{"id":"https://openalex.org/W205401210","doi":null,"title":"Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues.","display_name":"Glucocorticoid induction of the glaucoma gene MYOC in human and monkey trabecular meshwork cells and tissues.","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W205401210","mag":"205401210","pmid":"https://pubmed.ncbi.nlm.nih.gov/11431441"},"language":"en","primary_location":{"id":"pmid:11431441","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11431441","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/1773/19323","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028410916","display_name":"A.F. Clark","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086271","display_name":"Alcon (United States)","ror":"https://ror.org/000s8jb40","country_code":"US","type":"company","lineage":["https://openalex.org/I4210086271","https://openalex.org/I4210155258"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A F Clark","raw_affiliation_strings":["Glaucoma Research, Alcon Research, Ltd., 6201 South Freeway, Fort Worth, Texas 76135, USA. abe.clark@alconlabs.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Glaucoma Research, Alcon Research, Ltd., 6201 South Freeway, Fort Worth, Texas 76135, USA. abe.clark@alconlabs.com","institution_ids":["https://openalex.org/I4210086271"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028642773","display_name":"H. Thomas Steely","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H T Steely","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079130470","display_name":"Jaime E. Dickerson","orcid":"https://orcid.org/0000-0001-6748-9742","observed_orcids":["https://orcid.org/0000-0001-6748-9742"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J E Dickerson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002559777","display_name":"SHERRY L. ENGLISH-WRIGHT","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S English-Wright","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072548296","display_name":"Karen Stropki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Stropki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010846786","display_name":"Mitchell D. McCartney","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M D McCartney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111410879","display_name":"Nasreen Jacobson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Jacobson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072141013","display_name":"Allan R. Shepard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A R Shepard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079281560","display_name":"John I. Clark","orcid":"https://orcid.org/0000-0002-6651-5205","observed_orcids":["https://orcid.org/0000-0002-6651-5205"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J I Clark","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101548565","display_name":"Hiroshi Matsushima","orcid":"https://orcid.org/0000-0001-9838-0627","observed_orcids":["https://orcid.org/0000-0001-9838-0627"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Matsushima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016305380","display_name":"Elaine R. Peskind","orcid":"https://orcid.org/0000-0002-3667-9129","observed_orcids":["https://orcid.org/0000-0002-3667-9129"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E R Peskind","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052130722","display_name":"James B. Leverenz","orcid":"https://orcid.org/0000-0002-0896-0749","observed_orcids":["https://orcid.org/0000-0002-0896-0749"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J B Leverenz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059786842","display_name":"Charles W. Wilkinson","orcid":"https://orcid.org/0000-0002-5390-0294","observed_orcids":["https://orcid.org/0000-0002-5390-0294"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C W Wilkinson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071566681","display_name":"Ruth E. Swiderski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R E Swiderski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066474989","display_name":"John H. Fingert","orcid":"https://orcid.org/0000-0002-0377-0479","observed_orcids":["https://orcid.org/0000-0002-0377-0479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J H Fingert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048989892","display_name":"Val C. Sheffield","orcid":"https://orcid.org/0000-0002-6282-0835","observed_orcids":["https://orcid.org/0000-0002-6282-0835"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V C Sheffield","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5080924048","display_name":"Edwin M. Stone","orcid":"https://orcid.org/0000-0003-3343-4414","observed_orcids":["https://orcid.org/0000-0003-3343-4414"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E M Stone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":8.5614,"has_fulltext":true,"cited_by_count":161,"citation_normalized_percentile":{"value":0.97892414,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"42","issue":"8","first_page":"1769","last_page":"80"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10250","display_name":"Glaucoma and retinal disorders","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10563","display_name":"Corneal surgery and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myocilin","display_name":"myocilin","score":0.9010000228881836},{"id":"https://openalex.org/keywords/myoc-gene","display_name":"MYOC gene","score":0.9739999771118164},{"id":"https://openalex.org/keywords/glucocorticoids","display_name":"glucocorticoids","score":0.8700000047683716},{"id":"https://openalex.org/keywords/dexamethasone","display_name":"dexamethasone","score":0.9039999842643738},{"id":"https://openalex.org/keywords/trabecular-meshwork","display_name":"trabecular meshwork","score":0.9539999961853027},{"id":"https://openalex.org/keywords/ocular-hypertension","display_name":"ocular hypertension","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cortisone-acetate","display_name":"cortisone acetate","score":0.8040000200271606},{"id":"https://openalex.org/keywords/protein-secretion","display_name":"protein secretion","score":0.640999972820282},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.7440000176429749},{"id":"https://openalex.org/keywords/deglycosylation","display_name":"deglycosylation","score":0.8579999804496765},{"id":"https://openalex.org/keywords/anterior-segment","display_name":"anterior segment","score":0.4440000057220459},{"id":"https://openalex.org/keywords/monkey-model","display_name":"monkey model","score":0.5550000071525574},{"id":"https://openalex.org/keywords/gene-induction","display_name":"gene induction","score":0.5070000290870667},{"id":"https://openalex.org/keywords/intraocular-pressure","display_name":"intraocular pressure","score":0.625}],"concepts":[{"id":"https://openalex.org/C2781147369","wikidata":"https://www.wikidata.org/wiki/Q18029808","display_name":"Myocilin","level":4,"score":0.9952743649482727},{"id":"https://openalex.org/C2781121420","wikidata":"https://www.wikidata.org/wiki/Q750873","display_name":"Trabecular meshwork","level":3,"score":0.9074375629425049},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.6205340027809143},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5718653798103333},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5167845487594604},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4844644069671631},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.41858595609664917},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4119028151035309},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3436146378517151},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33388978242874146},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.32072925567626953},{"id":"https://openalex.org/C2778527774","wikidata":"https://www.wikidata.org/wiki/Q159701","display_name":"Glaucoma","level":2,"score":0.22929126024246216},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2265791893005371},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1444803774356842},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11620309948921204},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000099179","descriptor_name":"Myocilin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003348","descriptor_name":"Cortisone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D003348","descriptor_name":"Cortisone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003598","descriptor_name":"Cytoskeletal Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D005136","descriptor_name":"Eye Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005938","descriptor_name":"Glucocorticoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007429","descriptor_name":"Intraocular Pressure","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008254","descriptor_name":"Macaca nemestrina","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009798","descriptor_name":"Ocular Hypertension","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009798","descriptor_name":"Ocular Hypertension","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009798","descriptor_name":"Ocular Hypertension","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D014129","descriptor_name":"Trabecular Meshwork","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014129","descriptor_name":"Trabecular Meshwork","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014129","descriptor_name":"Trabecular Meshwork","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D015152","descriptor_name":"Blotting, Northern","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:11431441","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11431441","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"},{"id":"pmh:oai:digital.lib.washington.edu:1773/19323","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1773/19323","pdf_url":"http://hdl.handle.net/1773/19323","source":{"id":"https://openalex.org/S4306401128","display_name":"ResearchWorks at the University of Washington (University of Washington)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201448701","host_organization_name":"University of Washington","host_organization_lineage":["https://openalex.org/I201448701"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},{"id":"mag:205401210","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11431441","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:digital.lib.washington.edu:1773/19323","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1773/19323","pdf_url":"http://hdl.handle.net/1773/19323","source":{"id":"https://openalex.org/S4306401128","display_name":"ResearchWorks at the University of Washington (University of Washington)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201448701","host_organization_name":"University of Washington","host_organization_lineage":["https://openalex.org/I201448701"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4305535625","display_name":"Development and Maintenance of Lens Transparency","funder_award_id":"R01EY004542","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G7629573093","display_name":"Alzheimer's Disease Research Center","funder_award_id":"P50AG005136","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"},{"id":"https://openalex.org/G8555225148","display_name":"Molecular Genetics of Glaucoma","funder_award_id":"R01EY010564","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320306274","display_name":"Roy J. Carver Charitable Trust","ror":"https://ror.org/01ah2ch91"},{"id":"https://openalex.org/F4320306709","display_name":"Glaucoma Research Foundation","ror":"https://ror.org/05ez53b31"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W205401210.pdf","grobid_xml":"https://content.openalex.org/works/W205401210.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W9373301","https://openalex.org/W9772542","https://openalex.org/W38357145","https://openalex.org/W62854991","https://openalex.org/W91769371","https://openalex.org/W96503828","https://openalex.org/W118598956","https://openalex.org/W135828654","https://openalex.org/W137367617","https://openalex.org/W149140910","https://openalex.org/W151094017","https://openalex.org/W169484953","https://openalex.org/W202492744","https://openalex.org/W631486094","https://openalex.org/W1487304615","https://openalex.org/W1492007945","https://openalex.org/W1497092420","https://openalex.org/W1514272198","https://openalex.org/W1527157432","https://openalex.org/W1562353524","https://openalex.org/W1573343845","https://openalex.org/W1591818011","https://openalex.org/W1597473244","https://openalex.org/W1881612145","https://openalex.org/W1971485090","https://openalex.org/W1974582955","https://openalex.org/W1987986784","https://openalex.org/W1989399186","https://openalex.org/W1994153857","https://openalex.org/W2001024052","https://openalex.org/W2009784601","https://openalex.org/W2013348887","https://openalex.org/W2015820640","https://openalex.org/W2016317689","https://openalex.org/W2016750941","https://openalex.org/W2017038346","https://openalex.org/W2017992423","https://openalex.org/W2018866158","https://openalex.org/W2019636626","https://openalex.org/W2021769659","https://openalex.org/W2030835960","https://openalex.org/W2031214260","https://openalex.org/W2034658715","https://openalex.org/W2035107735","https://openalex.org/W2040155713","https://openalex.org/W2054113978","https://openalex.org/W2054380928","https://openalex.org/W2058128222","https://openalex.org/W2064417092","https://openalex.org/W2067215143","https://openalex.org/W2071067998","https://openalex.org/W2071077597","https://openalex.org/W2071647588","https://openalex.org/W2077297175","https://openalex.org/W2093516817","https://openalex.org/W2100159037","https://openalex.org/W2100556262","https://openalex.org/W2101108802","https://openalex.org/W2101792728","https://openalex.org/W2110310702","https://openalex.org/W2115441701","https://openalex.org/W2119521263","https://openalex.org/W2133749776","https://openalex.org/W2133989466","https://openalex.org/W2138940365","https://openalex.org/W2158230021","https://openalex.org/W2158732391","https://openalex.org/W2396983492","https://openalex.org/W2400800535","https://openalex.org/W2415139684","https://openalex.org/W2432328188","https://openalex.org/W4245839829","https://openalex.org/W4300509244"],"related_works":["https://openalex.org/W1715294105","https://openalex.org/W1970096778","https://openalex.org/W7097909474","https://openalex.org/W7097437363","https://openalex.org/W2052351336","https://openalex.org/W1487304615","https://openalex.org/W7096416496","https://openalex.org/W2067215143","https://openalex.org/W2384378033","https://openalex.org/W2001792122"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"examine":[2],"the":[3,11,19,154,175,183,211,216,221,244,249,266,273,277,288,299],"intracellular":[4],"and":[5,13,21,39,63,70,104,129,139,142,147,159,235],"extracellular":[6,105,250],"expression":[7,27,44,106],"of":[8,23,53,107,121,126,182,218,225,262,270,282,301,306,339],"myocilin":[9,40,108,122,184,219,230,263,283,302,321],"in":[10,18,30,109,149,186,191,210,220,232,272,312,314,328,331,336],"human":[12,32,57,65,111,156,189],"primate":[14],"trabecular":[15],"meshwork":[16],"(TM)":[17],"presence":[20],"absence":[22],"glucocorticoids.":[24],"METHODS:":[25],"Myocilin":[26,43],"was":[28,45,99,179,310],"examined":[29],"cultured":[31,68,110,155,226],"TM":[33,58,60,82,112,157,212,227,255,274,308],"cells":[34,158,228],"by":[35,174],"Northern":[36],"blot":[37],"analysis":[38,164,224],"antibody-mediated":[41],"immunoprecipitation.":[42],"quantified":[46],"using":[47,165],"high-resolution":[48],"two-dimensional":[49],"polyacrylamide":[50],"gel":[51],"electrophoresis":[52],"radiolabeled":[54],"proteins":[55,134,171,185,271,309],"from":[56,84],"cells,":[59],"tissue":[61,83],"explants,":[62],"perfused":[64],"anterior":[66],"segments":[67],"with":[69,92,96,202,215,248],"without":[71],"dexamethasone":[72],"(DEX)":[73],"for":[74,89],"14":[75],"to":[76,101,131,287,333],"21":[77],"days,":[78],"as":[79,81,172,239,241],"well":[80,240],"pigtailed":[85],"monkeys":[86],"treated":[87,199],"orally":[88],"1":[90,200],"year":[91,201],"cortisone":[93],"acetate.":[94],"Immunofluorescence":[95,223],"anti-myocilin":[97,166],"antibodies":[98,168],"used":[100],"localize":[102],"cellular":[103],"cells.":[113],"RESULTS:":[114],"Glucocorticoid":[115],"treatment":[116],"caused":[117],"a":[118,124],"significant":[119,180,260],"induction":[120,181,217,305],"mRNA,":[123],"tetrad":[125],"cell-associated":[127],"proteins,":[128],"8":[130],"20":[132],"secreted":[133,264],"(molecular":[135],"mass":[136],"[M(r)]":[137],"56":[138],"59":[140],"kDa":[141],"isoelectric":[143],"point":[144],"[pI]":[145],"5.2":[146],"5.3)":[148],"some,":[150],"but":[151],"not":[152],"all":[153],"explanted":[160],"tissues.":[161],"Western":[162],"immunoblot":[163],"peptide":[167],"identified":[169],"these":[170,307],"encoded":[173],"MYOC":[176],"gene.":[177],"There":[178],"three":[187],"perfusion-cultured":[188],"eyes,":[190],"which":[192,315],"DEX-induced":[193],"elevated":[194],"intraocular":[195],"pressure":[196],"developed.":[197,319],"Monkeys":[198],"cortisol":[203],"acetate":[204],"showed":[205],"steroid":[206],"glaucoma-like":[207],"morphologic":[208],"changes":[209],"that":[213],"correlated":[214],"TM.":[222],"localized":[229],"intracellularly":[231],"discrete":[233],"perinuclear":[234],"cytoplasmic":[236],"vesicular":[237],"deposits":[238],"extracellularly":[242],"on":[243],"cell":[245,256],"surface":[246],"associated":[247],"matrix.":[251],"In":[252],"several":[253],"DEX-treated":[254],"lines,":[257],"there":[258],"were":[259],"levels":[261],"into":[265],"media.":[267],"Enzymatic":[268],"deglycosylation":[269],"media":[275],"converted":[276],"higher":[278],"molecular":[279,290],"weight":[280,291],"isoforms":[281,292],"(approximately":[284],"57":[285],"kDa)":[286],"lower":[289],"(":[293],"approximately":[294],"55":[295],"kDa).":[296],"CONCLUSIONS:":[297],"Although":[298],"function":[300],"is":[303],"unknown,":[304],"found":[311],"eyes":[313],"glucocorticoid-induced":[316],"ocular":[317,329],"hypertension":[318,330],"Therefore,":[320],"may":[322],"play":[323],"an":[324],"important":[325],"pathogenic":[326],"role":[327,335],"addition":[332],"its":[334],"certain":[337],"forms":[338],"POAG.":[340]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
