{"id":"https://openalex.org/W2054440580","doi":"https://doi.org/10.1021/np9804233","title":"KR025, a New Cytotoxic Compound from Myxococcus fulvus","display_name":"KR025, a New Cytotoxic Compound from Myxococcus fulvus","publication_year":1999,"publication_date":"1999-02-19","ids":{"openalex":"https://openalex.org/W2054440580","doi":"https://doi.org/10.1021/np9804233","mag":"2054440580","pmid":"https://pubmed.ncbi.nlm.nih.gov/10096868"},"language":"en","primary_location":{"id":"doi:10.1021/np9804233","doi":"https://doi.org/10.1021/np9804233","is_oa":false,"landing_page_url":"https://doi.org/10.1021/np9804233","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113832507","display_name":"Jong\u2010Woong Ahn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151417","display_name":"Korea Research Institute of Chemical Technology","ror":"https://ror.org/043k4kk20","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210151417"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jong-Woong Ahn","raw_affiliation_strings":["Korea Research Institute of Chemical Technology, P.O. Box 107, Taejon 305-600, Korea, and Department of Horticulture, Kangnung National University, Kangnung 201-702, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea Research Institute of Chemical Technology, P.O. Box 107, Taejon 305-600, Korea, and Department of Horticulture, Kangnung National University, Kangnung 201-702, Korea","institution_ids":["https://openalex.org/I4210151417"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sung-Hee Woo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151417","display_name":"Korea Research Institute of Chemical Technology","ror":"https://ror.org/043k4kk20","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210151417"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sung-Hee Woo","raw_affiliation_strings":["Korea Research Institute of Chemical Technology, P.O. Box 107, Taejon 305-600, Korea, and Department of Horticulture, Kangnung National University, Kangnung 201-702, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea Research Institute of Chemical Technology, P.O. Box 107, Taejon 305-600, Korea, and Department of Horticulture, Kangnung National University, Kangnung 201-702, Korea","institution_ids":["https://openalex.org/I4210151417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109171268","display_name":"Chong Ock Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151417","display_name":"Korea Research Institute of Chemical Technology","ror":"https://ror.org/043k4kk20","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210151417"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chong-Ock Lee","raw_affiliation_strings":["Korea Research Institute of Chemical Technology, P.O. Box 107, Taejon 305-600, Korea, and Department of Horticulture, Kangnung National University, Kangnung 201-702, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea Research Institute of Chemical Technology, P.O. Box 107, Taejon 305-600, Korea, and Department of Horticulture, Kangnung National University, Kangnung 201-702, Korea","institution_ids":["https://openalex.org/I4210151417"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003811442","display_name":"Kwang\u2010Yun Cho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210151417","display_name":"Korea Research Institute of Chemical Technology","ror":"https://ror.org/043k4kk20","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210151417"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kwang-Yun Cho","raw_affiliation_strings":["Korea Research Institute of Chemical Technology, P.O. Box 107, Taejon 305-600, Korea, and Department of Horticulture, Kangnung National University, Kangnung 201-702, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea Research Institute of Chemical Technology, P.O. Box 107, Taejon 305-600, Korea, and Department of Horticulture, Kangnung National University, Kangnung 201-702, Korea","institution_ids":["https://openalex.org/I4210151417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064511653","display_name":"Byung\u2013Sup Kim","orcid":"https://orcid.org/0000-0001-5247-6658","observed_orcids":["https://orcid.org/0000-0001-5247-6658"]},"institutions":[{"id":"https://openalex.org/I4210151417","display_name":"Korea Research Institute of Chemical Technology","ror":"https://ror.org/043k4kk20","country_code":"KR","type":"facility","lineage":["https://openalex.org/I4210151417"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Byung-Sup Kim","raw_affiliation_strings":["Korea Research Institute of Chemical Technology, P.O. Box 107, Taejon 305-600, Korea, and Department of Horticulture, Kangnung National University, Kangnung 201-702, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Korea Research Institute of Chemical Technology, P.O. Box 107, Taejon 305-600, Korea, and Department of Horticulture, Kangnung National University, Kangnung 201-702, Korea","institution_ids":["https://openalex.org/I4210151417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113832507"],"corresponding_institution_ids":["https://openalex.org/I4210151417"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.566,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.78861789,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"62","issue":"3","first_page":"495","last_page":"496"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myxococcus-fulvus","display_name":"Myxococcus fulvus","score":0.9210000038146973},{"id":"https://openalex.org/keywords/bithiazole","display_name":"bithiazole","score":0.9539999961853027},{"id":"https://openalex.org/keywords/myxothiazol","display_name":"myxothiazol","score":0.9869999885559082},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7900000214576721},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.6290000081062317},{"id":"https://openalex.org/keywords/natural-product-isolation","display_name":"natural product isolation","score":0.8159999847412109},{"id":"https://openalex.org/keywords/structure-elucidation","display_name":"structure elucidation","score":0.953000009059906},{"id":"https://openalex.org/keywords/antibiotics","display_name":"antibiotics","score":0.35600000619888306}],"concepts":[{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.7909910678863525},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.611253023147583},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5912206172943115},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5904741287231445},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.45425134897232056},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4537698030471802},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.42461445927619934},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38005900382995605},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2631015181541443},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.22762471437454224},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013056","descriptor_name":"Spectrophotometry, Ultraviolet","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D013844","descriptor_name":"Thiazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016940","descriptor_name":"Myxococcus","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1021/np9804233","doi":"https://doi.org/10.1021/np9804233","is_oa":false,"landing_page_url":"https://doi.org/10.1021/np9804233","pdf_url":null,"source":{"id":"https://openalex.org/S166799026","display_name":"Journal of Natural Products","issn_l":"0163-3864","issn":["0163-3864","1520-6025"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Natural Products","raw_type":"journal-article"},{"id":"pmid:10096868","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10096868","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of natural products","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":7,"referenced_works":["https://openalex.org/W2000471926","https://openalex.org/W2004897578","https://openalex.org/W2083119773","https://openalex.org/W2088962879","https://openalex.org/W2109689528","https://openalex.org/W2328320010","https://openalex.org/W4244575181"],"related_works":["https://openalex.org/W2136421947","https://openalex.org/W2179967222","https://openalex.org/W3134433491","https://openalex.org/W2134131577","https://openalex.org/W2952916631","https://openalex.org/W4235667060","https://openalex.org/W2058257084","https://openalex.org/W2077468758","https://openalex.org/W1996178275","https://openalex.org/W1999869232"],"abstract_inverted_index":{"A":[0],"new":[1],"bithiazole,":[2],"KR-025":[3],"(1),":[4],"was":[5,12],"isolated":[6],"from":[7],"Myxococcus":[8],"fulvus.":[9],"Its":[10],"structure":[11],"elucidated":[13],"by":[14],"spectroscopic":[15],"analysis.":[16],"In":[17],"addition":[18],"to":[19],"1,":[20],"the":[21],"strain":[22],"produced":[23],"relatively":[24],"large":[25],"quantities":[26],"of":[27],"a":[28],"second,":[29],"closely":[30],"related":[31],"antibiotic,":[32],"myxothiazol.":[33],"These":[34],"compounds":[35],"demonstrated":[36],"potent":[37],"cytotoxicity":[38],"against":[39],"human":[40],"tumor":[41],"cells.":[42]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}