{"id":"https://openalex.org/W2053989901","doi":"https://doi.org/10.1007/bf02815410","title":"Sequential expression of c-fos protooncogene, TNF-alpha, and dynorphin genes in spinal cord following experimental traumatic injury","display_name":"Sequential expression of c-fos protooncogene, TNF-alpha, and dynorphin genes in spinal cord following experimental traumatic injury","publication_year":1994,"publication_date":"1994-10-01","ids":{"openalex":"https://openalex.org/W2053989901","doi":"https://doi.org/10.1007/bf02815410","mag":"2053989901","pmid":"https://pubmed.ncbi.nlm.nih.gov/7702707"},"language":"en","primary_location":{"id":"doi:10.1007/bf02815410","doi":"https://doi.org/10.1007/bf02815410","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02815410","pdf_url":null,"source":{"id":"https://openalex.org/S177864979","display_name":"Molecular and Chemical Neuropathology","issn_l":"1044-7393","issn":["1044-7393","2168-8729"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Chemical Neuropathology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103360587","display_name":"Alexander G. Yakovlev","orcid":"https://orcid.org/0009-0002-2773-2052","observed_orcids":["https://orcid.org/0009-0002-2773-2052"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. G. Yakovlev","raw_affiliation_strings":["Department of Neurology, Georgetown University Medical Center, Washington, DC 20007","Departments of Neurology and Pharmacology, Georgetown University Medical Center, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Georgetown University Medical Center, Washington, DC 20007","institution_ids":["https://openalex.org/I2799903593"]},{"raw_affiliation_string":"Departments of Neurology and Pharmacology, Georgetown University Medical Center, Washington, DC","institution_ids":["https://openalex.org/I2799903593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011395603","display_name":"Alan I. Faden","orcid":"https://orcid.org/0000-0003-0128-2348","observed_orcids":["https://orcid.org/0000-0003-0128-2348"]},"institutions":[{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. I. Faden","raw_affiliation_strings":["Departments of Neurology and Pharmacology, Georgetown University Medical Center, 3900 Reservoir Rd., N.W., 20007, Washington, DC","Departments of Neurology and Pharmacology, Georgetown University Medical Center, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Neurology and Pharmacology, Georgetown University Medical Center, 3900 Reservoir Rd., N.W., 20007, Washington, DC","institution_ids":["https://openalex.org/I2799903593"]},{"raw_affiliation_string":"Departments of Neurology and Pharmacology, Georgetown University Medical Center, Washington, DC","institution_ids":["https://openalex.org/I2799903593"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2799903593"],"apc_list":null,"apc_paid":null,"fwci":1.5962,"has_fulltext":false,"cited_by_count":119,"citation_normalized_percentile":{"value":0.84892368,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"23","issue":"2-3","first_page":"179","last_page":"190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.10249999910593033,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.019700000062584877,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8939999938011169},{"id":"https://openalex.org/keywords/dynorphin","display_name":"dynorphin","score":0.9369999766349792},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.8510000109672546},{"id":"https://openalex.org/keywords/spinal-cord-injury","display_name":"spinal cord injury","score":0.6980000138282776},{"id":"https://openalex.org/keywords/impact-trauma","display_name":"impact trauma","score":0.8100000023841858},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7829999923706055},{"id":"https://openalex.org/keywords/secondary-injury","display_name":"secondary injury","score":0.8629999756813049},{"id":"https://openalex.org/keywords/injury-severity","display_name":"injury severity","score":0.49300000071525574},{"id":"https://openalex.org/keywords/dose-response-relationship","display_name":"dose-response relationship","score":0.5590000152587891},{"id":"https://openalex.org/keywords/time-dependent-response","display_name":"time-dependent response","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C151077648","wikidata":"https://www.wikidata.org/wiki/Q324076","display_name":"Dynorphin","level":5,"score":0.8368245959281921},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.6299920082092285},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.6036678552627563},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.5934482216835022},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5616285800933838},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.47862616181373596},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.4746589958667755},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39315247535705566},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3880675733089447},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.30011260509490967},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.29177308082580566},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.26156002283096313},{"id":"https://openalex.org/C88016717","wikidata":"https://www.wikidata.org/wiki/Q417189","display_name":"Opioid peptide","level":4,"score":0.14038684964179993},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.11131918430328369},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.09670960903167725},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004399","descriptor_name":"Dynorphins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D004399","descriptor_name":"Dynorphins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011498","descriptor_name":"Protein Precursors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D013119","descriptor_name":"Spinal Cord Injuries","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016762","descriptor_name":"Genes, fos","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf02815410","doi":"https://doi.org/10.1007/bf02815410","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02815410","pdf_url":null,"source":{"id":"https://openalex.org/S177864979","display_name":"Molecular and Chemical Neuropathology","issn_l":"1044-7393","issn":["1044-7393","2168-8729"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Chemical Neuropathology","raw_type":"journal-article"},{"id":"pmid:7702707","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7702707","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and chemical neuropathology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8999999761581421,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1523390392","display_name":null,"funder_award_id":"R49/CCR306634","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"}],"funders":[{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1499203998","https://openalex.org/W1584278440","https://openalex.org/W1591639231","https://openalex.org/W1709529434","https://openalex.org/W1971457128","https://openalex.org/W1975347171","https://openalex.org/W1977729873","https://openalex.org/W1986103307","https://openalex.org/W1989033412","https://openalex.org/W1995666400","https://openalex.org/W1998822387","https://openalex.org/W2020404153","https://openalex.org/W2021789707","https://openalex.org/W2048692173","https://openalex.org/W2051971271","https://openalex.org/W2054912683","https://openalex.org/W2057819786","https://openalex.org/W2058481069","https://openalex.org/W2071394393","https://openalex.org/W2071822977","https://openalex.org/W2073138743","https://openalex.org/W2080943027","https://openalex.org/W2091182667","https://openalex.org/W2091599040","https://openalex.org/W2094043543","https://openalex.org/W2111940526","https://openalex.org/W2116234096","https://openalex.org/W2126994317","https://openalex.org/W2134812217","https://openalex.org/W2138254752","https://openalex.org/W2139856434","https://openalex.org/W2153288081","https://openalex.org/W2163556813","https://openalex.org/W2279329483","https://openalex.org/W2292619439"],"related_works":["https://openalex.org/W2046570168","https://openalex.org/W2059130466","https://openalex.org/W2023961353","https://openalex.org/W2035656054","https://openalex.org/W2126541456","https://openalex.org/W2363943063","https://openalex.org/W2057564712","https://openalex.org/W2044269265","https://openalex.org/W2039940333","https://openalex.org/W2063440901"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}