{"id":"https://openalex.org/W2054435015","doi":"https://doi.org/10.1093/jnci/djp273","title":"Incremental Advances in Excremental Cancer Detection Tests","display_name":"Incremental Advances in Excremental Cancer Detection Tests","publication_year":2009,"publication_date":"2009-08-21","ids":{"openalex":"https://openalex.org/W2054435015","doi":"https://doi.org/10.1093/jnci/djp273","mag":"2054435015","pmid":"https://pubmed.ncbi.nlm.nih.gov/19700654"},"language":"en","primary_location":{"id":"doi:10.1093/jnci/djp273","doi":"https://doi.org/10.1093/jnci/djp273","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/djp273","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090463240","display_name":"Steven H. Itzkowitz","orcid":"https://orcid.org/0000-0002-0436-5416","observed_orcids":["https://orcid.org/0000-0002-0436-5416"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S. H. Itzkowitz","raw_affiliation_strings":["Affiliation of author: The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Affiliation of author: The Dr. Henry D. Janowitz Division of Gastroenterology, Department of Medicine, Mount Sinai School of Medicine, New York, NY","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5090463240"],"corresponding_institution_ids":["https://openalex.org/I98704320"],"apc_list":{"value":5436,"currency":"USD","value_usd":5436},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"101","issue":"18","first_page":"1225","last_page":"1227"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10552","display_name":"Colorectal Cancer Screening and Detection","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer-screening","display_name":"colorectal cancer screening","score":0.9919999837875366},{"id":"https://openalex.org/keywords/stool-based-tests","display_name":"stool-based tests","score":0.824999988079071},{"id":"https://openalex.org/keywords/fecal-immunochemical-test","display_name":"fecal immunochemical test","score":0.8939999938011169},{"id":"https://openalex.org/keywords/guaiac-fecal-occult-blood-test","display_name":"guaiac fecal occult blood test","score":0.9629999995231628},{"id":"https://openalex.org/keywords/colorectal-adenoma","display_name":"colorectal adenoma","score":0.6489999890327454},{"id":"https://openalex.org/keywords/colorectal-cancer-detection","display_name":"colorectal cancer detection","score":0.5950000286102295},{"id":"https://openalex.org/keywords/noninvasive-screening","display_name":"non-invasive screening","score":0.6430000066757202},{"id":"https://openalex.org/keywords/screening-test-sensitivity-and-specificity","display_name":"screening sensitivity and specificity","score":0.5540000200271606},{"id":"https://openalex.org/keywords/false-positives-and-false-negatives","display_name":"false positives and false negatives","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C2985322473","wikidata":"https://www.wikidata.org/wiki/Q3044843","display_name":"Cancer detection","level":3,"score":0.5573712587356567},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.380725234746933},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30876660346984863},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29814761877059937},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13607752323150635}],"mesh":[{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000236","descriptor_name":"Adenoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002277","descriptor_name":"Carcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003111","descriptor_name":"Colonic Polyps","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D003113","descriptor_name":"Colonoscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D005243","descriptor_name":"Feces","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D005770","descriptor_name":"Gastrointestinal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009780","descriptor_name":"Occult Blood","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012680","descriptor_name":"Sensitivity and Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055088","descriptor_name":"Early Detection of Cancer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/jnci/djp273","doi":"https://doi.org/10.1093/jnci/djp273","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jnci/djp273","pdf_url":null,"source":{"id":"https://openalex.org/S98010888","display_name":"JNCI Journal of the National Cancer Institute","issn_l":"0027-8874","issn":["0027-8874","1460-2105"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JNCI Journal of the National Cancer Institute","raw_type":"journal-article"},{"id":"pmid:19700654","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19700654","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the National Cancer Institute","raw_type":"Comment"},{"id":"pmh:oai:open-archive.highwire.org:jnci:djp273v1","doi":null,"is_oa":false,"landing_page_url":"http://jnci.oxfordjournals.org/cgi/content/short/djp273v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1971786069","https://openalex.org/W1972168013","https://openalex.org/W1984646383","https://openalex.org/W1990578004","https://openalex.org/W2001463375","https://openalex.org/W2008862428","https://openalex.org/W2009647763","https://openalex.org/W2015754967","https://openalex.org/W2018247165","https://openalex.org/W2018871664","https://openalex.org/W2040928840","https://openalex.org/W2069663898","https://openalex.org/W2071723367","https://openalex.org/W2102999788","https://openalex.org/W2111853146","https://openalex.org/W2115888302","https://openalex.org/W2136864841","https://openalex.org/W2140533693","https://openalex.org/W2161968856","https://openalex.org/W2163054923","https://openalex.org/W2163214467","https://openalex.org/W2170029176","https://openalex.org/W4244090585"],"related_works":["https://openalex.org/W321496671","https://openalex.org/W7100046856","https://openalex.org/W2005875463","https://openalex.org/W3108647976","https://openalex.org/W4206287015","https://openalex.org/W4411087224","https://openalex.org/W7096738453","https://openalex.org/W7096529838","https://openalex.org/W7098636127","https://openalex.org/W2008666723"],"abstract_inverted_index":{"Colorectal":[0],"cancer":[1,241,265],"is":[2,17,38,133,153,272,330],"often":[3],"considered":[4],"the":[5,18,25,27,46,59,65,91,107,113,118,186,194,197,208,217,237,254,270,278,337],"most":[6,100],"preventable,":[7],"yet":[8],"least":[9],"prevented,":[10],"cancer.":[11,70],"What":[12],"makes":[13],"it":[14,122],"so":[15],"preventable":[16],"existence":[19],"of":[20,24,45,61,68,138,196,216,239],"a":[21,32,86,168,203,331],"precancerous":[22],"phase":[23],"disease,":[26],"adenomatous":[28],"polyp,":[29],"which":[30,76,226],"has":[31,77,111],"rather":[33,332],"long":[34],"dwell":[35],"time":[36],"and":[37,52,127,144,159,199,288,299,320,342],"usually":[39],"readily":[40],"detectable":[41],"by":[42,80,90,136,267],"structural":[43],"examinations":[44],"colon,":[47],"such":[48],"as":[49,167],"colonoscopy,":[50],"sigmoidoscopy,":[51],"more":[53,279],"recently,":[54],"computed":[55],"tomography":[56],"colonography.":[57],"Indeed,":[58,243],"removal":[60],"adenomas":[62],"markedly":[63],"reduces":[64,263],"subsequent":[66],"development":[67],"colorectal":[69,74,240,264,291],"Thus,":[71],"screening":[72,115,169,175,334],"for":[73,181,244,290,339],"cancer,":[75,292],"been":[78,230],"endorsed":[79],"all":[81],"major":[82],"medical":[83],"societies,":[84],"received":[85],"grade":[87],"A":[88],"recommendation":[89],"United":[92,119],"States":[93,120],"Preventive":[94],"Services":[95],"Task":[96],"Force":[97],"in":[98,117,193,214],"its":[99,139,149,164],"recent":[101],"guidelines":[102],"(":[103],"1":[104],").":[105],"Over":[106],"last":[108],"decade,":[109],"colonoscopy":[110,152,220],"become":[112],"preferred":[114],"test":[116,271],"because":[121,185],"not":[123,201,307],"only":[124],"detects":[125],"cancers":[126],"polyps":[128,143],"with":[129,156,253,304,336],"high":[130],"accuracy":[131],"but":[132,328],"also":[134],"therapeutic":[135],"virtue":[137],"ability":[140],"to":[141,210,227,310],"remove":[142],"even":[145],"early":[146],"cancers.":[147],"Despite":[148],"considerable":[150],"strengths,":[151],"still":[154],"associated":[155],"organizational,":[157],"logistical,":[158],"patient-related":[160],"barriers":[161],"that":[162],"limit":[163],"full":[165],"acceptance":[166],"method.":[170],"For":[171],"this":[172,261],"reason,":[173],"stool-based":[174,224,246],"tests":[176,187,247,316],"are":[177,188,222,293],"an":[178],"attractive":[179],"alternative":[180],"many":[182],"screen-eligible":[183],"people":[184],"noninvasive,":[189],"can":[190],"be":[191],"done":[192],"privacy":[195],"home,":[198],"do":[200],"require":[202],"cleansing":[204],"bowel":[205],"preparation":[206],"or":[207],"need":[209],"miss":[211],"work.":[212],"Moreover,":[213],"parts":[215],"world":[218],"where":[219],"resources":[221],"limited,":[223],"tests,":[225,276,327],"date":[228],"have":[229,285,317],"based":[231],"on":[232,249,301],"detecting":[233,250,297],"occult":[234,251,325],"blood,":[235],"remain":[236],"cornerstone":[238],"screening.":[242],"decades,":[245],"relied":[248],"blood":[252,326,329],"chemical":[255],"guaiac":[256,323],"reagent":[257],"(eg,":[258,282],"Hemoccult).":[259],"Whereas":[260],"approach":[262],"mortality":[266],"one-third":[268],"when":[269],"performed":[273],"annually,":[274],"guaiac-based":[275],"including":[277],"sensitive":[280],"versions":[281],"Hemoccult":[283],"SENSA),":[284],"limited":[286],"sensitivity":[287,319],"specificity":[289,321],"quite":[294],"poor":[295],"at":[296],"adenomas,":[298],"rely":[300],"patients":[302],"complying":[303],"annual,":[305],"if":[306],"biennial,":[308],"testing":[309],"demonstrate":[311],"efficacy.":[312],"Newer":[313],"fecal":[314,324],"immunochemical":[315],"better":[318],"than":[322],"nonspecific":[333],"target,":[335],"potential":[338],"false":[340,343],"positives":[341],"negatives.":[344]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}