{"id":"https://openalex.org/W2054447385","doi":"https://doi.org/10.1093/jnci/86.22.1702","title":"Increased Risk of Neuroectodermal Tumors and Stomach Cancer in Relatives of Patients With Ewing's Sarcoma Family of Tumors","display_name":"Increased Risk of Neuroectodermal Tumors and Stomach Cancer in Relatives of Patients With Ewing's Sarcoma Family of Tumors","publication_year":1994,"publication_date":"1994-11-16","ids":{"openalex":"https://openalex.org/W2054447385","doi":"https://doi.org/10.1093/jnci/86.22.1702","mag":"2054447385","pmid":"https://pubmed.ncbi.nlm.nih.gov/7966398"},"language":"en","primary_location":{"id":"doi:10.1093/jnci/86.22.1702","doi":"https://doi.org/10.1093/jnci/86.22.1702","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/86.22.1702","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"B. Novakovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"B. Novakovic","raw_affiliation_strings":["Genetic Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Epidemiology Branch, National Cancer Institute, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063007431","display_name":"Alisa M. Goldstein","orcid":"https://orcid.org/0000-0002-7538-3582","observed_orcids":["https://orcid.org/0000-0002-7538-3582"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. M. Goldstein","raw_affiliation_strings":["Genetic Epidemiology Branch, National Cancer Institute Bethesda, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Epidemiology Branch, National Cancer Institute Bethesda, Md","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080725919","display_name":"Leonard H. Wexler","orcid":"https://orcid.org/0000-0003-0724-8263","observed_orcids":["https://orcid.org/0000-0003-0724-8263"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L. H. Wexler","raw_affiliation_strings":["Pediatric Branch, National Cancer Institute Bethesda, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Branch, National Cancer Institute Bethesda, Md","institution_ids":["https://openalex.org/I4210140884"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103882729","display_name":"Miriam Tucker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4391012607","display_name":"Division of Cancer Epidemiology and Genetics","ror":"https://ror.org/00vkwep27","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. A. Tucker","raw_affiliation_strings":["Genetic Epidemiology Branch, National Cancer Institute Bethesda, Md"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genetic Epidemiology Branch, National Cancer Institute Bethesda, Md","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4391012607"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210140884"],"apc_list":{"value":5436,"currency":"USD","value_usd":5436},"apc_paid":null,"fwci":1.2673,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.80889743,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"86","issue":"22","first_page":"1702","last_page":"1706"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14078","display_name":"Multiple and Secondary Primary Cancers","score":0.03400000184774399,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ewing-sarcoma-family-of-tumors","display_name":"Ewing sarcoma family of tumors","score":0.9470000267028809},{"id":"https://openalex.org/keywords/neuroectodermal-tumors","display_name":"neuroectodermal tumors","score":0.8679999709129333},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.7789999842643738},{"id":"https://openalex.org/keywords/familial-cancer-risk","display_name":"familial cancer risk","score":0.8199999928474426},{"id":"https://openalex.org/keywords/family-members-of-cancer-patients","display_name":"relatives of cancer patients","score":0.6880000233650208},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8289999961853027},{"id":"https://openalex.org/keywords/brain-tumors","display_name":"brain tumors","score":0.8230000138282776},{"id":"https://openalex.org/keywords/bone-cancer","display_name":"bone cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/rectal-cancer","display_name":"rectal cancer","score":0.5479999780654907},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9639999866485596},{"id":"https://openalex.org/keywords/genetic-epidemiology","display_name":"genetic epidemiology","score":0.5139999985694885},{"id":"https://openalex.org/keywords/cancer-predisposition-syndromes","display_name":"cancer predisposition syndromes","score":0.46299999952316284},{"id":"https://openalex.org/keywords/hereditary-cancer-syndromes","display_name":"hereditary cancer","score":0.5429999828338623}],"concepts":[{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.7769366502761841},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7310689091682434},{"id":"https://openalex.org/C2777586341","wikidata":"https://www.wikidata.org/wiki/Q1138580","display_name":"Ewing's sarcoma","level":3,"score":0.6610543727874756},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6111789345741272},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.5941175818443298},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49039673805236816},{"id":"https://openalex.org/C2779454504","wikidata":"https://www.wikidata.org/wiki/Q189588","display_name":"Stomach cancer","level":3,"score":0.45123156905174255},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4430609941482544},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4279749393463135},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2766384482383728},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001859","descriptor_name":"Bone Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012306","descriptor_name":"Risk","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012512","descriptor_name":"Sarcoma, Ewing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D013274","descriptor_name":"Stomach Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D017599","descriptor_name":"Neuroectodermal Tumors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/jnci/86.22.1702","doi":"https://doi.org/10.1093/jnci/86.22.1702","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/86.22.1702","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},{"id":"pmid:7966398","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7966398","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Cancer Institute","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2985997542","https://openalex.org/W2277486399","https://openalex.org/W206333444","https://openalex.org/W2314152712","https://openalex.org/W3021192774","https://openalex.org/W4254038040","https://openalex.org/W2163925767","https://openalex.org/W4239084808","https://openalex.org/W7095669047","https://openalex.org/W2039446346"],"abstract_inverted_index":{"BACKGROUND:":[0],"Previous":[1],"studies":[2,408],"of":[3,7,20,25,31,38,42,52,56,62,76,89,100,110,139,165,233,255,304,317,324,336,353,382,390,396,432],"the":[4,48,68,72,77,98,157,301,430],"genetic":[5,419],"epidemiology":[6],"Ewing's":[8,26,39,59,393],"sarcoma":[9,27,40,60,394],"have":[10,332,422],"shown":[11],"neither":[12],"an":[13,333,350,379],"increased":[14,163,334,351,380],"incidence":[15,49,109],"nor":[16],"a":[17,32,95,252,282,404,423],"distinct":[18],"pattern":[19],"cancers":[21,53,235,338],"in":[22,54,102,112,182,319,388,425],"family":[23,41,61,113,149,395],"members":[24,114,150,323],"patients.":[28],"PURPOSE:":[29],"Because":[30],"new":[33],"biologic":[34],"and":[35,50,71,83,105,126,137,220,267,306,309,365,385,415,434],"cytogenetic":[36],"classification":[37],"tumors,":[43],"we":[44],"wanted":[45],"to":[46,93,313,411,416],"reinvestigate":[47],"distribution":[51],"relatives":[55,280],"probands":[57,326],"with":[58,117,151,327,392,437],"tumors.":[63],"METHODS:":[64],"Patients":[65],"treated":[66],"at":[67,154],"Pediatric":[69],"Branch":[70,75],"Radiation":[73],"Oncology":[74],"National":[78],"Cancer":[79],"Institute":[80],"between":[81],"1965":[82],"December":[84],"1992,":[85],"or":[86,315],"their":[87],"next":[88],"kin,":[90],"were":[91,141,180,236,246],"asked":[92],"complete":[94],"questionnaire":[96],"on":[97],"history":[99],"cancer":[101,111,166,189,222,257,269,284,308,318,367,387],"all":[103,337],"first-":[104],"second-degree":[106,320],"relatives.":[107,321],"The":[108],"was":[115,161,251,297],"compared":[116],"Connecticut":[118],"Tumor":[119],"Registry":[120],"rates":[121],"specific":[122],"for":[123,299],"sex,":[124],"age,":[125],"5-year":[127],"calendar-year":[128],"intervals.":[129],"Observed/expected":[130],"(O/E)":[131],"ratios,":[132],"95%":[133,172,195,205,216,228,263,275,291,344,361,373],"confidence":[134],"intervals":[135],"(CIs),":[136],"tests":[138],"homogeneity":[140],"calculated.":[142],"RESULTS:":[143],"Four":[144],"thousand":[145],"six":[146],"hundred":[147],"seventy-eight":[148],"196,640":[152],"person-years":[153],"risk":[155,164,335,352,381],"entered":[156],"analysis.":[158],"Overall,":[159],"there":[160],"no":[162],"(observed":[167,190,200,211,223,258,270,286,339,356,368],"472;":[168],"O/E":[169,192,202,213,225,260,272,288,341,358,370],"=":[170,174,193,197,203,207,214,218,226,230,261,265,273,277,289,293,342,346,359,363,371,375],"0.9;":[171,290],"CI":[173,196,206,217,229,264,276,292,345,362,374],"0.8-1.0).":[175],"However,":[176],"several":[177],"tumor":[178,210],"types":[179],"found":[181],"significant":[183,253,283],"excess.":[184],"These":[185],"tumors":[186,384,397,401],"included":[187],"stomach":[188,386],"34;":[191],"2.0;":[194],"1.4-2.8),":[198],"melanoma":[199,355],"23;":[201],"1.9;":[204,215],"1.2-2.8),":[208],"brain":[209],"18;":[212],"1.1-3.0),":[219],"bone":[221],"7;":[224],"4.2;":[227],"1.7-8.6).":[231],"Risks":[232],"these":[234,244,400,426],"higher":[237],"among":[238],"maternal":[239],"than":[240],"paternal":[241],"relatives,":[242],"but":[243,348],"differences":[245],"not":[247,331],"statistically":[248],"significant.":[249],"There":[250],"deficit":[254,285,296,303],"bladder":[256,305],"5;":[259],"0.2;":[262],"0.1-0.5)":[266],"rectal":[268,307],"0;":[271],"0.0;":[274],"0.0-0.1).":[278],"Second-degree":[279],"had":[281,349],"389;":[287],"0.8-0.95).":[294],"This":[295],"accounted":[298],"by":[300,428],"observed":[302],"is":[310],"probably":[311],"related":[312],"under-reporting":[314],"misclassification":[316],"Family":[322],"10":[325],"second":[328],"malignancies":[329],"did":[330],"20;":[340],"1.2;":[343],"0.7-1.8)":[347],"both":[354],"3;":[357],"7.3;":[360],"1.5-21.0)":[364],"breast":[366],"8;":[369],"3.2;":[372],"1.4-6.3).":[376],"CONCLUSION:":[377],"Finding":[378],"neuroectodermal":[383],"families":[389,427,436],"patients":[391],"suggests":[398],"that":[399],"might":[402],"share":[403],"common":[405],"etiology.":[406],"Further":[407],"should":[409],"try":[410],"confirm":[412],"this":[413],"hypothesis":[414],"examine":[417],"if":[418],"factors":[420],"may":[421],"role":[424],"assessing":[429],"mode":[431],"inheritance":[433],"examining":[435],"multiple":[438],"affected":[439],"members.":[440]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
