{"id":"https://openalex.org/W205408129","doi":"https://doi.org/10.1007/s00213-002-1384-8","title":"Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats","display_name":"Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats","publication_year":2003,"publication_date":"2003-03-11","ids":{"openalex":"https://openalex.org/W205408129","doi":"https://doi.org/10.1007/s00213-002-1384-8","mag":"205408129","pmid":"https://pubmed.ncbi.nlm.nih.gov/12632249"},"language":"en","primary_location":{"id":"doi:10.1007/s00213-002-1384-8","doi":"https://doi.org/10.1007/s00213-002-1384-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00213-002-1384-8","pdf_url":null,"source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112909290","display_name":"Steve P. Vickers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267997","display_name":"Vernalis (R&D) Limited (United Kingdom)","ror":"https://ror.org/05b1mdp86","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405267997"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"S. P. Vickers","raw_affiliation_strings":["Vernalis Research Limited, Oakdene Court, 613 Reading Road, RG41 5UA, Winnersh, Wokingham, UK. S.Vickers@vernalis.com","Vernalis Research Limited, Oakdene Court, Winnersh, Wokingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vernalis Research Limited, Oakdene Court, 613 Reading Road, RG41 5UA, Winnersh, Wokingham, UK. S.Vickers@vernalis.com","institution_ids":["https://openalex.org/I4405267997"]},{"raw_affiliation_string":"Vernalis Research Limited, Oakdene Court, Winnersh, Wokingham, UK","institution_ids":["https://openalex.org/I4405267997"]}]},{"author_position":"middle","author":{"id":null,"display_name":"L. J. Webster","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267997","display_name":"Vernalis (R&D) Limited (United Kingdom)","ror":"https://ror.org/05b1mdp86","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405267997"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"L. J. Webster","raw_affiliation_strings":["Vernalis Research Limited, Oakdene Court, 613 Reading Road, Winnersh, Wokingham, RG41 5UA, UK","Vernalis Research Limited, Oakdene Court, Winnersh, Wokingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vernalis Research Limited, Oakdene Court, 613 Reading Road, Winnersh, Wokingham, RG41 5UA, UK","institution_ids":["https://openalex.org/I4405267997"]},{"raw_affiliation_string":"Vernalis Research Limited, Oakdene Court, Winnersh, Wokingham, UK","institution_ids":["https://openalex.org/I4405267997"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064184390","display_name":"A. C. Wyatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267997","display_name":"Vernalis (R&D) Limited (United Kingdom)","ror":"https://ror.org/05b1mdp86","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405267997"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"A. Wyatt","raw_affiliation_strings":["Vernalis Research Limited, Oakdene Court, 613 Reading Road, Winnersh, Wokingham, RG41 5UA, UK","Vernalis Research Limited, Oakdene Court, Winnersh, Wokingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vernalis Research Limited, Oakdene Court, 613 Reading Road, Winnersh, Wokingham, RG41 5UA, UK","institution_ids":["https://openalex.org/I4405267997"]},{"raw_affiliation_string":"Vernalis Research Limited, Oakdene Court, Winnersh, Wokingham, UK","institution_ids":["https://openalex.org/I4405267997"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089441909","display_name":"Colin Trevor Dourish","orcid":"https://orcid.org/0000-0002-3403-6330","observed_orcids":["https://orcid.org/0000-0002-3403-6330"]},"institutions":[{"id":"https://openalex.org/I4405267997","display_name":"Vernalis (R&D) Limited (United Kingdom)","ror":"https://ror.org/05b1mdp86","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405267997"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"C. T. Dourish","raw_affiliation_strings":["Vernalis Research Limited, Oakdene Court, 613 Reading Road, Winnersh, Wokingham, RG41 5UA, UK","Vernalis Research Limited, Oakdene Court, Winnersh, Wokingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vernalis Research Limited, Oakdene Court, 613 Reading Road, Winnersh, Wokingham, RG41 5UA, UK","institution_ids":["https://openalex.org/I4405267997"]},{"raw_affiliation_string":"Vernalis Research Limited, Oakdene Court, Winnersh, Wokingham, UK","institution_ids":["https://openalex.org/I4405267997"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111548142","display_name":"G.A. Kennett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405267997","display_name":"Vernalis (R&D) Limited (United Kingdom)","ror":"https://ror.org/05b1mdp86","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405267997"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"G. A. Kennett","raw_affiliation_strings":["Vernalis Research Limited, Oakdene Court, 613 Reading Road, Winnersh, Wokingham, RG41 5UA, UK","Vernalis Research Limited, Oakdene Court, Winnersh, Wokingham, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vernalis Research Limited, Oakdene Court, 613 Reading Road, Winnersh, Wokingham, RG41 5UA, UK","institution_ids":["https://openalex.org/I4405267997"]},{"raw_affiliation_string":"Vernalis Research Limited, Oakdene Court, Winnersh, Wokingham, UK","institution_ids":["https://openalex.org/I4405267997"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112909290"],"corresponding_institution_ids":["https://openalex.org/I4405267997"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":null,"fwci":9.4271,"has_fulltext":false,"cited_by_count":207,"citation_normalized_percentile":{"value":0.98594756,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"167","issue":"1","first_page":"103","last_page":"111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10414","display_name":"Cannabis and Cannabinoid Research","score":0.9643999934196472,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.03280000016093254,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sr141716","display_name":"SR141716","score":0.9879999756813049},{"id":"https://openalex.org/keywords/rimonabant","display_name":"rimonabant","score":0.7839999794960022},{"id":"https://openalex.org/keywords/cb1-receptor-antagonist","display_name":"CB1 receptor antagonist","score":0.8460000157356262},{"id":"https://openalex.org/keywords/food-consumption","display_name":"dietary intake","score":0.8970000147819519},{"id":"https://openalex.org/keywords/weight-gain","display_name":"weight gain","score":0.972000002861023},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.9509999752044678},{"id":"https://openalex.org/keywords/zucker-rats","display_name":"Zucker rats","score":0.7329999804496765},{"id":"https://openalex.org/keywords/obese-zucker-rats","display_name":"Zucker fatty rats","score":0.6650000214576721},{"id":"https://openalex.org/keywords/sibutramine","display_name":"sibutramine","score":0.9190000295639038},{"id":"https://openalex.org/keywords/pair-feeding","display_name":"pair feeding","score":0.7319999933242798},{"id":"https://openalex.org/keywords/food-intake-reduction","display_name":"hypophagia","score":0.8510000109672546},{"id":"https://openalex.org/keywords/drug-withdrawal","display_name":"drug withdrawal","score":0.7099999785423279},{"id":"https://openalex.org/keywords/motor-side-effects","display_name":"motor side effects","score":0.6669999957084656},{"id":"https://openalex.org/keywords/tolerance-pharmacology-and-immunology","display_name":"tolerance (pharmacology and immunology)","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C2776433454","wikidata":"https://www.wikidata.org/wiki/Q412529","display_name":"Rimonabant","level":5,"score":0.7612659931182861},{"id":"https://openalex.org/C148001335","wikidata":"https://www.wikidata.org/wiki/Q421237","display_name":"Cannabinoid receptor","level":4,"score":0.709579348564148},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6853798627853394},{"id":"https://openalex.org/C2780871563","wikidata":"https://www.wikidata.org/wiki/Q422936","display_name":"Cannabinoid","level":3,"score":0.6812493801116943},{"id":"https://openalex.org/C2780433416","wikidata":"https://www.wikidata.org/wiki/Q5032579","display_name":"Cannabinoid receptor antagonist","level":5,"score":0.6639098525047302},{"id":"https://openalex.org/C2780320433","wikidata":"https://www.wikidata.org/wiki/Q3403879","display_name":"Weight gain","level":3,"score":0.5546334981918335},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5079343914985657},{"id":"https://openalex.org/C3018685816","wikidata":"https://www.wikidata.org/wiki/Q213449","display_name":"Food intake","level":2,"score":0.5055422782897949},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47912856936454773},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.46321019530296326},{"id":"https://openalex.org/C2778563155","wikidata":"https://www.wikidata.org/wiki/Q190067","display_name":"Tetrahydrocannabinol","level":4,"score":0.4503265619277954},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.44605332612991333},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4332626461982727},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39782509207725525},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3631015419960022}],"mesh":[{"descriptor_ui":"D000077285","descriptor_name":"Rimonabant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001067","descriptor_name":"Appetite Depressants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002186","descriptor_name":"Cannabinoids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003503","descriptor_name":"Cyclobutanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004435","descriptor_name":"Eating","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009043","descriptor_name":"Motor Activity","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010880","descriptor_name":"Piperidines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011924","descriptor_name":"Rats, Zucker","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011955","descriptor_name":"Receptors, Drug","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015430","descriptor_name":"Weight Gain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D043882","descriptor_name":"Receptors, Cannabinoid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/s00213-002-1384-8","doi":"https://doi.org/10.1007/s00213-002-1384-8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s00213-002-1384-8","pdf_url":null,"source":{"id":"https://openalex.org/S80334769","display_name":"Psychopharmacology","issn_l":"0033-3158","issn":["0033-3158","1432-2072"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"journal-article"},{"id":"pmid:12632249","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12632249","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychopharmacology","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.5400000214576721,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W1491109154","https://openalex.org/W1832918544","https://openalex.org/W1963482720","https://openalex.org/W1983509349","https://openalex.org/W1984562645","https://openalex.org/W1989073099","https://openalex.org/W2002212385","https://openalex.org/W2005418044","https://openalex.org/W2016017780","https://openalex.org/W2024653583","https://openalex.org/W2031231313","https://openalex.org/W2033818328","https://openalex.org/W2045608641","https://openalex.org/W2057089014","https://openalex.org/W2059977407","https://openalex.org/W2069294328","https://openalex.org/W2075237064","https://openalex.org/W2075894678","https://openalex.org/W2087444912","https://openalex.org/W2096529235","https://openalex.org/W2097494859","https://openalex.org/W2112924959","https://openalex.org/W2119458823","https://openalex.org/W2165269657","https://openalex.org/W2170064412","https://openalex.org/W2398527518","https://openalex.org/W4239977862"],"related_works":["https://openalex.org/W2033818328","https://openalex.org/W2904631956","https://openalex.org/W2117870936","https://openalex.org/W2118147078","https://openalex.org/W2045608641","https://openalex.org/W1970140633","https://openalex.org/W1977256878","https://openalex.org/W110543184","https://openalex.org/W2014327394","https://openalex.org/W2093735817"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":15}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}