University of Pennsylvania and the Veterans Administration Medical Center, Philadelphia, Pennsylvania (H.R.S.)","Pfizer Central Research, Groton, Connecticut (B.H.L)","University of California San Diego Medical Center, San Diego, California (D.L.B., M.H.W., G.S.F.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of the University of Pennsylvania and the Veterans Administration Medical Center, Philadelphia, Pennsylvania (H.R.S.)","institution_ids":["https://openalex.org/I2799810409"]},{"raw_affiliation_string":"Pfizer Central Research, Groton, Connecticut (B.H.L)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"University of California San Diego Medical Center, San Diego, California (D.L.B., M.H.W., G.S.F.)","institution_ids":["https://openalex.org/I4210132395"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024908446","display_name":"Gary S. Firestein","orcid":"https://orcid.org/0000-0003-3495-960X","observed_orcids":["https://orcid.org/0000-0003-3495-960X"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]},{"id":"https://openalex.org/I2799810409","display_name":"Hospital of the University of Pennsylvania","ror":"https://ror.org/02917wp91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799810409","https://openalex.org/I4210143392"]},{"id":"https://openalex.org/I4210132395","display_name":"University of California San Diego Medical Center","ror":"https://ror.org/03aw5sn18","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4210132395"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gary S. Firestein","raw_affiliation_strings":["Hospital of the University of Pennsylvania and the Veterans Administration Medical Center, Philadelphia, Pennsylvania (H.R.S.)","Pfizer Central Research, Groton, Connecticut (B.H.L)","University of California San Diego Medical Center, San Diego, California (D.L.B., M.H.W., G.S.F.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of the University of Pennsylvania and the Veterans Administration Medical Center, Philadelphia, Pennsylvania (H.R.S.)","institution_ids":["https://openalex.org/I2799810409"]},{"raw_affiliation_string":"Pfizer Central Research, Groton, Connecticut (B.H.L)","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"University of California San Diego Medical Center, San Diego, California (D.L.B., M.H.W., G.S.F.)","institution_ids":["https://openalex.org/I4210132395"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2645,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.55386762,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"4","first_page":"194","last_page":"202"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tenidap","display_name":"tenidap","score":0.9819999933242798},{"id":"https://openalex.org/keywords/piroxicam","display_name":"piroxicam","score":0.9760000109672546},{"id":"https://openalex.org/keywords/rheumatoid-arthritis","display_name":"rheumatoid arthritis","score":1.0},{"id":"https://openalex.org/keywords/stromelysin","display_name":"stromelysin","score":0.9459999799728394},{"id":"https://openalex.org/keywords/collagenase","display_name":"collagenase","score":0.9679999947547913},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.9909999966621399},{"id":"https://openalex.org/keywords/synovial-biopsy","display_name":"synovial biopsy","score":0.8209999799728394},{"id":"https://openalex.org/keywords/c-reactive-protein","display_name":"C-reactive protein","score":0.8759999871253967},{"id":"https://openalex.org/keywords/disease-modifying-antirheumatic-drugs","display_name":"disease-modifying antirheumatic drugs","score":0.828000009059906},{"id":"https://openalex.org/keywords/cytokine-modulation","display_name":"cytokine modulation","score":0.7269999980926514},{"id":"https://openalex.org/keywords/prostaglandin-inhibition","display_name":"prostaglandin inhibition","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C2778139025","wikidata":"https://www.wikidata.org/wiki/Q408676","display_name":"Piroxicam","level":3,"score":0.9673165082931519},{"id":"https://openalex.org/C2777575956","wikidata":"https://www.wikidata.org/wiki/Q187255","display_name":"Rheumatoid arthritis","level":2,"score":0.745651364326477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.720314085483551},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5772528648376465},{"id":"https://openalex.org/C2778394429","wikidata":"https://www.wikidata.org/wiki/Q304956","display_name":"Collagenase","level":3,"score":0.5270037055015564},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4347856342792511},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.42816150188446045},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.38799533247947693},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24052715301513672},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.22690707445144653},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1315496265888214},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.10408294200897217},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07602378726005554},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1097/00124743-199708000-00004","doi":"https://doi.org/10.1097/00124743-199708000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00124743-199708000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S129376536","display_name":"JCR Journal of Clinical Rheumatology","issn_l":"1076-1608","issn":["1076-1608","1536-7355"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JCR: Journal of Clinical Rheumatology","raw_type":"journal-article"},{"id":"pmid:19078187","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19078187","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2078321728","https://openalex.org/W2412083796","https://openalex.org/W2104459863","https://openalex.org/W2396170234","https://openalex.org/W2030256425","https://openalex.org/W259109300","https://openalex.org/W2037455750","https://openalex.org/W2152836517","https://openalex.org/W2036074288","https://openalex.org/W2417363091"],"abstract_inverted_index":{"This":[0],"study":[1],"evaluated":[2],"measures":[3,113],"of":[4,14,18,39,50,65,73,114,153,158,190],"metalloproteinase":[5],"gene":[6,125,131,162],"expression":[7,132,163],"in":[8,29,47,55,129,138,183],"synovial":[9,178],"biopsies":[10,26,179],"as":[11],"a":[12,48,56],"means":[13],"differentiating":[15],"the":[16,156,185],"activities":[17],"two":[19],"antirheumatic":[20,191],"therapies:":[21],"piroxicam":[22,74,86,103,148],"and":[23,27,42,85,120,147],"tenidap.":[24],"Synovial":[25],"quantitative":[28],"situ":[30],"hybridization":[31],"for":[32,67,75,187],"stromelysin":[33],"(STR),":[34],"collagenase":[35],"(COL),":[36],"tissue":[37],"inhibitor":[38],"metalloproteinase-1":[40],"(TIMP),":[41],"actin":[43],"mRNA":[44,91,95],"were":[45,79,108,133],"performed":[46],"subset":[49],"patients":[51],"with":[52,70,102,136,175],"rheumatoid":[53],"arthritis":[54],"larger":[57],"doubleblind":[58],"randomized":[59],"crossover":[60],"trial":[61],"comparing":[62],"120":[63],"mg/day":[64,72],"tenidap":[66,84,100,146,159],"6":[68,76],"weeks":[69],"20":[71],"weeks.":[77],"There":[78,107],"no":[80,109],"consistent":[81],"differences":[82],"between":[83,112],"on":[87,160],"COL":[88],"or":[89,116,123],"TIMP":[90,124],"expression,":[92],"but":[93],"STR":[94,130,161],"was":[96],"significantly":[97,134],"lower":[98],"after":[99],"compared":[101],"(p":[104,142],"=":[105,143],"0.037).":[106],"significant":[110],"associations":[111],"local":[115],"systemic":[117],"clinical":[118],"activity":[119],"STR,":[121],"COL,":[122],"expression.":[126],"However,":[127],"changes":[128,137],"correlated":[135],"serum":[139],"C-reactive":[140],"protein":[141],"0.016).":[144],"Because":[145],"are":[149],"both":[150],"potent":[151],"inhibitors":[152],"prostaglandin":[154],"production,":[155],"effect":[157],"may":[164,180],"be":[165,181],"due":[166],"to":[167],"its":[168],"additional":[169],"cytokine":[170],"modulating":[171],"activity.":[172],"Clinical":[173],"trials":[174],"data":[176],"from":[177],"useful":[182],"evaluating":[184],"potential":[186],"disease-modifying":[188],"effects":[189],"drugs.":[192]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
