{"id":"https://openalex.org/W2053973538","doi":null,"title":"Expression of cyclooxygenase-2 in the inflammatory changed porcine uterus.","display_name":"Expression of cyclooxygenase-2 in the inflammatory changed porcine uterus.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2053973538","mag":"2053973538","pmid":"https://pubmed.ncbi.nlm.nih.gov/19459433"},"language":"en","primary_location":{"id":"pmid:19459433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19459433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polish journal of veterinary sciences","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048362140","display_name":"Barbara Jana","orcid":"https://orcid.org/0000-0001-6508-2965","observed_orcids":["https://orcid.org/0000-0001-6508-2965"]},"institutions":[{"id":"https://openalex.org/I4210137647","display_name":"InLife Institute of Animal Reproduction and Food Research, Polish Academy of Sciences","ror":"https://ror.org/04cnktn59","country_code":"PL","type":"facility","lineage":["https://openalex.org/I4210137647","https://openalex.org/I99542240"]},{"id":"https://openalex.org/I99542240","display_name":"Polish Academy of Sciences","ror":"https://ror.org/01dr6c206","country_code":"PL","type":"government","lineage":["https://openalex.org/I99542240"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"B Jana","raw_affiliation_strings":["Division of Reproductive Endocrinology and Pathophysiology, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Tuwima 10, 10-747 Olsztyn, Poland. baja@pan.olsztyn.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Reproductive Endocrinology and Pathophysiology, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Tuwima 10, 10-747 Olsztyn, Poland. baja@pan.olsztyn.pl","institution_ids":["https://openalex.org/I4210137647","https://openalex.org/I99542240"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060577749","display_name":"Anna Koz\u0142owska","orcid":"https://orcid.org/0000-0001-6878-8496","observed_orcids":["https://orcid.org/0000-0001-6878-8496"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Koz\u0142owska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023145568","display_name":"Marlena Koszykowska","orcid":"https://orcid.org/0000-0003-3799-2237","observed_orcids":["https://orcid.org/0000-0003-3799-2237"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Koszykowska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025756894","display_name":"Mariusz Krzysztof Majewski","orcid":"https://orcid.org/0000-0001-5818-7689","observed_orcids":["https://orcid.org/0000-0001-5818-7689"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Majewski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.274,"has_fulltext":false,"cited_by_count":26,"citation_normalized_percentile":{"value":0.89622408,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"12","issue":"1","first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10584","display_name":"Reproductive Physiology in Livestock","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11580","display_name":"Veterinary Medicine and Surgery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/acute-endometritis","display_name":"acute endometritis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/porcine-uterus","display_name":"porcine uterus","score":0.8370000123977661},{"id":"https://openalex.org/keywords/escherichia-coli-infection","display_name":"Escherichia coli infection","score":0.7390000224113464},{"id":"https://openalex.org/keywords/metritis","display_name":"metritis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/endometrium","display_name":"endometrium","score":0.8389999866485596},{"id":"https://openalex.org/keywords/myometrium","display_name":"myometrium","score":0.9909999966621399},{"id":"https://openalex.org/keywords/uterine-artery","display_name":"uterine artery","score":0.7269999980926514},{"id":"https://openalex.org/keywords/vascular-endothelium","display_name":"vascular endothelium","score":0.7179999947547913},{"id":"https://openalex.org/keywords/cox-2-expression","display_name":"COX-2 expression","score":0.6140000224113464},{"id":"https://openalex.org/keywords/swine-reproductive-disease","display_name":"swine reproductive disease","score":0.5659999847412109},{"id":"https://openalex.org/keywords/gilts","display_name":"gilts","score":0.7749999761581421},{"id":"https://openalex.org/keywords/estrous-cycle","display_name":"estrous cycle","score":0.7940000295639038},{"id":"https://openalex.org/keywords/uterine-glands","display_name":"endometrial glands","score":0.7450000047683716},{"id":"https://openalex.org/keywords/luminal-epithelium","display_name":"luminal epithelium","score":0.6840000152587891},{"id":"https://openalex.org/keywords/cox-2-mrna","display_name":"COX-2 mRNA","score":0.6359999775886536}],"concepts":[{"id":"https://openalex.org/C2775846227","wikidata":"https://www.wikidata.org/wiki/Q1340774","display_name":"Endometritis","level":3,"score":0.901720404624939},{"id":"https://openalex.org/C1998276","wikidata":"https://www.wikidata.org/wiki/Q388121","display_name":"Estrous cycle","level":2,"score":0.7654229998588562},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.7027450203895569},{"id":"https://openalex.org/C2778227567","wikidata":"https://www.wikidata.org/wiki/Q3693643","display_name":"Uterine horns","level":3,"score":0.7015873193740845},{"id":"https://openalex.org/C2779066055","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Uterus","level":2,"score":0.6908188462257385},{"id":"https://openalex.org/C2779742232","wikidata":"https://www.wikidata.org/wiki/Q839508","display_name":"Endometrium","level":2,"score":0.654366672039032},{"id":"https://openalex.org/C2778164554","wikidata":"https://www.wikidata.org/wiki/Q2562472","display_name":"Myometrium","level":3,"score":0.6275445222854614},{"id":"https://openalex.org/C2779689624","wikidata":"https://www.wikidata.org/wiki/Q410251","display_name":"Cyclooxygenase","level":3,"score":0.603901743888855},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.5817906856536865},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5034937262535095},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4610956907272339},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.44488224387168884},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.42468202114105225},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.395644873380661},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36211517453193665},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.16469255089759827},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07729664444923401},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.06751745939254761},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013553","descriptor_name":"Swine Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D014599","descriptor_name":"Uterus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015971","descriptor_name":"Gene Expression Regulation, Enzymologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019522","descriptor_name":"Vaginal Discharge","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D019522","descriptor_name":"Vaginal Discharge","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019522","descriptor_name":"Vaginal Discharge","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051546","descriptor_name":"Cyclooxygenase 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:19459433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19459433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polish journal of veterinary sciences","raw_type":"Journal Article"},{"id":"mag:2053973538","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19459433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2077179057","https://openalex.org/W1991100490","https://openalex.org/W2039274017","https://openalex.org/W3049216784","https://openalex.org/W2030056935","https://openalex.org/W2039764213","https://openalex.org/W4251101681","https://openalex.org/W2084666971","https://openalex.org/W2383061331","https://openalex.org/W2062577434"],"abstract_inverted_index":{"In":[0],"the":[1,4,33,60,88,96,103,122,138,153,169,181,188,197,208,225,256,270,279,286,297,311,325,342,351,354,360,364,382],"present":[2,295,331],"study,":[3],"pattern":[5],"of":[6,32,38,43,59,86,99,140,172,186,207,218,224,255,269,282,299,310,324,336,353],"cyclooxygenase-2":[7],"(COX-2)":[8],"expression":[9,164,362],"in":[10,95,137,152,168,184,205,233,239,253,259,267,278,296,302,308,322,341,359,363,381],"health":[11,189,287],"and":[12,27,63,91,112,129,159,190,200,210,221,288,339],"inflamed":[13,193,212,245,289,303,343,383],"porcine":[14,344],"uteri":[15,268,309,323],"was":[16,93,165,251,276,293,347],"analyzed":[17],"using":[18],"real-time":[19],"reverse":[20],"transcriptase-polymerase":[21],"chain":[22],"reaction":[23,250],"(RT-PCR),":[24],"Western":[25],"blot":[26],"immunohistochemistry.":[28],"On":[29],"day":[30],"3":[31],"estrous":[34],"cycle,":[35],"50":[36,41],"ml":[37,42],"saline":[39],"or":[40,76,243],"Escherichia":[44],"coli":[45],"(E.":[46],"coli)":[47],"suspension":[48],"containing":[49],"10(9)":[50],"colony-forming":[51],"units/ml,":[52],"were":[53,132,203,227],"injected":[54],"into":[55],"each":[56],"uterine":[57,219,257],"horn":[58],"control":[61,123,209,271],"(n=6)":[62],"experimental":[64],"gilts":[65],"(n=7),":[66],"respectively.":[67],"This":[68],"latter":[69,260],"procedure":[70],"lead":[71],"to":[72,121,264,350],"a":[73,146],"moderately":[74,147,211,244],"(n=3)":[75],"severely":[77],"intense":[78],"(n=4)":[79],"acute":[80,117,148],"endometritis":[81,315],"after":[82],"eight":[83],"days.":[84],"Expression":[85],"both":[87,187,196],"COX-2":[89,126,154,198,232,249,337,361],"mRNA":[90,127,199,338],"protein":[92,130,160,201,340],"increased":[94],"endometrium":[97],"(ENDO)":[98],"animals":[100,141,173,234,240,312,326],"suffering":[101,174],"from":[102,175],"moderate":[104,191,328],"(P":[105,114,134,156,161],"<":[106,109,115,135,157,162],"0.05,":[107],"P":[108],"0.01,":[110],"respectively)":[111],"severe":[113,143,176,236,314],"0.01)":[116],"endometritis,":[118,177,237],"as":[119],"compared":[120,179,263],"tissues.":[124],"Moreover,":[125],"level":[128],"content":[131],"higher":[133],"0.05)":[136,158],"ENDO":[139],"with":[142,145,180,235,241,313,327],"than":[144,238,319],"endometritis.":[149],"An":[150,357],"elevation":[151],"gene":[155],"0.001)":[163],"also":[166],"observed":[167,183,266,277],"myometrium":[170],"(MYO)":[171],"when":[178,262],"levels":[182,202],"MYO":[185,206,226],"intensely":[192,229],"uteri.":[194,246],"However,":[195],"similar":[204],"organs.":[213,304],"The":[214,330],"luminal":[215],"epithelium,":[216],"some":[217,254,300,306],"glands":[220,258],"circular":[222],"layer":[223,281],"more":[228],"stained":[230],"for":[231,377],"healthy":[242],"Nonetheless,":[247],"stronger":[248,318],"found":[252,321],"group,":[261],"that":[265,320,372],"animals.":[272],"While":[273],"positive":[274],"COX-2-labeling":[275],"muscular":[280],"all":[283],"arteries":[284,301,307],"supplying":[285],"uteri,":[290],"such":[291],"staining":[292],"exclusively":[294],"endothelium":[298],"Likewise,":[305],"displayed":[316],"immunoreaction":[317],"inflammation.":[329,356],"study":[332],"revealed":[333],"an":[334],"up-regulation":[335],"uterus,":[345],"which":[346],"directly":[348],"related":[349],"intensity":[352],"organ":[355],"increase":[358],"uterus":[365],"challenged":[366],"by":[367],"E.":[368],"coli-induced":[369],"inflammation":[370],"indicates":[371],"this":[373],"enzyme":[374],"is":[375],"crucial":[376],"elevated":[378],"prostaglandins":[379],"production":[380],"organ.":[384]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}