{"id":"https://openalex.org/W2054154014","doi":"https://doi.org/10.7326/0003-4819-114-4-257","title":"Nonsteroidal Anti-inflammatory Drug Use and Increased Risk for Peptic Ulcer Disease in Elderly Persons","display_name":"Nonsteroidal Anti-inflammatory Drug Use and Increased Risk for Peptic Ulcer Disease in Elderly Persons","publication_year":1991,"publication_date":"1991-02-15","ids":{"openalex":"https://openalex.org/W2054154014","doi":"https://doi.org/10.7326/0003-4819-114-4-257","mag":"2054154014","pmid":"https://pubmed.ncbi.nlm.nih.gov/1987872"},"language":"en","primary_location":{"id":"doi:10.7326/0003-4819-114-4-257","doi":"https://doi.org/10.7326/0003-4819-114-4-257","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-114-4-257","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020436097","display_name":"Marie R. Griffin","orcid":"https://orcid.org/0000-0001-7114-7614","observed_orcids":["https://orcid.org/0000-0001-7114-7614"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie R. Griffin","raw_affiliation_strings":["Vanderbilt University School of Medicine, Nashville, Tennessee"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt University School of Medicine, Nashville, Tennessee","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110282289","display_name":"Joyce M. Piper","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joyce M. Piper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054459659","display_name":"James R. Daugherty","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James R. Daugherty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026677749","display_name":"Mary Snowden","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary Snowden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010558391","display_name":"Wayne A. Ray","orcid":"https://orcid.org/0000-0001-9188-9017","observed_orcids":["https://orcid.org/0000-0001-9188-9017"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wayne A. Ray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":45.4225,"has_fulltext":false,"cited_by_count":763,"citation_normalized_percentile":{"value":0.99959465,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"114","issue":"4","first_page":"257","last_page":"263"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11378","display_name":"Gastrointestinal Bleeding Diagnosis and Treatment","score":0.011900000274181366,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.007600000128149986,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonsteroidal-anti-inflammatory-drugs","display_name":"nonsteroidal anti-inflammatory drugs","score":0.9599999785423279},{"id":"https://openalex.org/keywords/peptic-ulcer","display_name":"peptic ulcer","score":0.9330000281333923},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.7160000205039978},{"id":"https://openalex.org/keywords/drug-induced-ulcers","display_name":"drug-induced ulcers","score":0.7059999704360962},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.7829999923706055},{"id":"https://openalex.org/keywords/medicaid-enrollees","display_name":"Medicaid enrollees","score":0.8569999933242798},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.5820000171661377}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9520120620727539},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.7185500264167786},{"id":"https://openalex.org/C2776534028","wikidata":"https://www.wikidata.org/wiki/Q1141363","display_name":"Medicaid","level":3,"score":0.6995517611503601},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6651055812835693},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5863611698150635},{"id":"https://openalex.org/C2778484676","wikidata":"https://www.wikidata.org/wiki/Q20707196","display_name":"Nonsteroidal","level":2,"score":0.5153366923332214},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.46459031105041504},{"id":"https://openalex.org/C2780656511","wikidata":"https://www.wikidata.org/wiki/Q172941","display_name":"Peptic ulcer","level":2,"score":0.45346298813819885},{"id":"https://openalex.org/C120195587","wikidata":"https://www.wikidata.org/wiki/Q2138790","display_name":"Absolute risk reduction","level":3,"score":0.4485718011856079},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3347635865211487},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.1534332036972046},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.09855112433433533},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000437","descriptor_name":"Alcoholism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000894","descriptor_name":"Anti-Inflammatory Agents, Non-Steroidal","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010437","descriptor_name":"Peptic Ulcer","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015986","descriptor_name":"Confounding Factors, Epidemiologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016017","descriptor_name":"Odds Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.7326/0003-4819-114-4-257","doi":"https://doi.org/10.7326/0003-4819-114-4-257","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-114-4-257","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:1987872","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1987872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of internal medicine","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G5682494406","display_name":null,"funder_award_id":"FD-U-000073","funder_id":"https://openalex.org/F4320332163","funder_display_name":"U.S. Food and Drug Administration"}],"funders":[{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W106047938","https://openalex.org/W1966155743","https://openalex.org/W1969927128","https://openalex.org/W1988257004","https://openalex.org/W1992897439","https://openalex.org/W1995294317","https://openalex.org/W2007260789","https://openalex.org/W2022399850","https://openalex.org/W2043990466","https://openalex.org/W2050386945","https://openalex.org/W2063811212","https://openalex.org/W2067379889","https://openalex.org/W2102758200","https://openalex.org/W2105870750","https://openalex.org/W2117680210","https://openalex.org/W2122159614","https://openalex.org/W2128646065","https://openalex.org/W2135066869","https://openalex.org/W2141248662","https://openalex.org/W2148972704","https://openalex.org/W2163226435","https://openalex.org/W2266405673","https://openalex.org/W2271597477","https://openalex.org/W2318051686","https://openalex.org/W2320705810","https://openalex.org/W2411419883","https://openalex.org/W2566184021","https://openalex.org/W3126760576"],"related_works":["https://openalex.org/W1969927128","https://openalex.org/W1926898034","https://openalex.org/W7097591687","https://openalex.org/W2122159614","https://openalex.org/W7098117681","https://openalex.org/W2151434890","https://openalex.org/W1980105641","https://openalex.org/W2618677665","https://openalex.org/W2031760606","https://openalex.org/W2002089838"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"evaluate":[2],"the":[3,14,41,84,113,130,143,152,165,175,180,186,223],"relative":[4,81,121,134],"risk":[5,82,114,122,135,148,188,215,235],"for":[6,50,83,129,142,196,216,252],"peptic":[7,52,87,172,257],"ulcer":[8,53,88,197,218,258],"disease":[9,54,89,198,219,259],"that":[10,100,211,233,244],"is":[11,167,220],"associated":[12,189,221],"with":[13,99,116,190,222,237],"use":[15,156,181,192,224,242,245],"of":[16,34,71,86,93,123,136,155,171,182,202,225,241,246,256],"nonaspirin":[17,94,226],"nonsteroidal":[18,95,227],"anti-inflammatory":[19,96,228],"drugs.":[20,229],"DESIGN:":[21],"Nested":[22],"case-control":[23],"study.":[24,42],"SETTING:":[25],"Tennessee":[26],"Medicaid":[27,30,73],"program.":[28],"PARTICIPANTS:":[29],"enrollees":[31],"65":[32],"years":[33],"age":[35],"or":[36],"older":[37],"were":[38],"included":[39],"in":[40,151,174],"The":[43,62,79,147,230],"1415":[44],"case":[45],"patients":[46],"had":[47],"been":[48],"hospitalized":[49],"confirmed":[51],"at":[55],"some":[56],"point":[57],"from":[58,119,179],"1984":[59],"through":[60],"1986.":[61],"7063":[63],"control":[64],"persons":[65],"represented":[66],"a":[67,120,133,212,253],"stratified":[68],"random":[69],"sample":[70,177],"other":[72,208],"enrollees.":[74],"MEASUREMENTS":[75],"AND":[76],"MAIN":[77],"RESULTS:":[78],"estimated":[80],"development":[85],"among":[90,101,260],"current":[91,111],"users":[92],"drugs,":[97,184],"compared":[98],"nonusers,":[102],"was":[103,149,193],"4.1":[104],"(95%":[105],"CI,":[106,160],"3.5":[107],"to":[108,127,132,140,162],"4.7).":[109],"For":[110],"users,":[112],"increased":[115],"increasing":[117],"dose,":[118],"2.8":[124],"(CI,":[125,138],"1.8":[126],"4.3)":[128],"lowest":[131],"8.0":[137],"4.4":[139],"14.8)":[141],"highest":[144],"dose":[145,238],"category.":[146],"greatest":[150],"first":[153],"month":[154],"(relative":[157],"risk,":[158],"7.2;":[159],"4.9":[161],"10.5).":[163],"If":[164],"association":[166],"fully":[168],"causal,":[169],"29%":[170],"ulcers":[173],"study":[176],"resulted":[178],"these":[183,247],"and":[185,239,243],"excess":[187],"such":[191],"17.4":[194],"hospitalizations":[195],"per":[199],"1000":[200],"person-years":[201],"exposure.":[203],"CONCLUSIONS:":[204],"These":[205],"data":[206,231],"support":[207],"findings":[209],"indicating":[210],"clinically":[213],"significant":[214],"serious":[217],"show":[232],"this":[234],"increases":[236],"recency":[240],"drugs":[248],"may":[249],"be":[250],"responsible":[251],"large":[254],"proportion":[255],"elderly":[261],"persons.":[262]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":10},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":25}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}