{"id":"https://openalex.org/W2054063883","doi":"https://doi.org/10.1021/bc060224s","title":"Acidic Hydrolysis of N-Ethoxybenzylimidazoles (NEBIs): Potential Applications as pH-Sensitive Linkers for Drug Delivery","display_name":"Acidic Hydrolysis of N-Ethoxybenzylimidazoles (NEBIs): Potential Applications as pH-Sensitive Linkers for Drug Delivery","publication_year":2007,"publication_date":"2007-01-30","ids":{"openalex":"https://openalex.org/W2054063883","doi":"https://doi.org/10.1021/bc060224s","mag":"2054063883","pmid":"https://pubmed.ncbi.nlm.nih.gov/17261055","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3260555"},"language":"en","primary_location":{"id":"doi:10.1021/bc060224s","doi":"https://doi.org/10.1021/bc060224s","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc060224s","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3260555","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088709270","display_name":"Seong Deok Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seong Deok Kong","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, and Department of Medicine and the Rebecca and John Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, MC 0819, La Jolla, California 92093. Received\u2009July 20, 2006"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, and Department of Medicine and the Rebecca and John Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, MC 0819, La Jolla, California 92093. Received\u2009July 20, 2006","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108369485","display_name":"A. Khai Luong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alice Luong","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, and Department of Medicine and the Rebecca and John Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, MC 0819, La Jolla, California 92093. Received\u2009July 20, 2006"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, and Department of Medicine and the Rebecca and John Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, MC 0819, La Jolla, California 92093. Received\u2009July 20, 2006","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085431984","display_name":"Gerald Manorek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald Manorek","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, and Department of Medicine and the Rebecca and John Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, MC 0819, La Jolla, California 92093. Received\u2009July 20, 2006"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, and Department of Medicine and the Rebecca and John Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, MC 0819, La Jolla, California 92093. Received\u2009July 20, 2006","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024148760","display_name":"Stephen B. Howell","orcid":"https://orcid.org/0000-0002-0877-8226","observed_orcids":["https://orcid.org/0000-0002-0877-8226"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen B. Howell","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, and Department of Medicine and the Rebecca and John Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, MC 0819, La Jolla, California 92093. Received\u2009July 20, 2006"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, and Department of Medicine and the Rebecca and John Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, MC 0819, La Jolla, California 92093. Received\u2009July 20, 2006","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047600505","display_name":"Jerry Yang","orcid":"https://orcid.org/0000-0002-8423-7376","observed_orcids":["https://orcid.org/0000-0002-8423-7376","https://orcid.org/0009-0008-6372-2269"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]},{"id":"https://openalex.org/I4390039236","display_name":"Moores Cancer Center","ror":"https://ror.org/01qkmtm61","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2800935791","https://openalex.org/I36258959","https://openalex.org/I4390039236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jerry Yang","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, and Department of Medicine and the Rebecca and John Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, MC 0819, La Jolla, California 92093. Received\u2009July 20, 2006"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0358, and Department of Medicine and the Rebecca and John Moores Cancer Center, University of California, San Diego, 3855 Health Sciences Drive, MC 0819, La Jolla, California 92093. Received\u2009July 20, 2006","institution_ids":["https://openalex.org/I36258959","https://openalex.org/I4390039236"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":1.1855,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.74929736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"18","issue":"2","first_page":"293","last_page":"296"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.5644999742507935,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Synthesis and biological activity","score":0.2280000001192093,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.025299999862909317,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acid-hydrolysis","display_name":"acid hydrolysis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/ph-sensitive-linker","display_name":"pH-sensitive linker","score":0.949999988079071},{"id":"https://openalex.org/keywords/cleavable-linkers","display_name":"cleavable linkers","score":0.9829999804496765},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.675000011920929},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.7179999947547913},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.9020000100135803},{"id":"https://openalex.org/keywords/hydrolysis-kinetics","display_name":"hydrolysis kinetics","score":0.8939999938011169},{"id":"https://openalex.org/keywords/substituent-effects","display_name":"substituent effects","score":0.7559999823570251},{"id":"https://openalex.org/keywords/ovarian-cancer-cells","display_name":"ovarian cancer cells","score":0.6890000104904175},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9049999713897705}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.951318621635437},{"id":"https://openalex.org/C94412978","wikidata":"https://www.wikidata.org/wiki/Q103135","display_name":"Hydrolysis","level":2,"score":0.8142144680023193},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.728766918182373},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.683214545249939},{"id":"https://openalex.org/C2780874372","wikidata":"https://www.wikidata.org/wiki/Q328692","display_name":"Imidazole","level":2,"score":0.5939950346946716},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.5885134339332581},{"id":"https://openalex.org/C184651966","wikidata":"https://www.wikidata.org/wiki/Q906356","display_name":"Aqueous solution","level":2,"score":0.5763012170791626},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5388185381889343},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.28962671756744385},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.27748045325279236},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.17904797196388245},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.059688717126846313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000143","descriptor_name":"Acids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001562","descriptor_name":"Benzimidazoles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006868","descriptor_name":"Hydrolysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1021/bc060224s","doi":"https://doi.org/10.1021/bc060224s","is_oa":false,"landing_page_url":"https://doi.org/10.1021/bc060224s","pdf_url":null,"source":{"id":"https://openalex.org/S155115410","display_name":"Bioconjugate Chemistry","issn_l":"1043-1802","issn":["1043-1802","1520-4812"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate Chemistry","raw_type":"journal-article"},{"id":"pmid:17261055","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17261055","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioconjugate chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2267348","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3260555","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3260555","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3260555","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Bioconjug Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2267348","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3260555","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G188814414","display_name":null,"funder_award_id":"CA-95298","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G2972427216","display_name":"Cisplatin resistance mediated by copper export pathways","funder_award_id":"R01CA095298","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":20,"referenced_works":["https://openalex.org/W55597549","https://openalex.org/W224340457","https://openalex.org/W568941435","https://openalex.org/W648363112","https://openalex.org/W1551442147","https://openalex.org/W1565731923","https://openalex.org/W1602020336","https://openalex.org/W1970163076","https://openalex.org/W1986475980","https://openalex.org/W1986960592","https://openalex.org/W1999887939","https://openalex.org/W2009306453","https://openalex.org/W2013980860","https://openalex.org/W2033385652","https://openalex.org/W2034486404","https://openalex.org/W2034672341","https://openalex.org/W2040273584","https://openalex.org/W2043028694","https://openalex.org/W2058417598","https://openalex.org/W2120103427"],"related_works":["https://openalex.org/W2312896007","https://openalex.org/W297047355","https://openalex.org/W2000285060","https://openalex.org/W343523509","https://openalex.org/W3112601229","https://openalex.org/W2031772179","https://openalex.org/W831835304","https://openalex.org/W2040273584","https://openalex.org/W1966004066","https://openalex.org/W2947623685"],"abstract_inverted_index":{"This":[0],"paper":[1],"describes":[2],"the":[3,62,66,70,74,124],"development":[4],"of":[5,9,26,29,36,54,65,76,91,105,150,162],"a":[6,95,140,147],"new":[7],"class":[8],"N-linked":[10],"imidazoles":[11],"as":[12],"potential":[13],"pH-sensitive,":[14],"cleavable":[15],"linkers":[16],"for":[17,145,159,164],"use":[18],"in":[19,40,47,69],"cancer":[20,135],"drug":[21,165],"delivery":[22,154,166],"systems.":[23],"Kinetic":[24],"analysis":[25],"eight":[27],"derivatives":[28],"N-ethoxybenzylimidazoles":[30],"(NEBIs)":[31],"showed":[32,101],"that":[33,112],"their":[34],"rates":[35,75],"hydrolysis":[37,77,106,122],"are":[38],"accelerated":[39],"mild":[41,79,108],"aqueous":[42],"acidic":[43,80],"solutions":[44,48],"compared":[45,110],"to":[46,72,87,111,132,152],"at":[49,113],"normal,":[50],"physiological":[51,115],"pH.":[52,116],"Incorporation":[53],"electron":[55,58],"donating":[56],"or":[57],"withdrawing":[59],"substituents":[60],"on":[61],"phenyl":[63],"ring":[64],"NEBI":[67,92,125,157],"resulted":[68],"ability":[71],"tune":[73],"under":[78,107],"conditions":[81],"with":[82],"half-lives":[83],"ranging":[84],"from":[85,121,123],"minutes":[86],"months.":[88],"A":[89],"derivative":[90],"carrying":[93],"doxorubicin,":[94],"widely":[96],"used":[97],"anticancer":[98],"agent,":[99],"also":[100],"an":[102],"increased":[103],"rate":[104],"acid":[109],"normal":[114],"The":[117],"doxorubicin":[118],"analogue":[119],"resulting":[120],"exhibited":[126],"good":[127],"cytotoxic":[128],"activity":[129],"when":[130],"exposed":[131],"human":[133],"ovarian":[134],"cells.":[136],"These":[137],"results":[138],"demonstrate":[139],"potentially":[141],"useful,":[142],"general":[143],"strategy":[144],"conjugating":[146],"wide":[148],"range":[149],"drugs":[151],"imidazole-containing":[153],"vessels":[155],"via":[156],"functionalities":[158],"controlled":[160],"release":[161],"therapeutics":[163],"applications.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
