{"id":"https://openalex.org/W2054037372","doi":"https://doi.org/10.1254/jjp.62.207","title":"Microinjection of \u03b1-Calcitonin Gene-Related Peptide into the Hypothalamus Activates Sympathetic Outflow in Rats","display_name":"Microinjection of \u03b1-Calcitonin Gene-Related Peptide into the Hypothalamus Activates Sympathetic Outflow in Rats","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2054037372","doi":"https://doi.org/10.1254/jjp.62.207","mag":"2054037372","pmid":"https://pubmed.ncbi.nlm.nih.gov/8371519"},"language":"en","primary_location":{"id":"doi:10.1254/jjp.62.207","doi":"https://doi.org/10.1254/jjp.62.207","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jjp.62.207","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021519819360391/pdf","source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.sciencedirect.com/science/article/pii/S0021519819360391/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104004813","display_name":"Takashi Hasegawa","orcid":"https://orcid.org/0009-0000-5362-531X","observed_orcids":["https://orcid.org/0009-0000-5362-531X"]},"institutions":[{"id":"https://openalex.org/I4210088960","display_name":"Kochi Medical School Hospital","ror":"https://ror.org/013rvtk45","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Hasegawa","raw_affiliation_strings":["Anesthesiology, Kochi Medical School, Nankoku, Kochi 783, Japan","Departments of Pharmacology, Kochi 783, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology, Kochi Medical School, Nankoku, Kochi 783, Japan","institution_ids":["https://openalex.org/I4210088960"]},{"raw_affiliation_string":"Departments of Pharmacology, Kochi 783, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108124814","display_name":"Kunihiko Yokotani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kunihiko Yokotani","raw_affiliation_strings":["Departments of Pharmacology, Kochi 783, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Kochi 783, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103520141","display_name":"Yasunobu Okuma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasunobu Okuma","raw_affiliation_strings":["Departments of Pharmacology, Kochi 783, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Kochi 783, Japan","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021928437","display_name":"Masanobu Manabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088960","display_name":"Kochi Medical School Hospital","ror":"https://ror.org/013rvtk45","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masanobu Manabe","raw_affiliation_strings":["Anesthesiology, Kochi Medical School, Nankoku, Kochi 783, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology, Kochi Medical School, Nankoku, Kochi 783, Japan","institution_ids":["https://openalex.org/I4210088960"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074476733","display_name":"Masahisa Hirakawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163770644","display_name":"Okayama University","ror":"https://ror.org/02pc6pc55","country_code":"JP","type":"education","lineage":["https://openalex.org/I163770644"]},{"id":"https://openalex.org/I4210088960","display_name":"Kochi Medical School Hospital","ror":"https://ror.org/013rvtk45","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210088960"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masahisa Hirakawa","raw_affiliation_strings":["Anesthesiology, Kochi Medical School, Nankoku, Kochi 783, Japan","Present address: Department of Anesthesiology, Okayama University Medical School, Okayama 700, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anesthesiology, Kochi Medical School, Nankoku, Kochi 783, Japan","institution_ids":["https://openalex.org/I4210088960"]},{"raw_affiliation_string":"Present address: Department of Anesthesiology, Okayama University Medical School, Okayama 700, Japan","institution_ids":["https://openalex.org/I163770644"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108453785","display_name":"Yoshitsugu Osumi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yoshitsugu Osumi","raw_affiliation_strings":["Departments of Pharmacology, Kochi 783, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Pharmacology, Kochi 783, Japan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108453785"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.6311,"has_fulltext":false,"cited_by_count":162,"citation_normalized_percentile":{"value":0.84582098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"62","issue":"2","first_page":"207","last_page":"210"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.9800000190734863,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0031999999191612005,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-calcitonin-gene-related-peptide","display_name":"alpha-calcitonin gene-related peptide","score":0.9629999995231628},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.9700000286102295},{"id":"https://openalex.org/keywords/paraventricular-nucleus","display_name":"paraventricular nucleus","score":0.9789999723434448},{"id":"https://openalex.org/keywords/sympathetic-outflow","display_name":"sympathetic outflow","score":0.9240000247955322},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9739999771118164},{"id":"https://openalex.org/keywords/epinephrine","display_name":"epinephrine","score":0.6460000276565552},{"id":"https://openalex.org/keywords/catecholamines","display_name":"catecholamines","score":0.8259999752044678},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.7839999794960022},{"id":"https://openalex.org/keywords/6-hydroxydopamine","display_name":"6-hydroxydopamine","score":0.7929999828338623},{"id":"https://openalex.org/keywords/electrical-stimulation","display_name":"electrical stimulation","score":0.46700000762939453},{"id":"https://openalex.org/keywords/hypothalamic-nuclei","display_name":"hypothalamic nuclei","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.730806291103363},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7296237945556641},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7024596929550171},{"id":"https://openalex.org/C62525196","wikidata":"https://www.wikidata.org/wiki/Q3311945","display_name":"Microinjection","level":2,"score":0.6774266958236694},{"id":"https://openalex.org/C198710026","wikidata":"https://www.wikidata.org/wiki/Q898218","display_name":"Renin\u2013angiotensin system","level":3,"score":0.6691771745681763},{"id":"https://openalex.org/C27016395","wikidata":"https://www.wikidata.org/wiki/Q128861","display_name":"Angiotensin-converting enzyme","level":3,"score":0.6386442184448242},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48081672191619873},{"id":"https://openalex.org/C2908560794","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin III","level":5,"score":0.4318392276763916},{"id":"https://openalex.org/C2777003273","wikidata":"https://www.wikidata.org/wiki/Q164386","display_name":"Hypothalamus","level":2,"score":0.41585439443588257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3159977197647095},{"id":"https://openalex.org/C123915805","wikidata":"https://www.wikidata.org/wiki/Q15332826","display_name":"Angiotensin II receptor type 1","level":4,"score":0.2022552490234375},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18257349729537964},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000803","descriptor_name":"Angiotensin I","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002216","descriptor_name":"Captopril","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013045","descriptor_name":"Species Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1254/jjp.62.207","doi":"https://doi.org/10.1254/jjp.62.207","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jjp.62.207","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021519819360391/pdf","source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},{"id":"pmid:8371519","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8371519","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese journal of pharmacology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1254/jjp.62.207","doi":"https://doi.org/10.1254/jjp.62.207","is_oa":true,"landing_page_url":"https://doi.org/10.1254/jjp.62.207","pdf_url":"https://www.sciencedirect.com/science/article/pii/S0021519819360391/pdf","source":{"id":"https://openalex.org/S190179609","display_name":"The Japanese Journal of Pharmacology","issn_l":"0021-5198","issn":["0021-5198","1347-3506"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310313602","host_organization_name":"Japanese Pharmacological Society","host_organization_lineage":["https://openalex.org/P4310313602"],"host_organization_lineage_names":["Japanese Pharmacological Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Japanese Journal of Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337519","display_name":"College of Agricultural, Consumer and Environmental Sciences, University of Illinois at Urbana-Champaign","ror":null}],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2054037372.pdf"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1815855529","https://openalex.org/W1965959070","https://openalex.org/W1975188133","https://openalex.org/W1980925491","https://openalex.org/W1984844894","https://openalex.org/W1991001977","https://openalex.org/W1991637403","https://openalex.org/W1996088836","https://openalex.org/W1998371838","https://openalex.org/W1999230592","https://openalex.org/W1999382567","https://openalex.org/W2011370181","https://openalex.org/W2012490357","https://openalex.org/W2018858967","https://openalex.org/W2019223615","https://openalex.org/W2019379154","https://openalex.org/W2027149971","https://openalex.org/W2032641816","https://openalex.org/W2033007843","https://openalex.org/W2035581625","https://openalex.org/W2040379540","https://openalex.org/W2043138008","https://openalex.org/W2048595469","https://openalex.org/W2052240762","https://openalex.org/W2053277833","https://openalex.org/W2056961458","https://openalex.org/W2057068116","https://openalex.org/W2057539756","https://openalex.org/W2064438027","https://openalex.org/W2067231489","https://openalex.org/W2071782926","https://openalex.org/W2079140157","https://openalex.org/W2086403888","https://openalex.org/W2086660963","https://openalex.org/W2086727023","https://openalex.org/W2087375731","https://openalex.org/W2090486706","https://openalex.org/W2092394510","https://openalex.org/W2093645564","https://openalex.org/W2111286589","https://openalex.org/W2118183612","https://openalex.org/W2120120377","https://openalex.org/W2129340317","https://openalex.org/W2152848856","https://openalex.org/W2154529549","https://openalex.org/W2164963364","https://openalex.org/W2170906003","https://openalex.org/W2224635858","https://openalex.org/W2288515684","https://openalex.org/W2339340132","https://openalex.org/W6696652370"],"related_works":["https://openalex.org/W2095955625","https://openalex.org/W2014772678","https://openalex.org/W4253807475","https://openalex.org/W413788681","https://openalex.org/W4225408990","https://openalex.org/W2090446942","https://openalex.org/W2048115294","https://openalex.org/W336939305","https://openalex.org/W2033007843","https://openalex.org/W2129035961"],"abstract_inverted_index":{"Effects":[0],"of":[1,15,42,48,61,97,122,126,146,164,172,200],"rat":[2],"\u03b1-calcitonin":[3],"gene-related":[4],"peptide":[5,128],"(\u03b1-CGRP)":[6],"microinjected":[7,31,70,213],"into":[8,32,71,101,118,129,153,214],"various":[9],"hypothalamic":[10,34,133],"nuclei":[11],"on":[12],"plasma":[13,40,59,144,170],"levels":[14,171],"catecholamines":[16],"and":[17,28,82,106,108,135,175,209],"arterial":[18,90],"blood":[19,91],"pressure":[20,92],"were":[21],"investigated":[22],"in":[23,51,58,89,143,169,179],"urethane-anesthetized":[24],"rats.":[25],"\u03b1-CGRP":[26,67,98,150,212],"(0.05":[27,68,99,151],"0.25":[29],"nmol)":[30,69,100,152],"the":[33,39,72,102,109,119,123,130,154,165,201,215,219],"paraventricular":[35],"nucleus":[36],"(PVN)":[37],"increased":[38],"level":[41,60,145],"noradrenaline":[43],"(NA),":[44],"but":[45],"not":[46,157],"that":[47,198],"adrenaline":[49],"(AD),":[50],"a":[52],"dose-dependent":[53],"manner.":[54],"A":[55,86],"similar":[56],"increase":[57,88,112,142,178],"NA":[62,147,174,180],"was":[63,93,113,138,156,181],"also":[64],"observed":[65,94],"by":[66,95,115,149,159,183,203],"preoptic":[73],"area":[74,134],"(POA),":[75],"anterior":[76],"hypothalamus":[77,80,84,137],"(AH),":[78],"dorsomedial":[79],"(DMH)":[81],"ventromedial":[83],"(VMH).":[85],"significant":[87],"microinjection":[96,117],"PVN":[103,155,166,202,216],"POA,":[104],"AH":[105],"DMH,":[107],"most":[110],"prominant":[111],"caused":[114],"its":[116],"PVN.":[120],"Microinjection":[121],"same":[124],"dose":[125],"this":[127],"VMH,":[131],"lateral":[132],"posterior":[136],"without":[139],"effect.":[140],"The":[141],"induced":[148],"affected":[158],"bilateral":[160],"adrenalectomy.":[161],"Electrical":[162],"stimulation":[163,205],"elicited":[167],"increases":[168],"both":[173,207],"AD.":[176],"This":[177],"abolished":[182],"chemical":[184],"sympathectomy":[185],"with":[186],"6-hydroxydopamine":[187],"(50":[188],"mg/kg,":[189],"i.v.,":[190],"3":[191],"days":[192],"before":[193],"experiments).":[194],"These":[195],"results":[196],"suggest":[197],"activation":[199],"electrical":[204],"elicits":[206],"sympathetic":[208,220],"adrenomedullary":[210],"outflow.":[211,221],"selectively":[217],"activates":[218]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
