{"id":"https://openalex.org/W2053936754","doi":"https://doi.org/10.1371/journal.pone.0074163","title":"Non-Catalytic Site HIV-1 Integrase Inhibitors Disrupt Core Maturation and Induce a Reverse Transcription Block in Target Cells","display_name":"Non-Catalytic Site HIV-1 Integrase Inhibitors Disrupt Core Maturation and Induce a Reverse Transcription Block in Target Cells","publication_year":2013,"publication_date":"2013-09-09","ids":{"openalex":"https://openalex.org/W2053936754","doi":"https://doi.org/10.1371/journal.pone.0074163","mag":"2053936754","pmid":"https://pubmed.ncbi.nlm.nih.gov/24040198","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3767657"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0074163","doi":"https://doi.org/10.1371/journal.pone.0074163","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0074163","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074163&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074163&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002269399","display_name":"Mini Balakrishnan","orcid":"https://orcid.org/0009-0007-1678-9949","observed_orcids":["https://orcid.org/0009-0007-1678-9949"]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mini Balakrishnan","raw_affiliation_strings":["Gilead Sciences Inc., Foster City, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences Inc., Foster City, California, United States of America","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071932214","display_name":"Stephen R. Yant","orcid":"https://orcid.org/0000-0002-4444-7483","observed_orcids":["https://orcid.org/0000-0002-4444-7483"]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen R. Yant","raw_affiliation_strings":["Gilead Sciences Inc., Foster City, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences Inc., Foster City, California, United States of America","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111728644","display_name":"Luong K. Tsai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luong Tsai","raw_affiliation_strings":["Gilead Sciences Inc., Foster City, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences Inc., Foster City, California, United States of America","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110103518","display_name":"Christopher O\u2019Sullivan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher O\u2019Sullivan","raw_affiliation_strings":["Gilead Sciences Inc., Foster City, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences Inc., Foster City, California, United States of America","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013059994","display_name":"Rujuta A. Bam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rujuta A. Bam","raw_affiliation_strings":["Gilead Sciences Inc., Foster City, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences Inc., Foster City, California, United States of America","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011932678","display_name":"Angela Tsai","orcid":"https://orcid.org/0000-0002-7836-6788","observed_orcids":["https://orcid.org/0000-0002-7836-6788"]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela Tsai","raw_affiliation_strings":["Gilead Sciences Inc., Foster City, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences Inc., Foster City, California, United States of America","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020678467","display_name":"Anita Niedziela\u2010Majka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anita Niedziela-Majka","raw_affiliation_strings":["Gilead Sciences Inc., Foster City, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences Inc., Foster City, California, United States of America","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025575375","display_name":"Kirsten M. Stray","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kirsten M. Stray","raw_affiliation_strings":["Gilead Sciences Inc., Foster City, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences Inc., Foster City, California, United States of America","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038957199","display_name":"Roman Sakowicz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roman Sakowicz","raw_affiliation_strings":["Gilead Sciences Inc., Foster City, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences Inc., Foster City, California, United States of America","institution_ids":["https://openalex.org/I4210140816"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030919816","display_name":"Tom\u00e1\u0161 Cihl\u00e1\u0159","orcid":"https://orcid.org/0000-0001-6840-0885","observed_orcids":["https://orcid.org/0000-0001-6840-0885"]},"institutions":[{"id":"https://openalex.org/I4210140816","display_name":"Gilead Sciences (United States)","ror":"https://ror.org/056546b03","country_code":"US","type":"company","lineage":["https://openalex.org/I4210140816"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomas Cihlar","raw_affiliation_strings":["Gilead Sciences Inc., Foster City, California, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gilead Sciences Inc., Foster City, California, United States of America","institution_ids":["https://openalex.org/I4210140816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002269399"],"corresponding_institution_ids":["https://openalex.org/I4210140816"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":11.8291,"has_fulltext":true,"cited_by_count":130,"citation_normalized_percentile":{"value":0.99101911,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"8","issue":"9","first_page":"e74163","last_page":"e74163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.7426999807357788,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.2551000118255615,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-integrase","display_name":"HIV-1 integrase","score":0.9750000238418579},{"id":"https://openalex.org/keywords/integrase-strand-transfer-inhibitors","display_name":"integrase strand transfer inhibitors","score":0.8880000114440918},{"id":"https://openalex.org/keywords/ledgf-p75","display_name":"LEDGF/p75","score":0.8009999990463257},{"id":"https://openalex.org/keywords/viral-dna-replication","display_name":"viral DNA replication","score":0.4350000023841858}],"concepts":[{"id":"https://openalex.org/C14430832","wikidata":"https://www.wikidata.org/wiki/Q412550","display_name":"Integrase","level":3,"score":0.9260092973709106},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.671629786491394},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5568161606788635},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.499176025390625},{"id":"https://openalex.org/C2777302000","wikidata":"https://www.wikidata.org/wiki/Q412251","display_name":"Integrase inhibitor","level":5,"score":0.47782328724861145},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.45677345991134644},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4132902920246124},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.39357849955558777},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.37467607855796814},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34761542081832886},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.33475932478904724},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2233891487121582},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.17828845977783203},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.13148397207260132},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.06513097882270813},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0}],"mesh":[{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D004279","descriptor_name":"DNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008156","descriptor_name":"Luciferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016662","descriptor_name":"Virus Integration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017930","descriptor_name":"Genes, Reporter","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019065","descriptor_name":"Virus Assembly","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019427","descriptor_name":"HIV Integrase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019427","descriptor_name":"HIV Integrase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019428","descriptor_name":"HIV Integrase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019428","descriptor_name":"HIV Integrase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D024882","descriptor_name":"Drug Resistance, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054303","descriptor_name":"HIV Reverse Transcriptase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0074163","doi":"https://doi.org/10.1371/journal.pone.0074163","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0074163","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074163&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2764268","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3767657","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3767657","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3767657","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:24040198","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24040198","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.812.4083","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.812.4083","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/32/ff/pone.0074163.PMC3767657.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:ab7f85858d794836a0e3f22e87f9d8d3","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ab7f85858d794836a0e3f22e87f9d8d3","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 9, p e74163 (2013)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/795122","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/_Non_Catalytic_Site_HIV_1_Integrase_Inhibitors_Disrupt_Core_Maturation_and_Induce_a_Reverse_Transcription_Block_in_Target_Cells_/795122","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0074163","doi":"https://doi.org/10.1371/journal.pone.0074163","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0074163","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0074163&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2053936754.pdf","grobid_xml":"https://content.openalex.org/works/W2053936754.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W90995244","https://openalex.org/W1034217151","https://openalex.org/W1517131856","https://openalex.org/W1964170347","https://openalex.org/W1966515818","https://openalex.org/W1971346164","https://openalex.org/W1975535299","https://openalex.org/W1980725180","https://openalex.org/W1981723408","https://openalex.org/W1983837630","https://openalex.org/W1985711767","https://openalex.org/W2009382828","https://openalex.org/W2012752176","https://openalex.org/W2017402153","https://openalex.org/W2021258736","https://openalex.org/W2025753253","https://openalex.org/W2027692137","https://openalex.org/W2029379203","https://openalex.org/W2029610031","https://openalex.org/W2033964251","https://openalex.org/W2044716709","https://openalex.org/W2049853774","https://openalex.org/W2054379113","https://openalex.org/W2059740818","https://openalex.org/W2059772834","https://openalex.org/W2065190721","https://openalex.org/W2068307875","https://openalex.org/W2078738195","https://openalex.org/W2082798259","https://openalex.org/W2085489729","https://openalex.org/W2087400133","https://openalex.org/W2099475302","https://openalex.org/W2099960858","https://openalex.org/W2106494657","https://openalex.org/W2107861752","https://openalex.org/W2111673257","https://openalex.org/W2114137926","https://openalex.org/W2115817524","https://openalex.org/W2123025266","https://openalex.org/W2126391063","https://openalex.org/W2130607828","https://openalex.org/W2136975219","https://openalex.org/W2136996190","https://openalex.org/W2144101850","https://openalex.org/W2150504993","https://openalex.org/W2152880150","https://openalex.org/W2155792409","https://openalex.org/W2156432090","https://openalex.org/W2158159244","https://openalex.org/W2164978656","https://openalex.org/W2166420278","https://openalex.org/W2169976205","https://openalex.org/W3142175547","https://openalex.org/W3149957759"],"related_works":["https://openalex.org/W7098357132","https://openalex.org/W2739221721","https://openalex.org/W3111289302","https://openalex.org/W2288390251","https://openalex.org/W2104937944","https://openalex.org/W2098564281","https://openalex.org/W4401325434","https://openalex.org/W2215026552","https://openalex.org/W3186502605","https://openalex.org/W2972234328"],"abstract_inverted_index":{"HIV-1":[0,219],"integrase":[1,13,22],"(IN)":[2],"is":[3,87,196],"the":[4,12,19,28,44,54,93,100,123,133,141,146,157,199,212],"target":[5,45,71,78,124],"for":[6],"two":[7],"classes":[8],"of":[9,62,67,102,159,171,180,203,214],"antiretrovirals:":[10],"i)":[11],"strand-transfer":[14],"inhibitors":[15,23],"(INSTIs)":[16],"and":[17,32,108,167,209,222],"ii)":[18],"non-catalytic":[20],"site":[21],"(NCINIs).":[24],"NCINIs":[25,77,103,160,189],"bind":[26],"at":[27,116],"IN":[29,134,172,204,216],"dimer":[30,135],"interface":[31,136],"are":[33],"thought":[34],"to":[35,89,140,198],"interfere":[36],"primarily":[37],"with":[38],"viral":[39],"DNA":[40],"(vDNA)":[41],"integration":[42],"in":[43,83,92,99,132,156,164],"cell":[46],"by":[47],"blocking":[48],"IN-vDNA":[49],"assembly":[50],"as":[51,53],"well":[52],"IN-LEDGF/p75":[55],"interaction.":[56],"Herein":[57],"we":[58],"show":[59],"that":[60,86,174,188,195],"treatment":[61,179],"virus-producing":[63],"cells,":[64,72],"but":[65,113,151],"not":[66,152,176],"mature":[68,181],"virions":[69],"or":[70,206],"drives":[73],"NCINI":[74],"antiviral":[75],"potency.":[76],"an":[79,168,215],"essential":[80],"late-stage":[81,143],"event":[82],"HIV":[84],"replication":[85],"insensitive":[88],"LEDGF":[90],"levels":[91],"producer":[94],"cells.":[95],"Virus":[96],"particles":[97],"produced":[98,155],"presence":[101,158],"displayed":[104],"normal":[105],"Gag-Pol":[106],"processing":[107],"endogenous":[109],"reverse":[110,147],"transcriptase":[111],"activity,":[112],"were":[114],"defective":[115],"initiating":[117],"vDNA":[118],"synthesis":[119],"following":[120],"entry":[121],"into":[122],"cell.":[125],"NCINI-resistant":[126],"virus":[127],"carrying":[128],"a":[129,192],"T174I":[130,153],"mutation":[131],"was":[137,175],"less":[138],"sensitive":[139],"compound-induced":[142],"effects,":[144],"including":[145],"transcription":[148],"block.":[149],"Wild-type,":[150],"virus,":[154],"exhibited":[161],"striking":[162],"defects":[163],"core":[165,220],"morphology":[166],"increased":[169],"level":[170],"oligomers":[173],"observed":[177,201],"upon":[178],"cell-free":[182],"particles.":[183],"Collectively,":[184],"these":[185],"results":[186],"reveal":[187],"act":[190],"through":[191],"novel":[193],"mechanism":[194],"unrelated":[197],"previously":[200],"inhibition":[202],"activity":[205],"IN-LEDGF":[207],"interaction,":[208],"instead":[210],"involves":[211],"disruption":[213],"function":[217],"during":[218],"maturation":[221],"assembly.":[223]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":18},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
