{"id":"https://openalex.org/W2054422229","doi":"https://doi.org/10.1074/jbc.m112.438416","title":"Glucosylceramide Transferase Activity Is Critical for Encystation and Viable Cyst Production by an Intestinal Protozoan, Giardia lamblia","display_name":"Glucosylceramide Transferase Activity Is Critical for Encystation and Viable Cyst Production by an Intestinal Protozoan, Giardia lamblia","publication_year":2013,"publication_date":"2013-04-15","ids":{"openalex":"https://openalex.org/W2054422229","doi":"https://doi.org/10.1074/jbc.m112.438416","mag":"2054422229","pmid":"https://pubmed.ncbi.nlm.nih.gov/23589290","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3675608"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m112.438416","doi":"https://doi.org/10.1074/jbc.m112.438416","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.438416","pdf_url":"http://www.jbc.org/article/S0021925820536818/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"http://www.jbc.org/article/S0021925820536818/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033184533","display_name":"Tavis L. Mendez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tavis L. Mendez","raw_affiliation_strings":["From Infectious Disease and Immunology; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","From Infectious Disease and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Infectious Disease and Immunology; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"From Infectious Disease and Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066139742","display_name":"Atasi De Chatterjee","orcid":"https://orcid.org/0009-0005-7768-7263","observed_orcids":["https://orcid.org/0009-0005-7768-7263"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Atasi De Chatterjee","raw_affiliation_strings":["From Infectious Disease and Immunology; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","From Infectious Disease and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Infectious Disease and Immunology; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"From Infectious Disease and Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059605667","display_name":"Trevor T. Duarte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trevor T. Duarte","raw_affiliation_strings":["From Infectious Disease and Immunology; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","From Infectious Disease and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Infectious Disease and Immunology; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"From Infectious Disease and Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005691190","display_name":"Felipe Gazos\u2010Lopes","orcid":"https://orcid.org/0000-0002-8431-8248","observed_orcids":["https://orcid.org/0000-0002-8431-8248"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Felipe Gazos-Lopes","raw_affiliation_strings":["From Infectious Disease and Immunology; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","From Infectious Disease and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Infectious Disease and Immunology; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"From Infectious Disease and Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063930827","display_name":"Leobarda Robles\u2010Mart\u00ednez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leobarda Robles-Martinez","raw_affiliation_strings":["From Infectious Disease and Immunology; Neuroscience and Metabolic Disorder Clusters, Border Biomedical Research Center, El Paso, Texas 79968-5808","From Infectious Disease and Immunology","Neuroscience and Metabolic Disorder Clusters, Border Biomedical Research Center, El Paso, Texas 79968-5808"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Infectious Disease and Immunology; Neuroscience and Metabolic Disorder Clusters, Border Biomedical Research Center, El Paso, Texas 79968-5808","institution_ids":[]},{"raw_affiliation_string":"From Infectious Disease and Immunology","institution_ids":[]},{"raw_affiliation_string":"Neuroscience and Metabolic Disorder Clusters, Border Biomedical Research Center, El Paso, Texas 79968-5808","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101910682","display_name":"Debarshi Roy","orcid":"https://orcid.org/0000-0002-4473-1986","observed_orcids":["https://orcid.org/0000-0002-4473-1986"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Debarshi Roy","raw_affiliation_strings":["From Infectious Disease and Immunology; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","From Infectious Disease and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Infectious Disease and Immunology; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"From Infectious Disease and Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101640566","display_name":"Jianjun Sun","orcid":"https://orcid.org/0000-0001-9399-7644","observed_orcids":["https://orcid.org/0000-0001-9399-7644"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianjun Sun","raw_affiliation_strings":["From Infectious Disease and Immunology; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","From Infectious Disease and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Infectious Disease and Immunology; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"From Infectious Disease and Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074005980","display_name":"Rosa A. Maldonado","orcid":"https://orcid.org/0000-0003-3180-7192","observed_orcids":["https://orcid.org/0000-0003-3180-7192"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosa A. Maldonado","raw_affiliation_strings":["From Infectious Disease and Immunology; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","From Infectious Disease and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Infectious Disease and Immunology; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"From Infectious Disease and Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Sukla Roychowdhury","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sukla Roychowdhury","raw_affiliation_strings":["Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808; Neuroscience and Metabolic Disorder Clusters, Border Biomedical Research Center, El Paso, Texas 79968-5808","Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","Neuroscience and Metabolic Disorder Clusters, Border Biomedical Research Center, El Paso, Texas 79968-5808"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808; Neuroscience and Metabolic Disorder Clusters, Border Biomedical Research Center, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"Neuroscience and Metabolic Disorder Clusters, Border Biomedical Research Center, El Paso, Texas 79968-5808","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054601444","display_name":"Igor Correia de Almeida","orcid":"https://orcid.org/0000-0002-2443-8213","observed_orcids":["https://orcid.org/0000-0002-2443-8213"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor C. Almeida","raw_affiliation_strings":["From Infectious Disease and Immunology; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","From Infectious Disease and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Infectious Disease and Immunology; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"From Infectious Disease and Immunology","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074865308","display_name":"Siddhartha Das","orcid":"https://orcid.org/0000-0002-9896-3520","observed_orcids":["https://orcid.org/0000-0002-9896-3520"]},"institutions":[{"id":"https://openalex.org/I164936912","display_name":"The University of Texas at El Paso","ror":"https://ror.org/04d5vba33","country_code":"US","type":"education","lineage":["https://openalex.org/I164936912"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Siddhartha Das","raw_affiliation_strings":["From Infectious Disease and Immunology; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808. Electronic address: sdas@utep.edu","Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","From Infectious Disease and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Infectious Disease and Immunology; Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808. Electronic address: sdas@utep.edu","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"Department of Biological Sciences, University of Texas at El Paso, El Paso, Texas 79968-5808","institution_ids":["https://openalex.org/I164936912"]},{"raw_affiliation_string":"From Infectious Disease and Immunology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074865308"],"corresponding_institution_ids":["https://openalex.org/I164936912"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.9739,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.82925163,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"288","issue":"23","first_page":"16747","last_page":"16760"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11086","display_name":"Parasitic Infections and Diagnostics","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11086","display_name":"Parasitic Infections and Diagnostics","score":0.7476000189781189,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.061500001698732376,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.05979999899864197,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/giardia-duodenalis","display_name":"Giardia lamblia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cyst-formation","display_name":"cyst formation","score":0.9800000190734863},{"id":"https://openalex.org/keywords/cyst-viability","display_name":"cyst viability","score":0.824999988079071},{"id":"https://openalex.org/keywords/sphingolipid-biosynthesis","display_name":"sphingolipid biosynthesis","score":0.9129999876022339},{"id":"https://openalex.org/keywords/lipid-homeostasis","display_name":"lipid homeostasis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/trophozoites","display_name":"trophozoites","score":0.6330000162124634},{"id":"https://openalex.org/keywords/morpholino-knockdown","display_name":"morpholino knockdown","score":0.7950000166893005}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7805970311164856},{"id":"https://openalex.org/C2780597408","wikidata":"https://www.wikidata.org/wiki/Q193211","display_name":"Cyst","level":2,"score":0.6445939540863037},{"id":"https://openalex.org/C2780626423","wikidata":"https://www.wikidata.org/wiki/Q155630","display_name":"Giardia lamblia","level":2,"score":0.5481812953948975},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4503803849220276},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42741236090660095},{"id":"https://openalex.org/C131934819","wikidata":"https://www.wikidata.org/wiki/Q135390","display_name":"Biogenesis","level":3,"score":0.4270067811012268},{"id":"https://openalex.org/C25095133","wikidata":"https://www.wikidata.org/wiki/Q573950","display_name":"Lipid droplet","level":2,"score":0.41865143179893494},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.20260417461395264},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08694356679916382},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.08345431089401245},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013107","descriptor_name":"Sphingolipids","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D013107","descriptor_name":"Sphingolipids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015800","descriptor_name":"Protozoan Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016695","descriptor_name":"Glycosyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016695","descriptor_name":"Glycosyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016829","descriptor_name":"Giardia lamblia","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D016829","descriptor_name":"Giardia lamblia","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016829","descriptor_name":"Giardia lamblia","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1074/jbc.m112.438416","doi":"https://doi.org/10.1074/jbc.m112.438416","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.438416","pdf_url":"http://www.jbc.org/article/S0021925820536818/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3022624","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3675608","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3675608","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3675608","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:23589290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23589290","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:scholarworks.utep.edu:bio_papers-1057","doi":null,"is_oa":false,"landing_page_url":"https://scholarworks.utep.edu/bio_papers/58","pdf_url":null,"source":{"id":"https://openalex.org/S4377196403","display_name":"scholarworks - UTEP (The University of Texas at El Paso)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I164936912","host_organization_name":"The University of Texas at El Paso","host_organization_lineage":["https://openalex.org/I164936912"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Departmental Papers (Biology)","raw_type":"text"},{"id":"pmh:oai:digitalcommons.utep.edu:bio_papers-1057","doi":null,"is_oa":true,"landing_page_url":"http://www.jbc.org/content/288/23/16747.short","pdf_url":null,"source":{"id":"https://openalex.org/S4377196403","display_name":"scholarworks - UTEP (The University of Texas at El Paso)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I164936912","host_organization_name":"The University of Texas at El Paso","host_organization_lineage":["https://openalex.org/I164936912"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Departmental Papers (Biology)","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1074/jbc.m112.438416","doi":"https://doi.org/10.1074/jbc.m112.438416","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m112.438416","pdf_url":"http://www.jbc.org/article/S0021925820536818/pdf","source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.4699999988079071}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1340722568","display_name":"Border Biomedical Research Center","funder_award_id":"G12RR008124","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1751573725","display_name":"RISE Research Scholars Program","funder_award_id":"R25GM069621","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2671105022","display_name":"SCORE Program at The University of Texas at El Paso","funder_award_id":"S06GM008012","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6357356708","display_name":"Sphingolipid and Mechanism of Cyst Formation by Giardia","funder_award_id":"R01AI095667","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8662055157","display_name":"Border Biomedical Research Center","funder_award_id":"G12MD007592","funder_id":"https://openalex.org/F4320337534","funder_display_name":"National Institute on Minority Health and Health Disparities"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337534","display_name":"National Institute on Minority Health and Health Disparities","ror":"https://ror.org/0493hgw16"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2054422229.pdf","grobid_xml":"https://content.openalex.org/works/W2054422229.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W36046902","https://openalex.org/W570949854","https://openalex.org/W1566032349","https://openalex.org/W1603076588","https://openalex.org/W1628875778","https://openalex.org/W1943240551","https://openalex.org/W1945483730","https://openalex.org/W1954683167","https://openalex.org/W1962379686","https://openalex.org/W1964890554","https://openalex.org/W1966404042","https://openalex.org/W1969213252","https://openalex.org/W1970057728","https://openalex.org/W1970101934","https://openalex.org/W1972589331","https://openalex.org/W1972591347","https://openalex.org/W1974509341","https://openalex.org/W1975460747","https://openalex.org/W1975976443","https://openalex.org/W1980181123","https://openalex.org/W1983785927","https://openalex.org/W2000717167","https://openalex.org/W2003598465","https://openalex.org/W2005516896","https://openalex.org/W2015223879","https://openalex.org/W2016185570","https://openalex.org/W2016675624","https://openalex.org/W2017859854","https://openalex.org/W2028768124","https://openalex.org/W2029617555","https://openalex.org/W2030823707","https://openalex.org/W2030973246","https://openalex.org/W2037446046","https://openalex.org/W2040080546","https://openalex.org/W2040864441","https://openalex.org/W2045186739","https://openalex.org/W2045988210","https://openalex.org/W2047176381","https://openalex.org/W2057007315","https://openalex.org/W2059510815","https://openalex.org/W2076767566","https://openalex.org/W2077752559","https://openalex.org/W2083214254","https://openalex.org/W2085806072","https://openalex.org/W2088080915","https://openalex.org/W2098531571","https://openalex.org/W2100945118","https://openalex.org/W2102622187","https://openalex.org/W2109179622","https://openalex.org/W2110173319","https://openalex.org/W2116627147","https://openalex.org/W2117188265","https://openalex.org/W2117255228","https://openalex.org/W2122601643","https://openalex.org/W2126338409","https://openalex.org/W2131680033","https://openalex.org/W2133401795","https://openalex.org/W2135160600","https://openalex.org/W2139307267","https://openalex.org/W2139654270","https://openalex.org/W2142893323","https://openalex.org/W2149128590","https://openalex.org/W2152977880","https://openalex.org/W2157408682","https://openalex.org/W2162739953","https://openalex.org/W2165641195","https://openalex.org/W2172260092","https://openalex.org/W2330199346","https://openalex.org/W6640731183"],"related_works":["https://openalex.org/W2555402553","https://openalex.org/W7020976225","https://openalex.org/W3016834856","https://openalex.org/W2258281144","https://openalex.org/W2117255228","https://openalex.org/W2043965880","https://openalex.org/W2337304933","https://openalex.org/W3157980990","https://openalex.org/W2260137757","https://openalex.org/W2089664625"],"abstract_inverted_index":{"The":[0,25,120,242],"production":[1,29,131,243],"of":[2,27,37,50,86,104,110,122,162,175,180,190,197,225,244,264,282],"viable":[3,169,245],"cysts":[4,116,246],"by":[5,125,247],"Giardia":[6,140,248,277],"is":[7,34,164,200,221,249,285],"essential":[8,250],"for":[9,16,166,236,251,298],"its":[10],"survival":[11],"in":[12,93,211,276],"the":[13,18,35,47,51,56,61,108,146,159,173,178,188,195,207,253],"environment":[14],"and":[15,23,67,96,113,132,151,168,183,205,228,231,258,262,272,289],"spreading":[17],"infection":[19,254],"via":[20,255],"contaminated":[21,256],"food":[22,257],"water.":[24,259],"hallmark":[26],"cyst":[28,43,58,69,98,152,170,229,270,290],"(also":[30],"known":[31],"as":[32],"encystation)":[33],"biogenesis":[36,66,95,227],"encystation-specific":[38],"vesicles":[39],"(ESVs)":[40],"that":[41,63,79,102,158,194,219],"transport":[42],"wall":[44],"proteins":[45],"to":[46,155,202,287],"plasma":[48,191],"membrane":[49,181],"trophozoite":[52],"before":[53,73],"laying":[54],"down":[55],"protective":[57],"wall.":[59],"However,":[60],"molecules":[62],"regulate":[64],"ESV":[65,94,130,226],"maintain":[68],"viability":[70,153,230],"have":[71],"never":[72],"been":[74],"identified.":[75],"Here,":[76],"we":[77],"report":[78],"giardial":[80],"glucosylceramide":[81,265,283],"transferase-1":[82],"(gGlcT1),":[83],"an":[84],"enzyme":[85,106,147],"sphingolipid":[87],"biosynthesis,":[88],"plays":[89],"a":[90,222],"key":[91,223],"role":[92],"maintaining":[97,206],"viability.":[99,119],"We":[100],"find":[101],"overexpression":[103,174],"this":[105,212],"induced":[107],"formation":[109],"aggregated/enlarged":[111],"ESVs":[112],"generated":[114,133],"clustered":[115],"with":[117,143],"reduced":[118],"silencing":[121],"gGlcT1":[123,163,176,198,220],"synthesis":[124,294],"antisense":[126],"morpholino":[127],"oligonucleotide":[128],"abolished":[129],"mostly":[134],"nonviable":[135],"cysts.":[136],"Interestingly,":[137],"when":[138],"gGlcT1-overexpressed":[139],"was":[141],"transfected":[142],"anti-gGlcT1":[144],"morpholino,":[145],"activity,":[148],"vesicle":[149],"biogenesis,":[150],"returned":[154],"normal,":[156],"suggesting":[157],"regulated":[160],"expression":[161,196,281],"important":[165],"encystation":[167,288],"production.":[171,291],"Furthermore,":[172],"increased":[177],"influx":[179],"lipids":[182],"fatty":[184],"acids":[185],"without":[186],"altering":[187],"fluidity":[189],"membranes,":[192],"indicating":[193],"activity":[199,267],"linked":[201,286],"lipid":[203,209,274],"internalization":[204],"overall":[208,273],"balance":[210,275],"parasite.":[213],"Taken":[214],"together,":[215],"our":[216],"results":[217],"suggest":[218],"player":[224],"therefore":[232],"could":[233,295],"be":[234,296],"targeted":[235,297],"developing":[237,299],"new":[238],"anti-giardial":[239,301],"therapies.":[240],"Background:":[241],"transmitting":[252],"Results:":[260],"Overexpression":[261],"knockdown":[263],"transferase":[266,284],"affect":[268],"encystation,":[269],"viability,":[271],".":[278],"Conclusion:":[279],"Regulated":[280],"Significance:":[292],"Glucosylceramide":[293],"novel":[300],"therapy.":[302]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}