{"id":"https://openalex.org/W2053889396","doi":"https://doi.org/10.1038/bjc.1997.572","title":"Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma","display_name":"Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma","publication_year":1997,"publication_date":"1997-12-01","ids":{"openalex":"https://openalex.org/W2053889396","doi":"https://doi.org/10.1038/bjc.1997.572","mag":"2053889396","pmid":"https://pubmed.ncbi.nlm.nih.gov/9400936","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2228174"},"language":"en","primary_location":{"id":"doi:10.1038/bjc.1997.572","doi":"https://doi.org/10.1038/bjc.1997.572","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.1997.572","pdf_url":"https://www.nature.com/articles/bjc1997572.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.nature.com/articles/bjc1997572.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037964830","display_name":"Ivan Bi\u00e8che","orcid":"https://orcid.org/0000-0002-2430-5429","observed_orcids":["https://orcid.org/0000-0002-2430-5429"]},"institutions":[{"id":"https://openalex.org/I4210116453","display_name":"H\u00f4pital Ren\u00e9 Huguenin","ror":"https://ror.org/0263jp665","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210116453"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"I Bi\u00e8che","raw_affiliation_strings":["Laboratoire d'Oncog\u00e9n\u00e9tique, Centre Ren\u00e9 Huguenin, St-Cloud, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Oncog\u00e9n\u00e9tique, Centre Ren\u00e9 Huguenin, St-Cloud, France","institution_ids":["https://openalex.org/I4210116453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110316664","display_name":"Catherine Nogu\u00e8s","orcid":"https://orcid.org/0009-0004-3940-9302","observed_orcids":["https://orcid.org/0009-0004-3940-9302"]},"institutions":[{"id":"https://openalex.org/I4210116453","display_name":"H\u00f4pital Ren\u00e9 Huguenin","ror":"https://ror.org/0263jp665","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210116453"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"C Nogu\u00e8s","raw_affiliation_strings":["Laboratoire d'Oncog\u00e9n\u00e9tique, Centre Ren\u00e9 Huguenin, St-Cloud, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Oncog\u00e9n\u00e9tique, Centre Ren\u00e9 Huguenin, St-Cloud, France","institution_ids":["https://openalex.org/I4210116453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089590978","display_name":"S Rivoilan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116453","display_name":"H\u00f4pital Ren\u00e9 Huguenin","ror":"https://ror.org/0263jp665","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210116453"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"S Rivoilan","raw_affiliation_strings":["Laboratoire d'Oncog\u00e9n\u00e9tique, Centre Ren\u00e9 Huguenin, St-Cloud, France","Laboratoire d'Oncogenetique and 2D6partement de Statistiques M6dicales, Centre Rend Huguenin, 35 rue Daily, F-92211 St-Cloud, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Oncog\u00e9n\u00e9tique, Centre Ren\u00e9 Huguenin, St-Cloud, France","institution_ids":["https://openalex.org/I4210116453"]},{"raw_affiliation_string":"Laboratoire d'Oncogenetique and 2D6partement de Statistiques M6dicales, Centre Rend Huguenin, 35 rue Daily, F-92211 St-Cloud, France","institution_ids":["https://openalex.org/I4210116453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048616949","display_name":"A Khodja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116453","display_name":"H\u00f4pital Ren\u00e9 Huguenin","ror":"https://ror.org/0263jp665","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210116453"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A Khodja","raw_affiliation_strings":["Laboratoire d'Oncog\u00e9n\u00e9tique, Centre Ren\u00e9 Huguenin, St-Cloud, France","Laboratoire d'Oncogenetique and 2D6partement de Statistiques M6dicales, Centre Rend Huguenin, 35 rue Daily, F-92211 St-Cloud, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Oncog\u00e9n\u00e9tique, Centre Ren\u00e9 Huguenin, St-Cloud, France","institution_ids":["https://openalex.org/I4210116453"]},{"raw_affiliation_string":"Laboratoire d'Oncogenetique and 2D6partement de Statistiques M6dicales, Centre Rend Huguenin, 35 rue Daily, F-92211 St-Cloud, France","institution_ids":["https://openalex.org/I4210116453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108425101","display_name":"Alain Latil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116453","display_name":"H\u00f4pital Ren\u00e9 Huguenin","ror":"https://ror.org/0263jp665","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210116453"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A Latil","raw_affiliation_strings":["Laboratoire d'Oncog\u00e9n\u00e9tique, Centre Ren\u00e9 Huguenin, St-Cloud, France","Laboratoire d'Oncogenetique and 2D6partement de Statistiques M6dicales, Centre Rend Huguenin, 35 rue Daily, F-92211 St-Cloud, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Oncog\u00e9n\u00e9tique, Centre Ren\u00e9 Huguenin, St-Cloud, France","institution_ids":["https://openalex.org/I4210116453"]},{"raw_affiliation_string":"Laboratoire d'Oncogenetique and 2D6partement de Statistiques M6dicales, Centre Rend Huguenin, 35 rue Daily, F-92211 St-Cloud, France","institution_ids":["https://openalex.org/I4210116453"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107840518","display_name":"Rosette Lidereau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116453","display_name":"H\u00f4pital Ren\u00e9 Huguenin","ror":"https://ror.org/0263jp665","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210116453"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"R Lidereau","raw_affiliation_strings":["Laboratoire d'Oncog\u00e9n\u00e9tique, Centre Ren\u00e9 Huguenin, St-Cloud, France","Laboratoire d'Oncogenetique and 2D6partement de Statistiques M6dicales, Centre Rend Huguenin, 35 rue Daily, F-92211 St-Cloud, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire d'Oncog\u00e9n\u00e9tique, Centre Ren\u00e9 Huguenin, St-Cloud, France","institution_ids":["https://openalex.org/I4210116453"]},{"raw_affiliation_string":"Laboratoire d'Oncogenetique and 2D6partement de Statistiques M6dicales, Centre Rend Huguenin, 35 rue Daily, F-92211 St-Cloud, France","institution_ids":["https://openalex.org/I4210116453"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5110316664"],"corresponding_institution_ids":["https://openalex.org/I4210116453"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":1.6002,"has_fulltext":true,"cited_by_count":16,"citation_normalized_percentile":{"value":0.81969172,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"76","issue":"11","first_page":"1416","last_page":"1418"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.9810000061988831,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.017400000244379044,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/loss-of-heterozygosity","display_name":"loss of heterozygosity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/brca2","display_name":"BRCA2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/sporadic-breast-cancer","display_name":"sporadic breast cancer","score":0.8610000014305115},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8809999823570251},{"id":"https://openalex.org/keywords/oestrogen-receptor","display_name":"oestrogen receptor","score":0.9539999961853027},{"id":"https://openalex.org/keywords/progesterone-receptor","display_name":"progesterone receptor","score":1.0},{"id":"https://openalex.org/keywords/metastasis-free-survival","display_name":"metastasis-free survival","score":0.996999979019165},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":1.0}],"concepts":[{"id":"https://openalex.org/C143589142","wikidata":"https://www.wikidata.org/wiki/Q2617554","display_name":"Loss of heterozygosity","level":4,"score":0.9417426586151123},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.730659008026123},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6903356313705444},{"id":"https://openalex.org/C3018521938","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast carcinoma","level":4,"score":0.6129492521286011},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5921040177345276},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.5800749063491821},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4922262728214264},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.47216054797172546},{"id":"https://openalex.org/C199163554","wikidata":"https://www.wikidata.org/wiki/Q1681619","display_name":"Univariate","level":3,"score":0.45999062061309814},{"id":"https://openalex.org/C2778001805","wikidata":"https://www.wikidata.org/wiki/Q189961","display_name":"Mammary gland","level":4,"score":0.45977625250816345},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.42994025349617004},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33100464940071106},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3255994915962219},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.256222128868103},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08406275510787964},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08230805397033691},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.07843807339668274},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.05894899368286133},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004273","descriptor_name":"DNA, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019656","descriptor_name":"Loss of Heterozygosity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D024682","descriptor_name":"BRCA2 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1038/bjc.1997.572","doi":"https://doi.org/10.1038/bjc.1997.572","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.1997.572","pdf_url":"https://www.nature.com/articles/bjc1997572.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2228174","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2228174","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Cancer","raw_type":"Text"},{"id":"pmid:9400936","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9400936","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of cancer","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.283.483","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.283.483","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/9f/96/Br_J_Cancer_1997_76(11)_1416-1418.tar.gz","raw_type":"text"}],"best_oa_location":{"id":"doi:10.1038/bjc.1997.572","doi":"https://doi.org/10.1038/bjc.1997.572","is_oa":true,"landing_page_url":"https://doi.org/10.1038/bjc.1997.572","pdf_url":"https://www.nature.com/articles/bjc1997572.pdf","source":{"id":"https://openalex.org/S62966998","display_name":"British Journal of Cancer","issn_l":"0007-0920","issn":["0007-0920","1532-1827"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2053889396.pdf","grobid_xml":"https://content.openalex.org/works/W2053889396.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1513717105","https://openalex.org/W1978669977","https://openalex.org/W1980191680","https://openalex.org/W1982553868","https://openalex.org/W2000437208","https://openalex.org/W2013561673","https://openalex.org/W2022303358","https://openalex.org/W2024986660","https://openalex.org/W2025047211","https://openalex.org/W2030093162","https://openalex.org/W2037954444","https://openalex.org/W2041762036","https://openalex.org/W2047977012","https://openalex.org/W2055294712","https://openalex.org/W2062880333","https://openalex.org/W2079388655","https://openalex.org/W2109465247","https://openalex.org/W2142811240","https://openalex.org/W2323778292","https://openalex.org/W4249792293"],"related_works":["https://openalex.org/W2187682988","https://openalex.org/W1980191680","https://openalex.org/W7097642454","https://openalex.org/W2001966478","https://openalex.org/W6988483369","https://openalex.org/W196588969","https://openalex.org/W2128763186","https://openalex.org/W2022303358","https://openalex.org/W2327013335","https://openalex.org/W2911677414"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
