{"id":"https://openalex.org/W2054346644","doi":"https://doi.org/10.1097/00000374-200102000-00016","title":"Third Trimester Binge Ethanol Exposure Results in Fetal Hypercapnea and Acidemia but Not Hypoxemia in Pregnant Sheep","display_name":"Third Trimester Binge Ethanol Exposure Results in Fetal Hypercapnea and Acidemia but Not Hypoxemia in Pregnant Sheep","publication_year":2001,"publication_date":"2001-02-01","ids":{"openalex":"https://openalex.org/W2054346644","doi":"https://doi.org/10.1097/00000374-200102000-00016","mag":"2054346644","pmid":"https://pubmed.ncbi.nlm.nih.gov/11236842"},"language":"en","primary_location":{"id":"doi:10.1097/00000374-200102000-00016","doi":"https://doi.org/10.1097/00000374-200102000-00016","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000374-200102000-00016","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109925815","display_name":"Timothy A. Cudd","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I173268674","display_name":"Texas A&M University System","ror":"https://ror.org/0034eay46","country_code":"US","type":"education","lineage":["https://openalex.org/I173268674"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Timothy A. Cudd","raw_affiliation_strings":["Department of Veterinary Physiology and Pharmacology, Texas A&M University (TAC) and the Department of Human Anatomy and Medical Neurobiology, College of Medicine, The Texas A&M University System Health Science Center (W-JAC, SEP, and JRW), College Station, Texas","Texas A&M University System, College Station, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology and Pharmacology, Texas A&M University (TAC) and the Department of Human Anatomy and Medical Neurobiology, College of Medicine, The Texas A&M University System Health Science Center (W-JAC, SEP, and JRW), College Station, Texas","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I173268674","https://openalex.org/I91045830"]},{"raw_affiliation_string":"Texas A&M University System, College Station, United States","institution_ids":["https://openalex.org/I173268674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111701926","display_name":"Wei\u2010Jung A. Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I173268674","display_name":"Texas A&M University System","ror":"https://ror.org/0034eay46","country_code":"US","type":"education","lineage":["https://openalex.org/I173268674"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei-Jung A. Chen","raw_affiliation_strings":["Department of Veterinary Physiology and Pharmacology, Texas A&M University (TAC) and the Department of Human Anatomy and Medical Neurobiology, College of Medicine, The Texas A&M University System Health Science Center (W-JAC, SEP, and JRW), College Station, Texas","Texas A&M University System, College Station, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology and Pharmacology, Texas A&M University (TAC) and the Department of Human Anatomy and Medical Neurobiology, College of Medicine, The Texas A&M University System Health Science Center (W-JAC, SEP, and JRW), College Station, Texas","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I173268674","https://openalex.org/I91045830"]},{"raw_affiliation_string":"Texas A&M University System, College Station, United States","institution_ids":["https://openalex.org/I173268674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074840621","display_name":"Scott E. Parnell","orcid":"https://orcid.org/0000-0003-2038-6548","observed_orcids":["https://orcid.org/0000-0003-2038-6548"]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I173268674","display_name":"Texas A&M University System","ror":"https://ror.org/0034eay46","country_code":"US","type":"education","lineage":["https://openalex.org/I173268674"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott E. Parnell","raw_affiliation_strings":["Department of Veterinary Physiology and Pharmacology, Texas A&M University (TAC) and the Department of Human Anatomy and Medical Neurobiology, College of Medicine, The Texas A&M University System Health Science Center (W-JAC, SEP, and JRW), College Station, Texas","Texas A&M University System, College Station, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology and Pharmacology, Texas A&M University (TAC) and the Department of Human Anatomy and Medical Neurobiology, College of Medicine, The Texas A&M University System Health Science Center (W-JAC, SEP, and JRW), College Station, Texas","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I173268674","https://openalex.org/I91045830"]},{"raw_affiliation_string":"Texas A&M University System, College Station, United States","institution_ids":["https://openalex.org/I173268674"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103448036","display_name":"James R. West","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125029298","display_name":"Texas A&M Health Science Center","ror":"https://ror.org/01tx6pn92","country_code":"US","type":"education","lineage":["https://openalex.org/I125029298","https://openalex.org/I91045830"]},{"id":"https://openalex.org/I173268674","display_name":"Texas A&M University System","ror":"https://ror.org/0034eay46","country_code":"US","type":"education","lineage":["https://openalex.org/I173268674"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James R. West","raw_affiliation_strings":["Department of Veterinary Physiology and Pharmacology, Texas A&M University (TAC) and the Department of Human Anatomy and Medical Neurobiology, College of Medicine, The Texas A&M University System Health Science Center (W-JAC, SEP, and JRW), College Station, Texas","Texas A&M University System, College Station, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Physiology and Pharmacology, Texas A&M University (TAC) and the Department of Human Anatomy and Medical Neurobiology, College of Medicine, The Texas A&M University System Health Science Center (W-JAC, SEP, and JRW), College Station, Texas","institution_ids":["https://openalex.org/I125029298","https://openalex.org/I173268674","https://openalex.org/I91045830"]},{"raw_affiliation_string":"Texas A&M University System, College Station, United States","institution_ids":["https://openalex.org/I173268674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5109925815"],"corresponding_institution_ids":["https://openalex.org/I125029298","https://openalex.org/I173268674","https://openalex.org/I91045830"],"apc_list":{"value":4110,"currency":"USD","value_usd":4110},"apc_paid":null,"fwci":1.3278,"has_fulltext":false,"cited_by_count":49,"citation_normalized_percentile":{"value":0.80585386,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"25","issue":"2","first_page":"269","last_page":"276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11633","display_name":"Prenatal Substance Exposure Effects","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11629","display_name":"Birth, Development, and Health","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12552","display_name":"Fetal and Pediatric Neurological Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/binge-ethanol-exposure","display_name":"binge ethanol exposure","score":0.8510000109672546},{"id":"https://openalex.org/keywords/maternal-alcohol-consumption","display_name":"maternal alcohol consumption","score":0.5339999794960022},{"id":"https://openalex.org/keywords/fetal-hypoxemia","display_name":"fetal hypoxemia","score":0.8730000257492065},{"id":"https://openalex.org/keywords/fetal-acidemia","display_name":"fetal acidemia","score":0.9769999980926514},{"id":"https://openalex.org/keywords/fetal-sheep-model","display_name":"fetal sheep model","score":0.7110000252723694},{"id":"https://openalex.org/keywords/third-trimester","display_name":"third trimester","score":0.7490000128746033},{"id":"https://openalex.org/keywords/fetal-blood-pressure","display_name":"fetal blood pressure","score":0.6679999828338623},{"id":"https://openalex.org/keywords/fetal-heart-rate","display_name":"fetal heart rate","score":0.9290000200271606},{"id":"https://openalex.org/keywords/fetal-acid-base-balance","display_name":"fetal acid-base balance","score":0.5609999895095825},{"id":"https://openalex.org/keywords/fetal-alcohol-spectrum-disorders","display_name":"fetal alcohol spectrum disorders","score":0.4350000023841858},{"id":"https://openalex.org/keywords/fetal-alcohol-syndrome","display_name":"fetal alcohol syndrome","score":0.31200000643730164},{"id":"https://openalex.org/keywords/fetal-alcohol-effects","display_name":"fetal alcohol effects","score":0.3799999952316284}],"concepts":[{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.7970929145812988},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7439168691635132},{"id":"https://openalex.org/C2776779939","wikidata":"https://www.wikidata.org/wiki/Q1479485","display_name":"Hypoxemia","level":2,"score":0.7414093613624573},{"id":"https://openalex.org/C46973012","wikidata":"https://www.wikidata.org/wiki/Q28627","display_name":"Gestation","level":3,"score":0.5580217242240906},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.547805666923523},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5433209538459778},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5043395757675171},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.5018835067749023},{"id":"https://openalex.org/C2780161600","wikidata":"https://www.wikidata.org/wiki/Q153","display_name":"Ethanol","level":2,"score":0.4885331392288208},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.3683304786682129},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.11470499634742737},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09601736068725586},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000014","descriptor_name":"Abnormalities, Drug-Induced","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000431","descriptor_name":"Ethanol","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000860","descriptor_name":"Hypoxia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005315","descriptor_name":"Fetal Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005315","descriptor_name":"Fetal Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D005865","descriptor_name":"Gestational Age","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006340","descriptor_name":"Heart Rate, Fetal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006935","descriptor_name":"Hypercapnia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012756","descriptor_name":"Sheep","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00000374-200102000-00016","doi":"https://doi.org/10.1097/00000374-200102000-00016","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000374-200102000-00016","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},{"id":"doi:10.1111/j.1530-0277.2001.tb02208.x","doi":"https://doi.org/10.1111/j.1530-0277.2001.tb02208.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1530-0277.2001.tb02208.x","pdf_url":null,"source":{"id":"https://openalex.org/S115510430","display_name":"Alcoholism Clinical and Experimental Research","issn_l":"0145-6008","issn":["0145-6008","1530-0277","2993-7175"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism: Clinical and Experimental Research","raw_type":"journal-article"},{"id":"pmid:11236842","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11236842","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alcoholism, clinical and experimental research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[],"awards":[{"id":"https://openalex.org/G469853990","display_name":null,"funder_award_id":"AA 10940","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"},{"id":"https://openalex.org/G8730641546","display_name":"Ovine model system for alcohol related birth defects","funder_award_id":"R01AA010940","funder_id":"https://openalex.org/F4320337330","funder_display_name":"National Institute on Alcohol Abuse and Alcoholism"}],"funders":[{"id":"https://openalex.org/F4320337330","display_name":"National Institute on Alcohol Abuse and Alcoholism","ror":"https://ror.org/02jzrsm59"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W205015529","https://openalex.org/W238832337","https://openalex.org/W586457042","https://openalex.org/W649000019","https://openalex.org/W1562811233","https://openalex.org/W1587107956","https://openalex.org/W1963821078","https://openalex.org/W1965572476","https://openalex.org/W1979721245","https://openalex.org/W1984042572","https://openalex.org/W1984394487","https://openalex.org/W1984834043","https://openalex.org/W1986681709","https://openalex.org/W1986905703","https://openalex.org/W2009852469","https://openalex.org/W2010843703","https://openalex.org/W2012725901","https://openalex.org/W2022317523","https://openalex.org/W2025792792","https://openalex.org/W2031370362","https://openalex.org/W2034323432","https://openalex.org/W2044158211","https://openalex.org/W2053738173","https://openalex.org/W2059489160","https://openalex.org/W2059905635","https://openalex.org/W2069848394","https://openalex.org/W2073454274","https://openalex.org/W2077512826","https://openalex.org/W2080131125","https://openalex.org/W2093691958","https://openalex.org/W2126888533","https://openalex.org/W2129188588","https://openalex.org/W2136742566","https://openalex.org/W2143437800","https://openalex.org/W2146123028","https://openalex.org/W2163015424","https://openalex.org/W2169842886","https://openalex.org/W2188085222","https://openalex.org/W2202603714","https://openalex.org/W2227607153","https://openalex.org/W2237272382","https://openalex.org/W2277134674","https://openalex.org/W2281321651","https://openalex.org/W2398704513","https://openalex.org/W2405141073","https://openalex.org/W2406011752","https://openalex.org/W2464765453","https://openalex.org/W4239393784"],"related_works":["https://openalex.org/W2164671364","https://openalex.org/W1979721245","https://openalex.org/W2148718461","https://openalex.org/W2009050469","https://openalex.org/W97723688","https://openalex.org/W2044158211","https://openalex.org/W1993951800","https://openalex.org/W2124739397","https://openalex.org/W2136322496","https://openalex.org/W1984394487"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,20,116],"mechanisms":[2],"by":[3,111,280,352],"which":[4],"maternal":[5,204,288,347],"ethanol":[6,42,89,138,148,220,239,253,258,271,276,282,313,318,348],"abuse":[7,349],"during":[8],"pregnancy":[9],"causes":[10],"neurodevelopmental":[11,341],"injury":[12],"in":[13,71,145,186,213,217,236,250,285,287,294,308,328,355],"the":[14,46,62,133,136,189,267],"fetus":[15],"are":[16,339,344,350],"not":[17,248,302,326],"well":[18],"understood.":[19],"purpose":[21],"of":[22,41,54,88,98,150,232],"this":[23,336],"study":[24],"was":[25],"to":[26,35,188,219,238,252,333],"use":[27],"a":[28,38,57,69,214,353],"chronically":[29],"instrumented":[30,120],"fetal":[31,50,65,200,209,224,245,290,329,356,360],"sheep":[32],"model":[33,311,337],"system":[34,338],"determine":[36],"if":[37],"binge":[39,257],"pattern":[40],"exposure":[43,259],"administered":[44],"throughout":[45,266],"third":[47,268],"trimester":[48,269],"reduced":[49],"arterial":[51,225,229],"partial":[52,230],"pressure":[53,206,211],"oxygen":[55],"(PaO2);":[56],"positive":[58],"finding":[59],"would":[60],"support":[61],"hypothesis":[63],"that":[64,273,307,315,343],"hypoxemia":[66],"may":[67],"play":[68],"role":[70],"mediating":[72],"ethanol-related":[73],"birth":[74],"defects.":[75],"METHODS:":[76],"Pregnant":[77],"ewes":[78],"received":[79],"saline":[80],"or":[81,85,131,362],"0.75,":[82,190],"1.25,":[83,191],"1.5,":[84,192],"1.75":[86,194],"g/kg":[87,195],"intravenously":[90],"over":[91],"1":[92],"hr":[93],"beginning":[94],"on":[95,121,128],"day":[96,122],"109":[97],"gestation":[99],"(term":[100],"=":[101],"145":[102],"days)":[103],"for":[104],"3":[105],"consecutive":[106,262],"days":[107,113,129,263],"per":[108,264],"week":[109,265],"followed":[110],"4":[112],"without":[114],"exposure.":[115],"fetuses":[117],"were":[118,126],"surgically":[119],"113,":[123],"and":[124,135,160,168,178,193,199,203,223,228,289,299],"experiments":[125],"performed":[127],"118":[130],"132,":[132],"6th":[134],"12th":[137],"exposure,":[139],"respectively.":[140,197],"RESULTS:":[141],"Ethanol":[142],"infusions":[143],"resulted":[144,284],"peak":[146],"blood":[147,205,210,275,295,317,358],"concentrations":[149,277,319],"80.8":[151],"+/-":[152,155,158,162,165,170,173,176,180,183],"6.5,":[153],"182.5":[154],"13.5,":[156],"224.4":[157],"13.9,":[159],"260.6":[161],"20.0":[163],"mg/dl":[164,182,324],"SEM":[166,184],"(maternal)":[167],"70.0":[169],"5.9,":[171],"149.7":[172],"9.0,":[174],"216.9":[175],"14.0,":[177],"233.3":[179],"19.8":[181],"(fetal)":[185],"response":[187,218,237,251],"doses,":[196],"Maternal":[198,222,241],"heart":[201,291],"rate":[202],"increased":[207,235],"whereas":[208,244],"decreased":[212,227,243],"dose-dependent":[215],"manner":[216],"infusions.":[221,240,254],"pH":[226],"pressures":[231],"carbon":[233],"dioxide":[234],"PaO2":[242,246],"did":[247],"change":[249],"CONCLUSIONS:":[255],"A":[256],"paradigm,":[260],"three":[261],"at":[270],"doses":[272,314],"created":[274],"commonly":[278],"achieved":[279],"human":[281],"abusers,":[283],"changes":[286,293],"rate,":[292],"pressure,":[296],"hypercapnea,":[297,361],"acidemia,":[298],"maternal,":[300],"but":[301],"fetal,":[303],"hypoxemia.":[304,330],"We":[305],"conclude":[306],"an":[309],"ovine":[310],"system,":[312],"create":[316],"as":[320,322],"high":[321],"260":[323],"do":[325],"result":[327],"Remaining":[331],"issues":[332],"address":[334],"with":[335,346],"whether":[340],"injuries":[342],"associated":[345],"mediated":[351],"reduction":[354],"cerebral":[357],"flow,":[359],"acidemia.":[363]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
