{"id":"https://openalex.org/W2054073715","doi":"https://doi.org/10.1073/pnas.96.25.14436","title":"Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops","display_name":"Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops","publication_year":1999,"publication_date":"1999-12-07","ids":{"openalex":"https://openalex.org/W2054073715","doi":"https://doi.org/10.1073/pnas.96.25.14436","mag":"2054073715","pmid":"https://pubmed.ncbi.nlm.nih.gov/10588723","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/24454"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.96.25.14436","doi":"https://doi.org/10.1073/pnas.96.25.14436","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.96.25.14436","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/24454","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062986426","display_name":"K. Gopal Murti","orcid":"https://orcid.org/0000-0001-9778-8575","observed_orcids":["https://orcid.org/0000-0001-9778-8575"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. G. Murti","raw_affiliation_strings":["Laboratory of Virology and Molecular Biology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105; and Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Virology and Molecular Biology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105; and Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309","institution_ids":["https://openalex.org/I1313298211","https://openalex.org/I188538660"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111750361","display_name":"David M. Prescott","orcid":"https://orcid.org/0000-0002-9798-9526","observed_orcids":["https://orcid.org/0000-0002-9798-9526"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]},{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D. M. Prescott","raw_affiliation_strings":["Laboratory of Virology and Molecular Biology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105; and Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Virology and Molecular Biology, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105; and Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309","institution_ids":["https://openalex.org/I1313298211","https://openalex.org/I188538660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111750361"],"corresponding_institution_ids":["https://openalex.org/I1313298211","https://openalex.org/I188538660"],"apc_list":null,"apc_paid":null,"fwci":6.9226,"has_fulltext":false,"cited_by_count":149,"citation_normalized_percentile":{"value":0.97475147,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"96","issue":"25","first_page":"14436","last_page":"14439"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.9883000254631042,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.0052999998442828655,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/telomeres","display_name":"telomeres","score":0.9929999709129333},{"id":"https://openalex.org/keywords/polytene-chromosomes","display_name":"polytene chromosomes","score":0.9729999899864197},{"id":"https://openalex.org/keywords/ciliates","display_name":"ciliates","score":0.7379999756813049},{"id":"https://openalex.org/keywords/t-loop","display_name":"T-loop","score":0.6179999709129333},{"id":"https://openalex.org/keywords/telomere-binding-proteins","display_name":"telomere-binding proteins","score":0.8529999852180481},{"id":"https://openalex.org/keywords/macronuclear-dna","display_name":"macronuclear DNA","score":0.8230000138282776},{"id":"https://openalex.org/keywords/hypotrich-ciliates","display_name":"hypotrich ciliates","score":0.6809999942779541}],"concepts":[{"id":"https://openalex.org/C51423104","wikidata":"https://www.wikidata.org/wiki/Q899773","display_name":"Polytene chromosome","level":4,"score":0.9527055025100708},{"id":"https://openalex.org/C177336024","wikidata":"https://www.wikidata.org/wiki/Q14872779","display_name":"Telomere","level":3,"score":0.7828556299209595},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.7533473968505859},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6725597977638245},{"id":"https://openalex.org/C99611785","wikidata":"https://www.wikidata.org/wiki/Q6453233","display_name":"Duplex (building)","level":3,"score":0.5825290679931641},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.47784945368766785},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.43197330832481384},{"id":"https://openalex.org/C2777166614","wikidata":"https://www.wikidata.org/wiki/Q1198419","display_name":"Tetrahymena","level":2,"score":0.4305492341518402},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4275251030921936},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4066026210784912},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3358173966407776},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14245519042015076}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002875","descriptor_name":"Chromosomes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016054","descriptor_name":"DNA, Protozoan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016615","descriptor_name":"Telomere","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016813","descriptor_name":"Oxytricha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.96.25.14436","doi":"https://doi.org/10.1073/pnas.96.25.14436","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.96.25.14436","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:24454","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/24454","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:10588723","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10588723","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:24454","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/24454","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G3439829674","display_name":"HYPOTRICH GENOME IN DEVELOPMENT AND EVOLUTION","funder_award_id":"R01GM056161","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G609259107","display_name":null,"funder_award_id":"CA21765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G7573229021","display_name":null,"funder_award_id":"GM56161","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G9000086855","display_name":null,"funder_award_id":"CA21765)","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000904664","display_name":"Cancer Center Support Grant (CCSG)","funder_award_id":"P30CA021765","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":18,"referenced_works":["https://openalex.org/W1680843967","https://openalex.org/W1912524364","https://openalex.org/W1968309671","https://openalex.org/W1973552223","https://openalex.org/W1980314212","https://openalex.org/W1986808310","https://openalex.org/W1992842240","https://openalex.org/W2028618193","https://openalex.org/W2032407757","https://openalex.org/W2033731825","https://openalex.org/W2050674095","https://openalex.org/W2070864352","https://openalex.org/W2072744580","https://openalex.org/W2087011288","https://openalex.org/W2094420152","https://openalex.org/W2102839588","https://openalex.org/W2147274177","https://openalex.org/W2430397204"],"related_works":["https://openalex.org/W2131501858","https://openalex.org/W1964688752","https://openalex.org/W2040660081","https://openalex.org/W2626164374","https://openalex.org/W2004378202","https://openalex.org/W7073557738","https://openalex.org/W30323203","https://openalex.org/W1448383444","https://openalex.org/W81622432","https://openalex.org/W2005576986"],"abstract_inverted_index":{"The":[0,40],"end":[1,47],"of":[2,12,35,48,74],"a":[3,9,13,26,49,55,63],"telomeric":[4,22,42],"DNA":[5,38,43,75],"sequence":[6,23,44],"isolated":[7],"from":[8],"polytene":[10],"chromosome":[11],"hypotrichous":[14],"ciliate":[15],"folds":[16],"back":[17],"and":[18,37],"hybridizes":[19],"with":[20,62],"downstream":[21],"to":[24],"form":[25,54],"t":[27,56],"loop":[28,57],"that":[29],"is":[30,60],"stable":[31],"in":[32,79],"the":[33,46,72,80],"absence":[34],"protein":[36],"cross-linking.":[39],"single-stranded,":[41],"at":[45],"macronuclear":[50],"molecule":[51],"does":[52],"not":[53],"but,":[58],"instead,":[59],"complexed":[61],"heterodimeric,":[64],"telomere-binding":[65],"protein.":[66],"Thus,":[67],"two":[68],"mechanisms":[69],"for":[70],"capping":[71],"ends":[73],"molecules":[76],"are":[77],"used":[78],"same":[81],"cell.":[82]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}