{"id":"https://openalex.org/W2054054935","doi":"https://doi.org/10.1038/npp.2009.40","title":"Attention Deficits and Hyperactivity Following Inhibition of cAMP-Dependent Protein Kinase Within the Medial Prefrontal Cortex of Rats","display_name":"Attention Deficits and Hyperactivity Following Inhibition of cAMP-Dependent Protein Kinase Within the Medial Prefrontal Cortex of Rats","publication_year":2009,"publication_date":"2009-04-22","ids":{"openalex":"https://openalex.org/W2054054935","doi":"https://doi.org/10.1038/npp.2009.40","mag":"2054054935","pmid":"https://pubmed.ncbi.nlm.nih.gov/19387423","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2721023"},"language":"en","primary_location":{"id":"doi:10.1038/npp.2009.40","doi":"https://doi.org/10.1038/npp.2009.40","is_oa":false,"landing_page_url":"https://doi.org/10.1038/npp.2009.40","pdf_url":null,"source":{"id":"https://openalex.org/S175030738","display_name":"Neuropsychopharmacology","issn_l":"0893-133X","issn":["0893-133X","1740-634X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2721023","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029790599","display_name":"Tracie A. Paine","orcid":"https://orcid.org/0000-0002-9780-0658","observed_orcids":["https://orcid.org/0000-0002-9780-0658"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tracie A Paine","raw_affiliation_strings":["Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Behavioral Genetics Laboratory, Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02478, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084260138","display_name":"Rachael L. Neve","orcid":"https://orcid.org/0000-0002-3854-5968","observed_orcids":["https://orcid.org/0000-0002-3854-5968"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachael L Neve","raw_affiliation_strings":["Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, MA, USA","Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]},{"raw_affiliation_string":"Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024383091","display_name":"William A. Carlezon","orcid":"https://orcid.org/0000-0002-4162-3947","observed_orcids":["https://orcid.org/0000-0002-4162-3947"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William A Carlezon","raw_affiliation_strings":["Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, MA, USA","Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]},{"raw_affiliation_string":"Department of Psychiatry, Behavioral Genetics Laboratory, Harvard Medical School, McLean Hospital, Belmont, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024383091"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":null,"fwci":2.2122,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.86055154,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"34","issue":"9","first_page":"2143","last_page":"2155"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.7954000234603882,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.7954000234603882,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.12129999697208405,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10042","display_name":"Neural and Behavioral Psychology Studies","score":0.04800000041723251,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.8939999938011169},{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.8669999837875366},{"id":"https://openalex.org/keywords/attention-deficits","display_name":"attention deficits","score":0.8029999732971191},{"id":"https://openalex.org/keywords/hyperactivity","display_name":"hyperactivity","score":0.972000002861023},{"id":"https://openalex.org/keywords/five-choice-serial-reaction-time-task","display_name":"5-choice serial reaction time task","score":0.8939999938011169},{"id":"https://openalex.org/keywords/rp-camps","display_name":"Rp-cAMPS","score":0.9950000047683716},{"id":"https://openalex.org/keywords/creb","display_name":"CREB","score":0.8299999833106995},{"id":"https://openalex.org/keywords/dopamine-d1-receptor","display_name":"dopamine D1 receptor","score":0.8600000143051147},{"id":"https://openalex.org/keywords/intracranial-self-stimulation","display_name":"intracranial self-stimulation","score":0.8519999980926514},{"id":"https://openalex.org/keywords/locomotor-activity","display_name":"locomotor activity","score":0.9290000200271606},{"id":"https://openalex.org/keywords/motivation","display_name":"motivation","score":0.7149999737739563},{"id":"https://openalex.org/keywords/attention-disorders","display_name":"attention disorders","score":0.5460000038146973}],"concepts":[{"id":"https://openalex.org/C1629964","wikidata":"https://www.wikidata.org/wiki/Q106950729","display_name":"CREB","level":4,"score":0.77678382396698},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.7502807378768921},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.680431067943573},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.63248610496521},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6163192391395569},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.5835568308830261},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.48189741373062134},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40535977482795715},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.26190996170043945},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.2223038673400879},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.10269039869308472},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001288","descriptor_name":"Attention","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001288","descriptor_name":"Attention","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D003216","descriptor_name":"Conditioning, Operant","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003216","descriptor_name":"Conditioning, Operant","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006948","descriptor_name":"Hyperkinesis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006948","descriptor_name":"Hyperkinesis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008124","descriptor_name":"Locomotion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008124","descriptor_name":"Locomotion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009042","descriptor_name":"Motivation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012201","descriptor_name":"Reward","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013873","descriptor_name":"Thionucleotides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017362","descriptor_name":"Cyclic AMP Response Element-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047428","descriptor_name":"Protein Kinase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/npp.2009.40","doi":"https://doi.org/10.1038/npp.2009.40","is_oa":false,"landing_page_url":"https://doi.org/10.1038/npp.2009.40","pdf_url":null,"source":{"id":"https://openalex.org/S175030738","display_name":"Neuropsychopharmacology","issn_l":"0893-133X","issn":["0893-133X","1740-634X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology","raw_type":"journal-article"},{"id":"pmid:19387423","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19387423","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2721023","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2721023","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuropsychopharmacology","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2721023","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2721023","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Neuropsychopharmacology","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1060159567","display_name":null,"funder_award_id":"MH063266","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G1516746877","display_name":null,"funder_award_id":"R01-MH063266","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G7239955458","display_name":null,"funder_award_id":"MH063266","funder_id":"https://openalex.org/F4320311440","funder_display_name":"National Alliance for Research on Schizophrenia and Depression"},{"id":"https://openalex.org/G9000894046","display_name":"Roles of nuleus accumbens CREB and Kappa function in depression","funder_award_id":"5r01mh063266-25","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320311440","display_name":"National Alliance for Research on Schizophrenia and Depression","ror":"https://ror.org/03a63f080"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W249845531","https://openalex.org/W1497282495","https://openalex.org/W1508977838","https://openalex.org/W1564862048","https://openalex.org/W1599746996","https://openalex.org/W1659384861","https://openalex.org/W1870077474","https://openalex.org/W1928329059","https://openalex.org/W1964374986","https://openalex.org/W1974167019","https://openalex.org/W1976939343","https://openalex.org/W1977698553","https://openalex.org/W1979761329","https://openalex.org/W1980915383","https://openalex.org/W1986552088","https://openalex.org/W1988214498","https://openalex.org/W1995248718","https://openalex.org/W2014885375","https://openalex.org/W2016713233","https://openalex.org/W2016866955","https://openalex.org/W2017187845","https://openalex.org/W2018312069","https://openalex.org/W2020174502","https://openalex.org/W2025868648","https://openalex.org/W2026721213","https://openalex.org/W2027606489","https://openalex.org/W2028127185","https://openalex.org/W2030852267","https://openalex.org/W2050530976","https://openalex.org/W2053544091","https://openalex.org/W2056607057","https://openalex.org/W2057684612","https://openalex.org/W2057855503","https://openalex.org/W2059570857","https://openalex.org/W2067046066","https://openalex.org/W2070735891","https://openalex.org/W2086095238","https://openalex.org/W2086543171","https://openalex.org/W2088359631","https://openalex.org/W2113408108","https://openalex.org/W2113603549","https://openalex.org/W2117518771","https://openalex.org/W2119410682","https://openalex.org/W2128138139","https://openalex.org/W2139856187","https://openalex.org/W2158052449","https://openalex.org/W2163815564","https://openalex.org/W2200434255","https://openalex.org/W2321413400","https://openalex.org/W2955504961","https://openalex.org/W4241609236"],"related_works":["https://openalex.org/W7098256978","https://openalex.org/W2117518771","https://openalex.org/W2112593299","https://openalex.org/W2077470918","https://openalex.org/W2140736710","https://openalex.org/W2017995966","https://openalex.org/W3120514943","https://openalex.org/W2086095238","https://openalex.org/W1870077474","https://openalex.org/W2406326786"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}