{"id":"https://openalex.org/W2053883508","doi":"https://doi.org/10.1177/0091270010397051","title":"From Mouse to Man: Predictions of Human Pharmacokinetics of Orally Administered Docetaxel From Preclinical Studies","display_name":"From Mouse to Man: Predictions of Human Pharmacokinetics of Orally Administered Docetaxel From Preclinical Studies","publication_year":2011,"publication_date":"2011-04-20","ids":{"openalex":"https://openalex.org/W2053883508","doi":"https://doi.org/10.1177/0091270010397051","mag":"2053883508","pmid":"https://pubmed.ncbi.nlm.nih.gov/21505085"},"language":"en","primary_location":{"id":"doi:10.1177/0091270010397051","doi":"https://doi.org/10.1177/0091270010397051","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0091270010397051","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065885053","display_name":"Stijn L.W. Koolen","orcid":"https://orcid.org/0000-0002-0973-7530","observed_orcids":["https://orcid.org/0000-0002-0973-7530"]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"S. L. W. Koolen","raw_affiliation_strings":["Slotervaart Hospital, Department of Pharmacy and Pharmacology, Louwesweg 6, 1066 EC Amsterdam, The Netherlands. s.koolen@nki.nl","Divisions of Clinical Pharmacology, The Netherlands Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Slotervaart Hospital, Department of Pharmacy and Pharmacology, Louwesweg 6, 1066 EC Amsterdam, The Netherlands. s.koolen@nki.nl","institution_ids":["https://openalex.org/I2802065108"]},{"raw_affiliation_string":"Divisions of Clinical Pharmacology, The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064255458","display_name":"Robert A.B. van Waterschoot","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"R. A. B. van Waterschoot","raw_affiliation_strings":["Molecular Biology, The Netherlands Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology, The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034151807","display_name":"Olaf van Tellingen","orcid":"https://orcid.org/0000-0002-1037-6269","observed_orcids":["https://orcid.org/0000-0002-1037-6269"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"O. van Tellingen","raw_affiliation_strings":["Clinical Chemistry, The Netherlands Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Chemistry, The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045217576","display_name":"Alfred H. Schinkel","orcid":"https://orcid.org/0000-0002-4215-8602","observed_orcids":["https://orcid.org/0000-0002-4215-8602"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. H. Schinkel","raw_affiliation_strings":["Molecular Biology, The Netherlands Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Biology, The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062227574","display_name":"Jos H. Beijnen","orcid":"https://orcid.org/0000-0003-0118-561X","observed_orcids":["https://orcid.org/0000-0003-0118-561X"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. H. Beijnen","raw_affiliation_strings":["Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute/Slotervaart Hospital","Division of Drug Toxicology, Section of Biomedical Analysis, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands","Divisions of Clinical Pharmacology, The Netherlands Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy & Pharmacology, The Netherlands Cancer Institute/Slotervaart Hospital","institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Division of Drug Toxicology, Section of Biomedical Analysis, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Divisions of Clinical Pharmacology, The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000418012","display_name":"Jan H.M. Schellens","orcid":"https://orcid.org/0000-0001-6832-1976","observed_orcids":["https://orcid.org/0000-0001-6832-1976"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J. H. M. Schellens","raw_affiliation_strings":["Division of Drug Toxicology, Section of Biomedical Analysis, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands","Divisions of Clinical Pharmacology, The Netherlands Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Drug Toxicology, Section of Biomedical Analysis, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Divisions of Clinical Pharmacology, The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2898336195"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010531755","display_name":"Alwin D. R. Huitema","orcid":"https://orcid.org/0000-0003-1939-4639","observed_orcids":["https://orcid.org/0000-0003-1939-4639"]},"institutions":[{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A. D. R. Huitema","raw_affiliation_strings":["Divisions of Clinical Pharmacology, The Netherlands Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Divisions of Clinical Pharmacology, The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2898336195"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5065885053"],"corresponding_institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.4343,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.57575413,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"52","issue":"3","first_page":"370","last_page":"380"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.04520000144839287,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":1.0},{"id":"https://openalex.org/keywords/oral-pharmacokinetics","display_name":"oral pharmacokinetics","score":0.7739999890327454},{"id":"https://openalex.org/keywords/human-pharmacokinetic-prediction","display_name":"human pharmacokinetic prediction","score":0.8159999847412109},{"id":"https://openalex.org/keywords/cyp3a","display_name":"CYP3A","score":0.8050000071525574},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9269999861717224},{"id":"https://openalex.org/keywords/ritonavir","display_name":"ritonavir","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cyp3a-inhibition","display_name":"CYP3A inhibition","score":0.7879999876022339},{"id":"https://openalex.org/keywords/drug-efflux","display_name":"drug efflux","score":0.6039999723434448},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.6050000190734863},{"id":"https://openalex.org/keywords/allometric-scaling","display_name":"allometric scaling","score":0.7160000205039978},{"id":"https://openalex.org/keywords/nonlinear-mixed-effects-models","display_name":"nonlinear mixed-effects models","score":0.8830000162124634},{"id":"https://openalex.org/keywords/oral-anticancer-drugs","display_name":"oral anticancer drugs","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.9667240381240845},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.8457891345024109},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7829729914665222},{"id":"https://openalex.org/C11824378","wikidata":"https://www.wikidata.org/wiki/Q5014970","display_name":"CYP3A","level":4,"score":0.7176059484481812},{"id":"https://openalex.org/C2778707650","wikidata":"https://www.wikidata.org/wiki/Q412902","display_name":"P-glycoprotein","level":4,"score":0.6616364121437073},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6110968589782715},{"id":"https://openalex.org/C2779298103","wikidata":"https://www.wikidata.org/wiki/Q422618","display_name":"Ritonavir","level":5,"score":0.4984447956085205},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.44491708278656006},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3275424838066101},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3021284341812134},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2704109847545624},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2523358464241028},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.16102755069732666},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.10964974761009216},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1054307222366333},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.07934725284576416},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.0},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004353","descriptor_name":"Drug Evaluation, Preclinical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019438","descriptor_name":"Ritonavir","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020168","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B, Member 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D065607","descriptor_name":"Cytochrome P-450 Enzyme Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/0091270010397051","doi":"https://doi.org/10.1177/0091270010397051","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0091270010397051","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:21505085","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21505085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W74649421","https://openalex.org/W103833911","https://openalex.org/W152943885","https://openalex.org/W1492229869","https://openalex.org/W1834241234","https://openalex.org/W1883813157","https://openalex.org/W1965479467","https://openalex.org/W1974574813","https://openalex.org/W1977059612","https://openalex.org/W1997211805","https://openalex.org/W2006522017","https://openalex.org/W2025612288","https://openalex.org/W2032268660","https://openalex.org/W2042094602","https://openalex.org/W2047120948","https://openalex.org/W2050088084","https://openalex.org/W2054044100","https://openalex.org/W2066464642","https://openalex.org/W2077159622","https://openalex.org/W2087478209","https://openalex.org/W2091698470","https://openalex.org/W2094434087","https://openalex.org/W2094775362","https://openalex.org/W2102536616","https://openalex.org/W2120416054","https://openalex.org/W2126871433","https://openalex.org/W2145962128","https://openalex.org/W2150549589","https://openalex.org/W2155315199","https://openalex.org/W2169965478","https://openalex.org/W2582743722","https://openalex.org/W4233628679","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W1883813157","https://openalex.org/W2032268660","https://openalex.org/W2095019580","https://openalex.org/W1834241234","https://openalex.org/W2980223320","https://openalex.org/W1983044168","https://openalex.org/W3124580747","https://openalex.org/W2000200648","https://openalex.org/W2170429725","https://openalex.org/W3017061365"],"abstract_inverted_index":{"Intravenously":[0],"administered":[1],"docetaxel":[2,29,59,154],"is":[3,20],"approved":[4],"for":[5],"the":[6,33,36,44,56,108,128],"treatment":[7],"of":[8,11,28,35,52,58,92,107,153],"various":[9],"types":[10],"cancer.":[12],"An":[13],"oral":[14],"regimen,":[15],"in":[16,23,62,120,156],"combination":[17],"with":[18,82,115,143],"ritonavir,":[19],"being":[21],"evaluated":[22],"clinical":[24,144],"trials.":[25],"The":[26,50,90,105],"pharmacokinetics":[27,57],"are":[30],"determined":[31],"by":[32],"activity":[34],"metabolizing":[37],"enzyme":[38],"cytochrome":[39],"P450":[40],"3A":[41],"(CYP3A)":[42],"and":[43,99,124,139],"drug":[45],"efflux":[46],"transporter":[47],"P-glycoprotein":[48],"(P-gp).":[49],"effects":[51],"these":[53,77,93],"proteins":[54],"on":[55],"were":[60,97],"investigated":[61],"different":[63],"mouse":[64],"models":[65],"that":[66],"lack":[67],"1":[68],"or":[69,80,83],"both":[70],"detoxifying":[71],"systems.":[72],"Docetaxel":[73],"was":[74,130,141],"given":[75],"to":[76,132,150],"mice":[78],"orally":[79],"intravenously":[81],"without":[84],"a":[85,117],"strong":[86],"CYP3A":[87],"inhibitor,":[88],"ritonavir.":[89],"data":[91],"2":[94],"preclinical":[95,109],"studies":[96,110],"pooled":[98],"analyzed":[100],"using":[101,136],"nonlinear":[102],"mixed-effects":[103],"modeling.":[104],"results":[106],"could":[111],"be":[112],"integrated":[113],"successfully,":[114],"only":[116],"small":[118],"difference":[119],"residual":[121],"error":[122],"(33%":[123],"26%,":[125],"respectively).":[126],"Subsequently,":[127],"model":[129,148],"used":[131],"predict":[133],"human":[134],"exposure":[135,155],"allometric":[137],"scaling":[138],"this":[140],"compared":[142],"trial":[145],"data.":[146],"This":[147],"led":[149],"adequate":[151],"predictions":[152],"humans.":[157]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}