{"id":"https://openalex.org/W2054068221","doi":"https://doi.org/10.1002/jor.1100130410","title":"Microvessel endothelial cells and pericytes increase proliferation and repress osteoblast phenotypic markers in rat calvarial bone cell cultures","display_name":"Microvessel endothelial cells and pericytes increase proliferation and repress osteoblast phenotypic markers in rat calvarial bone cell cultures","publication_year":1995,"publication_date":"1995-07-01","ids":{"openalex":"https://openalex.org/W2054068221","doi":"https://doi.org/10.1002/jor.1100130410","mag":"2054068221","pmid":"https://pubmed.ncbi.nlm.nih.gov/7674071"},"language":"en","primary_location":{"id":"doi:10.1002/jor.1100130410","doi":"https://doi.org/10.1002/jor.1100130410","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jor.1100130410","pdf_url":null,"source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"A. R. Jones","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A. R. Jones","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, USA","Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087926625","display_name":"Corinna C.A. Clark","orcid":"https://orcid.org/0000-0002-1077-9383","observed_orcids":["https://orcid.org/0000-0002-1077-9383"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. C. Clark","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043516951","display_name":"Carl T. Brighton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. T. Brighton","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, U.S.A","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":3970,"currency":"USD","value_usd":3970},"apc_paid":null,"fwci":0.1179,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.37971757,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"13","issue":"4","first_page":"553","last_page":"561"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.9502000212669373,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.015599999576807022,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microvascular-endothelial-cells","display_name":"microvascular endothelial cells","score":0.871999979019165},{"id":"https://openalex.org/keywords/pericytes","display_name":"pericytes","score":0.9919999837875366},{"id":"https://openalex.org/keywords/osteoblast-proliferation","display_name":"osteoblast proliferation","score":0.8050000071525574},{"id":"https://openalex.org/keywords/osteoblast-phenotype","display_name":"osteoblast phenotype","score":0.8299999833106995},{"id":"https://openalex.org/keywords/conditioned-medium","display_name":"conditioned medium","score":0.7009999752044678},{"id":"https://openalex.org/keywords/osteocalcin","display_name":"osteocalcin","score":0.8420000076293945},{"id":"https://openalex.org/keywords/mineralization","display_name":"mineralization","score":0.6890000104904175},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9100000262260437},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C2776436680","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microvessel","level":3,"score":0.7681339979171753},{"id":"https://openalex.org/C2778260815","wikidata":"https://www.wikidata.org/wiki/Q917177","display_name":"Osteoblast","level":3,"score":0.6744325160980225},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.5156506299972534},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5068400502204895},{"id":"https://openalex.org/C131075544","wikidata":"https://www.wikidata.org/wiki/Q415863","display_name":"Osteocalcin","level":4,"score":0.49366340041160583},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4481675326824188},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4225386381149292},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.4215025305747986},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39615464210510254},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.3117007613182068},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1885186731815338},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.11908191442489624},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07453656196594238},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002450","descriptor_name":"Cell Communication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003584","descriptor_name":"Cytological Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D004730","descriptor_name":"Endothelium, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008833","descriptor_name":"Microcirculation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012886","descriptor_name":"Skull","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/jor.1100130410","doi":"https://doi.org/10.1002/jor.1100130410","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jor.1100130410","pdf_url":null,"source":{"id":"https://openalex.org/S12558119","display_name":"Journal of Orthopaedic Research\u00ae","issn_l":"0736-0266","issn":["0736-0266","1554-527X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Orthopaedic Research","raw_type":"journal-article"},{"id":"pmid:7674071","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7674071","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of orthopaedic research : official publication of the Orthopaedic Research Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1653616501","display_name":null,"funder_award_id":"AR18033-18","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W4248270","https://openalex.org/W91016331","https://openalex.org/W199546835","https://openalex.org/W410508409","https://openalex.org/W1485771066","https://openalex.org/W1587747486","https://openalex.org/W1960834864","https://openalex.org/W1965770390","https://openalex.org/W1969085849","https://openalex.org/W1969251725","https://openalex.org/W1977779461","https://openalex.org/W1982987807","https://openalex.org/W1994858403","https://openalex.org/W2003523753","https://openalex.org/W2004646567","https://openalex.org/W2009902709","https://openalex.org/W2010449052","https://openalex.org/W2013456954","https://openalex.org/W2014624625","https://openalex.org/W2014795764","https://openalex.org/W2026764472","https://openalex.org/W2044183367","https://openalex.org/W2052127095","https://openalex.org/W2057547518","https://openalex.org/W2070145069","https://openalex.org/W2073780395","https://openalex.org/W2079953735","https://openalex.org/W2085216816","https://openalex.org/W2088822460","https://openalex.org/W2095589986","https://openalex.org/W2097038881","https://openalex.org/W2098400443","https://openalex.org/W2108337314","https://openalex.org/W2115641485","https://openalex.org/W2122805183","https://openalex.org/W2126800859","https://openalex.org/W2128118061","https://openalex.org/W2129228358","https://openalex.org/W2129789701","https://openalex.org/W2156347579","https://openalex.org/W2164486535","https://openalex.org/W2181263782","https://openalex.org/W2242333378","https://openalex.org/W2288473469","https://openalex.org/W2306485344","https://openalex.org/W2341093174","https://openalex.org/W2396483744","https://openalex.org/W2401454962","https://openalex.org/W2409809974","https://openalex.org/W2415110481","https://openalex.org/W2494883120","https://openalex.org/W2914333680"],"related_works":["https://openalex.org/W7027399182","https://openalex.org/W2033609596","https://openalex.org/W2030643309","https://openalex.org/W2768222022","https://openalex.org/W2010449052","https://openalex.org/W2044183367","https://openalex.org/W1968160382","https://openalex.org/W2351948778","https://openalex.org/W1835096966","https://openalex.org/W2090275264"],"abstract_inverted_index":{"To":[0],"investigate":[1],"the":[2,105,110,124,133,141,151,155,199,207],"influence":[3,169],"of":[4,13,38,63,102,107,112,157,170,189,195,201,206],"microvessel":[5,84,97,125,134,172],"cells":[6,16,20,40,65,68,85,159,173,177],"on":[7,154,174],"osteoblasts,":[8],"we":[9],"exposed":[10],"osteoblast-enriched":[11,175],"cultures":[12,48,101,136,156],"rat":[14],"calvarial":[15,176],"to":[17,66,74,83,93,120,129,146,164,180],"cultured":[18],"endothelial":[19,39,67],"and":[21,29,55,90,109,192,203],"pericytes":[22,42],"using":[23],"feeder-layer":[24],"co-cultures,":[25],"co-culture":[26,87],"dish":[27,88],"inserts,":[28],"conditioned":[30,95,122,130,166],"media":[31,94,121,131],"experiments.":[32],"When":[33],"co-cultured":[34],"with":[35],"growth-arrested":[36],"feeder-layers":[37],"or":[41],"for":[43,137],"10":[44],"days,":[45,139],"bone":[46,64,103,158],"cell":[47,53,135,147,190],"showed":[49],"an":[50],"increase":[51],"in":[52,57,86,198],"number":[54,111],"reduction":[56,197],"alkaline":[58],"phosphatase":[59],"activity.":[60],"The":[61,168],"response":[62,73,78],"was":[69,79,178],"nearly":[70,150],"twice":[71],"their":[72],"pericytes.":[75],"A":[76],"similar":[77],"demonstrated":[80],"by":[81,91,96,118,123,185],"exposure":[82,92,119,128,163],"inserts":[89],"cells.":[98,126],"In":[99],"long-term":[100],"cells,":[104],"levels":[106],"osteocalcin":[108],"mineralized":[113],"nodules":[114],"both":[115],"were":[116],"reduced":[117],"Transient":[127],"from":[132,143],"3":[138],"during":[140],"period":[142],"initial":[144],"plating":[145],"confluence,":[148],"produced":[149],"same":[152],"effect":[153],"as":[160],"did":[161],"continuous":[162],"these":[165],"media.":[167],"isolated":[171],"found":[179],"be":[181],"primarily":[182],"mitogenic,":[183],"mediated":[184],"soluble":[186],"factors,":[187],"independent":[188],"contact,":[191],"a":[193],"cause":[194],"prolonged":[196],"expression":[200],"early":[202],"late":[204],"markers":[205],"osteoblast":[208],"phenotype.":[209]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
