{"id":"https://openalex.org/W2053919973","doi":"https://doi.org/10.4236/ojgas.2014.41002","title":"Evaluating the evolving evidence: The challenges of molecular-targeted therapy in management of gastric cancer","display_name":"Evaluating the evolving evidence: The challenges of molecular-targeted therapy in management of gastric cancer","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2053919973","doi":"https://doi.org/10.4236/ojgas.2014.41002","mag":"2053919973"},"language":"en","primary_location":{"id":"doi:10.4236/ojgas.2014.41002","doi":"https://doi.org/10.4236/ojgas.2014.41002","is_oa":true,"landing_page_url":"https://doi.org/10.4236/ojgas.2014.41002","pdf_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=41874","source":{"id":"https://openalex.org/S2764965309","display_name":"Open Journal of Gastroenterology","issn_l":"2163-9450","issn":["2163-9450","2163-9469"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320480","host_organization_name":"Scientific Research Publishing","host_organization_lineage":["https://openalex.org/P4310320480"],"host_organization_lineage_names":["Scientific Research Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Journal of Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=41874","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060205479","display_name":"Yasar Ahmed","orcid":"https://orcid.org/0000-0002-0691-9718","observed_orcids":["https://orcid.org/0000-0002-0691-9718"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasar Albushra Abdul Rahiem Ahmed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113055895","display_name":"Mohamed Ali","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohamed Ali","raw_affiliation_strings":["Advanced Oncology Research, Department of Medical Oncology, National Cancer Institute, Khartoum, Sudan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Advanced Oncology Research, Department of Medical Oncology, National Cancer Institute, Khartoum, Sudan","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14281583,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"04","issue":"01","first_page":"6","last_page":"15"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-gastric-cancer","display_name":"metastatic gastric cancer","score":0.8519999980926514},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.8550000190734863},{"id":"https://openalex.org/keywords/her2-positive-gastric-cancer","display_name":"HER2-positive gastric cancer","score":0.9369999766349792},{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.9929999709129333},{"id":"https://openalex.org/keywords/her2-targeted-therapy","display_name":"HER2-targeted therapy","score":0.7269999980926514},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.8140000104904175},{"id":"https://openalex.org/keywords/met-inhibitors","display_name":"MET inhibitors","score":0.7450000047683716},{"id":"https://openalex.org/keywords/hedgehog-pathway-inhibitors","display_name":"Hedgehog pathway inhibitors","score":0.949999988079071},{"id":"https://openalex.org/keywords/salvage-therapy","display_name":"salvage therapy","score":0.7490000128746033},{"id":"https://openalex.org/keywords/molecular-pathways","display_name":"molecular pathways","score":0.7269999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8726974129676819},{"id":"https://openalex.org/C2781230642","wikidata":"https://www.wikidata.org/wiki/Q492646","display_name":"Targeted therapy","level":3,"score":0.7483713030815125},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.642708420753479},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.6221217513084412},{"id":"https://openalex.org/C2778539099","wikidata":"https://www.wikidata.org/wiki/Q6120","display_name":"Hedgehog","level":3,"score":0.4883086681365967},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47614216804504395},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.46847003698349},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4438897371292114},{"id":"https://openalex.org/C2779551604","wikidata":"https://www.wikidata.org/wiki/Q7290345","display_name":"Ramucirumab","level":3,"score":0.41140806674957275},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3657270073890686},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34374260902404785},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.2570430040359497},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.19788414239883423},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.4236/ojgas.2014.41002","doi":"https://doi.org/10.4236/ojgas.2014.41002","is_oa":true,"landing_page_url":"https://doi.org/10.4236/ojgas.2014.41002","pdf_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=41874","source":{"id":"https://openalex.org/S2764965309","display_name":"Open Journal of Gastroenterology","issn_l":"2163-9450","issn":["2163-9450","2163-9469"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320480","host_organization_name":"Scientific Research Publishing","host_organization_lineage":["https://openalex.org/P4310320480"],"host_organization_lineage_names":["Scientific Research Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Journal of Gastroenterology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.4236/ojgas.2014.41002","doi":"https://doi.org/10.4236/ojgas.2014.41002","is_oa":true,"landing_page_url":"https://doi.org/10.4236/ojgas.2014.41002","pdf_url":"http://www.scirp.org/journal/PaperDownload.aspx?paperID=41874","source":{"id":"https://openalex.org/S2764965309","display_name":"Open Journal of Gastroenterology","issn_l":"2163-9450","issn":["2163-9450","2163-9469"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320480","host_organization_name":"Scientific Research Publishing","host_organization_lineage":["https://openalex.org/P4310320480"],"host_organization_lineage_names":["Scientific Research Publishing"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Open Journal of Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5953006933","display_name":null,"funder_award_id":"J50101","funder_id":"https://openalex.org/F4320335766","funder_display_name":"Shanghai Leading Academic Discipline Project"}],"funders":[{"id":"https://openalex.org/F4320335766","display_name":"Shanghai Leading Academic Discipline Project","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2053919973.pdf","grobid_xml":"https://content.openalex.org/works/W2053919973.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1868761359","https://openalex.org/W1967287782","https://openalex.org/W1994368214","https://openalex.org/W1998120215","https://openalex.org/W1999500450","https://openalex.org/W2012466427","https://openalex.org/W2054590679","https://openalex.org/W2054915531","https://openalex.org/W2059755429","https://openalex.org/W2066256741","https://openalex.org/W2072966188","https://openalex.org/W2080881382","https://openalex.org/W2100439220","https://openalex.org/W2104892374","https://openalex.org/W2109491042","https://openalex.org/W2113760232","https://openalex.org/W2114734455","https://openalex.org/W2122983196","https://openalex.org/W2139468685","https://openalex.org/W2144574890","https://openalex.org/W2151255733","https://openalex.org/W2152176528","https://openalex.org/W2152362765","https://openalex.org/W2153845297","https://openalex.org/W2155167083","https://openalex.org/W2159967578","https://openalex.org/W2160161167","https://openalex.org/W2163007274","https://openalex.org/W2164326402","https://openalex.org/W2165411051","https://openalex.org/W2241983385","https://openalex.org/W2300659078","https://openalex.org/W2337728056","https://openalex.org/W2338264424","https://openalex.org/W2472807784","https://openalex.org/W2549494681","https://openalex.org/W2589800177","https://openalex.org/W2595379700","https://openalex.org/W2600443679"],"related_works":["https://openalex.org/W2409716481","https://openalex.org/W1994368214","https://openalex.org/W2031473726","https://openalex.org/W2032434514","https://openalex.org/W1966316693","https://openalex.org/W2208807101","https://openalex.org/W2104354334","https://openalex.org/W3032806506","https://openalex.org/W3159546116","https://openalex.org/W2343901867"],"abstract_inverted_index":{"Over":[0],"the":[1,14,34,41,63,96,106,124],"past":[2],"decade,":[3],"a":[4,58],"multitude":[5],"of":[6,16,36,43,51,60,65,98,108,130],"molecular":[7,23],"targeted":[8,38,137],"agents":[9],"have":[10],"been":[11],"explored":[12],"in":[13,22,29,82,123,133],"treatment":[15,42,64,121],"advanced":[17,44,73],"metastatic":[18,46,75,99],"gastric.":[19],"Recent":[20],"advances":[21],"signaling":[24],"pathways":[25],"that":[26],"are":[27,81],"dysregulated":[28],"gastric":[30,47,100],"cancer":[31,101],"lead":[32],"to":[33,53],"development":[35],"new":[37],"therapies":[39,80],"for":[40,62],"and":[45,77,115,127],"cancer.":[48],"The":[49],"addition":[50],"trastuzumab":[52],"first-line":[54],"chemotherapy":[55],"is":[56],"now":[57],"standard":[59],"care":[61],"Human":[66],"epidermal":[67],"growth":[68],"factor":[69,113],"receptor":[70],"(HER2-)":[71],"positive":[72],"or":[74],"disease,":[76],"other":[78,136],"HER2-targeted":[79],"late-stage":[83],"clinical":[84,90],"development.":[85],"Findings":[86],"from":[87],"recent":[88],"major":[89],"trials":[91],"provide":[92],"important":[93],"insight":[94],"into":[95],"future":[97],"management,":[102],"which":[103],"may":[104],"include":[105],"use":[107],"anti-angiogenesis,":[109],"Mesenchymal":[110],"epithelial":[111],"transition":[112],"(MET)":[114],"Hedgehog":[116],"Pathways":[117],"Inhibitortherapy":[118],"across":[119],"multiple":[120],"lines,":[122],"salvage":[125],"setting,":[126],"as":[128],"part":[129],"novel":[131],"regimens":[132],"combination":[134],"with":[135],"agents.":[138]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}
